Bbox1 | gamma-butyrobetaine hydroxylase 1
GeneMGI:1891372
Physiological systems
23 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Reproductive system Embryo Growth/size/body region Nervous system Behavior/neurological Mortality/aging Cardiovascular system Craniofacial
15 No significant impact
1 Not tested
Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:76Adult tissues
83Embryo tissues
preweaning lethality, incomplete penetrance | 2 supporting datasets | Bbox1tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
enlarged heart | 1 supporting dataset | Bbox1tm1b(KOMP)Wtsi | homozygote | Early adult | N/A * | ||
unresponsive to tactile stimuli | 1 supporting dataset | Bbox1tm1b(KOMP)Wtsi | homozygote | E18.5 | N/A * | ||
unresponsive to tactile stimuli | 1 supporting dataset | Bbox1tm1b(KOMP)Wtsi | heterozygote | E18.5 | N/A * | ||
abnormal craniofacial morphology | 1 supporting dataset | Bbox1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
abnormal forebrain morphology | 1 supporting dataset | Bbox1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
abnormal neural tube closure | 1 supporting dataset | Bbox1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
abnormal hindbrain morphology | 1 supporting dataset | Bbox1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
abnormal midbrain morphology | 1 supporting dataset | Bbox1tm1b(KOMP)Wtsi | homozygote | E12.5 | N/A * | ||
increased heart weight | 1 supporting dataset | Bbox1tm1b(KOMP)Wtsi | homozygote | Early adult | 2.85x10-5 |
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External links
No external links available for Bbox1.
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Bbox1em1(IMPC)Bay | Exon Deletion | | mouse |
Bbox1em2(IMPC)Bay | | mouse | |
Bbox1tm1a(KOMP)Mbp | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |
Bbox1tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Bbox1tm1b(KOMP)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Bbox1tm2a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell |