Bbox1 | gamma-butyrobetaine hydroxylase 1

Physiological systems

23 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Reproductive system Embryo Growth/size/body region Nervous system Behavior/neurological Mortality/aging Cardiovascular system Craniofacial

15 No significant impact

1 Not tested

Gene metrics:10Significant phenotypes
0Associated diseases
Expression examined in:76Adult tissues
83Embryo tissues

Phenotypes

preweaning lethality, incomplete penetrance2 supporting datasetsBbox1tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
enlarged heart1 supporting datasetBbox1tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
unresponsive to tactile stimuli1 supporting datasetBbox1tm1b(KOMP)WtsihomozygoteE18.5N/A * 
unresponsive to tactile stimuli1 supporting datasetBbox1tm1b(KOMP)WtsiheterozygoteE18.5N/A * 
abnormal craniofacial morphology1 supporting datasetBbox1tm1b(KOMP)WtsihomozygoteE12.5N/A * 
abnormal forebrain morphology1 supporting datasetBbox1tm1b(KOMP)WtsihomozygoteE12.5N/A * 
abnormal neural tube closure1 supporting datasetBbox1tm1b(KOMP)WtsihomozygoteE12.5N/A * 
abnormal hindbrain morphology1 supporting datasetBbox1tm1b(KOMP)WtsihomozygoteE12.5N/A * 
abnormal midbrain morphology1 supporting datasetBbox1tm1b(KOMP)WtsihomozygoteE12.5N/A * 
increased heart weight1 supporting datasetBbox1tm1b(KOMP)WtsihomozygoteEarly adult2.85x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Bbox1em1(IMPC)BayExon Deletionmouse
Bbox1em2(IMPC)Baymouse
Bbox1tm1a(KOMP)MbpKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
Bbox1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Bbox1tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Bbox1tm2a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell

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