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Gene: Brat1 MGI:1891679

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Gene Summary

Name:
BRCA1-associated ATM activator 1
Synonyms:
Baat1

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, incomplete penetrance Brat1em1(IMPC)Bay HOM   Early adult 0.00
abnormal placenta size Brat1em1(IMPC)Bay HOM E18.5 0.00
abnormal embryo size Brat1em1(IMPC)Bay HOM E18.5 0.00
embryonic growth retardation Brat1em1(IMPC)Bay HOM E18.5 0.00
abnormal embryo size Brat1em1(IMPC)Bay HET E18.5 0.00

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Eye Morphology

VIP of right eye

16 Images

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Eye Morphology

VIP of right fundus

15 Images

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Eye Morphology

VIP of left eye

16 Images

View images
Eye Morphology

VIP of left fundus

16 Images

View images

Human diseases caused by Brat1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Brat1 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal
OMIM:614498
Neurodevelopmental Disorder With Cerebellar Atrophy And With Or Without Seizures
OMIM:618056

The table below shows human diseases predicted to be associated to Brat1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal
OMIM:614498
Neurodevelopmental Disorder With Cerebellar Atrophy And With Or Without Seizures
OMIM:618056

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Brat1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Brat1.

No publications found that use IMPC mice or data for Brat1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Brat1tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Brat1tm2e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Brat1em1(IMPC)Bay Exon Deletion Mice

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