banner
Genes Phenotypes Help, News, Blog

Gene: Cldn15 MGI:1913103

Log in to follow
Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
claudin 15
Synonyms:
2210009B08Rik

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Cldn15 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Cldn15 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Lactose Intolerance, Adult Type
Lactose intolerance, Diarrhea, Decreased small intestinal mucosa lactase level OMIM:223100
Diarrhea 9
Diarrhea, Villous atrophy OMIM:618168
Diarrhea 2, With Microvillus Atrophy, With Or Without Cholestasis
Villous atrophy, Abnormal intestine morphology, Protracted diarrhea OMIM:251850
Diarrhea 11, Malabsorptive, Congenital
Diarrhea, Villous atrophy OMIM:618662
Diarrhea 5, With Tufting Enteropathy, Congenital
Intractable diarrhea, Villous atrophy, Crypt hyperplasia OMIM:613217
Epilepsy With Bilateral Occipital Calcifications
Celiac disease OMIM:226810
Meckel Diverticulum
Meckel diverticulum OMIM:155140
Blood Group, Cromer System
Protein-losing enteropathy OMIM:613793
Chronic Diarrhea Due To Glucoamylase Deficiency
Abnormal small intestinal mucosa morphology, Malabsorption, Decreased small intestinal mucosa lac... ORPHA:103907
Diarrhea 7, Protein-Losing Enteropathy Type
Diarrhea, Vomiting, Protein-losing enteropathy, Villous atrophy OMIM:615863
Diarrhea 12, With Microvillus Atrophy
Villous atrophy, Microvillus inclusions, Secretory diarrhea, Vomiting, Microvillar PAS-positive s... OMIM:619445
Lactase Deficiency, Congenital
Lactose intolerance, Diarrhea, Decreased small intestinal mucosa lactase level OMIM:223000
Jejunal Atresia
Jejunal atresia OMIM:243600
Autoinflammatory Disease, Familial, Behcet-Like 3
Ileitis OMIM:618287
Bile Acid Malabsorption, Primary, 1
Increased fecal bile acid, Fat malabsorption, Chronic diarrhea, Steatorrhea OMIM:613291
Multiple Intestinal Atresia
Gastrointestinal atresia, Duodenal stenosis ORPHA:2300
Chylomicron Retention Disease
Diarrhea, Vomiting, Accumulation of lipid droplets in small-bowel enterocytes, Steatorrhea OMIM:246700
Proprotein Convertase 1/3 Deficiency
Diarrhea, Malabsorption, Villous atrophy OMIM:600955
Inflammatory Skin And Bowel Disease, Neonatal, 1
Villous atrophy, Duodenitis, Bloody diarrhea OMIM:614328
Microvillus Inclusion Disease
Diarrhea, Abnormal small intestinal villus morphology, Villous atrophy ORPHA:2290
Inflammatory Bowel Disease (Crohn Disease) 30
Gastritis, Duodenitis, Chronic diarrhea, Pancolitis, Bloody diarrhea, Vomiting, Abnormal intestin... OMIM:619079
Appendicitis, Proneness To
Abnormal large intestine morphology OMIM:107700
Secondary Short Bowel Syndrome
Abnormal small intestine morphology, Villous atrophy, Aganglionic megacolon, Small intestinal dys... ORPHA:95427
Congenital Tufting Enteropathy
Villous atrophy, Abnormal small intestinal mucosa morphology, Elevated fecal osmolality, Malabsor... ORPHA:92050
Trichohepatoenteric Syndrome 2
Villous atrophy, Diarrhea, Chronic diarrhea, Bloody diarrhea, Colitis OMIM:614602
Vascular Hyalinosis
Hematochezia, Diarrhea, Protein-losing enteropathy, Malabsorption OMIM:277175
Autoinflammation With Infantile Enterocolitis
Episodic vomiting, Villous atrophy, Secretory diarrhea, Enterocolitis OMIM:616050
Congenital Disorder Of Glycosylation, Type Ib
Villous atrophy, Diarrhea, Vomiting, Protein-losing enteropathy, Steatorrhea OMIM:602579
Pancreatic Lipase Deficiency
Fat malabsorption, Steatorrhea OMIM:614338
Congenital Short Bowel Syndrome
Abnormal peristalsis, Projectile vomiting, Intestinal malrotation, Chronic diarrhea, Decreased in... OMIM:615237
Deafness, Nerve Type, With Mesenteric Diverticula Of Small Bowel And Progressive Sensory Neuropathy
Small bowel diverticula, Fat malabsorption, Jejunoileal ulceration OMIM:221400
Duodenal Atresia
Duodenal atresia OMIM:223400
Alpha-Heavy Chain Disease
Abnormal small intestine morphology, Malabsorption ORPHA:100025
Mitochondrial Complex Iv Deficiency, Nuclear Type 19
Increased mitochondrial number, Protein-losing enteropathy OMIM:619063
Congenital Disorder Of Glycosylation, Type Id
Villous atrophy, Diarrhea, High palate, Vomiting, Bifid uvula OMIM:601110
Small Bowel Atresia
Intestinal hypoplasia, Jejunal atresia, Vomiting, Intestinal malrotation ORPHA:1201
Hypercholanemia, Familial 1
Fat malabsorption, Steatorrhea OMIM:607748
Immunodeficiency 85 And Autoimmunity
Villous atrophy, Chronic diarrhea, Vomiting OMIM:619510
Bare Lymphocyte Syndrome, Type Ii
Malabsorption, Villous atrophy, Colitis, Protracted diarrhea OMIM:209920
Refractory Celiac Disease
Villous atrophy, Malabsorption, Chronic diarrhea, Protein-losing enteropathy, Jejunitis ORPHA:398063
Pancreatic Colipase Deficiency
Chronic diarrhea, Steatorrhea, Cholelithiasis, Fat malabsorption, Exocrine pancreatic insufficiency ORPHA:309108
Tremor-Nystagmus-Duodenal Ulcer Syndrome
Duodenal ulcer ORPHA:3350
Visceral Myopathy 2
Intestinal obstruction, Necrotizing enterocolitis, Gastroparesis, Intestinal malrotation, Intesti... OMIM:619350
Duodenal Ulcer Due To Antral G-Cell Hyperfunction
Duodenal ulcer OMIM:126840
Feingold Syndrome Type 2
Jejunal atresia ORPHA:391646
Duodenal Ulcer, Hyperpepsinogenemic I
Duodenal ulcer OMIM:126850
Martinez-Frias Syndrome
Intestinal hypoplasia, Hypoplasia of the gallbladder, Jejunal atresia, Intestinal malrotation, Tr... OMIM:601346
Mitchell-Riley Syndrome
Absent gallbladder, Jejunal atresia, Intestinal malrotation, Malabsorption, Diarrhea, Anteriorly ... OMIM:615710
Annular Pancreas
Annular pancreas, High intestinal obstruction, Duodenal stenosis ORPHA:675
Pancreas, Annular
Annular pancreas, High intestinal obstruction, Duodenal stenosis OMIM:167750
Nk-Cell Enteropathy
Colonic diverticula, Duodenal ulcer, Abnormal gastric mucosa morphology, Diarrhea, Hematochezia, ... ORPHA:263665
Congenital Enterocyte Heparan Sulfate Deficiency
Hematochezia, Diarrhea, Protein-losing enteropathy ORPHA:103910
Netherton Syndrome
Villous atrophy, Recurrent infection of the gastrointestinal tract, Intestinal atresia OMIM:256500
Umbilical Cord Ulceration-Intestinal Atresia Syndrome
Duodenal atresia, Intestinal atresia ORPHA:3405
Primary Intestinal Lymphangiectasia
Increased stool alpha1-antitrypsin concentration, Chronic diarrhea, Functional abnormality of the... ORPHA:90362
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Villous atrophy, Chronic diarrhea, Ileus OMIM:304790
Agammaglobulinemia 4, Autosomal Recessive
Protein-losing enteropathy OMIM:613502
Duodenal Atresia
Annular pancreas, Duodenal atresia ORPHA:1203
Tremor, Nystagmus, And Duodenal Ulcer
Duodenal ulcer OMIM:190310
Chronic Intestinal Pseudoobstruction
Pyloric stenosis, Abnormal intestine morphology, Intestinal malrotation ORPHA:2978
Osteootohepatoenteric Syndrome
Ileoileal intussusception, Villous atrophy, Increased intestinal transit time, Secretory diarrhea... OMIM:619377
Mirror Polydactyly-Vertebral Segmentation-Limbs Defects Syndrome
Aplasia of the thymus, Duodenal atresia ORPHA:3004
Intestinal Pseudoobstruction, Neuronal, Chronic Idiopathic, X-Linked
Intestinal pseudo-obstruction, Intestinal malrotation, Pyloric stenosis, Vomiting, Congenital sho... OMIM:300048
Eosinophilic Gastroenteritis
Abnormality of the gastrointestinal tract, Malabsorption, Diarrhea, Steatorrhea, Hematochezia, Vo... ORPHA:2070
Deafness-Small Bowel Diverticulosis-Neuropathy Syndrome
Malabsorption, Chronic diarrhea, Duodenal ulcer, Steatorrhea ORPHA:3217
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Small intestinal polyposis, Duodenal polyposis, Rectal polyposis, Adenomatous colonic polyposis, ... ORPHA:329971
Heterotaxy, Visceral, 11, Autosomal, With Male Infertility
Intestinal malrotation, Duodenal atresia OMIM:619608
Gastrointestinal Defects And Immunodeficiency Syndrome 1
Intestinal obstruction, Jejunal atresia, Intestinal malrotation, Ileal atresia, Rectal atresia, E... OMIM:243150
Immunodeficiency 31C
Villous atrophy, Diarrhea, Gastrointestinal eosinophilia, Protein-losing enteropathy, Intussuscep... OMIM:614162
Immunodeficiency, Common Variable, 8, With Autoimmunity
Atrophic gastritis, Villous atrophy, Chronic diarrhea, Inflammation of the large intestine, Colitis OMIM:614700
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Villous atrophy, Chronic diarrhea OMIM:606367
Hennekam Lymphangiectasia-Lymphedema Syndrome 3
Hydrocele testis, Protein-losing enteropathy OMIM:618154
Alg1-Cdg
Abnormality of the gastrointestinal tract, Chronic diarrhea, Protein-losing enteropathy ORPHA:79327
Autoinflammatory Syndrome, Familial, Behcet-Like 1
Colitis, Ileal ulcer OMIM:616744
Mungan Syndrome
Barrett esophagus, Intestinal pseudo-obstruction, Gastroparesis, Hypoperistalsis, Megaduodenum OMIM:611376
Mpi-Cdg
Gastrointestinal hemorrhage, Diarrhea, Vomiting, Protein-losing enteropathy ORPHA:79319
Thoraco-Abdominal Enteric Duplication
Intestinal malrotation, Duodenal stenosis ORPHA:1759
Abetalipoproteinemia
Fat malabsorption OMIM:200100
Congenital Contractural Arachnodactyly
Intestinal malrotation, High palate, Tracheoesophageal fistula, Duodenal atresia ORPHA:115
Polyposis, Skin Pigmentation, Alopecia, And Fingernail Changes
Malabsorption, Diarrhea, Xerostomia, Hematochezia, Hamartomatous polyposis, Vomiting, Protein-los... OMIM:175500
Cholestasis, Progressive Familial Intrahepatic, 2
Diarrhea, Fat malabsorption, Hepatocellular carcinoma OMIM:601847
Fanconi Anemia, Complementation Group W
Decreased response to growth hormone stimulation test, Duodenal atresia OMIM:617784
Trigonocephaly 1
High, narrow palate, Meckel diverticulum OMIM:190440
Parenteral Nutrition-Associated Cholestasis
Biliary hyperplasia, Cholelithiasis, Villous atrophy ORPHA:567983
Colonic Atresia
Peptic ulcer, Colonic atresia, Duodenal stenosis ORPHA:1198
Pearson Marrow-Pancreas Syndrome
Villous atrophy, Pancreatic fibrosis, Malabsorption, Chronic diarrhea, Vomiting, Steatorrhea, Exo... OMIM:557000
Familial Adenomatous Polyposis 4
Ovarian cyst, Duodenal polyposis, Adenomatous colonic polyposis, Gastric adenocarcinoma OMIM:617100
Attenuated Familial Adenomatous Polyposis
Duodenal polyposis, Neoplasm of the stomach, Rectal polyposis, Adenomatous colonic polyposis, Lar... ORPHA:220460
Congenital Disorder Of Glycosylation, Type Ia
Villous atrophy, Diarrhea, Vomiting, Steatorrhea OMIM:212065
Alg6-Cdg
Macroglossia, Protein-losing enteropathy ORPHA:79320
Cholestasis, Progressive Familial Intrahepatic, 1
Cholelithiasis, Diarrhea, Fat malabsorption OMIM:211600
Bile Acid Synthesis Defect, Congenital, 1
Acholic stools, Diarrhea, Fat malabsorption, Steatorrhea OMIM:607765
Feingold Syndrome
Esophageal atresia, Annular pancreas, Duodenal atresia ORPHA:1305
Microphthalmia-Microtia-Fetal Akinesia Syndrome
Duodenal stenosis ORPHA:2547
Syndromic Diarrhea
Villous atrophy, Gastritis, Hepatoblastoma, Bloody diarrhea, Colitis, Hypoplasia of the thymus, I... ORPHA:84064
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome
Villous atrophy, Diarrhea, Esophageal carcinoma, Enterocolitis, Abnormal intestine morphology ORPHA:391487
Gastrointestinal Ulceration, Recurrent, With Dysfunctional Platelets
Esophageal ulceration, Gastric ulcer, Duodenal ulcer OMIM:618372
X-Linked Cerebral-Cerebellar-Coloboma Syndrome
Meckel diverticulum, Dysphagia ORPHA:163961
Cog8-Cdg
Protein-losing enteropathy ORPHA:95428
Chylomicron Retention Disease
Fat malabsorption, Diarrhea, Vomiting, Steatorrhea ORPHA:71
Serkal Syndrome
Malrotation of small bowel ORPHA:139466
Congenital Bile Acid Synthesis Defect Type 3
Fat malabsorption, Bile duct proliferation ORPHA:79302
Trichohepatoenteric Syndrome 1
Intractable diarrhea, Villous atrophy, Bifid uvula OMIM:222470
Visceral Myopathy 1
Gastroparesis, Aganglionic megacolon, Intestinal pseudo-obstruction, Diarrhea, Vomiting, Constipa... OMIM:155310
Immunodeficiency 87 And Autoimmunity
Atrophic gastritis, Necrotizing enterocolitis, Villous atrophy, Secretory diarrhea, Cleft palate,... OMIM:619573
Immunodeficiency 82 With Systemic Inflammation
Villous atrophy, Gastritis, Duodenal ulcer, Diarrhea, Colitis, Vomiting, Anoperineal fistula, Cro... OMIM:619381
Congenital Disorder Of Glycosylation, Type Ih
Cryptorchidism, Diarrhea, Vomiting, Protein-losing enteropathy OMIM:608104
Bile Acid Synthesis Defect, Congenital, 4
Hematochezia, Fat malabsorption OMIM:214950
Vertebral, Cardiac, Tracheoesophageal, Renal, And Limb Defects
Esophageal atresia, Submucous cleft hard palate, Tracheoesophageal fistula, Duodenal atresia OMIM:619227
Alg9-Cdg
Villous atrophy, Diarrhea, Hypoplasia of the ovary, Gastroesophageal reflux, Vomiting, Hypoplasti... ORPHA:79328
Plasminogen Deficiency, Type I
Duodenal ulcer OMIM:217090
Fanconi Anemia, Complementation Group B
Esophageal atresia, Tracheoesophageal fistula, Duodenal atresia OMIM:300514
Pericardial And Diaphragmatic Defect
Meckel diverticulum, Intestinal malrotation, Abnormal gastrointestinal tract morphology ORPHA:2847
Menke-Hennekam Syndrome 2
Chronic constipation, Duodenal ulcer OMIM:618333
Fryns Syndrome
Aganglionic megacolon, Intestinal malrotation, Cryptorchidism, Cleft palate, Ectopic anus, High p... ORPHA:2059
Intellectual Developmental Disorder, Autosomal Dominant 53
Cryptorchidism, Gastrointestinal dysmotility, Intestinal malrotation, Duodenal atresia OMIM:617798
Zollinger-Ellison Syndrome
Gastrointestinal hemorrhage, Intestinal obstruction, Hyperparathyroidism, Duodenal ulcer, Peptic ... ORPHA:913
Esophageal Atresia
Barrett esophagus, Intestinal malrotation, Pyloric stenosis, Gastrointestinal dysmotility, Anorec... ORPHA:1199
Stromme Syndrome
Jejunal atresia, Intestinal malrotation, Cleft palate, Duodenal atresia OMIM:243605
Juvenile Polyposis Of Infancy
Gastrointestinal hemorrhage, High, narrow palate, Diarrhea, Rectal prolapse, Adenomatous colonic ... ORPHA:79076
Mednik Syndrome
Jejunal atresia, Diarrhea, Volvulus, Microcolon OMIM:609313
Microform Holoprosencephaly
Panhypopituitarism, Cleft palate, Duodenal atresia ORPHA:280200
Congenital Tracheal Stenosis
Abnormal stomach morphology, Tracheoesophageal fistula, Duodenal stenosis, Meckel diverticulum, A... ORPHA:141127
Congenital Alveolar Capillary Dysplasia
Absent gallbladder, Aganglionic megacolon, Intestinal malrotation, Annular pancreas, Tracheoesoph... ORPHA:210122
Scedosporiosis
Abnormal jejunum morphology ORPHA:449280
Oculoskeletodental Syndrome
Macroglossia, Protein-losing enteropathy, Cryptorchidism OMIM:618440
Metachromatic Leukodystrophy
Bowel incontinence, Abnormal stomach morphology, Neoplasm of the gallbladder, Abnormal gallbladde... ORPHA:512
Feingold Syndrome Type 1
Jejunal atresia, Esophageal atresia, Gastrointestinal atresia, Anal atresia, Duodenal atresia ORPHA:391641
Systemic Sclerosis
Abnormality of the gastrointestinal tract, Abnormal small intestine morphology, Barrett esophagus... ORPHA:90291
Trichothiodystrophy 3, Photosensitive
Bilateral cryptorchidism, Pyloric stenosis, Meckel diverticulum OMIM:616395
Hypoplasminogenemia
Duodenal ulcer, Abnormality of the ovary ORPHA:722
Congenital Bile Acid Synthesis Defect Type 2
Fat malabsorption, Steatorrhea ORPHA:79303
Apc-Related Attenuated Familial Adenomatous Polyposis
Neoplasm of the pancreas, Duodenal polyposis, Adenomatous colonic polyposis, Esophageal carcinoma... ORPHA:247806
Gist-Plus Syndrome
Gastrointestinal stroma tumor, Intussusception, Intestinal polyposis OMIM:175510
Matthew-Wood Syndrome
Cryptorchidism, Annular pancreas, Aplasia/Hypoplasia of the pancreas, Duodenal stenosis ORPHA:2470
Fanconi Anemia, Complementation Group F
Cryptorchidism, Decreased response to growth hormone stimulation test, Duodenal atresia OMIM:603467
Intussusception
Intussusception OMIM:147710
Diarrhea 10, Protein-Losing Enteropathy Type
Hematochezia, Cryptorchidism, Secretory diarrhea, Protein-losing enteropathy OMIM:618183
Dextrocardia
Pancreatic hypoplasia, Meckel diverticulum, Intestinal malrotation ORPHA:1666
Cat Eye Syndrome
Anal stenosis, Intestinal malrotation, Rectal fistula, Rectal atresia, Cleft palate, Volvulus, Me... OMIM:115470
Mosaic Variegated Aneuploidy Syndrome 2
Decreased response to growth hormone stimulation test, Duodenal atresia OMIM:614114
Gardner Syndrome
Neoplasm of the pancreas, Duodenal polyposis, Ampulla of Vater carcinoma, Adenomatous colonic pol... ORPHA:79665
Holoprosencephaly 13, X-Linked
Submucous cleft hard palate, Cleft palate, Gastroesophageal reflux, Median cleft palate, Duodenal... OMIM:301043
Familial Adenomatous Polyposis 1
Duodenal polyposis, Adenomatous colonic polyposis, Multiple gastric polyps, Desmoid tumors, Small... OMIM:175100
Mullerian Derivatives, Persistence Of, With Lymphangiectasia And Postaxial Polydactyly
Cryptorchidism, Pancreatic lymphangiectasis, Cleft palate, High palate, Protein-losing enteropathy OMIM:235255
Feingold Syndrome 1
Jejunal atresia, Esophageal atresia, Gastrointestinal atresia, Tracheoesophageal fistula, High pa... OMIM:164280
Whim Syndrome
Abnormal small intestine morphology, Parotitis ORPHA:51636
Familial Adenomatous Polyposis Due To 5Q22.2 Microdeletion
Duodenal polyposis, Adenomatous colonic polyposis, Desmoid tumors, Intestinal bleeding, High pala... ORPHA:261584
Miller-Dieker Lissencephaly Syndrome
Cryptorchidism, Cleft palate, Duodenal atresia OMIM:247200
Juvenile Polyposis Syndrome
Gastrointestinal hemorrhage, Small intestinal polyposis, Juvenile gastrointestinal polyposis, Neo... ORPHA:2929
Mosaic Variegated Aneuploidy Syndrome 1
Cryptorchidism, Cleft palate, Duodenal atresia OMIM:257300
Acrocephalopolydactylous Dysplasia
Hypoplastic colon, Hypoplasia of the small intestine, Pancreatic fibrosis OMIM:200995
Maternal Uniparental Disomy Of Chromosome 4
Diarrhea, Fat malabsorption ORPHA:96180
Diets-Jongmans Syndrome
Cryptorchidism, Duodenal atresia OMIM:618846
Dyrk1A-Related Intellectual Disability Syndrome
Anterior pituitary hypoplasia, Pyloric stenosis, Cryptorchidism, Gastroesophageal reflux, Vomitin... ORPHA:464306
Fryns Syndrome
Ectopic pancreatic tissue, Aganglionic megacolon, Intestinal malrotation, Esophageal atresia, Cry... OMIM:229850
Müllerian Derivatives-Lymphangiectasia-Polydactyly Syndrome
Cryptorchidism, Pancreatic lymphangiectasis, High palate, Protein-losing enteropathy ORPHA:1655
Jacobsen Syndrome
Intestinal malrotation, Pyloric stenosis, Cryptorchidism, Abnormality of the anus, Ectopic anus, ... ORPHA:2308
Mosaic Variegated Aneuploidy Syndrome
Intestinal polyposis, Cleft palate, Colon cancer, Stomach cancer, Duodenal atresia ORPHA:1052
Intellectual Disability Syndrome Due To A Dyrk1A Point Mutation
Cryptorchidism, Posterior pituitary hypoplasia, Gastroesophageal reflux, Vomiting, Duodenal atresia ORPHA:464311
Familial Adenomatous Polyposis
Cholangiocarcinoma, Duodenal polyposis, Pancreatic adenocarcinoma, Stomach cancer, Pituitary aden... ORPHA:733
Isolated Biliary Atresia
Atretic gallbladder, Acholic stools, Fat malabsorption, Bile duct proliferation, Hypopituitarism ORPHA:30391
Iniencephaly
Anal atresia, Duodenal atresia ORPHA:63259
Tarp Syndrome
Cleft palate, Tongue nodules, Glossoptosis, High palate, Meckel diverticulum OMIM:311900
Focal Dermal Hypoplasia
Gastroesophageal reflux, Duodenal atresia ORPHA:2092
Multiple Endocrine Neoplasia Type 1
Pituitary corticotropic cell adenoma, Pituitary gonadotropic cell adenoma, Zollinger-Ellison synd... ORPHA:652
Neurodevelopmental Disorder With Or Without Anomalies Of The Brain, Eye, Or Heart
Cryptorchidism, Furrowed tongue, High palate, Gastroesophageal reflux, Annular pancreas, Duodenal... OMIM:616975
Hennekam Lymphangiectasia-Lymphedema Syndrome 1
Cryptorchidism, Rectal prolapse, Narrow palate, Protein-losing enteropathy, Intestinal lymphangie... OMIM:235510
Alveolar Capillary Dysplasia With Misalignment Of Pulmonary Veins
Intestinal malrotation, Esophageal atresia, Tracheoesophageal fistula, Cleft palate, Congenital s... OMIM:265380
Distal Deletion 12Q
Unilateral cryptorchidism, High, narrow palate, Esophageal atresia, Pyloric stenosis, Annular pan... ORPHA:96149
Spondyloocular Syndrome
Unilateral cryptorchidism, Duodenal ulcer OMIM:605822
Musculocontractural Ehlers-Danlos Syndrome
Cryptorchidism, Malrotation of small bowel, Cleft palate, High palate, Constipation ORPHA:2953
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency
Cryptorchidism, Duodenal atresia ORPHA:468631
Tarp Syndrome
Cryptorchidism, Cleft palate, Glossoptosis, Abnormal duodenum morphology, Tongue nodules ORPHA:2886
Mosaic Trisomy 16
Anteriorly placed anus, Abnormality of the gastrointestinal tract, Meckel diverticulum ORPHA:1708
Heterotaxy, Visceral, 5, Autosomal
Intestinal malrotation, Duodenal atresia OMIM:270100
Zygomycosis
Gastrointestinal hemorrhage, Gastritis, Hematemesis, Diarrhea, Peritonitis, Enterocolitis, Hemato... ORPHA:73263
Autosomal Recessive Polycystic Kidney Disease
Gastrointestinal hemorrhage, Cholangiocarcinoma, Biliary hyperplasia, Pancreatic cysts, Esophagea... ORPHA:731
Heterotaxy, Visceral, 1, X-Linked
Posteriorly placed anus, Anal atresia, Duodenal atresia OMIM:306955
Townes-Brocks Syndrome 1
Anal stenosis, Rectoperineal fistula, Cryptorchidism, Tracheoesophageal fistula, Gastroesophageal... OMIM:107480
Ehlers-Danlos Syndrome, Musculocontractural Type, 1
Intestinal malrotation, Hiatus hernia, Cryptorchidism, Cleft palate, High palate, Constipation, A... OMIM:601776
Abetalipoproteinemia
Fat malabsorption, Chronic diarrhea, Vomiting, Steatorrhea ORPHA:14
Trisomy 8P
Cryptorchidism, Malrotation of small bowel, Cleft palate, Constipation, Aplasia/Hypoplasia of the... ORPHA:264450
Shwachman-Diamond Syndrome
Abnormality of the gastrointestinal tract, Hypopituitarism, Decreased response to growth hormone ... ORPHA:811
Fraser Syndrome 1
Cryptorchidism, Abnormal small intestine morphology, Cleft palate, Abnormality of the anus OMIM:219000
Autosomal Recessive Cutis Laxa Type 1
Pyloric stenosis, Small bowel diverticula ORPHA:90349
Charge Syndrome
Hypoparathyroidism, Anal stenosis, Decreased response to growth hormone stimulation test, Esophag... OMIM:214800
Coffin-Siris Syndrome 1
Duodenal ulcer, Intestinal malrotation, Cryptorchidism, Cleft palate, Gastric ulcer, High palate,... OMIM:135900
Autosomal Dominant Cutis Laxa
Vomiting, Small bowel diverticula ORPHA:90348
Genitopatellar Syndrome
Anal stenosis, Cryptorchidism, Malrotation of small bowel, Anteriorly placed anus, Dysphagia, Ana... OMIM:606170
Liver Disease, Severe Congenital
Chronic gastritis, Biliary hyperplasia, Diarrhea, Peritonitis, Hydrocele testis, Vomiting, Protei... OMIM:619991
Viss Syndrome
Chronic gastritis, Duodenitis, Intestinal malrotation, Cleft soft palate, Submucous cleft soft pa... OMIM:619472

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Cldn15

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Cldn15.

No publications found that use IMPC mice or data for Cldn15.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Cldn15tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Cldn15tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter