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Gene: Ackr2 MGI:1891697

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
atypical chemokine receptor 2
Synonyms:
chemokine decoy receptor D6,  Ccbp2,  D6

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ackr2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ackr2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Acne Inversa, Familial, 3
Chronic furunculosis, Perifolliculitis, Acne inversa, Recurrent cutaneous abscess formation OMIM:613737
Lymphoblastic Transformation, Intrinsic Defect In
Chronic mucocutaneous candidiasis OMIM:247450
Lymphoblastic Transformation, Inhibition Of
Chronic mucocutaneous candidiasis OMIM:247430
Lymphokine Deficiency
Chronic mucocutaneous candidiasis OMIM:247650
Candidiasis, Familial, 6
Chronic mucocutaneous candidiasis OMIM:613956
Acne Inversa, Familial, 1
Acne inversa OMIM:142690
Chilblain Lupus 2
Chilblains OMIM:614415
Benign Cephalic Histiocytosis
Inflammatory abnormality of the skin, Skin rash ORPHA:157997
Paget Disease, Extramammary
Eczematoid dermatitis OMIM:167300
Immunodeficiency 51
Pneumonia, Folliculitis, Chronic mucocutaneous candidiasis, Eczematoid dermatitis, Cutaneous absc... OMIM:613953
Dissecting Cellulitis Of The Scalp
Pruritus, Recurrent skin infections ORPHA:345
Kerion Celsi
Inflammatory abnormality of the skin, Recurrent skin infections, Recurrent cutaneous abscess form... ORPHA:499
Intellectual Developmental Disorder, Fra12A Type
Erythroderma OMIM:136630
Immunodeficiency 107, Susceptibility To Invasive Staphylococcus Aureus Infection
Chronic furunculosis, Cutaneous abscess OMIM:619986
Erythroderma, Lethal Congenital
Congenital exfoliative erythroderma OMIM:227090
Erythema Nodosum, Familial
Erythema nodosum OMIM:132990
Familial Reactive Perforating Collagenosis
Inflammatory abnormality of the skin, Maculopapular exanthema, Crusting erythematous dermatitis, ... ORPHA:79147
Perifolliculitis Capitis Abscedens Et Suffodiens, Familial
Perifolliculitis OMIM:260910
Chronic Actinic Dermatitis
Allergic rhinitis, Eczematoid dermatitis, Erythroderma, Late onset atopic dermatitis, Pruritus ORPHA:330064
Acne Inversa, Familial, 2, With Or Without Dowling-Degos Disease
Chronic furunculosis, Perifolliculitis, Acne inversa, Recurrent cutaneous abscess formation OMIM:613736
Erythroderma Desquamativum
Seborrheic dermatitis ORPHA:314
Bullous Diffuse Cutaneous Mastocytosis
Pruritus, Erythroderma ORPHA:280785
Ichthyosis, Congenital, Autosomal Recessive 7
Erythroderma OMIM:615022
Immunodeficiency 53
Recurrent otitis media, Recurrent pneumonia, Skin rash OMIM:617585
Seborrhea-Like Dermatitis With Psoriasiform Elements
Seborrheic dermatitis OMIM:610227
Pityriasis Rubra Pilaris
Pustule, Pruritus, Erythroderma, Eczematoid dermatitis ORPHA:2897
Candidiasis, Familial, 8
Cheilitis, Seborrheic dermatitis, Blepharitis, Chronic oral candidiasis OMIM:615527
Mannose-Binding Lectin Deficiency
Recurrent skin infections OMIM:614372
Erythrokeratodermia Variabilis Et Progressiva 1
Erythroderma OMIM:133200
Verrucous Hemangioma
Inflammatory abnormality of the skin ORPHA:464318
Lymphatic Malformation 3
Recurrent skin infections OMIM:613480
Epidermolytic Hyperkeratosis 1
Erythroderma OMIM:113800
Ige Responsiveness, Atopic
Allergic rhinitis, Eczematoid dermatitis OMIM:147050
Complement Component C1R/C1S Deficiency
Discoid lupus rash, Nephritis, Arthritis OMIM:216950
Immunodeficiency 15A
Acne inversa, Chronic mucocutaneous candidiasis, Cutaneous abscess, Recurrent otitis media, Recur... OMIM:618204
Keratolytic Winter Erythema
Pustule ORPHA:50943
Inflammatory Bowel Disease 28, Autosomal Recessive
Folliculitis, Pyoderma, Crohn's disease, Perianal abscess, Enterocolitis, Colitis OMIM:613148
Ichthyosis, Congenital, Autosomal Recessive 10
Erythroderma OMIM:615024
Epidermolytic Hyperkeratosis 2A, Autosomal Dominant
Erythroderma OMIM:620150
X-Linked Intellectual Disability-Seizures-Psoriasis Syndrome
Psoriasiform dermatitis ORPHA:3052
Impaired Intellectual Development And Psoriasis
Psoriasiform dermatitis OMIM:309480
Chronic Recurrent Multifocal Osteomyelitis 3
Osteomyelitis, Palmoplantar pustulosis OMIM:259680
Quinquaud Folliculitis Decalvans
Pustule, Recurrent skin infections ORPHA:346
Immunodeficiency 66
Pustule, Recurrent skin infections OMIM:618847
Epidermodysplasia Verruciformis
Pustule, Seborrheic dermatitis, Recurrent skin infections ORPHA:302
Erosive Pustular Dermatosis Of The Scalp
Pustule ORPHA:222
Ichthyosis Vulgaris
Eczematoid dermatitis OMIM:146700
Bullous Impetigo
Pustule, Septic arthritis, Recurrent bacterial skin infections ORPHA:36237
Complement Component 5 Deficiency
Generalized seborrheic dermatitis OMIM:609536
Ichthyosis Prematurity Syndrome
Allergic rhinitis, Pruritus, Erythroderma OMIM:608649
Congenital Ichthyosiform Erythroderma
Pruritus, Keratitis, Erythroderma ORPHA:79394
Congenital Lethal Erythroderma
Congenital exfoliative erythroderma ORPHA:1954
Agammaglobulinemia 9, Autosomal Recessive
Seborrheic dermatitis, Eczematoid dermatitis OMIM:619693
Inflammatory Skin And Bowel Disease, Neonatal, 1
Pustule, Erythroderma, Blepharitis OMIM:614328
Peeling Skin Syndrome 1
Pruritus, Erythroderma OMIM:270300
Hydroa Vacciniforme
Papulovesicular eruption, Keratitis, Eczematoid dermatitis, Malar rash, Superficial dermal periva... ORPHA:330058
Deafness, Neural, With Atypical Atopic Dermatitis
Late onset atopic dermatitis OMIM:221700
Immunodeficiency 50
Eczematoid dermatitis OMIM:300988
Dermatitis, Atopic
Allergic rhinitis, Atopic dermatitis, Eczematoid dermatitis, Pruritus, Conjunctivitis, Recurrent ... OMIM:603165
Alopecia-Intellectual Disability Syndrome 4
Erythroderma OMIM:618840
Proteasome-Associated Autoinflammatory Syndrome 5
Skin rash OMIM:619175
Elastoderma
Eczematoid dermatitis, Erysipelas ORPHA:228240
Autosomal Dominant Epidermolytic Ichthyosis
Erythroderma ORPHA:312
Pressure-Induced Localized Lipoatrophy
Inflammatory abnormality of the skin ORPHA:90160
Pemphigus Foliaceus
Psoriasiform dermatitis, Crusting erythematous dermatitis, Pustule, Erythroderma, Pruritus ORPHA:79481
Drug Reaction With Eosinophilia And Systemic Symptoms
Hepatitis, Interstitial pneumonitis, Skin rash, Infectious encephalitis, Pustule, Erythroderma, M... ORPHA:139402
T-B+ Severe Combined Immunodeficiency Due To Cd3Delta/Cd3Epsilon/Cd3Zeta
Pneumonia, Recurrent pneumonia, Hepatitis, Otitis media, Erythroderma, Chronic oral candidiasis ORPHA:169160
Chilblain Lupus
Discoid lupus rash, Inflammatory abnormality of the skin, Malar rash, Skin rash, Pruritis on hand ORPHA:90280
Psoriasis 15, Pustular, Susceptibility To
Psoriasiform dermatitis OMIM:616106
Copper Deficiency, Familial Benign
Seborrheic dermatitis OMIM:121270
Mycosis Fungoides
Pruritus, Psoriasiform dermatitis, Eczematoid dermatitis OMIM:254400
Interstitial Granulomatous Dermatitis With Arthritis
Inflammatory abnormality of the skin, Pruritus, Rheumatoid arthritis ORPHA:79099
Netherton Syndrome
Allergic rhinitis, Eczematoid dermatitis, Chronic rhinitis, Erythroderma, Recurrent skin infections OMIM:256500
Phoar2-Enteropathy Syndrome
Seborrheic dermatitis, Acne OMIM:614441
Ichthyosis With Erythrokeratoderma
Pruritus, Erythroderma OMIM:620507
Hyper-Ige Syndrome 5, Autosomal Recessive, With Recurrent Infections
Recurrent otitis media, Atopic dermatitis, Recurrent skin infections, Cutaneous abscess OMIM:618944
Ichthyosis, Hystrix-Like, With Deafness
Punctate keratitis, Erythroderma OMIM:602540
Inflammatory Bowel Disease 25, Autosomal Recessive
Perianal abscess, Folliculitis, Enterocolitis, Pancolitis OMIM:612567
Ichthyosis With Confetti
Pruritus, Erythroderma OMIM:609165
Immunodeficiency 11B With Atopic Dermatitis
Pneumonia, Atopic dermatitis, Ulcerative colitis, Disseminated molluscum contagiosum, Colonic eos... OMIM:617638
Zinc Deficiency, Transient Neonatal
Eczematoid dermatitis OMIM:608118
Mal De Meleda
Inflammatory abnormality of the skin, Superficial dermal perivascular inflammatory infiltrate ORPHA:87503
Immunodeficiency 58
Allergic rhinitis, Recurrent pneumonia, Bronchiectasis, Eczematoid dermatitis, Cutaneous abscess,... OMIM:618131
Erythrokeratodermia Variabilis Et Progressiva 6
Pruritus, Superficial dermal perivascular inflammatory infiltrate OMIM:618531
Ichthyosis, Congenital, Autosomal Recessive 5
Erythroderma OMIM:604777
Ichthyosis, Congenital, Autosomal Recessive 9
Erythroderma OMIM:615023
Immunodeficiency 85 And Autoimmunity
Oligoarthritis, Erythroderma, Eczematoid dermatitis OMIM:619510
Lamellar Ichthyosis
Pruritus, Erythroderma, Chronic otitis media ORPHA:313
Papa Syndrome
Crohn's disease, Increased inflammatory response, Pustule, Myositis, Arthritis, Acne ORPHA:69126
Immunodeficiency 25
Recurrent pneumonia, Erythroderma OMIM:610163
Immunodysregulation, Polyendocrinopathy, And Enteropathy, X-Linked
Hepatitis, Eczematoid dermatitis, Erythroderma, Glomerulonephritis, Arthritis OMIM:304790
Hypertrophic Osteoarthropathy, Primary, Autosomal Dominant
Seborrheic dermatitis, Acne OMIM:167100
Generalized Pustular Psoriasis
Palmoplantar pustulosis, Pustule, Erythroderma, Arthritis, Cheilitis, Uveitis ORPHA:247353
Wiskott-Aldrich Syndrome 2
Eczematoid dermatitis OMIM:614493
Juvenile Arthritis
Skin rash OMIM:618795
Hyper-Ige Syndrome 3, Autosomal Recessive, With Recurrent Infections
Atopic dermatitis, Recurrent pneumonia, Eczematoid dermatitis, Cutaneous abscess, Chronic mucocut... OMIM:618282
Panniculitis-Induced Localized Lipodystrophy
Inflammatory abnormality of the skin ORPHA:90159
Netherton Syndrome
Skin rash, Erythroderma, Eczematoid dermatitis ORPHA:634
Ichthyosis, Congenital, Autosomal Recessive 1
Erythroderma OMIM:242300
Spinocerebellar Ataxia 34
Erythroderma OMIM:133190
Omenn Syndrome
Pneumonia, Pruritus, Erythroderma, Thyroiditis ORPHA:39041
Sézary Syndrome
Pruritus, Erythroderma ORPHA:3162
Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-Ige
Eosinophilic infiltration of the esophagus, Psoriasiform dermatitis, Erythroderma, Recurrent skin... OMIM:615508
Pruritic Urticarial Papules And Plaques Of Pregnancy
Pruritus on foot, Eczematoid dermatitis, Pruritis on breast, Pruritis on hand, Pruritis on abdome... ORPHA:64745
Harlequin Ichthyosis
Erythroderma ORPHA:457
Bathing Suit Ichthyosis
Erythroderma ORPHA:100976
Immunodeficiency 41 With Lymphoproliferation And Autoimmunity
Eczematoid dermatitis, Psoriasiform dermatitis, Erythroderma, Thyroiditis, Chronic oral candidiasis OMIM:606367
Ichthyosis, Congenital, Autosomal Recessive 6
Erythroderma OMIM:612281
Idiopathic Localized Lipodystrophy
Pruritus, Inflammatory abnormality of the skin ORPHA:90158
Familial Hemophagocytic Lymphohistiocytosis
Skin rash, Infectious encephalitis, Erythroderma, Colitis, Maculopapular exanthema ORPHA:540
Immunodeficiency, Common Variable, 12, With Autoimmunity
Atrophic gastritis, Recurrent pneumonia, Recurrent sinusitis, Recurrent skin infections, Bronchie... OMIM:616576
Diffuse Cutaneous Mastocytosis
Pruritus, Erythroderma ORPHA:79456
Keratitis-Ichthyosis-Deafness Syndrome, Autosomal Recessive
Conjunctivitis, Erythroderma OMIM:242150
Neutropenia, Severe Congenital, X-Linked
Eczematoid dermatitis OMIM:300299
Immunodeficiency 57 With Autoinflammation
Inflammation of the large intestine, Skin rash, Perianal abscess, Gastritis, Bronchiectasis OMIM:618108
Protoporphyria, Erythropoietic, 1
Pruritus, Eczematoid dermatitis OMIM:177000
Letterer-Siwe Disease
Seborrheic dermatitis, Stomatitis OMIM:246400
Congenital Disorder Of Glycosylation, Type If
Erythroderma OMIM:609180
Biotinidase Deficiency
Conjunctivitis, Recurrent skin infections, Skin rash, Seborrheic dermatitis OMIM:253260
Yao Syndrome
Uveitis, Inflammatory abnormality of the skin, Skin rash, Keratoconjunctivitis sicca, Arthritis, ... OMIM:617321
Peeling Skin Syndrome 6
Atopic dermatitis, Pruritus OMIM:618084
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Erythroderma ORPHA:169154
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Inflammation of the large intestine, Eczematoid dermatitis, Lymphadenitis, Erythroderma OMIM:615895
Omenn Syndrome
Pneumonia, Erythroderma OMIM:603554
Hypertrophic Osteoarthropathy, Primary, Autosomal Recessive, 1
Seborrheic dermatitis, Eczematoid dermatitis, Arthritis OMIM:259100
Majeed Syndrome
Osteomyelitis, Inflammatory abnormality of the skin, Skin rash OMIM:609628
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Recurrent otitis media, Recurrent pneumonia, Inflammatory abnormality of the skin, Sinusitis ORPHA:277
Rat-Bite Fever
Lymphadenitis, Parotitis, Morbilliform rash, Skin rash, Pustule, Myocarditis, Oligoarthritis, Pan... ORPHA:31205
X-Linked Dominant Chondrodysplasia Punctata
Erythroderma ORPHA:35173
Transketolase Deficiency
Conjunctivitis, Seborrheic dermatitis, Uveitis ORPHA:488618
Pachydermoperiostosis
Eczematoid dermatitis, Osteomyelitis, Seborrheic dermatitis, Arthritis, Acne ORPHA:2796
Hyperzincemia With Functional Zinc Depletion
Skin rash OMIM:601979
Centrifugal Lipodystrophy
Inflammatory abnormality of the skin, Lymphadenitis ORPHA:90156
Immunoskeletal Dysplasia With Neurodevelopmental Abnormalities
Erythroderma OMIM:617425
Trichothiodystrophy 1, Photosensitive
Keratoconjunctivitis sicca, Erythroderma OMIM:601675
Vexas Syndrome
Arteritis, Inflammatory abnormality of the skin, Neutrophilic infiltration of the skin, Nasal cho... OMIM:301054
Idiopathic Hypereosinophilic Syndrome
Inflammatory abnormality of the skin, Eczematoid dermatitis, Colitis, Erythroderma, Pancreatitis,... ORPHA:3260
Sapho Syndrome
Inflammation of the large intestine, Osteomyelitis, Psoriasiform dermatitis, Skin rash, Palmoplan... ORPHA:793
Chondrodysplasia Punctata 2, X-Linked Dominant
Erythroderma OMIM:302960
Majeed Syndrome
Inflammatory abnormality of the skin, Osteomyelitis, Synovitis, Pustule, Abnormal inflammatory re... ORPHA:77297
3-Methylcrotonyl-Coa Carboxylase 2 Deficiency
Seborrheic dermatitis OMIM:210210
Graft Versus Host Disease
Pneumonia, Inflammatory abnormality of the skin, Fasciitis, Acute hepatitis, Chronic hepatitis, M... ORPHA:39812
Trichothiodystrophy
Congenital exfoliative erythroderma, Conjunctivitis, Keratoconjunctivitis sicca, Eczematoid derma... ORPHA:33364
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Pneumonia, Inflammatory abnormality of the skin, Eczematoid dermatitis, Hepatitis, Osteomyelitis,... ORPHA:37042
Melkersson-Rosenthal Syndrome
Inflammatory abnormality of the skin, Cheilitis ORPHA:2483
Intellectual Disability-Seizures-Macrocephaly-Obesity Syndrome
Seborrheic dermatitis, Eczematoid dermatitis ORPHA:369950
Uremic Pruritus
Pruritus, Inflammatory abnormality of the skin, Recurrent skin infections ORPHA:94059
Hemihyperplasia-Multiple Lipomatosis Syndrome
Seborrheic dermatitis ORPHA:276280
Neurodevelopmental Disorder With Epilepsy And Hemochromatosis
Seborrheic dermatitis, Aspiration pneumonia OMIM:301072
Monosomy 22
Seborrheic dermatitis ORPHA:96123
Agammaglobulinemia-Microcephaly-Craniosynostosis-Severe Dermatitis Syndrome
Seborrheic dermatitis, Eczematoid dermatitis, Superficial dermal perivascular inflammatory infilt... ORPHA:83617
22Q11.2 Deletion Syndrome
Seborrheic dermatitis, Acne, Chronic otitis media, Arthritis ORPHA:567
Multiple Congenital Anomalies-Hypotonia-Seizures Syndrome 2
Seborrheic dermatitis OMIM:300868
Malakoplakia
Inflammatory abnormality of the skin, Urinary bladder inflammation, Skin rash, Orchitis, Pruritus ORPHA:556
Thrombocytopenia-Absent Radius Syndrome
Seborrheic dermatitis OMIM:274000
Ifap Syndrome 1, With Or Without Bresheck Syndrome
Recurrent skin infections, Erythroderma, Eczematoid dermatitis, Keratitis OMIM:308205
Digeorge Syndrome
Recurrent pneumonia, Recurrent otitis media, Recurrent sinusitis, Seborrheic dermatitis, Acne OMIM:188400

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ackr2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ackr2.

No publications found that use IMPC mice or data for Ackr2.

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MGI Allele Allele Type Produced
Ackr2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Ackr2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Ackr2tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells

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