Gene Summary

Name:
trafficking protein particle complex 2
Synonyms:
1110066L09Rik,  Sedl,  MIP-2A,  TRS20,  1810064C02Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased bronchoconstrictive response Trappc2tm1.1(KOMP)Vlcg HEM Early adult 0.00
increased pulmonary ventilation Trappc2tm1.1(KOMP)Vlcg HEM Early adult 0.00
hydrometra Trappc2tm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased pulmonary ventilation Trappc2tm1.1(KOMP)Vlcg HOM Early adult 0.00
decreased pulmonary ventilation Trappc2tm1.1(KOMP)Vlcg HEM Early adult 0.00
decreased body length Trappc2tm1.1(KOMP)Vlcg HEM Early adult 0.00

Download data as:  TSV  XLS

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Viewing: all phenotypes
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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland  Section images hemizygote 100% (1 of 1)
Adrenal gland  Section images heterozygote 100% (1 of 1)
Aorta  Section images hemizygote 100% (1 of 1)
Blood  Section images hemizygote 100% (1 of 1)
Blood  Section images heterozygote 100% (1 of 1)
Bone marrow  Section images hemizygote 100% (1 of 1)
Bone marrow  Section images heterozygote 100% (1 of 1)
Brown adipose tissue  Section images hemizygote 100% (1 of 1)
Brown adipose tissue  Section images heterozygote 100% (1 of 1)
Cecum  Section images hemizygote 100% (1 of 1)
Cerebellum  Section images hemizygote 100% (1 of 1)
Cerebellum  Section images heterozygote 100% (1 of 1)
Colon  Section images hemizygote 100% (1 of 1)
Colon  Section images heterozygote 100% (1 of 1)
Duodenum  Section images hemizygote 100% (1 of 1)
Duodenum  Section images heterozygote 100% (1 of 1)
Epididymis  Section images hemizygote 100% (1 of 1)
Esophagus  Section images hemizygote 100% (1 of 1)
Esophagus  Section images heterozygote 100% (1 of 1)
Eye  Section images hemizygote 100% (1 of 1)
Eye  Section images heterozygote 100% (1 of 1)
Harderian gland  Section images heterozygote 100% (1 of 1)
Ileum  Section images hemizygote 100% (1 of 1)
Ileum  Section images heterozygote 100% (1 of 1)
Jejunum  Section images hemizygote 100% (1 of 1)
Kidney  Section images hemizygote 100% (1 of 1)
Kidney  Section images heterozygote 100% (1 of 1)
Lung  Section images hemizygote 100% (1 of 1)
Lung  Section images heterozygote 100% (1 of 1)
Mesenteric adipose tissue  Section images hemizygote 100% (1 of 1)
Midbrain  Section images hemizygote 100% (1 of 1)
Midbrain  Section images heterozygote 100% (1 of 1)
Olfactory lobe  Section images hemizygote 100% (1 of 1)
Olfactory lobe  Section images heterozygote 100% (1 of 1)
Oviduct  Section images heterozygote 100% (1 of 1)
Pancreas  Section images hemizygote 100% (1 of 1)
Parathyroid gland  Section images hemizygote 100% (1 of 1)
Parotid gland  Section images hemizygote 100% (1 of 1)
Penis  Section images hemizygote 100% (1 of 1)
Pituitary gland  Section images hemizygote 100% (1 of 1)
Pituitary gland  Section images heterozygote 100% (1 of 1)
Prostate gland  Section images hemizygote 100% (1 of 1)
Quadriceps  Section images hemizygote 100% (1 of 1)
Skin  Section images hemizygote 100% (1 of 1)
Skin  Section images heterozygote 100% (1 of 1)
Spinal cord  Section images hemizygote 100% (1 of 1)
Spinal cord  Section images heterozygote 100% (1 of 1)
Spleen  Section images hemizygote 100% (1 of 1)
Stomach  Section images hemizygote 100% (1 of 1)
Stomach  Section images heterozygote 100% (1 of 1)
Sublingual gland  Section images hemizygote 100% (1 of 1)
Submandibular gland  Section images hemizygote 100% (1 of 1)
Testis  Section images hemizygote 100% (1 of 1)
Thymus  Section images hemizygote 100% (1 of 1)
Thymus  Section images heterozygote 100% (1 of 1)
Thyroid gland  Section images hemizygote 100% (1 of 1)
Tongue  Section images hemizygote 100% (1 of 1)
Tongue  Section images heterozygote 100% (1 of 1)
Trachea  Section images heterozygote 100% (1 of 1)
Trigeminal V nerve  Section images hemizygote 100% (1 of 1)
Trigeminal V nerve  Section images heterozygote 100% (1 of 1)
Urinary bladder  Section images hemizygote 100% (1 of 1)
Urinary bladder  Section images heterozygote 100% (1 of 1)
Uterus  Section images heterozygote 100% (1 of 1)
Vagina  Section images heterozygote 100% (1 of 1)
Vas deferens  Section images hemizygote 100% (1 of 1)
Vesicular gland  Section images hemizygote 100% (1 of 1)
Aorta N/A heterozygote Not available
Brain N/A hemizygote 100% (1 of 1)
Brain N/A heterozygote 100% (1 of 1)
Brainstem N/A hemizygote Not available
Brainstem N/A heterozygote Not available
Cartilage tissue N/A hemizygote Not available
Cartilage tissue N/A heterozygote Not available
Cecum N/A heterozygote Not available
Cerebral cortex N/A hemizygote Not available
Cerebral cortex N/A heterozygote Not available
Chest bone N/A hemizygote Not available
Chest bone N/A heterozygote Not available
Diaphragm N/A hemizygote 0.0% (0 of 1)
Diaphragm N/A heterozygote 0.0% (0 of 1)
Epididymis N/A heterozygote Not available
Gall bladder N/A hemizygote Not available
Gall bladder N/A heterozygote Not available
Gonadal fat pad N/A hemizygote 0.0% (0 of 1)
Gonadal fat pad N/A heterozygote 0.0% (0 of 1)
Harderian gland N/A hemizygote 0.0% (0 of 1)
Heart N/A hemizygote Not available
Heart N/A heterozygote Not available
Hindlimb N/A hemizygote Not available
Hindlimb N/A heterozygote Not available
Hippocampus N/A hemizygote Not available
Hippocampus N/A heterozygote Not available
Hypothalamus N/A hemizygote Not available
Hypothalamus N/A heterozygote Not available
Jejunum N/A heterozygote Not available
Large intestine N/A hemizygote 100% (1 of 1)
Large intestine N/A heterozygote 100% (1 of 1)
Liver N/A hemizygote 0.0% (0 of 1)
Liver N/A heterozygote 0.0% (0 of 1)
Lower urinary tract N/A hemizygote Not available
Lower urinary tract N/A heterozygote Not available
Lymph node N/A hemizygote Not available
Lymph node N/A heterozygote Not available
Mammary gland N/A hemizygote Not available
Mammary gland N/A heterozygote Not available
Mesenteric adipose tissue N/A heterozygote 0.0% (0 of 1)
Mesenteric lymph node N/A hemizygote 0.0% (0 of 1)
Mesenteric lymph node N/A heterozygote 0.0% (0 of 1)
Ovary N/A hemizygote Not available
Ovary N/A heterozygote Not available
Oviduct N/A hemizygote Not available
Pancreas N/A heterozygote 0.0% (0 of 1)
Parathyroid gland N/A heterozygote 0.0% (0 of 1)
Parotid gland N/A heterozygote 0.0% (0 of 1)
Penis N/A heterozygote Not available
Peripheral nervous system N/A hemizygote Not available
Peripheral nervous system N/A heterozygote Not available
Peyer's patch N/A hemizygote Not available
Peyer's patch N/A heterozygote Not available
Prostate gland N/A heterozygote Not available
Quadriceps N/A heterozygote 0.0% (0 of 1)
Sciatic nerve N/A hemizygote 0.0% (0 of 1)
Sciatic nerve N/A heterozygote 0.0% (0 of 1)
Skeletal muscle N/A hemizygote Not available
Skeletal muscle N/A heterozygote Not available
Small intestine N/A hemizygote 100% (1 of 1)
Small intestine N/A heterozygote 100% (1 of 1)
Spleen N/A heterozygote 0.0% (0 of 1)
Stomach pyloric region N/A hemizygote Not available
Stomach pyloric region N/A heterozygote Not available
Striatum N/A hemizygote Not available
Striatum N/A heterozygote Not available
Sublingual gland N/A heterozygote 0.0% (0 of 1)
Submandibular gland N/A heterozygote 0.0% (0 of 1)
Testis N/A heterozygote Not available
Thyroid gland N/A heterozygote 0.0% (0 of 1)
Trachea N/A hemizygote Not available
Uterus N/A hemizygote Not available
Vagina N/A hemizygote Not available
Vas deferens N/A heterozygote Not available
Vascular system N/A hemizygote Not available
Vascular system N/A heterozygote Not available
Vesicular gland N/A heterozygote Not available
White adipose tissue N/A hemizygote Not available
White adipose tissue N/A heterozygote Not available
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.67% (4 of 598)
aorta 0.17% (1 of 598)
blood 0.0%
bone marrow 0.0%
brain 0.84% (5 of 598)
brainstem 0.33% (2 of 598)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 598)
cecum 5.73% (22 of 384)
cerebellum 0.5% (3 of 598)
cerebral cortex 0.33% (2 of 598)
chest bone Unavailable
colon 15.71% (22 of 140)
diaphragm 0.0%
duodenum 3.57% (5 of 140)
epididymis 14.29% (21 of 147)
esophagus 1.66% (7 of 422)
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland 0.71% (1 of 140)
heart 0.33% (2 of 598)
hindlimb 0.0%
hippocampus 0.5% (3 of 598)
hypothalamus 0.33% (2 of 598)
ileum 14.29% (20 of 140)
jejunum 8.57% (12 of 140)
kidney 4.52% (27 of 598)
large intestine 5.35% (32 of 598)
liver 0.0%
lower urinary tract 0.17% (1 of 598)
lung 0.33% (2 of 598)
lymph node 0.17% (1 of 598)
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node 0.31% (1 of 323)
midbrain 0.0%
olfactory lobe 0.33% (2 of 598)
ovary 0.17% (1 of 598)
oviduct 0.0%
pancreas 0.84% (5 of 598)
parathyroid gland 0.17% (1 of 576)
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.33% (2 of 598)
peyers patch 0.0%
pituitary gland 0.17% (1 of 598)
prostate gland 2.17% (13 of 598)
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.17% (1 of 598)
small intestine 5.35% (32 of 598)
spinal cord 0.5% (3 of 598)
spleen 0.5% (3 of 598)
stomach 3.68% (22 of 598)
stomach pyloric region 0.0%
striatum 0.5% (3 of 598)
sublingual gland 0.0%
submandibular gland 1.38% (2 of 145)
testis 1% (6 of 598)
thymus 0.17% (1 of 598)
thyroid gland 3.01% (18 of 598)
tongue 3.57% (5 of 140)
trachea 0.5% (3 of 598)
trigeminal v nerve 0.0%
urinary bladder 0.0%
uterus 0.33% (2 of 598)
vagina 0.0%
vas deferens 4.56% (18 of 395)
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Adult LacZ

LacZ Images Section

128 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

X-ray

XRay Images Forepaw

10 Images

X-ray

XRay Images Skull Lateral Orientation

10 Images

X-ray

XRay Images Hind Leg and Hip

10 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

Human diseases caused by Trappc2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Trappc2 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Spondyloepiphyseal Dysplasia Tarda, X-Linked
OMIM:313400
Spondyloepiphyseal Dysplasia Tarda
ORPHA:93284

The table below shows human diseases predicted to be associated to Trappc2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Uterine Anomalies
Abnormality of the uterus, Bicornuate uterus OMIM:192000
Testicular Regression Syndrome
Decreased testicular size, Absent testis, Agonadism, Abnormal morphology of female internal genit... ORPHA:983
46,Xy Sex Reversal 3
Penoscrotal hypospadias, Ambiguous genitalia, Clitoral hypertrophy, Exaggerated rugosity of the l... OMIM:612965
Obesity-Hypoventilation Syndrome
Hypoventilation OMIM:257500
Ovarian Dysgenesis 6
Hypoplasia of the uterus, Hypergonadotropic hypogonadism OMIM:618078
Chronic Pneumonitis Of Infancy
Intercostal retractions, Hyperventilation, Cough, Hypoxemia, Respiratory distress, Reduced forced... ORPHA:91359
46,Xx Ovotesticular Difference Of Sex Development
Cryptorchidism, Abnormal morphology of female internal genitalia, Ambiguous genitalia, Polycystic... ORPHA:2138
Athabaskan Brainstem Dysgenesis Syndrome
Central hypoventilation OMIM:601536
Premature Ovarian Failure 3
Hypoplasia of the uterus OMIM:608996
Diethylstilbestrol Syndrome
Cryptorchidism, Micropenis, Abnormality of the uterus, Abnormal testis morphology, Testicular dys... ORPHA:1916
46,Xy Sex Reversal 11
Gonadal dysgenesis with female appearance, male, Urogenital sinus anomaly, Abnormal internal geni... OMIM:273250
Central Hypoventilation Syndrome, Congenital, 3
Respiratory failure, Central hypoventilation, Apnea OMIM:619483
46,Xy Sex Reversal 7
Dysgerminoma, Gonadoblastoma, Hypoplasia of the fallopian tube, Hypoplasia of the uterus, Streak ... OMIM:233420
Mayer-Rokitansky-Kuster-Hauser Syndrome
Aplasia of the vagina, Hypoplasia of the uterus OMIM:277000
Leydig Cell Hypoplasia
Cryptorchidism, Micropenis, Ambiguous genitalia, Abnormal vas deferens morphology, Abnormal inter... ORPHA:755
Testicular Agenesis
Absent testis, Micropenis, Urethrovaginal fistula, Ambiguous genitalia, Urogenital sinus anomaly,... ORPHA:325124
Mitochondrial Complex I Deficiency, Nuclear Type 9
Breathing dysregulation, Hypoventilation OMIM:618232
46,Xy Gonadal Dysgenesis-Motor And Sensory Neuropathy Syndrome
Gonadal dysgenesis with female appearance, male, Gonadoblastoma, Testicular dysgenesis, Hypoplasi... ORPHA:168563
Ovarian Dysgenesis 2
Streak ovary, Hypoplasia of the uterus, Hypergonadotropic hypogonadism OMIM:300510
46,Xx Sex Reversal 2
Perineal hypospadias, Micropenis, Hypoplasia of the vagina, Hypoplasia of the uterus, Azoospermia... OMIM:278850
Premature Ovarian Failure 7
Clitoral hypertrophy, Hypoplasia of the uterus, Gonadal dysgenesis OMIM:612964
Encephalopathy, Neonatal Severe, Due To Mecp2 Mutations
Respiratory insufficiency, Central hypoventilation, Apnea OMIM:300673
Complete Androgen Insensitivity Syndrome
Aplasia/Hypoplasia of the fallopian tube, Abnormal morphology of female internal genitalia, Femal... ORPHA:99429
Ullrich Congenital Muscular Dystrophy 2
Nocturnal hypoventilation OMIM:616470
Partial Androgen Insensitivity Syndrome
Perineal hypospadias, Micropenis, Ambiguous genitalia, Fused labia majora, Clitoral hypertrophy, ... ORPHA:90797
Mullerian Aplasia And Hyperandrogenism
Aplasia of the fallopian tube, Aplasia of the vagina, Abnormal external genitalia, Aplasia of the... OMIM:158330
Joubert Syndrome 17
Hyperventilation OMIM:614615
Postpoliomyelitis Syndrome
Respiratory insufficiency, Hypoventilation ORPHA:2942
Vaginal Atresia
Uterus didelphys, Cervicitis, Imperforate hymen, Transverse vaginal septum, Vaginal atresia, Abno... ORPHA:65681
Fructose-1,6-Bisphosphatase Deficiency
Dyspnea, Apnea, Hyperventilation OMIM:229700
Hypogonadotropic Hypogonadism 12 With Or Without Anosmia
Hypoplasia of the ovary, Cryptorchidism, Decreased testicular size, Micropenis, Hypoplasia of the... OMIM:614841
Perry Syndrome
Central hypoventilation ORPHA:178509
Perrault Syndrome 6
Streak ovary, Hypoplasia of the uterus OMIM:617565
Premature Ovarian Failure 13
Hypoplasia of the uterus OMIM:617442
Mitochondrial Complex I Deficiency, Nuclear Type 10
Sleep apnea, Respiratory failure, Central hypoventilation, Apnea OMIM:618233
Hypogonadotropic Hypogonadism 8 With Or Without Anosmia
Decreased testicular size, Cryptorchidism, Micropenis, Hypoplasia of the uterus, Azoospermia, Hyp... OMIM:614837
Perrault Syndrome 3
Streak ovary, Hypoplasia of the uterus, Hypergonadotropic hypogonadism OMIM:614129
Perry Syndrome
Respiratory insufficiency, Respiratory arrest, Hypoventilation, Central hypoventilation OMIM:168605
Neurodevelopmental Disorder With Poor Language And Loss Of Hand Skills
Apnea, Hyperventilation OMIM:617903
Renal And Mullerian Duct Hypoplasia
Anteriorly displaced urethral meatus, Aplasia of the uterus, Hydrocele testis OMIM:266810
Myasthenic Syndrome, Congenital, 20, Presynaptic
Stridor, Hypoventilation, Apnea OMIM:617143
Premature Ovarian Failure 6
Streak ovary, Hypoplasia of the uterus OMIM:612310
Hypogonadotropic Hypogonadism 13 With Or Without Anosmia
Hypogonadotropic hypogonadism, Hypoplasia of the uterus OMIM:614842
Hydatidiform Mole
Enlarged uterus ORPHA:99927
Premature Ovarian Failure 18
Hypoplasia of the ovary, Hypoplasia of the uterus OMIM:619203
Pitt-Hopkins-Like Syndrome 2
Hyperventilation OMIM:614325
Muscular Dystrophy, Duchenne Type
Restrictive ventilatory defect, Respiratory insufficiency due to muscle weakness, Hypoventilation... OMIM:310200
Joubert Syndrome 8
Hyperventilation OMIM:612291
Central Hypoventilation Syndrome, Congenital, 1
Hypercapnia, Hypoxemia, Hypoventilation, Central hypoventilation, Apnea, Nocturnal hypoventilation OMIM:209880
Adult-Onset Cervical Dystonia, Dyt23 Type
Hyperventilation ORPHA:420492
Lumbar Syndrome
Cryptorchidism, Micropenis, Ambiguous genitalia, Hypoplastic labia majora, Bifid uterus, Bifid sc... ORPHA:83628
Autosomal Dominant Nocturnal Frontal Lobe Epilepsy
Hyperventilation ORPHA:98784
Pitt-Hopkins-Like Syndrome 1
Hyperventilation OMIM:610042
Holocarboxylase Synthetase Deficiency
Tachypnea, Hyperventilation OMIM:253270
Childhood Absence Epilepsy
Hyperventilation ORPHA:64280
Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To 5Q31.3 Microdeletion
Aspiration pneumonia, Hypoventilation, Apnea, Respiratory distress, Recurrent pneumonia ORPHA:314655
Fructose-1,6-Bisphosphatase Deficiency
Dyspnea, Intermittent hyperventilation, Respiratory distress, Episodic tachypnea, Apneic episodes... ORPHA:348
Congenital Adrenal Hyperplasia Due To 17-Alpha-Hydroxylase Deficiency
Micropenis, Ambiguous genitalia, male, Precocious puberty in females, Female external genitalia i... ORPHA:90793
Rett Syndrome
Intermittent hyperventilation, Apnea OMIM:312750
Proximal Spinal Muscular Atrophy
Neonatal respiratory distress, Restrictive ventilatory defect, Respiratory insufficiency due to m... ORPHA:70
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Hyperventilation OMIM:618775
Synaptic Congenital Myasthenic Syndromes
Neonatal respiratory distress, Pulmonary arterial hypertension, Respiratory insufficiency, Hypove... ORPHA:98915
46,Xy Difference Of Sex Development-Adrenal Insufficiency Due To Cyp11A1 Deficiency
Decreased testicular size, Cryptorchidism, Abnormality of the Leydig cells, Ambiguous genitalia, ... ORPHA:168558
Townes-Brocks Syndrome 2
Bifid uterus, Rectovaginal fistula, Hypospadias OMIM:617466
Inherited Isolated Adrenal Insufficiency Due To Partial Cyp11A1 Deficiency
Decreased testicular size, Cryptorchidism, Abnormality of the Leydig cells, Ambiguous genitalia, ... ORPHA:289548
Mayer-Rokitansky-K├╝ster-Hauser Syndrome
Aplasia of the uterus, Hypoplasia of the vagina ORPHA:3109
Hypoparathyroidism, Sensorineural Deafness, And Renal Dysplasia Syndrome
Septate vagina, Aplasia of the vagina, Aplasia of the uterus, Uterus didelphys OMIM:146255
Developmental And Epileptic Encephalopathy 2
Hyperventilation OMIM:300672
Congenital Disorder Of Glycosylation, Type Iib
Hypoventilation, Hypoplastic female external genitalia OMIM:606056
Encephalitis Lethargica
Hyperventilation ORPHA:83600
Adrenal Hyperplasia, Congenital, Due To Steroid 11-Beta-Hydroxylase Deficiency
Decreased testicular size, Hypoplasia of the vagina, Clitoral hypertrophy, Hypoplasia of the uter... OMIM:202010
Cholera
Aspiration pneumonia, Tachypnea, Hyperventilation ORPHA:173
Biotinidase Deficiency
Respiratory distress, Apnea, Hyperventilation ORPHA:79241
Hypotonia, Hypoventilation, Impaired Intellectual Development, Dysautonomia, Epilepsy, And Eye Abnormalities
Sleep apnea, Recurrent pneumonia, Hypoventilation OMIM:618493
Bethlem Myopathy
Reduced maximal expiratory pressure, Hypoventilation ORPHA:610
Lethal Omphalocele-Cleft Palate Syndrome
Bifid uterus ORPHA:2736
Prader-Willi Syndrome
Cryptorchidism, Micropenis, External genital hypoplasia, Hypoplastic labia minora, Hypoventilatio... OMIM:176270
Mogs-Cdg
External genital hypoplasia, Hypoventilation, Apnea, Respiratory distress, Hydrocele testis ORPHA:79330
Rabin-Pappas Syndrome
Tracheomalacia, Hypoventilation OMIM:620155
Cntnap2-Related Developmental And Epileptic Encephalopathy
Intermittent hyperventilation ORPHA:163681
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
Aspiration, Pulmonary arterial hypertension, Respiratory insufficiency, Intercostal muscle weakne... ORPHA:258
Meckel Syndrome 14
Pneumothorax, Cardiorespiratory arrest, Ambiguous genitalia, Aplasia of the uterus OMIM:619879
Oeis Complex
Absent scrotum, Cryptorchidism, Micropenis, Ambiguous genitalia, male, Epispadias, Labial hypopla... OMIM:258040
Central Hypoventilation Syndrome, Congenital, 2, And Autonomic Dysfunction
Aspiration pneumonia, Hypopnea, Restrictive ventilatory defect, Hypoventilation, Apnea OMIM:619482
Infantile Hypotonia-Oculomotor Anomalies-Hyperkinetic Movements-Developmental Delay Syndrome
Sleep apnea, Central apnea, Hyperventilation ORPHA:522077
Cocaine Intoxication
Hyperventilation, Cough, Respiratory distress, Pneumothorax, Tachypnea, Wheezing ORPHA:90068
Mitochondrial Dna-Associated Leigh Syndrome
Episodic respiratory distress, Dyspnea, Apnea, Hyperventilation ORPHA:255210
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Septate vagina, Vaginal atresia, Aplasia of the uterus, Uterus didelphys ORPHA:2237
Intellectual Developmental Disorder, Autosomal Dominant 57
Hyperventilation OMIM:618050
Intellectual Developmental Disorder, Autosomal Dominant 54
Apnea, Hyperventilation OMIM:617799
Classic Congenital Adrenal Hyperplasia Due To 21-Hydroxylase Deficiency
Testicular adrenal rest tumor, Decreased testicular size, Ambiguous genitalia, Fused labia majora... ORPHA:90794
Pitt-Hopkins Syndrome
Sleep apnea, Abnormal pattern of respiration, Hyperventilation ORPHA:2896
Intellectual Developmental Disorder With Microcephaly And Pontine And Cerebellar Hypoplasia
Intermittent hyperventilation OMIM:300749
Pitt-Hopkins Syndrome
Intermittent hyperventilation OMIM:610954
Spondylocostal Dysostosis With Anal Atresia And Urogenital Anomalies
Aplasia of the vagina, Absent external genitalia, Aplasia of the uterus OMIM:271520
Pontocerebellar Hypoplasia Type 7
Cryptorchidism, Micropenis, Ambiguous genitalia, Microphallus, Clitoral hypertrophy, Abnormal scr... ORPHA:284339
Thrombocytopenia-Absent Radius Syndrome
Aplasia of the uterus ORPHA:3320
Charcot-Marie-Tooth Disease Type 4C
Respiratory insufficiency, Hypoventilation ORPHA:99949
Chromosome 17Q12 Deletion Syndrome
Cryptorchidism, Ovarian cyst, Unicornuate uterus, Aplasia of the vagina, Aplasia of the uterus OMIM:614527
Ehlers-Danlos Syndrome, Vascular Type
Repeated pneumothoraces, Pulmonary bulla, Cervical insufficiency, Cryptorchidism, Spontaneous pne... OMIM:130050
Phocomelia, Schinzel Type
Cryptorchidism, Hypoplasia of penis, Aplasia of the uterus ORPHA:2879
Acute Liver Failure
Abnormal pattern of respiration, Abnormal respiratory system physiology, Hypocapnia, Hyperventila... ORPHA:90062
Cardiac-Urogenital Syndrome
Tracheomalacia, Cryptorchidism, Penoscrotal hypospadias, Micropenis, Ambiguous genitalia, Bifid s... OMIM:618280
Craniofrontonasal Dysplasia-Poland Anomaly Syndrome
Bifid uterus, Abnormal reproductive system morphology ORPHA:1521
Microcephaly-Corpus Callosum Hypoplasia-Intellectual Disability-Facial Dysmorphism Syndrome
Aplasia of the vagina, Aplasia of the uterus ORPHA:457284
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Tracheomalacia, Hypoventilation OMIM:203700
Fanconi Anemia, Complementation Group L
Micropenis, Aplasia of the uterus OMIM:614083
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Cardiorespiratory arrest, Hypoventilation, Central hypoventilation, Obstructive sleep apnea, Asthma ORPHA:293987
Exstrophy-Epispadias Complex
Cryptorchidism, Bifid penis, Penoscrotal transposition, Epispadias, Absent penis, Bifid uterus, C... ORPHA:322
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Cryptorchidism, Aspiration pneumonia, Central sleep apnea, Hypoventilation, Apnea, Obstructive sl... ORPHA:438213
Limb-Mammary Syndrome
Aplasia of the ovary, Aplasia of the uterus ORPHA:69085
Autosomal Recessive Polycystic Kidney Disease
Recurrent pneumonia, Spontaneous pneumothorax, Respiratory failure, Hypoventilation ORPHA:731
Thrombocytopenia-Absent Radius Syndrome
Aplasia of the uterus OMIM:274000
Wolf-Hirschhorn Syndrome
Hypospadias, Cryptorchidism, Precocious puberty, Aplasia of the uterus OMIM:194190
Coffin-Siris Syndrome 1
Clitoral hypertrophy, Cryptorchidism, Hypospadias, Aplasia of the uterus OMIM:135900
Hydrolethalus Syndrome 1
Bifid uterus, Abnormal vagina morphology, Hypospadias OMIM:236680
Ulna And Fibula, Absence Of, With Severe Limb Deficiency
Cryptorchidism, Aplasia of the uterus, Anteriorly displaced genitalia, Small scrotum, Hypospadias OMIM:276820
Townes-Brocks Syndrome 1
Rectoperineal fistula, Cryptorchidism, Bifid uterus, Bifid scrotum, Rectovaginal fistula, Hypospa... OMIM:107480
Neu-Laxova Syndrome 1
Bifid uterus, Cryptorchidism OMIM:256520
Okamoto Syndrome
Bifid uterus ORPHA:2729
Vascular Ehlers-Danlos Syndrome
Cryptorchidism, Respiratory insufficiency, Uterine rupture, Sleep apnea, Cystocele, Pneumothorax,... ORPHA:286
Loeys-Dietz Syndrome
Uterine rupture ORPHA:60030
Pallister-Killian Syndrome
Cryptorchidism, Hyperventilation, Labial hypoplasia, Hypoplastic labia majora, Small scrotum, Hyp... OMIM:601803
Norrie Disease
Cryptorchidism, Uterine rupture ORPHA:649
Spondyloepiphyseal Dysplasia Tarda
ORPHA:93284
Spondyloepiphyseal Dysplasia Tarda, X-Linked
OMIM:313400

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Trappc2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Trappc2.

No publications found that use IMPC mice or data for Trappc2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Trappc2tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Trappc2tm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Trappc2tm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice, Tissue
Trappc2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells

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