Gene Summary

Name:
NADH:ubiquinone oxidoreductase subunit A9
Synonyms:
1010001N11Rik

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Ndufa9em1(IMPC)J HOM   Early adult 0.00
embryonic lethality prior to organogenesis Ndufa9em1(IMPC)J HOM   E9.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ndufa9 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Ndufa9 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Leigh Syndrome With Leukodystrophy
ORPHA:255241
Mitochondrial Complex I Deficiency, Nuclear Type 26
OMIM:618247

The table below shows human diseases predicted to be associated to Ndufa9 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Leigh Syndrome With Leukodystrophy
ORPHA:255241
Mitochondrial Complex I Deficiency, Nuclear Type 26
OMIM:618247

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ndufa9

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ndufa9.

There are 1 publication which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Nuclear-encoded mitochondrial ribosomal proteins are required to initiate gastrulation. Development (Cambridge, England) (May 2020) Ndufa9em1(IMPC)J 32376682

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MGI Allele Allele Type Produced
Ndufa9em1(IMPC)J Exon Deletion Mice
Ndufa9tm119146(L1L2_gt2) Targeting vectors
Ndufa9tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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