Genes Phenotypes

Gene: Bbox1

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Name
butyrobetaine (gamma), 2-oxoglutarate dioxygenase 1 (gamma-butyrobetaine hydroxylase)
MGI ID
MGI:1891372
Synonyms
N/A
Viability
Homozygous - Viable Homozygous - Subviable
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (13) Measurements chart (317) All data table (2042)
Expression & images (138) Disease models (0) Order (6)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased heart weight Bbox1tm1b(KOMP)Wtsi HOM Early adult 2.28×10-05
abnormal midbrain morphology Bbox1tm1b(KOMP)Wtsi HOM E12.5 0.00
decreased heart rate Bbox1tm1a(KOMP)Wtsi HOM Early adult 3.41×10-06
abnormal craniofacial morphology Bbox1tm1b(KOMP)Wtsi HOM E12.5 0.00
preweaning lethality, incomplete penetrance Bbox1tm1b(KOMP)Wtsi HOM Early adult 0.00
male infertility Bbox1tm1a(KOMP)Wtsi HOM Early adult 0.00
prolonged RR interval Bbox1tm1a(KOMP)Wtsi HOM Early adult 1.46×10-06
abnormal behavior Bbox1tm1b(KOMP)Wtsi HOM Early adult 1.21×10-05
enlarged heart Bbox1tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal neural tube closure Bbox1tm1b(KOMP)Wtsi HOM E12.5 0.00
abnormal forebrain morphology Bbox1tm1b(KOMP)Wtsi HOM E12.5 0.00
increased body length Bbox1tm1b(KOMP)Wtsi HOM Early adult 7.54×10-05
abnormal hindbrain morphology Bbox1tm1b(KOMP)Wtsi HOM E12.5 0.00

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 8 No  (2/584) N/A
Aorta 8 No N/A
Blood 2 No N/A
Bone 6 No  (2/6)  Section images
Bone marrow 2 No N/A
Brain 8 No  (6/8)  Wholemount images  Section images
Brainstem 8 No  (4/8)  Wholemount images
Brown adipose tissue 8 No N/A
Cartilage tissue 8 No  (6/8)  Wholemount images  Section images
Cecum 4 No  (12/379) N/A
Cerebellum 8 No  (4/8)  Wholemount images  Section images
Cerebral cortex 8 No N/A
Chest bone 2 No N/A
Colon 2 No  (12/127) N/A
Diaphragm 2 No N/A
Duodenum 2 No  (2/127) N/A
Epididymis 4 No  (18/134)  (1/4)  Section images
Esophagus 8 No  (7/415)  (2/8)  Wholemount images
Eye 8 No N/A
Gall bladder 6 No N/A
Gonadal fat pad 2 No N/A
Harderian gland 2 No N/A
Heart 8 No N/A
Hindlimb 2 No N/A
Hippocampus 8 No N/A
Hypothalamus 8 No N/A
Ileum 2 No  (14/127)  (1/2)  Section images
Jejunum 2 No  (6/127)  (1/2)  Section images
Kidney 8 No  (18/584)  (8/8)  Wholemount images  Section images
Large intestine 8 No  (10/584)  (2/8)  Section images
Liver 8 No  (3/8)  Wholemount images  Section images
Lower urinary tract 8 No  (4/8)  Wholemount images
Lung 8 No  (4/8)  Wholemount images  Section images
Lymph node 8 No N/A
Mammary gland 8 No N/A
Mesenteric adipose tissue 2 No N/A
Mesenteric lymph node 2 No N/A
Midbrain 4 No  (4/4)  Section images
Olfactory lobe 8 No N/A
Oral epithelium 4 No  (2/4)  Wholemount images
Ovary 8 No  (1/584)  (1/8)  Section images
Oviduct 8 No  (4/8)  Wholemount images  Section images
Pancreas 8 No  (5/584) N/A
Parathyroid gland 6 No N/A
Parotid gland 2 No N/A
Penis 2 No  (1/2)  Section images
Peripheral nervous system 8 No  (2/8)  Wholemount images
Peyer's patch 8 No N/A
Pituitary gland 8 No N/A
Prostate gland 8 No  (12/584)  (2/8)  Wholemount images  Section images
Quadriceps 2 No N/A
Sciatic nerve 2 No N/A
Skeletal muscle 8 No N/A
Skin 8 No  (8/8)  Wholemount images  Section images
Small intestine 8 No  (9/584)  (3/8)  Wholemount images  Section images
Spinal cord 8 No  (6/8)  Wholemount images  Section images
Spleen 8 No  (2/584) N/A
Stomach 8 No  (12/584)  (6/8)  Wholemount images  Section images
Stomach pyloric region 2 No N/A
Striatum 8 No  (2/8)  Wholemount images
Sublingual gland 2 No N/A
Submandibular gland 4 No  (2/132)  (1/4)  Section images
Testis 8 No  (2/584)  (4/8)  Wholemount images  Section images
Thalamus 2 No N/A
Thymus 8 No N/A
Thyroid gland 8 No  (15/584)  (3/8)  Wholemount images  Section images
Tongue 2 No  (5/127)  (1/2)  Section images
Trachea 8 No  (2/8)  Section images
Trigeminal V nerve 4 No N/A
Urinary bladder 4 No  (2/4)  Section images
Uterus 8 No  (2/8)  Wholemount images  Section images
Vagina 2 No N/A
Vas deferens 4 No  (15/388)  (1/4)  Wholemount images  Section images
Vascular system 8 No N/A
Vesicular gland 4 No N/A
White adipose tissue 8 No N/A
LacZ Wholemount Images
digestive system (4)
Liver expression
MA:0000358
endocrine system (1)
Thyroid gland expression
MA:0000129
exocrine system (1)
Lower Urinary Tract expression
Prostate gland expression
MA:0002636
MA:0000404
integumental system (3)
Cartilage tissue expression
Skin expression
MA:0000104
MA:0000151
nervous system (8)
Brain expression
MA:0000168
postnatal mouse (28)
Brain expression
MA:0000168
reproductive system (6)
Lower Urinary Tract expression
Oviduct expression
MA:0002636
MA:0000385
respiratory system (2)
Lung expression
MA:0000415
set of connective tissues (4)
Cartilage tissue expression
Skin expression
MA:0000104
MA:0000151
trunk (14)
Kidney expression
MA:0000368
urinary system (5)
Kidney expression
MA:0000368
LacZ Section Images
Unassigned Top Level MA (11)
digestive system (12)
Ileum expression
MA:0000339
endocrine system (1)
Thyroid gland expression
MA:0000129
exocrine system (3)
Prostate gland expression
MA:0000404
integumental system (7)
Skin expression
MA:0000151
musculoskeletal system (1)
Bone expression
MA:0001459
nervous system (6)
Brain expression
MA:0000168
postnatal mouse (54)
Bone expression
MA:0001459
reproductive system (16)
Epididymis expression
MA:0000397
respiratory system (4)
Lung expression
MA:0000415
sensory organ (1)
Tongue expression
MA:0000347
set of connective tissues (1)
Cartilage tissue expression
MA:0000104
trunk (37)
Epididymis expression
MA:0000397
urinary system (8)
Kidney expression
MA:0000368
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 3  (1/57) N/A
Axial skeleton 3  (1/61) N/A
Brain 6  (6/504)  (3/7) N/A
Central nervous system ganglion 3  (1/70) N/A
Cranium 3  (1/61) N/A
Dorsal root ganglion 5  (1/57)  (2/5) N/A
Ear 6  (1/504) N/A
Embryo 6  (1/505)  (6/7)  Wholemount images
Outer ear 3  (1/66) N/A
Eye 6  (1/504) N/A
Femur pre-cartilage condensation 3  (1/52)  (2/3) N/A
Foot 6  (1/504)  (1/7) N/A
Forearm 3  (1/297)  (2/3) N/A
Forebrain 6  (1/504) N/A
Forelimb 6  (1/504)  (6/7) N/A
Fronto-nasal process 5  (1/58) N/A
Gut 3  (1/56) N/A
Hand 6  (1/503)  (1/7) N/A
Head 6  (5/504)  (4/7) N/A
Head mesenchyme 3  (1/57) N/A
Heart 6  (1/504) N/A
Heart ventricle 3  (1/57) N/A
Hindbrain 6  (6/504)  (2/7) N/A
Hindlimb 6  (1/503)  (6/7) N/A
Humerus pre-cartilage condensation 3  (1/61)  (2/3) N/A
Inner ear 3  (1/61) N/A
Intestine 3  (1/55) N/A
Liver 6  (1/504) N/A
Lower leg 3  (1/297) N/A
Lung 6  (1/500) N/A
Mandibular process 6  (1/504) N/A
Maxillary process 6  (1/504)  (3/7) N/A
Mesonephros of female 3  (1/52) N/A
Mesonephros of male 3  (1/52) N/A
Metanephros 3  (1/52) N/A
Midbrain 6  (1/504) N/A
Nasal septum 3  (1/57) N/A
Nose 5  (1/70) N/A
Notochord 3  (1/57)  (2/3) N/A
Oral cavity 6  (1/504) N/A
Outflow tract 3  (1/57) N/A
Pancreas 3  (1/52) N/A
Pericardium 3  (1/52) N/A
Pharynx 3  (1/52) N/A
Radius-ulna pre-cartilage condensation 3  (1/61)  (2/3) N/A
Rib pre-cartilage condensation 3  (1/54) N/A
Skeleton 3  (1/70) N/A
Skin 6  (1/504) N/A
Spinal cord 5  (1/69)  (3/5) N/A
Stomach 3  (1/52) N/A
Tail 6  (1/504)  (1/7) N/A
Tail somite 6  (1/504) N/A
Thoracic vertebral cartilage condensation 4  (1/52)  (1/4) N/A
Tongue 3  (1/52) N/A
Trachea 3  (1/56) N/A
Trunk mesenchyme 3  (1/57) N/A
Umbilical artery embryonic part 3  (1/57) N/A
Umbilical vein embryonic part 3  (1/57) N/A
Upper arm 3  (1/297)  (2/3) N/A
Upper leg 3  (1/297)  (2/3) N/A
Urinary system 3  (1/56) N/A
Vibrissa 3  (1/66) N/A

 Associated Images

Adult LacZ: LacZ Images Section
65 Images
Adult LacZ: LacZ Images Wholemount
28 Images
Embryo LacZ: LacZ images wholemount
21 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
21 Images
X-ray: XRay Images Whole Body Dorso Ventral
20 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
19 Images
Echo: M-Mode Images
32 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Bbox1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells, Tissue
Bbox1em1(IMPC)Bay Exon Deletion Mice, Tissue
Bbox1em2(IMPC)Bay Conditional Ready Mice
Bbox1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Bbox1tm1a(KOMP)Mbp KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Bbox1tm2a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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