banner
Genes Phenotypes Help, News, Blog

Gene: Tmem9 MGI:1913491

Log in to follow

Gene Summary

Name:
transmembrane protein 9
Synonyms:
1500015G18Rik

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased body weight Tmem9tm1a(EUCOMM)Wtsi HOM Early adult 1.82×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images
Tmem9tm1a(EUCOMM)Wtsi
body, WT, Female, WTSI
Tmem9tm1a(EUCOMM)Wtsi
head, WT, Female, WTSI
Tmem9tm1a(EUCOMM)Wtsi
head, WT, Female, WTSI
Tmem9tm1a(EUCOMM)Wtsi
forearm, WT, Female, WTSI
Tmem9tm1a(EUCOMM)Wtsi
forearm, WT, Female, WTSI

View all 169 images

Tmem9tm1a(EUCOMM)Wtsi
eye, fused cornea and lens, corneal opacity, corneal vascularization, HOM, Female, WTSI
Tmem9tm1a(EUCOMM)Wtsi
eye, abnormal pupil morphology, corneal opacity, fused cornea and lens, abnormal placement of pupils, impaired pupillary reflex, HOM, Female, WTSI
Tmem9tm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI
Tmem9tm1a(EUCOMM)Wtsi
back skin, HOM, Female, WTSI

Human diseases caused by Tmem9 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tmem9

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tmem9.

There are 14 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression. Cellular signalling (January 2024) Tmem97tm1.1(KOMP)Vlcg 38290642
Highly specific σ2R/TMEM97 ligand FEM-1689 alleviates neuropathic pain and inhibits the integrated stress response. Proceedings of the National Academy of Sciences of the United States of America (December 2023) Tmem97tm1(KOMP)Vlcg PMC10756276
σ2R/TMEM97 in retinal ganglion cell degeneration. Scientific reports (December 2022) Tmem97tm1(KOMP)Vlcg PMC9715665
Differential Responses to Sigma-1 or Sigma-2 Receptor Ablation in Adiposity, Fat Oxidation, and Sexual Dimorphism. International journal of molecular sciences (September 2022) Tmem97tm1.1(KOMP)Vlcg PMC9506228
TMEM97 ablation aggravates oxidant-induced retinal degeneration. Cellular signalling (July 2021) Tmem97tm1.1(KOMP)Vlcg 34245862
The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception. Molecular brain (November 2020) Tmem97tm1.1(KOMP)Vlcg PMC7659117
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Tmem98tm1a(EUCOMM)Wtsi PMC7263671
TMEM9-v-ATPase Activates Wnt/β-Catenin Signaling via APC Lysosomal Degradation for Liver Regeneration and Tumorigenesis. Hepatology (Baltimore, Md.) (May 2020) Tmem9tm1d(EUCOMM)Wtsi 32380568
The nanophthalmos protein TMEM98 inhibits MYRF self-cleavage and is required for eye size specification. PLoS genetics (April 2020) Tmem98tm1a(EUCOMM)Wtsi Tmem98tm1b(EUCOMM)Wtsi Tmem98tm1c(EUCOMM)Wtsi Tmem98tm1d(EUCOMM)Wtsi PMC7153906
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Tmem9tm1a(EUCOMM)Wtsi Tmem98tm1a(EUCOMM)Wtsi Tmem98tm1a(EUCOMM)Wtsi PMC6671969
Missense Mutations in the Human Nanophthalmos Gene TMEM98 Cause Retinal Defects in the Mouse. Investigative ophthalmology & visual science (July 2019) Tmem98tm1a(EUCOMM)Wtsi Tmem98tm1b(EUCOMM)Wtsi 31266059
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Tmem9tm1a(EUCOMM)Wtsi Tmem98tm1a(EUCOMM)Wtsi PMC6459510
TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling. Nature cell biology (October 2018) Tmem9tm1c(EUCOMM)Wtsi Tmem9tm1a(EUCOMM)Wtsi Tmem9tm1d(EUCOMM)Wtsi 30374053
Novel skin phenotypes revealed by a genome-wide mouse reverse genetic screen. Nature communications (April 2014) Tmem98tm1a(EUCOMM)Wtsi PMC3996542

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Tmem9tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter