Genes Phenotypes

Gene: Smurf2

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Name
SMAD specific E3 ubiquitin protein ligase 2
MGI ID
MGI:1913563
Synonyms
2810411E22Rik
Viability
Homozygous - Subviable
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (1) Measurements chart (24) All data table (301)
Expression & images (67) Disease models (0) Histopathology (1) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Smurf2tm1b(EUCOMM)Wtsi HOM Early adult 0.00

Download data as:  TSV  XLS

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Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584) N/A
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No N/A
Brain 2 No N/A
Brainstem 2 No N/A
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No N/A
Cerebellum 2 No N/A
Cerebral cortex 2 No N/A
Esophagus 2 No  (7/415)  (1/2)  Wholemount images
Eye 2 No  (1/2)  Wholemount images
Gall bladder 2 No N/A
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No N/A
Hypothalamus 2 No N/A
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (1/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No N/A
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584) N/A
Parathyroid gland 2 No N/A
Peripheral nervous system 2 No N/A
Peyer's patch 2 No N/A
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584) N/A
Skeletal muscle 2 No N/A
Skin 2 No N/A
Small intestine 2 No  (9/584)  (2/2)  Wholemount images
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No N/A
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584)  (1/2)  Wholemount images
Trachea 2 No N/A
Uterus 2 No  (1/2)  Wholemount images
Vascular system 2 No  (2/2)  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (2)
Heart expression
Aorta expression
MA:0000072
MA:0000062
digestive system (3)
Esophagus expression
Stomach expression
MA:0000352
MA:0000353
endocrine system (1)
Thyroid gland expression
MA:0000129
postnatal mouse (12)
Esophagus expression
Stomach expression
MA:0000352
MA:0000353
reproductive system (2)
Ovary expression
Oviduct expression
Uterus expression
MA:0000384
MA:0000385
MA:0000389
respiratory system (1)
Lung expression
MA:0000415
sensory organ (1)
Eye expression
MA:0000261
trunk (8)
Esophagus expression
Stomach expression
MA:0000352
MA:0000353
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Brain 2  (6/504)  (3/4) N/A
Ear 2  (1/504) N/A
Embryo 2  (1/505)  (4/4) N/A
Eye 2  (1/504)  (1/4) N/A
Foot 2  (1/504)  (1/4) N/A
Forebrain 2  (1/504)  (2/4) N/A
Forelimb 2  (1/504)  (2/4) N/A
Hand 2  (1/503)  (1/4) N/A
Head 2  (5/504)  (3/4) N/A
Heart 2  (1/504)  (2/4) N/A
Hindbrain 2  (6/504)  (2/4) N/A
Hindlimb 2  (1/503)  (3/4) N/A
Liver 2  (1/504)  (1/4) N/A
Lung 2  (1/500)  (1/4) N/A
Mandibular process 2  (1/504)  (1/4) N/A
Maxillary process 2  (1/504)  (1/4) N/A
Midbrain 2  (1/504)  (2/4) N/A
Oral cavity 2  (1/504) N/A
Skin 2  (1/504)  (1/4) N/A
Tail 2  (1/504)  (2/4) N/A
Tail somite 2  (1/504) N/A

 Associated Images

Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Adult LacZ: LacZ Images Wholemount
12 Images
Embryo LacZ: LacZ images wholemount
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - inflammation Smurf2tm1b(EUCOMM)Wtsi HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Smurf2tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Smurf2tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice

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