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Gene: Tspan13 MGI:1913359

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Gene Summary

Name:
tetraspanin 13
Synonyms:
1100001I23Rik,  Tm4sf13

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased bone mineral content Tspan13em1(IMPC)Kmpc HOM Early adult 9.09×10-08
increased total body fat amount Tspan13em1(IMPC)Kmpc HOM Early adult 8.29×10-06
decreased prepulse inhibition Tspan13em1(IMPC)Kmpc HOM Early adult 5.31×10-06
decreased fasting circulating glucose level Tspan13em1(IMPC)Kmpc HOM Early adult 3.22×10-05
decreased bone mineral density Tspan13em1(IMPC)Kmpc HOM Early adult 7.38×10-06
abnormal bone structure Tspan13em1(IMPC)Kmpc HOM Early adult 1.81×10-05
abnormal vibrissa morphology Tspan13em1(IMPC)Kmpc HOM Late adult 2.00×10-06
decreased thigmotaxis Tspan13em1(IMPC)Kmpc HOM Late adult 1.32×10-08
abnormal behavior Tspan13em1(IMPC)Kmpc HOM Early adult 5.39×10-06
increased grip strength Tspan13em1(IMPC)Kmpc HOM Early adult 7.48×10-05
abnormal behavior Tspan13em1(IMPC)Kmpc HOM Late adult 1.32×10-08
decreased thigmotaxis Tspan13em1(IMPC)Kmpc HOM Early adult 5.39×10-06
increased heart weight Tspan13em1(IMPC)Kmpc HOM Late adult 1.29×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

Images Slit Lamp

2 Images

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Eye Morphology

Images Slit Lamp

1 Images

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Electrocardiogram (ECG)

Waveform Image

18 Images

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Human diseases caused by Tspan13 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tspan13 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ethanolaminosis
Cardiomegaly OMIM:227150
Pandas
Anorexia, Impulsivity, Abnormal fear-induced behavior, Depression, Irritability, Tics, Attention ... ORPHA:66624
Mucopolysaccharidosis, Type Iiib
Hepatomegaly, Hyperactivity, Cardiomegaly, Aggressive behavior, Splenomegaly, Synophrys, Asymmetr... OMIM:252920
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Hyperactivity, Anorexia, Aggressive behavior, Abnormal fear-induced behavior, Irritability, Abnor... ORPHA:3077
Congenital Tricuspid Valve Dysplasia
Hepatomegaly, Cardiomegaly, Pericardial effusion, Anomalous pulmonary venous return, Abnormal tri... ORPHA:555874

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tspan13

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tspan13.

No publications found that use IMPC mice or data for Tspan13.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Tspan13em1Llp Intra-exon deletion Mice
Tspan13tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Tspan13tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Tspan13em1(IMPC)Kmpc Indel Mice

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