Genes Phenotypes

Gene: Bbox1

Name
butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)
MGI ID
MGI:1891372
Synonyms
N/A
Viability
Homozygous - Viable Homozygous - Subviable
View
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (13) Measurements chart (315) All data table (1850)
Expression & images (138) Disease models (0) Order (6)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal craniofacial morphology Bbox1tm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
enlarged heart Bbox1tm1b(KOMP)Wtsi HOM postnatal 0.00
prolonged RR interval Bbox1tm1a(KOMP)Wtsi HOM postnatal 1.95×10-06
abnormal hindbrain morphology Bbox1tm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
abnormal behavior Bbox1tm1b(KOMP)Wtsi HOM postnatal 1.50×10-05
male infertility Bbox1tm1a(KOMP)Wtsi HOM postpartum stage 0.00
abnormal midbrain morphology Bbox1tm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
abnormal forebrain morphology Bbox1tm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
abnormal neural tube closure Bbox1tm1b(KOMP)Wtsi HOM embryonic day 12.5 0.00
increased body length Bbox1tm1b(KOMP)Wtsi HOM postnatal 8.11×10-05
preweaning lethality, incomplete penetrance Bbox1tm1b(KOMP)Wtsi HOM n/a 0.00
increased heart weight Bbox1tm1b(KOMP)Wtsi HOM postnatal 4.33×10-05
decreased heart rate Bbox1tm1a(KOMP)Wtsi HOM postnatal 4.07×10-06

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 8 No  (2/584) N/A
Aorta 8 No N/A
Blood 2 No N/A
Bone 6 No  (2/6)  Section images
Bone marrow 2 No N/A
Brain 8 No  (6/8)  Wholemount images  Section images
Brainstem 8 No  (4/8)  Wholemount images
Brown adipose tissue 8 No N/A
Cartilage tissue 8 No  (6/8)  Wholemount images  Section images
Cecum 4 No  (12/383) N/A
Cerebellum 8 No  (4/8)  Wholemount images  Section images
Cerebral cortex 8 No N/A
Chest bone 2 No N/A
Colon 2 No  (12/127) N/A
Diaphragm 2 No N/A
Duodenum 2 No  (2/127) N/A
Epididymis 4 No  (18/134)  (1/4) N/A
Esophagus 8 No  (7/415)  (2/8)  Wholemount images
Eye 8 No N/A
Gall bladder 6 No N/A
Gonadal fat pad 2 No N/A
Harderian gland 2 No N/A
Heart 8 No N/A
Hindlimb 2 No N/A
Hippocampus 8 No N/A
Hypothalamus 8 No N/A
Ileum 2 No  (14/127)  (1/2) N/A
Jejunum 2 No  (6/127)  (1/2) N/A
Kidney 8 No  (18/584)  (8/8)  Wholemount images  Section images
Large intestine 8 No  (10/584)  (2/8)  Section images
Liver 8 No  (3/8)  Wholemount images  Section images
Lower urinary tract 8 No  (4/8)  Wholemount images
Lung 8 No  (4/8)  Wholemount images  Section images
Lymph node 8 No N/A
Mammary gland 8 No N/A
Mesenteric adipose tissue 2 No N/A
Mesenteric lymph node 2 No N/A
Midbrain 4 No  (4/4)  Section images
Olfactory lobe 8 No N/A
Oral epithelium 4 No  (2/4)  Wholemount images
Ovary 8 No  (1/584)  (1/8)  Section images
Oviduct 8 No  (4/8)  Wholemount images  Section images
Pancreas 8 No  (5/584) N/A
Parathyroid gland 6 No N/A
Parotid gland 2 No N/A
Penis 2 No  (1/2) N/A
Peripheral nervous system 8 No  (2/8)  Wholemount images
Peyer's patch 8 No N/A
Pituitary gland 8 No N/A
Prostate gland 8 No  (12/584)  (2/8)  Wholemount images
Quadriceps 2 No N/A
Sciatic nerve 2 No N/A
Skeletal muscle 8 No N/A
Skin 8 No  (8/8)  Wholemount images  Section images
Small intestine 8 No  (9/584)  (3/8)  Wholemount images  Section images
Spinal cord 8 No  (6/8)  Wholemount images  Section images
Spleen 8 No  (2/584) N/A
Stomach 8 No  (12/584)  (6/8)  Wholemount images  Section images
Stomach pyloric region 2 No N/A
Striatum 8 No  (2/8)  Wholemount images
Sublingual gland 2 No N/A
Submandibular gland 4 No  (2/132)  (1/4)  Section images
Testis 8 No  (2/584)  (4/8)  Wholemount images  Section images
Thalamus 2 No N/A
Thymus 8 No N/A
Thyroid gland 8 No  (15/584)  (3/8)  Wholemount images  Section images
Tongue 2 No  (5/127)  (1/2) N/A
Trachea 8 No  (2/8)  Section images
Trigeminal V nerve 4 No N/A
Urinary bladder 4 No  (2/4) N/A
Uterus 8 No  (2/8)  Wholemount images  Section images
Vagina 2 No N/A
Vas deferens 4 No  (15/388)  (1/4)  Wholemount images
Vascular system 8 No N/A
Vesicular gland 4 No N/A
White adipose tissue 8 No N/A
LacZ Wholemount Images
digestive system (4)
Liver expression
MA:0000358
endocrine system (1)
Thyroid gland expression
MA:0000129
exocrine system (1)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
integumental system (3)
Cartilage tissue expression
Skin expression
MA:0000104
MA:0000151
nervous system (8)
Brain expression
MA:0000168
postnatal mouse (28)
Brain expression
MA:0000168
reproductive system (6)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
respiratory system (2)
Lung expression
MA:0000415
set of connective tissues (4)
Cartilage tissue expression
MA:0000104
trunk (14)
Kidney expression
MA:0000368
urinary system (5)
Kidney expression
MA:0000368
LacZ Section Images
digestive system (5)
Large Intestine expression
MA:0000333
endocrine system (1)
Thyroid gland expression
MA:0000129
exocrine system (1)
Submandibular Gland expression
MA:0001589
integumental system (1)
Skin expression
MA:0000151
musculoskeletal system (1)
Bone expression
MA:0001459
nervous system (4)
Brain expression
MA:0000168
postnatal mouse (20)
Bone expression
MA:0001459
reproductive system (4)
Ovary expression
MA:0000384
respiratory system (3)
Lung expression
MA:0000415
set of connective tissues (1)
Cartilage tissue expression
MA:0000104
trunk (12)
Kidney expression
MA:0000368
urinary system (1)
Kidney expression
MA:0000368
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 3  (1/47) N/A
Axial skeleton 3  (1/51) N/A
Brain 6  (6/485)  (3/7) N/A
Central nervous system ganglion 3  (1/51) N/A
Cranium 3  (1/46) N/A
Dorsal root ganglion 5  (1/47)  (2/5) N/A
Ear 6  (1/485) N/A
Embryo 6  (1/485)  (6/7)  Wholemount images
Outer ear 3  (1/47) N/A
Eye 6  (1/485) N/A
Femur pre-cartilage condensation 3  (1/46)  (2/3) N/A
Foot 6  (1/485)  (1/7) N/A
Forearm 3  (1/282)  (2/3) N/A
Forebrain 6  (1/485) N/A
Forelimb 6  (1/485)  (6/7) N/A
Fronto-nasal process 5  (1/48) N/A
Gut 3  (1/50) N/A
Hand 6  (1/485)  (1/7) N/A
Head 6  (5/485)  (4/7) N/A
Head mesenchyme 3  (1/47) N/A
Heart 6  (1/485) N/A
Heart ventricle 3  (1/47) N/A
Hindbrain 6  (6/485)  (2/7) N/A
Hindlimb 6  (1/485)  (6/7) N/A
Humerus pre-cartilage condensation 3  (1/46)  (2/3) N/A
Inner ear 3  (1/46) N/A
Intestine 3  (1/47) N/A
Liver 6  (1/485) N/A
Lower leg 3  (1/282) N/A
Lung 6  (1/485) N/A
Mandibular process 6  (1/485) N/A
Maxillary process 6  (1/485)  (3/7) N/A
Mesonephros of female 3  (1/46) N/A
Mesonephros of male 3  (1/46) N/A
Metanephros 3  (1/46) N/A
Midbrain 6  (1/485) N/A
Nasal septum 3  (1/47) N/A
Nose 5  (1/51) N/A
Notochord 3  (1/47)  (2/3) N/A
Oral cavity 6  (1/485) N/A
Outflow tract 3  (1/47) N/A
Pancreas 3  (1/46) N/A
Pericardium 3  (1/46) N/A
Pharynx 3  (1/46) N/A
Radius-ulna pre-cartilage condensation 3  (1/46)  (2/3) N/A
Rib pre-cartilage condensation 3  (1/46) N/A
Skeleton 3  (1/51) N/A
Skin 6  (1/485) N/A
Spinal cord 5  (1/50)  (3/5) N/A
Stomach 3  (1/46) N/A
Tail 6  (1/485)  (1/7) N/A
Tail somite 6  (1/485) N/A
Thoracic vertebral cartilage condensation 4  (1/46)  (1/4) N/A
Tongue 3  (1/46) N/A
Trachea 3  (1/50) N/A
Trunk mesenchyme 3  (1/47) N/A
Umbilical artery embryonic part 3  (1/47) N/A
Umbilical vein embryonic part 3  (1/47) N/A
Upper arm 3  (1/282)  (2/3) N/A
Upper leg 3  (1/282)  (2/3) N/A
Urinary system 3  (1/50) N/A
Vibrissa 3  (1/47) N/A

 Associated Images

Echo: M-Mode Images
32 Images
Embryo LacZ: LacZ images wholemount
21 Images
X-ray: XRay Images Lateral Orientation
21 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
19 Images
X-ray: XRay Images Dorso Ventral
20 Images
Auditory Brain Stem Response: Click-evoked + 6 to 30kHz tone waveforms (pdf format)
4 Images
Adult LacZ: LacZ Images Wholemount
28 Images
Original Image
Adult LacZ: LacZ Images Section
20 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
Sleep Wake: Wake state (bmp file)
4 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Bbox1em2(IMPC)Bay Conditional Ready Mice
Bbox1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Bbox1tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Bbox1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Bbox1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells, Tissue
Bbox1em1(IMPC)Bay Exon Deletion Mice, Tissue

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