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Gene: Ier3ip1 MGI:1913441

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Gene Summary

Name:
immediate early response 3 interacting protein 1
Synonyms:
1110057H19Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
increased circulating alanine transaminase level Ier3ip1em1(IMPC)J HET Early adult 3.30×10-09
preweaning lethality, complete penetrance Ier3ip1em1(IMPC)J HOM   Early adult 0.00
abnormal vocalization Ier3ip1em1(IMPC)J HET Early adult 1.69×10-06
embryonic lethality prior to organogenesis Ier3ip1em1(IMPC)J HOM   E9.5 0.00
decreased locomotor activity Ier3ip1em1(IMPC)J HET Early adult 9.37×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

PDF thumbnail PDF
Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

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Human diseases caused by Ier3ip1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ier3ip1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Microcephaly, Epilepsy, And Diabetes Syndrome 1
OMIM:614231

The table below shows human diseases predicted to be associated to Ier3ip1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Pentosuria
Abnormal circulating carbohydrate concentration, Abnormality of circulating enzyme level ORPHA:2843
Microcephaly, Epilepsy, And Diabetes Syndrome 1
OMIM:614231

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ier3ip1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ier3ip1.

No publications found that use IMPC mice or data for Ier3ip1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Ier3ip1em1(IMPC)J Exon Deletion Mice
Ier3ip1tm436543(L1L2_GT1_LF2A_LacZ_BetactP_neo) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ier3ip1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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