Genes Phenotypes

Gene: Smurf2

Name
SMAD specific E3 ubiquitin protein ligase 2
MGI ID
MGI:1913563
Synonyms
2810411E22Rik
Viability
Homozygous - Subviable
Other links
MGI   Ensembl  
Significant phenotypes (7) All measurements (370) Expression & images (67) Disease models (0) Histopathology (1) Order (2)
View data by physiological system
Significant
Not Significant
Not tested
Body weight
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Smurf2tm1b(EUCOMM)Wtsi HOM n/a 0.00
decreased hemoglobin content Smurf2tm1b(EUCOMM)Wtsi HET postnatal 3.45×10-06
decreased hemoglobin content Smurf2tm1b(EUCOMM)Wtsi HOM postnatal 1.80×10-10
decreased lean body mass Smurf2tm1b(EUCOMM)Wtsi HOM postnatal 3.54×10-06
abnormal head size Smurf2tm1b(EUCOMM)Wtsi HOM postnatal 3.41×10-05
thrombocytopenia Smurf2tm1b(EUCOMM)Wtsi HET postnatal 3.32×10-06
increased heart weight Smurf2tm1b(EUCOMM)Wtsi HET postnatal 8.59×10-07

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415)  (1/2)  Wholemount images
Eye 2 No  (1/2)  Wholemount images
Gall bladder 2 No N/A
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (1/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2)  Wholemount images
Trachea 2 No N/A
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (2)
Heart expression
Aorta expression
MA:0000072
MA:0000062
digestive system (3)
Esophagus expression
Stomach expression
MA:0000352
MA:0000353
endocrine system (1)
Thyroid gland expression
MA:0000129
postnatal mouse (12)
Esophagus expression
Stomach expression
MA:0000352
MA:0000353
reproductive system (2)
Ovary expression
Oviduct expression
Uterus expression
MA:0000384
MA:0000385
MA:0000389
respiratory system (1)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
trunk (8)
Esophagus expression
Stomach expression
MA:0000352
MA:0000353
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/485)  (3/4) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485)  (4/4) N/A
Eye 2  (1/485)  (1/4) N/A
Foot 2  (1/485)  (1/4) N/A
Forebrain 2  (1/485)  (2/4) N/A
Forelimb 2  (1/485)  (2/4) N/A
Hand 2  (1/485)  (1/4) N/A
Head 2  (5/485)  (3/4) N/A
Heart 2  (1/485)  (2/4) N/A
Hindbrain 2  (6/485)  (2/4) N/A
Hindlimb 2  (1/485)  (3/4) N/A
Liver 2  (1/485)  (1/4) N/A
Lung 2  (1/485)  (1/4) N/A
Mandibular process 2  (1/485)  (1/4) N/A
Maxillary process 2  (1/485)  (1/4) N/A
Midbrain 2  (1/485)  (2/4) N/A
Oral cavity 2  (1/485) N/A
Skin 2  (1/485)  (1/4) N/A
Tail 2  (1/485)  (2/4) N/A
Tail somite 2  (1/485) N/A

 Associated Images

X-ray: XRay Images Lateral Orientation
19 Images
Embryo LacZ: LacZ images wholemount
8 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
18 Images
X-ray: XRay Images Dorso Ventral
19 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Adult LacZ: LacZ Images Wholemount
12 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - inflammation Smurf2tm1b(EUCOMM)Wtsi HOM postnatal

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Smurf2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Smurf2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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