Gene Summary

Name:
guanosine monophosphate reductase
Synonyms:
2310004P21Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Gmprem1(IMPC)Bay HOM   Early adult 0.00
abnormal zygomatic bone morphology Gmprem1(IMPC)Bay HOM   Early adult 4.91×10-05
abnormal eye anterior chamber depth Gmprem1(IMPC)Bay HOM Early adult 4.28×10-07

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Forepaw

9 Images

Eye Morphology

VIP of right fundus

4 Images

Eye Morphology

VIP of left eye

4 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

9 Images

Eye Morphology

VIP of left fundus

4 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Skull Lateral Orientation

9 Images

Eye Morphology

VIP of right eye

4 Images

Human diseases caused by Gmpr mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Gmpr by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Nephrogenic Diabetes Insipidus-Intracranial Calcification-Facial Dysmorphism Syndrome
Supernumerary tooth, Carious teeth, Micrognathia, Hypoplasia of the zygomatic bone ORPHA:3145
Intellectual Disability-Short Stature-Hypertelorism Syndrome
Hypoplasia of the zygomatic bone ORPHA:3074
Teeth, Noneruption Of, With Maxillary Hypoplasia And Genu Valgum
Multiple non-erupting secondary teeth, Delayed eruption of primary teeth, Eruption failure, Maxil... OMIM:273050
Pectus Excavatum-Macrocephaly-Dysplastic Nails Syndrome
Hypoplasia of the zygomatic bone ORPHA:2835
Severe Oculo-Renal-Cerebellar Syndrome
Cataract, Mandibular prognathia, Hypoplasia of the zygomatic bone ORPHA:2715
Aortic Arch Anomaly-Facial Dysmorphism-Intellectual Disability Syndrome
Carious teeth, Mandibular prognathia, Hypoplasia of the zygomatic bone ORPHA:1110
Distal 17P13.1 Microdeletion Syndrome
Retrognathia, Hypoplasia of the zygomatic bone ORPHA:319171
Toluene Embryopathy
Micrognathia, Hypoplasia of the zygomatic bone ORPHA:1920
Facial Dysmorphism-Shawl Scrotum-Joint Laxity Syndrome
Mandibular prognathia, Hypoplasia of the zygomatic bone ORPHA:1778
Marshall Syndrome
Ectopia lentis, Cataract, Hypoplasia of the zygomatic bone, Micrognathia, Hypoplasia of the maxilla ORPHA:560
Nager Syndrome
Micrognathia, Hypoplasia of the zygomatic bone, Hypoplasia of the maxilla ORPHA:245
Pfeiffer Syndrome
Mandibular prognathia, Hypoplasia of the zygomatic bone ORPHA:710
Dysostosis, Stanescu Type
Carious teeth, Abnormal dental enamel morphology, Hypoplasia of the zygomatic bone, Hypoplasia of... ORPHA:1798
Brachytelephalangy-Dysmorphism-Kallmann Syndrome
Hypoplasia of the zygomatic bone ORPHA:1295
Cleidocranial Dysplasia
Delayed eruption of teeth, Carious teeth, Abnormal dental enamel morphology, Mandibular prognathi... ORPHA:1452
X-Linked Mandibulofacial Dysostosis
Micrognathia, Hypoplasia of the zygomatic bone ORPHA:1131
Acrofacial Dysostosis, Catania Type
Microretrognathia, Carious teeth, Hypoplasia of the zygomatic bone ORPHA:1786
Cleft Lip/Palate-Ectodermal Dysplasia Syndrome
Micrognathia, Carious teeth, Abnormal dental enamel morphology, Hypoplasia of the zygomatic bone ORPHA:3253
Prolidase Deficiency
Carious teeth, Micrognathia, Hypoplasia of the zygomatic bone ORPHA:742
Ectodermal Dysplasia-Intellectual Disability-Central Nervous System Malformation Syndrome
Abnormal dental enamel morphology, Retrognathia, Hypoplasia of the zygomatic bone ORPHA:1812
Flat Face-Microstomia-Ear Anomaly Syndrome
Micrognathia, Hypoplasia of the zygomatic bone ORPHA:1968
Cohen Syndrome
Micrognathia, Iris coloboma, Hypoplasia of the zygomatic bone, Hypoplasia of the maxilla ORPHA:193
Antley-Bixler Syndrome
Hypoplasia of the zygomatic bone ORPHA:83
Treacher-Collins Syndrome
Abnormal dental enamel morphology, Iris coloboma, Cataract, Hypoplasia of the zygomatic bone, Ret... ORPHA:861
Acro-Renal-Mandibular Syndrome
Micrognathia, Hypoplasia of the zygomatic bone ORPHA:958
Cutis Gyrata-Acanthosis Nigricans-Craniosynostosis Syndrome
Hypoplasia of the zygomatic bone ORPHA:1555
Ablepharon Macrostomia Syndrome
Corneal erosion, Corneal opacity, Hypoplasia of the zygomatic bone, Hypoplasia of the maxilla ORPHA:920
Hajdu-Cheney Syndrome
Iris coloboma, Cataract, Hypoplasia of the zygomatic bone, Micrognathia, Abnormality of the mandible ORPHA:955
Cardiofaciocutaneous Syndrome
Hypoplasia of the zygomatic bone ORPHA:1340
Holoprosencephaly
Iris coloboma, Hypoplasia of the zygomatic bone ORPHA:2162
Hypoglossia-Hypodactyly Syndrome
Micrognathia, Hypoplasia of the zygomatic bone ORPHA:989
Orofaciodigital Syndrome Type 1
Abnormal dental enamel morphology, Micrognathia, Hypoplasia of the zygomatic bone ORPHA:2750
Pancreatic Agenesis-Holoprosencephaly Syndrome
Hypoplasia of the zygomatic bone ORPHA:556955
Williams Syndrome
Abnormal dental enamel morphology, Carious teeth, Posterior embryotoxon, Aplasia/Hypoplasia of th... ORPHA:904
Charge Syndrome
Delayed eruption of teeth, Iris coloboma, Hypoplasia of the zygomatic bone ORPHA:138

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Gmpr

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Gmpr.

No publications found that use IMPC mice or data for Gmpr.

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MGI Allele Allele Type Produced
Gmprtm42454(L1L2_Pgk_PM) Targeting vectors
Gmprem1(IMPC)Bay Exon Deletion Mice
Gmprtm2a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Gmprtm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Gmprtm42454(L1L2_gt0) Targeting vectors

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