Gene Summary

Name:
NADH:ubiquinone oxidoreductase complex assembly factor 8
Synonyms:
1810043H04Rik

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal forebrain development Ndufaf8em1(IMPC)Bay HOM E9.5 0.00
preweaning lethality, complete penetrance Ndufaf8em1(IMPC)Bay HOM   Early adult 0.00
embryonic growth retardation Ndufaf8em1(IMPC)Bay HOM E9.5 0.00
abnormal heart morphology Ndufaf8em1(IMPC)Bay HOM E9.5 0.00
abnormal midbrain development Ndufaf8em1(IMPC)Bay HOM E9.5 0.00
abnormal embryo size Ndufaf8em1(IMPC)Bay HET E12.5 0.00
embryonic lethality prior to tooth bud stage Ndufaf8em1(IMPC)Bay HOM   E12.5 0.00
embryonic growth retardation Ndufaf8em1(IMPC)Bay HET E12.5 0.00
abnormal embryo size Ndufaf8em1(IMPC)Bay HOM E9.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of right fundus

14 Images

Eye Morphology

VIP of right eye

14 Images

Eye Morphology

VIP of left fundus

14 Images

MicroCT E9.5

Embryo reconstruction

3 Images

Eye Morphology

VIP of left eye

14 Images

Human diseases caused by Ndufaf8 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ndufaf8 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Mitochondrial Complex I Deficiency, Nuclear Type 34
Intrauterine growth retardation OMIM:618776
Isolated Complex I Deficiency
Intrauterine growth retardation, Hypertrophic cardiomyopathy ORPHA:2609

The table below shows human diseases predicted to be associated to Ndufaf8 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Mitochondrial Complex I Deficiency, Nuclear Type 34
Intrauterine growth retardation OMIM:618776
Aprosencephaly And Cerebellar Dysgenesis
Aprosencephaly OMIM:601374
Isolated Complex I Deficiency
Intrauterine growth retardation, Hypertrophic cardiomyopathy ORPHA:2609

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ndufaf8

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ndufaf8.

No publications found that use IMPC mice or data for Ndufaf8.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ndufaf8em1(IMPC)Bay Exon Deletion Mice
Ndufaf8tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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