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Gene: Sdhc MGI:1913302

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Gene Summary

Name:
succinate dehydrogenase complex, subunit C, integral membrane protein
Synonyms:
0610010E03Rik

Order Alleles

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
thrombocytosis Sdhctm1a(EUCOMM)Wtsi HET Early adult 2.07×10-06
preweaning lethality, complete penetrance Sdhctm1b(EUCOMM)Wtsi HOM   Early adult 0.00
increased body weight Sdhctm1a(EUCOMM)Wtsi HET Early adult 5.11×10-05
embryonic lethality prior to tooth bud stage Sdhctm1b(EUCOMM)Wtsi HOM   E12.5 0.00

Download data as:  TSV  XLS

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lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland N/A heterozygote 100% (2 of 2)
Aorta N/A heterozygote 50% (1 of 2)
Bone N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 100% (2 of 2)
Brainstem N/A heterozygote 100% (2 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 100% (2 of 2)
Cerebral cortex N/A heterozygote 100% (2 of 2)
Esophagus N/A heterozygote 100% (2 of 2)
Eye N/A heterozygote 0.0% (0 of 2)
Gall bladder N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote 100% (2 of 2)
Hippocampus N/A heterozygote 100% (2 of 2)
Hypothalamus N/A heterozygote 100% (2 of 2)
Kidney N/A heterozygote 100% (2 of 2)
Large intestine N/A heterozygote 100% (2 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote 100% (2 of 2)
Lung N/A heterozygote 100% (2 of 2)
Lymph node N/A heterozygote 0.0% (0 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 100% (2 of 2)
Oral epithelium N/A heterozygote 0.0% (0 of 2)
Ovary N/A heterozygote 0.0% (0 of 2)
Oviduct N/A heterozygote 50% (1 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Parathyroid gland N/A heterozygote 100% (2 of 2)
Peripheral nervous system N/A heterozygote 100% (2 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Pituitary gland N/A heterozygote 100% (2 of 2)
Prostate gland N/A heterozygote 0.0% (0 of 2)
Skeletal muscle N/A heterozygote 0.0% (0 of 2)
Skin N/A heterozygote 0.0% (0 of 2)
Small intestine N/A heterozygote 100% (2 of 2)
Spinal cord N/A heterozygote 100% (2 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach N/A heterozygote 100% (2 of 2)
Striatum N/A heterozygote 100% (2 of 2)
Testis N/A heterozygote 50% (1 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Trachea N/A heterozygote 0.0% (0 of 2)
Uterus N/A heterozygote 0.0% (0 of 2)
Vascular system N/A heterozygote 100% (2 of 2)
White adipose tissue N/A heterozygote 0.0% (0 of 2)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
bone 0.0%
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
esophagus 0.0%
eye 0.0%
gall bladder 0.0%
heart 0.0%
hippocampus 0.0%
hypothalamus 0.0%
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
mammary gland 0.0%
olfactory lobe 0.0%
oral epithelium 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
peripheral nervous system 0.0%
peyers patch 0.0%
pituitary gland 0.0%
prostate gland 0.0%
skeletal muscle 0.0%
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
striatum 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
trachea 0.0%
uterus 0.0%
vascular system 0.0%
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Histopathology

Images

10 Images

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Adult LacZ

LacZ Images Wholemount

17 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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Echo

M-Mode Images

32 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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PDF thumbnail PDF
Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

5 Images

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Legacy Phenotype Associated Images
Sdhctm1a(EUCOMM)Wtsi
body, HET, Female, WTSI
Sdhctm1a(EUCOMM)Wtsi
head, HET, Female, WTSI
Sdhctm1a(EUCOMM)Wtsi
body, HET, Female, WTSI
Sdhctm1a(EUCOMM)Wtsi
body, HET, Female, WTSI
Sdhctm1a(EUCOMM)Wtsi
head, HET, Female, WTSI

View all 263 images

Sdhctm1a(EUCOMM)Wtsi
polydactyly, HET, Male, WTSI
Sdhctm1a(EUCOMM)Wtsi
paw, hindlimb, HET, Male, WTSI
Sdhctm1a(EUCOMM)Wtsi
eye, cornea/lens fusion, corneal opacity, impaired pupillary reflex, HET, Female, WTSI
Sdhctm1a(EUCOMM)Wtsi
back skin, HET, Female, WTSI

Human diseases caused by Sdhc mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Sdhc by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Carney-Stratakis Syndrome
Weight loss ORPHA:97286
Hereditary Pheochromocytoma-Paraganglioma
Weight loss ORPHA:29072
Cowden Syndrome
Failure to thrive ORPHA:201
Gastrointestinal Stromal Tumor
Anemia ORPHA:44890
Gastrointestinal Stromal Tumor
OMIM:606764
Paraganglioma And Gastric Stromal Sarcoma
OMIM:606864
Pheochromocytoma/Paraganglioma Syndrome 3
OMIM:605373

The table below shows human diseases predicted to be associated to Sdhc by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Thrombocythemia 2
Thrombocytosis OMIM:601977
Thrombocythemia 3
Thrombocytosis OMIM:614521
Thrombocythemia 1
Impaired ADP-induced platelet aggregation, Splenomegaly, Thrombocytosis, Impaired collagen-induce... OMIM:187950
Asplenia, Isolated Congenital
Howell-Jolly bodies, Asplenia, Thrombocytosis OMIM:271400
Maturity-Onset Diabetes Of The Young, Type 11
Obesity, Overweight OMIM:613375
Neutropenia, Severe Congenital, 1, Autosomal Dominant
Acute monocytic leukemia, Congenital agranulocytosis, Thrombocytosis, Eosinophilia, Neutropenia, ... OMIM:202700
Immunodeficiency 69
Hemophagocytosis, Failure to thrive, Hepatosplenomegaly, Pancytopenia, Leukocytosis, Splenomegaly... OMIM:618963
Triglyceride Storage Disease, Type Ii
Obesity OMIM:190430
Juvenile Arthritis
Leukocytosis, Thrombocytosis OMIM:618795
Obesity
Obesity, Increased waist to hip ratio OMIM:601665
Polycythemia Vera
Increased hematocrit, Leukocytosis, Splenomegaly, Increased red blood cell mass, Increased circul... OMIM:263300
Acquired Idiopathic Sideroblastic Anemia
Normocytic anemia, Megaloblastic erythroid hyperplasia, Hypochromic anemia, Pancytopenia, Erythro... ORPHA:75564
Spermatogenic Failure, X-Linked, 1
Obesity OMIM:305700
Dehydrated Hereditary Stomatocytosis 2
Increased mean corpuscular volume, Increased mean corpuscular hemoglobin concentration, Thrombocy... OMIM:616689
Chronic Myeloid Leukemia
Abnormal granulocyte morphology, Leukocytosis, Splenomegaly, Abnormal basophil morphology, Thromb... ORPHA:521
Myelodysplastic Syndrome Associated With Isolated Del(5Q) Chromosome Abnormality
Abnormal neutrophil morphology, Leukopenia, Abnormal erythrocyte morphology, Macrocytic anemia, A... ORPHA:86841
Immunodeficiency 27A
Hepatosplenomegaly, Leukocytosis, Splenomegaly, Weight loss, Thrombocytosis, Anemia, Histiocytosis OMIM:209950
Abdominal Obesity-Metabolic Syndrome 1
Abdominal obesity OMIM:605552
Abdominal Obesity-Metabolic Syndrome Quantitative Trait Locus 2
Abdominal obesity OMIM:605572
Immunodeficiency 14B, Autosomal Recessive
Neutrophilia, Thrombocytosis, Leukocytosis, B lymphocytopenia, Monocytosis OMIM:619281
Combined Immunodeficiency And Megaloblastic Anemia With Or Without Hyperhomocysteinemia
Hypersegmentation of neutrophil nuclei, Lymphopenia, Pancytopenia, Macrocytic anemia, Anemia of i... OMIM:617780
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Microcytic anemia, Hepatosplenomegaly, Pancytopenia, Thrombocytosis OMIM:604416
Primary Myelofibrosis
Extramedullary hematopoiesis, Hepatosplenomegaly, Pancytopenia, Leukocytosis, Splenomegaly, Throm... ORPHA:824
Essential Thrombocythemia
Acute leukemia, Abnormality of thrombocytes, Leukocytosis, Splenomegaly, Abnormal platelet morpho... ORPHA:3318
Bardet-Biedl Syndrome 11
Obesity OMIM:615988
Thumb Stiffness-Brachydactyly-Intellectual Disability Syndrome
Obesity ORPHA:1078
Bardet-Biedl Syndrome 14
Obesity OMIM:615991
Bardet-Biedl Syndrome 13
Obesity OMIM:615990
Hypoinsulinemic Hypoglycemia And Body Hemihypertrophy
Large for gestational age, Truncal obesity ORPHA:293964
Intellectual Developmental Disorder, X-Linked 97
Obesity OMIM:300803
Hyperinsulinemic Hypoglycemia, Familial, 1
Large for gestational age OMIM:256450
Bardet-Biedl Syndrome 18
Obesity OMIM:615995
Hypoinsulinemic Hypoglycemia With Hemihypertrophy
Large for gestational age, Obesity, Truncal obesity OMIM:240900
Heme Oxygenase 1 Deficiency
Asplenia, Hemolytic anemia, Coombs-positive hemolytic anemia, Thrombocytosis OMIM:614034
Thrombocytopenia 4
Abnormal platelet volume, Thrombocytopenia OMIM:612004
Hyperinsulinemic Hypoglycemia, Familial, 2
Large for gestational age OMIM:601820
Immunodeficiency 92
Thrombocytosis, Leukocytosis, Lymphocytosis, Decreased proportion of class-switched memory B cell... OMIM:619652
Mitochondrial Complex Iv Deficiency, Nuclear Type 14
Obesity OMIM:619058
Sickle Cell Anemia
Splenic infarction, Hypochromic anemia, Increased mean corpuscular volume, Persistence of hemoglo... ORPHA:232
Autism, Susceptibility To, X-Linked 6
Obesity OMIM:300872
Sting-Associated Vasculopathy, Infantile-Onset
Failure to thrive, Lymphopenia, Leukopenia, Thrombocytosis, Anemia OMIM:615934
Body Mass Index Quantitative Trait Locus 20
Tall stature, Obesity OMIM:618406
Bleeding Disorder, Platelet-Type, 15
Platelet anisocytosis, Impaired clot retraction, Impaired ADP-induced platelet aggregation, Throm... OMIM:615193
Coronary Artery Disease, Autosomal Dominant, 1
Obesity OMIM:608320
Familial Thrombocytosis
Chronic myelogenous leukemia, Splenomegaly, Acute myeloid leukemia, Weight loss, Thrombocytosis ORPHA:71493
Obesity And Hypopigmentation
Overgrowth, Obesity OMIM:620195
Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy
Anemia, Iron deficiency anemia, Thrombocytosis OMIM:226300
Gastrointestinal Defects And Immunodeficiency Syndrome 1
Lymphopenia, Leukocytosis, Autoimmune hemolytic anemia, Hypoplasia of the thymus, Impaired lympho... OMIM:243150
Polycythemia Vera
Acute leukemia, Polycythemia, Leukocytosis, Splenomegaly, Weight loss, Thrombocytosis ORPHA:729
Celiac Disease, Susceptibility To, 1
Failure to thrive, Macrocytic anemia, Iron deficiency anemia, Weight loss, Thrombocytosis OMIM:212750
Ankylosing Vertebral Hyperostosis With Tylosis
Obesity ORPHA:2206
Beta-Ketothiolase Deficiency
Weight loss, Leukocytosis, Thrombocytosis ORPHA:134
Autoerythrocyte Sensitization Syndrome
Abnormal erythrocyte morphology, Impaired platelet adhesion, Autoimmune thrombocytopenia, Thrombo... ORPHA:324636
3-Hydroxy-3-Methylglutaric Aciduria
Leukopenia, Leukocytosis, Weight loss, Thrombocytosis, Anemia ORPHA:20
Poems Syndrome
Splenomegaly, Weight loss, Polycythemia, Thrombocytosis ORPHA:2905
Diamond-Blackfan Anemia
Macrocytic dyserythropoietic anemia, Increased mean corpuscular volume, Persistence of hemoglobin... ORPHA:124
Autoinflammatory Syndrome, Familial, X-Linked, Behcet-Like 2
Decreased proportion of memory B cells, Reduced natural killer cell count, Iron deficiency anemia... OMIM:301074
Microduplication Xp11.22P11.23 Syndrome
Obesity ORPHA:217377
Obesity Due To Melanocortin 4 Receptor Deficiency
Obesity, Childhood-onset truncal obesity ORPHA:71529
Bardet-Biedl Syndrome 22
Obesity, Large for gestational age OMIM:617119
Prolactin Deficiency With Obesity And Enlarged Testes
Obesity OMIM:264120
Interstitial Lung And Liver Disease
Anemia, Failure to thrive, Thrombocytosis OMIM:615486
Hypothyroidism, Congenital, Nongoitrous, 6
Anemia, Increased body weight, Increased body mass index OMIM:614450
Congenital Disorder Of Glycosylation, Type Ia
Failure to thrive, Thrombocytosis OMIM:212065
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Obesity ORPHA:329249
Erythrocytosis, Familial, 7
Increased circulating hemoglobin concentration, Increased hematocrit, Polycythemia OMIM:617981
Erythrocytosis, Familial, 6
Increased circulating hemoglobin concentration, Increased hematocrit, Polycythemia OMIM:617980
Diamond-Blackfan Anemia 1
Increased mean corpuscular volume, Failure to thrive, Persistence of hemoglobin F, Elevated red c... OMIM:105650
Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy
Hypochromic anemia, Leukocytosis, Failure to thrive, Thrombocytosis OMIM:618213
Trichohepatoenteric Syndrome 1
Failure to thrive, Splenomegaly, Thrombocytosis, Small for gestational age, Increased mean platel... OMIM:222470
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Obesity ORPHA:88643
Cortisone Reductase Deficiency 2
Obesity OMIM:614662
Idiopathic Hypereosinophilic Syndrome
Failure to thrive, Hepatosplenomegaly, Thrombocytosis, Leukocytosis, Splenomegaly, Eosinophilia, ... ORPHA:3260
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
Lymphopenia, Pancytopenia, Hepatosplenomegaly, Leukopenia, Leukocytosis, Splenomegaly, Thrombocyt... OMIM:615688
Cogan Syndrome
Anemia, Leukocytosis, Thrombocytosis ORPHA:1467
Hepatic Veno-Occlusive Disease
Increased body weight ORPHA:890
Polycystic Ovary Syndrome 1
Obesity OMIM:184700
Syndromic Diarrhea
Lymphopenia, Splenomegaly, Hypoplasia of the thymus, Thrombocytosis, Small for gestational age, I... ORPHA:84064
Hypothyroidism, Central, With Testicular Enlargement
Overweight OMIM:300888
Obesity-Hypoventilation Syndrome
Obesity OMIM:257500
Cortisone Reductase Deficiency 1
Obesity OMIM:604931
Brucellosis
Failure to thrive, Hypersplenism, Leukopenia, Leukocytosis, Splenomegaly, Weight loss, Thrombocyt... ORPHA:1304
Neuroleptic Malignant Syndrome
Leukocytosis, Thrombocytopenia, Thrombocytosis ORPHA:94093
Abcd Syndrome
Large for gestational age, Polycythemia OMIM:600501
Coenzyme Q10 Deficiency, Primary, 2
Obesity, Overweight OMIM:614651
Encephalomyopathy, Mitochondrial, Due To Voltage-Dependent Anion Channel Deficiency
Failure to thrive, Large for gestational age, Thrombocytopenia, Neutropenia, Anemia OMIM:614520
Wilson Disease
Failure to thrive, Splenomegaly, Increased body weight, Weight loss, Thrombocytopenia, Anemia ORPHA:905
Phip-Related Behavioral Problems-Intellectual Disability-Obesity-Dysmorphic Features Syndrome
Increased body weight ORPHA:589905
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Increased body weight ORPHA:276608
Hypogonadotropic Hypogonadism 27 Without Anosmia
Obesity OMIM:619755
Thyroid Hormone Resistance, Generalized, Autosomal Recessive
Increased body weight, Small for gestational age OMIM:274300
Acth-Independent Macronodular Adrenal Hyperplasia 2
Increased body weight, Abdominal obesity OMIM:615954
Kawasaki Disease
Leukocytosis, Thrombocytosis ORPHA:2331
Abdominal Obesity-Metabolic Syndrome 4
Elevated hemoglobin A1c, Obesity OMIM:618620
Blue Diaper Syndrome
Increased body weight ORPHA:94086
Leukocyte Adhesion Deficiency
Abnormality of neutrophil physiology, Polycythemia, Thrombocytosis, Leukocytosis, Impaired neutro... ORPHA:2968
Doors Syndrome
Thrombocytosis ORPHA:79500
Smith-Magenis Syndrome
Increased body weight OMIM:182290
Intellectual Developmental Disorder, X-Linked, Syndromic, Nascimento Type
Increased body weight OMIM:300860
Hellp Syndrome
Microangiopathic hemolytic anemia, Hemolytic anemia, Increased body weight, Thrombocytopenia, Dec... ORPHA:244242
Congenital Hyperinsulinism Due To Hnf4A Deficiency
Increased body weight, Large for gestational age ORPHA:263455
Pruritic Urticarial Papules And Plaques Of Pregnancy
Increased body weight ORPHA:64745
Insulinoma
Increased body weight ORPHA:97279
Pigmented Nodular Adrenocortical Disease, Primary, 4
Increased body weight OMIM:615830
Glycogen Storage Disease Due To Liver Phosphorylase Kinase Deficiency
Failure to thrive, Splenomegaly, Increased body weight, Abnormal erythrocyte enzyme concentration... ORPHA:264580
Sotos Syndrome
Increased body weight, Tall stature, Overgrowth OMIM:117550
Insulin-Resistance Syndrome Type B
Abnormality of body weight, Leukopenia, Decreased body weight, Increased body weight, Weight loss... ORPHA:2298
Glycogen Storage Disease Due To Liver And Muscle Phosphorylase Kinase Deficiency
Anemia, Increased body weight, Splenomegaly ORPHA:79240
Adrenocortical Carcinoma
Increased body weight, Weight loss ORPHA:1501
Magel2-Related Prader-Willi-Like Syndrome
Increased body weight, Failure to thrive, Abdominal obesity ORPHA:398069
Cushing Syndrome Due To Bilateral Macronodular Adrenocortical Disease
Increased body weight, Abdominal obesity ORPHA:189427
Cushing Disease
Lymphopenia, Leukocytosis, Increased body weight, Truncal obesity, Abdominal obesity, Decreased e... ORPHA:96253
Cushing Syndrome Due To Ectopic Acth Secretion
Lymphopenia, Leukocytosis, Increased body weight, Weight loss, Truncal obesity, Abdominal obesity... ORPHA:99889
Carney Complex
Increased body weight, Tall stature, Abdominal obesity ORPHA:1359
Carney-Stratakis Syndrome
Weight loss ORPHA:97286
Hereditary Pheochromocytoma-Paraganglioma
Weight loss ORPHA:29072
Cowden Syndrome
Failure to thrive ORPHA:201
Gastrointestinal Stromal Tumor
Anemia ORPHA:44890
Gastrointestinal Stromal Tumor
OMIM:606764
Paraganglioma And Gastric Stromal Sarcoma
OMIM:606864
Pheochromocytoma/Paraganglioma Syndrome 3
OMIM:605373

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

Phenotype Allele Zygosity Sex Life Stage
Eye with optic nerve - atrophy Sdhctm1a(EUCOMM)Wtsi HET Early adult

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sdhc.

There are 6 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Attempts to understand the mechanisms of mitochondrial diseases: The reverse genetics of mouse models for mitochondrial disease. Biochimica et biophysica acta. General subjects (December 2020) Sdhctm1c(EUCOMM)Wtsi 33358867
Unexpected obesity, rather than tumorigenesis, in a conditional mouse model of mitochondrial complex II deficiency. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (November 2020) Sdhctm1a(EUCOMM)Wtsi PMC7861419
A conditional mouse model of complex II deficiency manifesting as Leigh-like syndrome. FASEB journal : official publication of the Federation of American Societies for Experimental Biology (August 2019) Sdhctm1c(EUCOMM)Wtsi Sdhctm1a(EUCOMM)Wtsi 31469588
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Sdhctm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Sdhctm1a(EUCOMM)Wtsi PMC6459510
Oxygen concentration controls epigenetic effects in models of familial paraganglioma. PloS one (May 2015) Sdhctm1c(EUCOMM)Wtsi Sdhctm1a(EUCOMM)Wtsi PMC4436181

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MGI Allele Allele Type Produced
Sdhctm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Sdhctm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Sdhctm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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