Pde4dip | phosphodiesterase 4D interacting protein (myomegalin)

GeneMGI:1891434Synonyms: D3Bwg1078e, 4732458A06Rik, +3 more

Physiological systems

21 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Vision/eye Hematopoietic system Skeleton Mortality/aging

17 No significant impact

3 Not tested

Gene metrics:7Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
62Embryo tissues

Phenotypes

increased bone mineral content1 supporting datasetPde4diptm1b(KOMP)WtsiheterozygoteEarly adult5.86x10-5 
preweaning lethality, complete penetrance3 supporting datasetsPde4diptm1b(KOMP)WtsihomozygoteEarly adultN/A * 
abnormal retina outer nuclear layer morphology2 supporting datasetsPde4diptm1b(KOMP)WtsiheterozygoteEarly adult2.45x10-5 
abnormal eye anterior chamber depth1 supporting datasetPde4diptm1b(KOMP)WtsiheterozygoteEarly adult1.38x10-6 
decreased total retina thickness1 supporting datasetPde4diptm1b(KOMP)WtsiheterozygoteEarly adult4.39x10-5 
increased hemoglobin content1 supporting datasetPde4diptm1b(KOMP)WtsiheterozygoteEarly adult4.37x10-7 
increased cornea thickness1 supporting datasetPde4diptm1b(KOMP)WtsiheterozygoteEarly adult3.28x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoteWholemount images
100% (2/2)0.7% (4/570)
aortaheterozygoteWholemount images
100% (2/2)0.19% (1/533)
boneheterozygoteWholemount images
100% (2/2)0% (0/394)
brainheterozygoteWholemount images
100% (2/2)0.86% (5/579)
brainstemheterozygoten/a0% (0/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoteWholemount images
100% (2/2)0.22% (1/454)
cerebellumheterozygoten/a0% (0/2)0.56% (3/532)
cerebral cortexheterozygoten/a0% (0/2)0.41% (2/491)
esophagusheterozygoteWholemount images
100% (2/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Pde4diptm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Pde4diptm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Pde4diptm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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