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Gene: Ripk2 MGI:1891456

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
receptor (TNFRSF)-interacting serine-threonine kinase 2
Synonyms:
RIP2,  D4Bwg0615e,  CCK,  2210420D18Rik,  CARDIAK,  RICK,  CARD3

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Ripk2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ripk2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Immunodeficiency, X-Linked, With Deficiency Of 115,000 Dalton Surface Glycoprotein
Recurrent bacterial infections, Abnormality of T cell physiology, Recurrent viral infections, Rec... OMIM:308220
Monocyte Chemotactic Disorder
Cutaneous anergy, Chronic mucocutaneous candidiasis OMIM:252250
Immune Deficiency, Familial Variable
Decreased circulating IgG level, Decreased circulating IgA level, Recurrent infections OMIM:146830
Gamma-A-Globulin, Defect In Assembly Of
Recurrent respiratory infections, Decreased circulating IgA level OMIM:137050
Retinal Telangiectasia And Hypogammaglobulinemia
Reduced delayed hypersensitivity, Decreased circulating IgG level OMIM:267900
Immunodeficiency, Common Variable, 4
Decreased circulating total IgM, Complete or near-complete absence of specific antibody response ... OMIM:613494
Immunodeficiency With Hyper-Igm, Type 2
Impaired Ig class switch recombination, Recurrent respiratory infections, Recurrent infection of ... OMIM:605258
Immunodeficiency 18
Recurrent otitis media, Recurrent respiratory infections, Defective T cell proliferation, Recurre... OMIM:615615
Pa Polymorphism Of Alpha-2-Globulin
Abnormal immunoglobulin level OMIM:260100
Immunodeficiency 35
Recurrent respiratory infections, Recurrent viral infections, Increased circulating IgE level, Re... OMIM:611521
Immunodeficiency 24
Recurrent viral infections, Decreased circulating IgG2 level, Partial absence of specific antibod... OMIM:615897
Candidiasis, Familial, 1
Cutaneous anergy, Recurrent viral infections, Chronic mucocutaneous candidiasis OMIM:114580
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 4
Decreased circulating antibody level, Recurrent infections, Agammaglobulinemia OMIM:616911
Immunodeficiency, Partial Combined, With Absence Of Hla Determinants And Beta-2-Microglobulin From Lymphocytes
Decreased circulating IgG level, Recurrent bacterial infections, Recurrent candida infections OMIM:242870
Immunodeficiency, Common Variable, 5
Chronic decreased circulating total IgG, Recurrent bacterial infections, Recurrent respiratory in... OMIM:613495
Immunoglobulin A Deficiency 1
Recurrent respiratory infections, Recurrent infection of the gastrointestinal tract, Decreased ci... OMIM:137100
Immunodeficiency, Common Variable, 3
Recurrent respiratory infections, Decreased circulating total IgM, Reduced isohemagglutinin level... OMIM:613493
Immunodeficiency With Hyper-Igm, Type 5
Impaired Ig class switch recombination, Recurrent bacterial infections, Decreased circulating IgA... OMIM:608106
Agammaglobulinemia 2, Autosomal Recessive
Recurrent respiratory infections, Decreased circulating total IgM, Meningitis, Decreased circulat... OMIM:613500
Immunodeficiency With Hyper-Igm, Type 3
Impaired Ig class switch recombination, Recurrent bacterial infections, Decreased circulating IgA... OMIM:606843
Agammaglobulinemia 8A, Autosomal Dominant
Recurrent otitis media, Recurrent infections, Post-vaccination polio, Agammaglobulinemia OMIM:616941
Immunodeficiency 86
BCGitis, Decreased circulating IgG level, Impaired oxidative burst, Increased circulating IgM level OMIM:619549
B-Cell Expansion With Nfkb And T-Cell Anergy
Decreased circulating total IgM, Decreased circulating IgA level, Decreased specific antibody res... OMIM:616452
Immunoglobulin A Deficiency 2
Recurrent sinopulmonary infections, Recurrent infection of the gastrointestinal tract, Decreased ... OMIM:609529
Immunodeficiency, Common Variable, 7
Recurrent urinary tract infections, Recurrent respiratory infections, Chronic (near) absent circu... OMIM:614699
Histiocytosis, Familial Lipochrome
Increased circulating antibody level, Recurrent infections OMIM:235900
Immunodeficiency 61
Recurrent respiratory infections, Decreased circulating total IgM, Frequent Giardia lamblia infes... OMIM:300310
Agammaglobulinemia 10, Autosomal Dominant
Recurrent respiratory infections, Decreased circulating total IgM, Meningitis, Decreased circulat... OMIM:619707
Agammaglobulinemia 4, Autosomal Recessive
Decreased circulating total IgM, Decreased circulating IgA level, Recurrent bacterial infections,... OMIM:613502
Immunoglobulin Kappa Light Chain Deficiency
Recurrent respiratory infections, Abnormal immunoglobulin level, Recurrent infections OMIM:614102
Persistent Polyclonal B-Cell Lymphocytosis
Decreased circulating total IgM, Recurrent infections OMIM:606445
Immunodeficiency 33
Increased circulating IgA level, Decreased circulating total IgM, Recurrent bacterial infections,... OMIM:300636
Immunodeficiency 95
Recurrent respiratory infections, Recurrent viral pneumonia, Recurrent viral upper respiratory tr... OMIM:619773
Immunodeficiency 11
Recurrent respiratory infections, Reduced antigen-specific T cell proliferation, Agammaglobulinem... OMIM:615206
Immunodeficiency 62
Decreased circulating total IgM, Reduced isohemagglutinin level, Recurrent lower respiratory trac... OMIM:618459
Immunodeficiency 50
Recurrent urinary tract infections, Recurrent respiratory infections, Decreased circulating antib... OMIM:300988
Immunodeficiency 44
Decreased circulating total IgM, Decreased circulating IgA level, Abnormal circulating IgG level,... OMIM:616636
Agammaglobulinemia 6, Autosomal Recessive
Decreased circulating total IgM, Decreased circulating IgA level, Recurrent bacterial infections,... OMIM:612692
Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin
Decreased circulating IgA level OMIM:235500
Agammaglobulinemia 7, Autosomal Recessive
Recurrent respiratory infections, Recurrent infections, Panhypogammaglobulinemia, Agammaglobulinemia OMIM:615214
Hyper-Ige Recurrent Infection Syndrome 5, Autosomal Recessive
Decreased circulating total IgM, Increased circulating interleukin 6 concentration, Increased cir... OMIM:618944
Immunodeficiency Due To Defect In Mapbp-Interacting Protein
Decreased circulating total IgM, Recurrent bronchopulmonary infections OMIM:610798
Caspase 8 Deficiency
Recurrent sinopulmonary infections, Decreased circulating total IgM, Complete or near-complete ab... OMIM:607271
Severe Combined Immunodeficiency, X-Linked
Decreased circulating total IgM, Recurrent bacterial meningitis, Decreased circulating IgA level,... OMIM:300400
Immunodeficiency 72 With Autoinflammation And Lymphoproliferation
Molluscum contagiosum, Increased circulating IgE level, Herpes simplex encephalitis, Increased ci... OMIM:618982
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Recurrent respiratory infections, Persistent CMV viremia, Recurrent viral infections, Chronic act... OMIM:300853
Immunodeficiency, Common Variable, 14
Decreased circulating total IgM, Decreased specific antibody response to vaccination, Decreased c... OMIM:617765
Immunodeficiency 15B
Chronic oral candidiasis, Agammaglobulinemia, Decreased lymphocyte proliferation in response to m... OMIM:615592
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Recurrent respiratory infections, Decreased circulating total IgM, Decreased circulating IgG level OMIM:618987
Immunodeficiency, Common Variable, 2
Meningitis, Recurrent bacterial infections, Decreased circulating IgA level, Impaired T cell func... OMIM:240500
Agammaglobulinemia 3, Autosomal Recessive
Absent isohemagglutinin level, Recurrent bacterial infections, Recurrent lower respiratory tract ... OMIM:613501
Combined Cellular And Humoral Immune Defects With Granulomas
Recurrent respiratory infections, Decreased circulating IgG level OMIM:233650
Immunodeficiency Due To Selective Anti-Polysaccharide Antibody Deficiency
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... ORPHA:70593
Immunodeficiency 78 With Autoimmunity And Developmental Delay
Persistent CMV viremia, Recurrent oral herpes, Recurrent lower respiratory tract infections, Incr... OMIM:619220
Wiskott-Aldrich Syndrome 2
Defective T cell proliferation, Reduced natural killer cell activity, Recurrent infections OMIM:614493
Lymphoproliferative Syndrome 3
Partial absence of specific antibody response to tetanus vaccine, Decreased circulating antibody ... OMIM:618261
Reticular Dysgenesis
Lack of T cell function, Sepsis, Impaired T cell function OMIM:267500
Immunodeficiency 25
Increased circulating IgA level, Decreased circulating IgG2 level, Increased circulating IgE leve... OMIM:610163
Immunodeficiency 96
Decreased circulating total IgM, Decreased circulating IgA level, Recurrent lower respiratory tra... OMIM:619774
Immunodeficiency 37
Infectious encephalitis, Decreased circulating antibody level, Recurrent infections OMIM:616098
Immunodeficiency, Common Variable, 1
Decreased circulating total IgM, Decreased circulating IgA level, Recurrent bacterial infections,... OMIM:607594
Facial Dysmorphism, Immunodeficiency, Livedo, And Short Stature
Decreased circulating total IgM, Recurrent lower respiratory tract infections, Recurrent upper re... OMIM:615139
Bare Lymphocyte Syndrome, Type Ii
Recurrent urinary tract infections, Recurrent viral infections, Cutaneous anergy, Recurrent lower... OMIM:209920
T-B+ Severe Combined Immunodeficiency Due To Cd3Delta/Cd3Epsilon/Cd3Zeta
Increased circulating antibody level, Recurrent abscess formation, Failure to thrive secondary to... ORPHA:169160
Severe Combined Immunodeficiency Due To Dclre1C Deficiency
Recurrent viral infections, Recurrent bacterial infections, Decreased circulating IgA level, Chro... ORPHA:275
Immunodeficiency-Centromeric Instability-Facial Anomalies Syndrome 2
Decreased circulating total IgM, Decreased circulating IgA level, Decreased circulating IgG level... OMIM:614069
Immunodeficiency 14B, Autosomal Recessive
Decreased circulating total IgM, Decreased circulating IgA level, Candida esophagitis, Reduced na... OMIM:619281
Immunodeficiency, Common Variable, 10
Decreased circulating total IgM, Frequent Giardia lamblia infestation, Recurrent oral herpes, Dec... OMIM:615577
Hyper-Ige Recurrent Infection Syndrome 2, Autosomal Recessive
Recurrent sinopulmonary infections, Decreased circulating total IgM, Disseminated molluscum conta... OMIM:243700
Vulvovaginal Gingival Syndrome
Abnormality of tumor necrosis factor secretion ORPHA:83453
Agammaglobulinemia 8B, Autosomal Recessive
Decreased circulating total IgM, Partial absence of specific antibody response to tetanus vaccine... OMIM:619824
Immunodeficiency 89 And Autoimmunity
Increased circulating IgA level, Increased circulating IgE level, Reduced circulating interleukin... OMIM:619632
Immunodeficiency 11B With Atopic Dermatitis
Increased circulating IgE level, Decreased circulating total IgM, Severe cytomegalovirus infectio... OMIM:617638
Transcobalamin Deficiency
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level... ORPHA:859
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Abnormal immunoglobulin level, Recurrent bacterial skin infections, Sepsis, Decreased circulating... ORPHA:276
Immunodeficiency With Hyper-Igm, Type 1
Increased circulating IgA level, Impaired Ig class switch recombination, Meningitis, Sepsis, Decr... OMIM:308230
Immunodeficiency 102
Decreased circulating total IgM, Increased circulating interleukin 6 concentration, Partial absen... OMIM:301082
Immunodeficiency 64 With Lymphoproliferation
Increased circulating IgA level, Recurrent lower respiratory tract infections, Increased circulat... OMIM:618534
Immunodeficiency 70
Decreased circulating total IgM, Decreased circulating total IgA, Decreased circulating total IgG... OMIM:618969
Immunodeficiency 56
Recurrent respiratory infections, Recurrent infections, Recurrent infection of the gastrointestin... OMIM:615207
Splenomegaly Syndrome With Splenic Germinal Center Hypoplasia And Reduced Circulating T Helper Cells
Cutaneous anergy OMIM:183350
Adult Acute Respiratory Distress Syndrome
Abnormality of tumor necrosis factor secretion, Increased circulating interleukin 6 concentration... ORPHA:70578
Immunodeficiency 63 With Lymphoproliferation And Autoimmunity
Recurrent urinary tract infections, Recurrent respiratory infections, Persistent CMV viremia, Inc... OMIM:618495
Immunodeficiency 67
Increased circulating IgE level, Recurrent staphylococcal infections, Recurrent streptococcal inf... OMIM:607676
Immunodeficiency By Defective Expression Of Mhc Class Ii
Recurrent respiratory infections, Recurrent viral infections, Abnormality of humoral immunity, Re... ORPHA:572
Ectodermal Dysplasia And Immunodeficiency 1
Increased circulating IgA level, Severe cytomegalovirus infection, Molluscum contagiosum, Recurre... OMIM:300291
Acute Lung Injury
Abnormality of tumor necrosis factor secretion, Abnormality of serum cytokine level, Increased ci... ORPHA:178320
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Increased circulating IgA level, Neonatal sepsis, Recurrent viral infections, Increased circulati... ORPHA:169154
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Reduced antigen-specific T cell proliferation, Increased circulating IgE level, Reduced delayed h... OMIM:617241
Familial Hemophagocytic Lymphohistiocytosis
Abnormality of tumor necrosis factor secretion, Increased circulating interferon-gamma concentrat... ORPHA:540
Hyper-Ige Recurrent Infection Syndrome 3, Autosomal Recessive
Recurrent respiratory infections, Increased circulating IgE level, Chronic mucocutaneous candidia... OMIM:618282
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Decreased circulating total IgM, Recurrent viral infections, Recurrent enteroviral infections, De... ORPHA:331206
Autoinflammation, Antibody Deficiency, And Immune Dysregulation
Recurrent sinopulmonary infections, Decreased circulating total IgM, Bronchiolitis, Decreased cir... OMIM:614878
Selective Igm Deficiency
Recurrent shingles, Decreased specific antibody response to vaccination, Recurrent herpes, Chroni... ORPHA:331235
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
Recurrent respiratory infections, Decreased circulating total IgM, Recurrent viral infections, Re... ORPHA:35078
Agammaglobulinemia, X-Linked
Recurrent urinary tract infections, Decreased circulating total IgM, Meningitis, Sepsis, Decrease... OMIM:300755
T-Cell Immunodeficiency With Thymic Aplasia
Recurrent urinary tract infections, Recurrent streptococcus pneumoniae infections, Meningitis, Ol... ORPHA:83471
Immunodeficiency 36 With Lymphoproliferation
Persistent CMV viremia, Recurrent bacterial infections, Decreased circulating IgA level, Recurren... OMIM:616005
Agammaglobulinemia 1, Autosomal Recessive
Recurrent respiratory infections, Recurrent enteroviral infections, Recurrent bacterial infection... OMIM:601495
Immunodeficiency 60 And Autoimmunity
Recurrent sinopulmonary infections, Decreased circulating total IgM, Decreased circulating IgA le... OMIM:618394
Immunodeficiency, Ovarian Dysgenesis, And Pulmonary Fibrosis
Decreased circulating total IgM, Decreased circulating IgG level, Decreased circulating IgA level OMIM:611926
Immune Dysregulation With Autoimmunity, Immunodeficiency, And Lymphoproliferation
Decreased circulating total IgM, Sepsis, Decreased circulating IgA level, Recurrent lower respira... OMIM:616100
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Abnormality of B cell physiology, Meningitis, Cutaneous anergy, Recurrent lower respiratory tract... OMIM:600802
Immunodeficiency 85 And Autoimmunity
Recurrent respiratory infections, Decreased circulating total IgM, Decreased circulating IgA leve... OMIM:619510
Macrophage Activation Syndrome
Abnormality of tumor necrosis factor secretion, Increased circulating interferon-gamma concentrat... ORPHA:158061
Recurrent Infections Associated With Rare Immunoglobulin Isotypes Deficiency
Recurrent urinary tract infections, Recurrent respiratory infections, Decreased circulating total... ORPHA:183675
Immunodeficiency 22
Decreased circulating total IgM, Decreased circulating IgA level, Recurrent lower respiratory tra... OMIM:615758
Immunodeficiency 92
Persistent CMV viremia, BCGosis, Partial absence of specific antibody response to tetanus vaccine... OMIM:619652
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Lack of T cell function, Increased circulating IgE level ORPHA:277
Epilepsy-Telangiectasia Syndrome
Decreased circulating antibody level, Decreased circulating IgA level ORPHA:1951
Autoinflammatory Disease, Systemic, X-Linked
Decreased circulating total IgM, Decreased circulating IgG level, Complete or near-complete absen... OMIM:301081
Sweet Syndrome
Abnormality of tumor necrosis factor secretion, Increased circulating interleukin 6 concentration... ORPHA:3243
Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy
Recurrent respiratory infections, Increased circulating IgE level, Candida esophagitis, Severe va... OMIM:618213
Car T Cell Therapy-Associated Cytokine Release Syndrome
Increased circulating interferon-gamma concentration, Abnormality of serum cytokine level, Increa... ORPHA:542323
Wiskott-Aldrich Syndrome
Increased circulating IgA level, Decreased circulating total IgM, Decreased specific anti-polysac... OMIM:301000
Aregenerative Anemia
Bone marrow hypocellularity, Abnormality of interleukin secretion ORPHA:101096
Psoriasis-Related Juvenile Idiopathic Arthritis
Abnormality of tumor necrosis factor secretion ORPHA:85436
Infection-Related Hemolytic Uremic Syndrome
Increased circulating interleukin 6 concentration, Meningitis, Severe infection, Abnormality of c... ORPHA:544482
Parenteral Nutrition-Associated Cholestasis
Abnormality of cytokine secretion ORPHA:567983
Orotic Aciduria
Impaired T cell function OMIM:258900
Hereditary Orotic Aciduria
Impaired T cell function ORPHA:30
Sarcoidosis, Susceptibility To, 1
Increased circulating antibody level, Abnormality of T cell physiology OMIM:181000
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Abnormality of T cell physiology ORPHA:2237

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ripk2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ripk2.

No publications found that use IMPC mice or data for Ripk2.

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MGI Allele Allele Type Produced
Ripk2tm33746(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ripk2tm33746(L1L2_gt2) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Ripk2tm1(NCOM)Mfgc Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Ripk2em1(IMPC)Ics Deletion Mice

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