Gene: Carm1 MGI:1913208

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Gene Summary

Name:
coactivator-associated arginine methyltransferase 1
Synonyms:
Prmt4

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased lymphocyte cell number Carm1tm1b(EUCOMM)Hmgu HET   Early adult 2.91×10-05
preweaning lethality, complete penetrance Carm1tm1b(EUCOMM)Hmgu HOM   Early adult 0.00

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Carm1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Carm1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Immunodeficiency 40
OMIM:616433
Okt4 Epitope Deficiency
OMIM:613949
Immunodeficiency 8
OMIM:615401
Short-Limb Skeletal Dysplasia With Severe Combined Immunodeficiency
OMIM:200900
Immunodeficiency 18
OMIM:615615
Granulomas, Congenital Cerebral
OMIM:306300
Genitourinary Tract Anomalies
OMIM:305690
Krabbe Disease, Atypical, Due To Saposin A Deficiency
OMIM:611722
Mitochondrial Complex I Deficiency, Nuclear Type 30
OMIM:301021
Lethal Congenital Contracture Syndrome 3
OMIM:611369
Immunodeficiency 42
OMIM:616622
Surfactant Metabolism Dysfunction, Pulmonary, 3
OMIM:610921
Arthrogryposis, Distal, With Mental Retardation And Characteristic Facies
OMIM:208081
Surfactant Metabolism Dysfunction, Pulmonary, 1
OMIM:265120
Glaucoma-Sleep Apnea Syndrome
ORPHA:2085
Developmental And Epileptic Encephalopathy 71
OMIM:618328
Larynx Atresia
ORPHA:1202
Lymphoid System Deterioration, Progressive
OMIM:247630
Spinal Muscular Atrophy, Type I
OMIM:253300
Reticular Dysgenesis
OMIM:267500
Laryngeal Abductor Paralysis
ORPHA:2808
Asbestos Intoxication
ORPHA:2302
Immunodeficiency 19
OMIM:615617
Neutropenia, Lethal Congenital, With Eosinophilia
OMIM:257100
Interstitial Pneumonitis, Desquamative, Familial
OMIM:263000
Epidermolysis Bullosa With Diaphragmatic Hernia
OMIM:226735
Surfactant Metabolism Dysfunction, Pulmonary, 2
OMIM:610913
Hernia, Anterior Diaphragmatic
OMIM:306950
Myopathy, Myofibrillar, Fatal Infantile Hypertonic, Alpha-B Crystallin-Related
OMIM:613869
Combined Cellular And Humoral Immune Defects With Granulomas
OMIM:233650
Pneumocystosis
ORPHA:723
Lethal Osteosclerotic Bone Dysplasia
ORPHA:1832
Immunodeficiency 50
OMIM:300988
Lymphopenic Hypergammaglobulinemia, Antibody Deficiency, Autoimmune Hemolytic Anemia, And Glomerulonephritis
OMIM:247800
Immunodeficiency 24
OMIM:615897
Hereditary Motor And Sensory Neuropathy, Okinawa Type
ORPHA:90117
Neutropenia, Severe Congenital, 2, Autosomal Dominant
OMIM:613107
Lung Agenesis, Congenital Heart Defects, And Thumb Anomalies Syndrome
OMIM:601612
Congenital Pulmonary Airway Malformation
ORPHA:2444
Pulmonary Hemosiderosis
OMIM:178550
Butyrylcholinesterase Deficiency
ORPHA:132
Idiopathic Acute Eosinophilic Pneumonia
ORPHA:724
Autosomal Dominant Limb-Girdle Muscular Dystrophy Type 1A
ORPHA:266
Combined Oxidative Phosphorylation Deficiency 51
OMIM:619057
Pulmonary Hypoplasia, Primary
OMIM:265430
Acute Interstitial Pneumonia
ORPHA:79126
Myopathy, Areflexia, Respiratory Distress, And Dysphagia, Early-Onset
OMIM:614399
Ceroid Lipofuscinosis, Neuronal, 10
OMIM:610127
T-Cell Immunodeficiency, Recurrent Infections, And Autoimmunity With Or Without Cardiac Malformations
OMIM:614868
Chronic Beryllium Disease
ORPHA:133
Pontocerebellar Hypoplasia, Type 1C
OMIM:616081
Staphylococcal Necrotizing Pneumonia
ORPHA:36238
Fibuloulnar Aplasia Or Hypoplasia With Renal Abnormalities
OMIM:228940
Larsen-Like Syndrome, Lethal Type
OMIM:245650
Nemaline Myopathy 8
OMIM:615348
Ciliary Dyskinesia, Primary, 44
OMIM:618781
Bronchopulmonary Dysplasia
ORPHA:70589
Thanatophoric Dysplasia, Glasgow Variant
OMIM:273680
Immunodeficiency 21
OMIM:614172
Tracheobronchopathia Osteochondroplastica
ORPHA:3348
Arthrogryposis Multiplex Congenita 6
OMIM:619334
Acute Lung Injury
ORPHA:178320
Ciliary Dyskinesia, Primary, 42
OMIM:618695
22q11 deletion syndrome (Velocardiofacial / DiGeorge syndrome)
DECIPHER:16
Omenn Syndrome
OMIM:603554
Pontocerebellar Hypoplasia, Type 4
OMIM:225753
Multiple Mitochondrial Dysfunctions Syndrome 1
OMIM:605711
Spondylometaphyseal Dysplasia, X-Linked
OMIM:313420
Recurrent Respiratory Papillomatosis
ORPHA:60032
Infant Acute Respiratory Distress Syndrome
ORPHA:70587
Congenital Arthrogryposis With Anterior Horn Cell Disease
OMIM:611890
Mitochondrial Dna Depletion Syndrome 9 (Encephalomyopathic Type With Methylmalonic Aciduria)
OMIM:245400
Surfactant Metabolism Dysfunction, Pulmonary, 5
OMIM:614370
Mitochondrial Dna Depletion Syndrome, Myopathic Form
ORPHA:254875
Isolated Anencephaly
ORPHA:563609
Cystic Hamartoma Of Lung And Kidney
ORPHA:2111
Ciliary Dyskinesia, Primary, 21
OMIM:615294
Cernunnos-Xlf Deficiency
ORPHA:169079
Ciliary Dyskinesia, Primary, 23
OMIM:615451
Respiratory Underresponsiveness To Hypoxia And Hypercapnia
OMIM:267480
Scedosporiosis
ORPHA:449280
Allergic Bronchopulmonary Aspergillosis
ORPHA:1164
Gastrointestinal Defects And Immunodeficiency Syndrome
OMIM:243150
Mitochondrial Complex I Deficiency, Nuclear Type 18
OMIM:618240
Muscular Dystrophy, Congenital, 1B
OMIM:604801
Spondyloepiphyseal Dysplasia With Atlantoaxial Instability
OMIM:600561
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
OMIM:617241
Spinal Muscular Atrophy, Lower Extremity-Predominant, 2B, Prenatal Onset, Autosomal Dominant
OMIM:618291
Ciliary Dyskinesia, Primary, 32
OMIM:616481
Severe Combined Immunodeficiency, X-Linked
OMIM:300400
Multiple Mitochondrial Dysfunctions Syndrome 2 With Hyperglycinemia
OMIM:614299
Ciliary Dyskinesia, Primary, 30
OMIM:616037
Vacterl Association With Hydrocephalus
OMIM:276950
Oculopharyngeal Myopathy With Leukoencephalopathy 1
OMIM:618637
3-Methylglutaconic Aciduria, Type Viii
OMIM:617248
Congenital Neuronal Ceroid Lipofuscinosis
ORPHA:168486
Immunodeficiency 13
OMIM:615518
Tracheal Agenesis
ORPHA:3346
Motor Neuron Disease With Dementia And Ophthalmoplegia
OMIM:600333
Combined Oxidative Phosphorylation Deficiency 28
OMIM:616794
Autoimmune Hemolytic Anemia-Autoimmune Thrombocytopenia-Primary Immunodeficiency Syndrome
ORPHA:444463
Immunodeficiency 76
OMIM:619164
Adult Acute Respiratory Distress Syndrome
ORPHA:70578
Epidermodysplasia Verruciformis, Susceptibility To, 5
OMIM:618309
Ciliary Dyskinesia, Primary, 11
OMIM:612649
Immunodeficiency 54
OMIM:609981
Primary Ciliary Dyskinesia
ORPHA:244
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
OMIM:619313
Spinal Muscular Atrophy-Progressive Myoclonic Epilepsy Syndrome
ORPHA:2590
Respiratory Distress Syndrome In Premature Infants
OMIM:267450
Imperforate Oropharynx-Costovertebral Anomalies Syndrome
ORPHA:2759
Hyperekplexia 4
OMIM:618011
Avian Influenza
ORPHA:454836
Multiple Mitochondrial Dysfunctions Syndrome 3
OMIM:615330
Ciliary Dyskinesia, Primary, 15
OMIM:613808
Immunodeficiency 52
OMIM:617514
Ciliary Dyskinesia, Primary, 18
OMIM:614874
Spinal Muscular Atrophy With Congenital Bone Fractures 2
OMIM:616867
Congenital Muscular Dystrophy With Intellectual Disability
ORPHA:370968
Neonatal Acute Respiratory Distress Due To Sp-B Deficiency
ORPHA:217563
Myalgia-Eosinophilia Syndrome Associated With Tryptophan
ORPHA:2582
Hepatic Veno-Occlusive Disease
ORPHA:890
Combined Oxidative Phosphorylation Deficiency 52
OMIM:619386
Laryngotracheoesophageal Cleft
ORPHA:2004
Neutropenia, Severe Congenital, 4, Autosomal Recessive
OMIM:612541
Combined Oxidative Phosphorylation Deficiency 4
OMIM:610678
Geleophysic Dysplasia 3
OMIM:617809
Thoracic Dysplasia-Hydrocephalus Syndrome
OMIM:273730
Mitochondrial Complex I Deficiency, Nuclear Type 10
OMIM:618233
Peroxisome Biogenesis Disorder 2A (Zellweger)
OMIM:214110
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 1
OMIM:604320
Transcobalamin Deficiency
ORPHA:859
Peroxisome Biogenesis Disorder 4A (Zellweger)
OMIM:614862
Neuromyelitis Optica Spectrum Disorder
ORPHA:71211
Combined Immunodeficiency Due To Partial Rag1 Deficiency
ORPHA:231154
Postsynaptic Congenital Myasthenic Syndromes
ORPHA:98913
Leigh Syndrome
OMIM:256000
Intermediate Nemaline Myopathy
ORPHA:171433
Pulmonary Alveolar Proteinosis With Hypogammaglobulinemia
OMIM:618042
Combined Oxidative Phosphorylation Deficiency 37
OMIM:618329
Progressive External Ophthalmoplegia-Myopathy-Emaciation Syndrome
ORPHA:352447
Lethal Congenital Contracture Syndrome 10
OMIM:617022
Amyotrophic Lateral Sclerosis
ORPHA:803
Tmem70-Related Mitochondrial Encephalo-Cardio-Myopathy
ORPHA:1194
Short-Rib Thoracic Dysplasia 19 With Or Without Polydactyly
OMIM:617895
Myopathy, Myofibrillar, 9, With Early Respiratory Failure
OMIM:603689
Nephronophthisis 2
OMIM:602088
Myopathy, Centronuclear, X-Linked
OMIM:310400
Metatropic Dysplasia
OMIM:156530
Cryptosporidiosis
ORPHA:1549
Hereditary Motor And Sensory Neuropathy, Type Iic
OMIM:606071
Renal Dysplasia-Limb Defects Syndrome
OMIM:266910
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
ORPHA:169154
Muscular Dystrophy, Duchenne Type
OMIM:310200
Adult Idiopathic Neutropenia
ORPHA:2688
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
OMIM:618986
Proximal Spinal Muscular Atrophy
ORPHA:70
Ataxia-Telangiectasia
OMIM:208900
Combined Immunodeficiency And Megaloblastic Anemia With Or Without Hyperhomocysteinemia
OMIM:617780
Congenital Muscular Dystrophy, Ullrich Type
ORPHA:75840
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
ORPHA:277
Congenital Tricuspid Valve Dysplasia
ORPHA:555874
Mercury Poisoning
ORPHA:330021
Sandestig-Stefanova Syndrome
OMIM:618804
Glycogen Storage Disease Due To Acid Maltase Deficiency, Infantile Onset
ORPHA:308552
Combined Immunodeficiency-Enteropathy Spectrum
ORPHA:436252
Severe Neurodegenerative Syndrome With Lipodystrophy
ORPHA:363400
Encephalopathy, Progressive, Early-Onset, With Brain Edema And/Or Leukoencephalopathy, 1
OMIM:617186
Mitochondrial Complex Iii Deficiency, Nuclear Type 8
OMIM:615838
Neuropathy, Hereditary Motor And Sensory, Type Vib, With Optic Atrophy
OMIM:616505
Car T Cell Therapy-Associated Cytokine Release Syndrome
ORPHA:542323
Fibrodysplasia Ossificans Progressiva
OMIM:135100
Acitretin/Etretinate Embryopathy
ORPHA:40366
T-Cell Immunodeficiency With Thymic Aplasia
OMIM:242700
Deafness-Lymphedema-Leukemia Syndrome
ORPHA:3226
Peripartum Cardiomyopathy
ORPHA:563
Riddle Syndrome
ORPHA:420741
Hemochromatosis, Type 3
OMIM:604250
Congenital Multicore Myopathy With External Ophthalmoplegia
ORPHA:98905
Bone Marrow Failure Syndrome 6
OMIM:618849
Osteopetrosis, Autosomal Recessive 5
OMIM:259720
Brain-Lung-Thyroid Syndrome
ORPHA:209905
Combined Oxidative Phosphorylation Defect Type 23
ORPHA:444013
Autoinflammatory Syndrome, Familial, Behcet-Like
OMIM:616744
Spinocerebellar Ataxia Type 1
ORPHA:98755
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
OMIM:602450
Radio-Renal Syndrome
ORPHA:3015
Hyperuricemia, Pulmonary Hypertension, Renal Failure, And Alkalosis Syndrome
OMIM:613845
Snakebite Envenomation
ORPHA:449285
Severe Congenital Nemaline Myopathy
ORPHA:171430
Lethal Congenital Contracture Syndrome 2
OMIM:607598
Syndromic Diarrhea
ORPHA:84064
Thoracic Dysplasia-Hydrocephalus Syndrome
ORPHA:1861
Multiple Acyl-Coa Dehydrogenase Deficiency
ORPHA:26791
Pelizaeus-Merzbacher Disease, Connatal Form
ORPHA:280210
Oculocerebrofacial Syndrome, Kaufman Type
ORPHA:2707
Lymphangiectasia, Intestinal
OMIM:152800
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal
OMIM:608836
Immunodeficiency 31C
OMIM:614162
Combined Oxidative Phosphorylation Deficiency 3
OMIM:610505
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Negative, Nk Cell-Negative, Due To Adenosine Deaminase Deficiency
OMIM:102700
Nocardiosis
ORPHA:31204
Laminin Subunit Alpha 2-Related Congenital Muscular Dystrophy
ORPHA:258
Aplasia Cutis Congenita With Intestinal Lymphangiectasia
OMIM:207731
Glycine Encephalopathy With Normal Serum Glycine
OMIM:617301
Kagami-Ogata Syndrome Due To Maternal 14Q32.2 Microdeletion
ORPHA:254528
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
ORPHA:331206
Wiskott-Aldrich Syndrome
ORPHA:906
3-Methylglutaconic Aciduria Type 7
ORPHA:445038
Autosomal Dominant Severe Congenital Neutropenia
ORPHA:486
Boutonneuse Fever
ORPHA:83313
Leigh Syndrome With Cardiomyopathy
ORPHA:70474
Immunodeficiency 36
OMIM:616005
Mitochondrial Trifunctional Protein Deficiency
OMIM:609015
Otopalatodigital Syndrome, Type Ii
OMIM:304120
Mirror Polydactyly-Vertebral Segmentation-Limbs Defects Syndrome
ORPHA:3004
Infantile Krabbe Disease
ORPHA:206436
Macrocephaly/Autism Syndrome
OMIM:605309
Noonan Syndrome 12
OMIM:618624
Glycogen Storage Disease Due To Acid Maltase Deficiency
ORPHA:365
Poliomyelitis
ORPHA:2912
Early-Onset Progressive Diffuse Brain Atrophy-Microcephaly-Muscle Weakness-Optic Atrophy Syndrome
ORPHA:496641
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
ORPHA:276
22Q11.2 Deletion Syndrome
ORPHA:567
Central Nervous System Calcification-Deafness-Tubular Acidosis-Anemia Syndrome
ORPHA:3240
Mitochondrial Trifunctional Protein Deficiency
ORPHA:746
Eec Syndrome
ORPHA:1896
Treacher-Collins Syndrome
ORPHA:861
Purine Nucleoside Phosphorylase Deficiency
ORPHA:760
Arterial Tortuosity Syndrome
ORPHA:3342
Bloom Syndrome
ORPHA:125
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
OMIM:600802
Proteus-Like Syndrome
ORPHA:2969
Niemann-Pick Disease, Type C2
OMIM:607625
Aplasia Cutis Congenita-Intestinal Lymphangiectasia Syndrome
ORPHA:1116
Malignant Atrophic Papulosis
ORPHA:679
Congenital Fiber-Type Disproportion Myopathy
ORPHA:2020
Short Rib-Polydactyly Syndrome
ORPHA:1505
Lethal Acantholytic Erosive Disorder
ORPHA:158687
Leigh Syndrome
ORPHA:506
Pgm3-Cdg
ORPHA:443811
T-B+ Severe Combined Immunodeficiency Due To Cd3Delta/Cd3Epsilon/Cd3Zeta
ORPHA:169160
Nijmegen Breakage Syndrome
ORPHA:647
S-Adenosylhomocysteine Hydrolase Deficiency
ORPHA:88618
Granulomatous Disease, Chronic, Autosomal Recessive, 5
OMIM:618935
Myopathy, Epilepsy, And Progressive Cerebral Atrophy
OMIM:619036
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 9
OMIM:616538
Immunodeficiency 49
OMIM:617237
Cyclic Neutropenia
ORPHA:2686
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
ORPHA:35078
Severe Generalized Junctional Epidermolysis Bullosa
ORPHA:79404
Schimke Immunoosseous Dysplasia
OMIM:242900
Autoimmune Lymphoproliferative Syndrome, Type V
OMIM:616100
Mitochondrial Complex I Deficiency, Nuclear Type 1
OMIM:252010
Myhre Syndrome
OMIM:139210
Ear-Patella-Short Stature Syndrome
ORPHA:2554
Icf Syndrome
ORPHA:2268
Kagami-Ogata Syndrome Due To Paternal Uniparental Disomy Of Chromosome 14
ORPHA:96334
Costello Syndrome
OMIM:218040
Cartilage-Hair Hypoplasia
OMIM:250250
Tuberous Sclerosis Complex
ORPHA:805
Niemann-Pick Disease Type C
ORPHA:646
Congenital Progressive Bone Marrow Failure-B-Cell Immunodeficiency-Skeletal Dysplasia Syndrome
ORPHA:508542
Purine Nucleoside Phosphorylase Deficiency
OMIM:613179
Autosomal Recessive Polycystic Kidney Disease
ORPHA:731
Monosomy 22
ORPHA:96123
Sting-Associated Vasculopathy, Infantile-Onset
OMIM:615934
Listeriosis
ORPHA:533
Microcephalic Osteodysplastic Primordial Dwarfism Types I And Iii
ORPHA:2636
Truncus Arteriosus
ORPHA:3384
Abetalipoproteinemia
ORPHA:14
Microphthalmia With Linear Skin Defects Syndrome
ORPHA:2556
Ulbright-Hodes Syndrome
ORPHA:3404
Autoimmune Lymphoproliferative Syndrome
ORPHA:3261
Steinert Myotonic Dystrophy
ORPHA:273
Wiskott-Aldrich Syndrome
OMIM:301000
Mirage Syndrome
OMIM:617053
Immunodeficiency 23
OMIM:615816
Dyskeratosis Congenita, Autosomal Dominant 1
OMIM:127550
Secondary Intestinal Lymphangiectasia
ORPHA:90363
Proteasome-Associated Autoinflammatory Syndrome 3
OMIM:617591
Brain Malformations-Musculoskeletal Abnormalities-Facial Dysmorphism-Intellectual Disability Syndrome
ORPHA:500150
Wiskott-Aldrich Syndrome, Autosomal Dominant
OMIM:600903
Vasculitis, Autoinflammation, Immunodeficiency, And Hematologic Defects Syndrome
OMIM:615688
Fusariosis
ORPHA:228119
Common Variable Immunodeficiency
ORPHA:1572
Short-Limb Skeletal Dysplasia With Severe Combined Immunodeficiency
ORPHA:935
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome
ORPHA:391487
Proteus Syndrome
ORPHA:744
Whim Syndrome
ORPHA:51636

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Carm1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Carm1.

No publications found that use IMPC mice or data for Carm1.

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MGI Allele Allele Type Produced
Carm1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Carm1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice

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