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Gene: Taf12 MGI:1913714

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Gene Summary

Name:
TATA-box binding protein associated factor 12
Synonyms:
Taf2J,  2810422D08Rik,  20kDa

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal neural tube morphology Taf12em1(IMPC)Mbp HET E9.5 0.00
embryonic lethality prior to organogenesis Taf12em1(IMPC)Mbp HOM   E9.5 0.00
abnormal hindbrain development Taf12em1(IMPC)Mbp HET E9.5 0.00
abnormal neural tube closure Taf12em1(IMPC)Mbp HET E9.5 0.00
preweaning lethality, complete penetrance Taf12em1(IMPC)Mbp HOM   Early adult 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

27 Images

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Gross Morphology Embryo E9.5

Images

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

69 Images

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Human diseases caused by Taf12 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Taf12 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Neural tube defect OMIM:615041
Spina Bifida-Hypospadias Syndrome
Spina bifida, Spinal dysraphism ORPHA:3176
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Hydrocephalus, Congenital, 5, Susceptibility To
Aqueductal stenosis, Noncommunicating hydrocephalus OMIM:620241
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Craniorachischisis
Cervical spina bifida, Myelomeningocele, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Microtia-Anotia
Holoprosencephaly OMIM:600674
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Isolated Posterior Meningocele
Hydrocephalus, Lipomyelomeningocele, Meningocele, Neural tube defect, Occipital meningocele ORPHA:268810
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Alg3-Cdg
Neural tube defect ORPHA:79321
Sacral Defect With Anterior Meningocele
Myeloschisis, Myelomeningocele, Meningocele, Hydrocephalus, Dermal sinus tract OMIM:600145
Semilobar Holoprosencephaly
Neural tube defect, Hydrocephalus ORPHA:220386
Alobar Holoprosencephaly
Neural tube defect, Hydrocephalus ORPHA:93925
Midline Interhemispheric Variant Of Holoprosencephaly
Neural tube defect, Hydrocephalus ORPHA:93926
Lobar Holoprosencephaly
Neural tube defect, Hydrocephalus ORPHA:93924
Schinzel-Giedion Syndrome
Neural tube defect, Umbilical hernia ORPHA:798

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Taf12

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Taf12.

No publications found that use IMPC mice or data for Taf12.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Taf12tm1(KOMP)Mbp Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Taf12em1(IMPC)Mbp Intra-exon deletion Mice, Tissue

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