Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
embryonic growth retardation | Brat1em1(IMPC)Bay | HOM | E18.5 | 0.00 | ||
abnormal placenta size | Brat1em1(IMPC)Bay | HOM | E18.5 | 0.00 | ||
abnormal embryo size | Brat1em1(IMPC)Bay | HET | E18.5 | 0.00 | ||
preweaning lethality, incomplete penetrance | Brat1em1(IMPC)Bay | HOM | Early adult | 0.00 | ||
abnormal embryo size | Brat1em1(IMPC)Bay | HOM | E18.5 | 0.00 |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases associated to Brat1 by orthology or direct annotation.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal | OMIM:614498 | ||
Neurodevelopmental Disorder With Cerebellar Atrophy And With Or Without Seizures | OMIM:618056 |
The table below shows human diseases predicted to be associated to Brat1 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Rigidity And Multifocal Seizure Syndrome, Lethal Neonatal | OMIM:614498 | ||
Neurodevelopmental Disorder With Cerebellar Atrophy And With Or Without Seizures | OMIM:618056 |
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Brat1tm2a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Brat1tm2e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
Brat1em1(IMPC)Bay | Exon Deletion | Mice |
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