Srsf4 - serine and arginine-rich splicing factor 4 | International Mouse Phenotyping Consortium

Genes Phenotypes

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Gene: Srsf4

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Name

serine and arginine-rich splicing factor 4

MGI ID

MGI:1890577

Synonyms

Sfrs4 MNCb-2616 5730499P16Rik SRp75

Viability

Homozygous - Subviable

Embryo viewer

N/A

Phenotype	Allele	Zyg	Life Stage	P Value
preweaning lethality, incomplete penetrance	Srsf4^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	0.00
abnormal tail movements	Srsf4^{tm1a(EUCOMM)Wtsi}	HET	Early adult	8.64×10^-06
abnormal coat/hair pigmentation	Srsf4^{tm1a(EUCOMM)Wtsi}	HOM	Early adult	9.77×10^-05
abnormal coat/hair pigmentation	Srsf4^{tm1a(EUCOMM)Wtsi}	HET	Early adult	9.98×10^-05
increased circulating creatinine level	Srsf4^{tm1a(EUCOMM)Wtsi}	HET	Early adult	1.87×10^-05

Expression

Table Images

Expression No Expression Ambiguous No Tissue Available

Anatomy	#HET Specimens	HOM Images?	WT Expr	Mutant Expr	Images
Adrenal gland	4	No	(2/584)	(4/4)	N/A
Aorta	4	No			N/A
Blood vessel	4	No		(4/4)	N/A
Bone	4	No			N/A
Brain	4	No		(4/4)	N/A
Brainstem	4	No			N/A
Brown adipose tissue	4	No			N/A
Cartilage tissue	4	No		(4/4)	N/A
Cerebellum	4	No			N/A
Cerebral cortex	4	No			N/A
Eye	4	No		(1/4)	N/A
Gall bladder	4	No		(2/4)	N/A
Heart	4	No		(2/4)	N/A
Hippocampus	4	No			N/A
Hypothalamus	4	No			N/A
Kidney	4	No	(18/584)	(4/4)	N/A
Large intestine	4	No	(10/584)	(3/4)	N/A
Liver	4	No		(3/4)	N/A
Lower urinary tract	4	No		(4/4)	N/A
Lung	4	No		(4/4)	N/A
Lymph node	4	No		(2/4)	N/A
Mammary gland	4	No			N/A
Esophagus	4	No		(4/4)	N/A
Olfactory lobe	4	No			N/A
Ovary	4	No	(1/584)	(2/4)	N/A
Oviduct	4	No		(2/4)	N/A
Pancreas	4	No	(5/584)	(2/4)	N/A
Parathyroid gland	4	No		(4/4)	N/A
Peripheral nervous system	4	No		(3/4)	N/A
Peyer's patch	4	No		(4/4)	N/A
Pituitary gland	4	No		(1/4)	N/A
Prostate gland	4	No	(12/584)	(2/4)	N/A
Skeletal muscle tissue	4	No		(4/4)	N/A
Skin	4	No		(4/4)	N/A
Small intestine	4	No	(9/584)	(3/4)	N/A
Spinal cord	4	No		(4/4)	N/A
Spleen	4	No	(2/584)	(4/4)	N/A
Stomach	4	No	(12/584)	(2/4)	N/A
Striatum	4	No			N/A
Testis	4	No	(2/584)	(2/4)	N/A
Thymus	4	No		(4/4)	N/A
Thyroid gland	4	No	(15/584)	(4/4)	N/A
Trachea	4	No		(4/4)	N/A
Uterus	4	No		(2/4)	N/A
White adipose tissue	4	No			N/A

LacZ Wholemount Images

LacZ Section Images

Srsf4^{tm1a(EUCOMM)Wtsi}
oesophagus, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
kidney, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
inguinal fat pad, skin, mammary gland, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
eye, HET, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
lung, HET, Female, WTSI

View all 27 images

Srsf4^{tm1a(EUCOMM)Wtsi}
oesophagus, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
kidney, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
lung, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
uterus, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
urinary bladder, lower urinary tract, HET, Female, WTSI

View all 16 images

Srsf4^{tm1a(EUCOMM)Wtsi}
oesophagus, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
peyer's patch, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
large intestine, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
gall bladder, HET, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
peyer's patch, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
spleen, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
thymus, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
lymph node, HET, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
peripheral nervous system, pituitary gland, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
brain, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
spinal cord, HET, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
inguinal fat pad, skin, mammary gland, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
cartilage tissue, HET, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
brown adipose tissue, HET, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
kidney, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
urinary bladder, lower urinary tract, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
lower urinary tract, urinary bladder, HET, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
inguinal fat pad, skin, mammary gland, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
brown adipose tissue, HET, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
thyroid gland, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
adrenal gland, HET, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
inguinal fat pad, skin, mammary gland, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
skin, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
uterus, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
testis, HET, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
eye, HET, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
eye, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
heart, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
inguinal fat pad, skin, mammary gland, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
lung, HET, Female, WTSI

No Embryo expression data was found for this gene.

Associated Images

Legacy Phenotype Associated Images

Srsf4^{tm1a(EUCOMM)Wtsi}
head, HET, Female, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
body, HET, Female, WTSI

View all 142 images

Srsf4^{tm1a(EUCOMM)Wtsi}
anterior commissure, decreased anterior commissure size, HOM, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
HOM, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
anterior commissure, decreased anterior commissure size, HOM, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
HOM, Male, WTSI

Srsf4^{tm1a(EUCOMM)Wtsi}
anterior commissure, decreased anterior commissure size, HOM, Male, WTSI

View all 6 images

Srsf4^{tm1a(EUCOMM)Wtsi}
eye, cornea/lens fusion, corneal vascularization, corneal opacity, abnormal cornea morphology, mydriasis, narrow eye opening, HOM, Female, WTSI