Gene Summary

Name:
downstream neighbor of SON
Synonyms:
Donson,  1110025J21Rik,  ORF60

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images

View all 157 images

View all 9 images

Human diseases caused by Donson mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Donson by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Microcephaly, Short Stature, And Limb Abnormalities
OMIM:617604
Microcephaly-Micromelia Syndrome
OMIM:251230

The table below shows human diseases predicted to be associated to Donson by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Microcephaly, Short Stature, And Limb Abnormalities
OMIM:617604
Microcephaly-Micromelia Syndrome
OMIM:251230

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Donson

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Donson.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Donsontm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Donsontm40897(L1L2_gt0) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Donsontm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Donsontm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Donsontm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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