Genes Phenotypes

Gene: Vps4a

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Name
vacuolar protein sorting 4A
MGI ID
MGI:1890520
Synonyms
4930589C15Rik
Viability
Homozygous - Lethal
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (9) Measurements chart (238) All data table (611)
Expression & images (111) Disease models (0) Order (2)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
cataract Vps4atm1b(EUCOMM)Hmgu HET Early adult 3.43×10-05
tremors Vps4atm1b(EUCOMM)Hmgu HET Early adult 8.22×10-05
abnormal embryo size Vps4atm1b(EUCOMM)Hmgu HOM E18.5 0.00
enlarged spleen Vps4atm1b(EUCOMM)Hmgu HET Early adult 0.00
preweaning lethality, complete penetrance Vps4atm1b(EUCOMM)Hmgu HOM Early adult 0.00
abnormal body wall morphology Vps4atm1b(EUCOMM)Hmgu HOM E18.5 0.00
abnormal skin morphology Vps4atm1b(EUCOMM)Hmgu HET Early adult 0.00
protruding tongue Vps4atm1b(EUCOMM)Hmgu HOM E18.5 0.00
abnormal lens morphology Vps4atm1b(EUCOMM)Hmgu HET Early adult 1.27×10-05

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Select physiological systems to view:
Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  Wholemount images
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No N/A
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No N/A
Cartilage tissue 2 No  (2/2) N/A
Cecum 2 No  (12/379) N/A
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No N/A
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (1/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No N/A
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No  Wholemount images
Ovary 2 No  (1/584)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (2/2)  Wholemount images
Peyer's patch 2 No N/A
Pituitary gland 2 No  (2/2)  Wholemount images
Prostate gland 2 No  (12/584)  Wholemount images
Skeletal muscle 2 No  Wholemount images
Skin 2 No  Wholemount images
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No  (2/2)  Wholemount images
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2)  Wholemount images
Thymus 2 No N/A
Thyroid gland 2 No  (15/584) N/A
Trachea 2 No  (2/2)  Wholemount images
Trigeminal V nerve 2 No  (2/2)  Wholemount images
Uterus 2 No  (1/2)  Wholemount images
Vas deferens 2 No  (15/388)  (1/2)  Wholemount images
Vascular system 2 No  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
cardiovascular system (1)
Heart expression
Vascular System no expression
Aorta expression
Kidney expression
MA:0000072
MA:0002718
MA:0000062
MA:0000368
digestive system (3)
Large Intestine expression
MA:0000333
endocrine system (2)
Adrenal gland no expression
MA:0000116
exocrine system (1)
Lower Urinary Tract expression
Prostate gland ambiguous
MA:0002636
MA:0000404
integumental system (1)
Skin ambiguous
MA:0000151
musculoskeletal system (1)
Skeletal Muscle no expression
MA:0003148
nervous system (7)
Cerebral Cortex expression
Brain expression
Striatum expression
Hippocampus expression
Hypothalamus expression
Cerebellum expression
Brainstem expression
Olfactory Lobe expression
MA:0000185
MA:0000168
MA:0000891
MA:0000191
MA:0000173
MA:0000198
MA:0000169
MA:0002413
postnatal mouse (23)
Adrenal gland no expression
MA:0000116
reproductive system (3)
Lower Urinary Tract expression
Prostate gland ambiguous
MA:0002636
MA:0000404
respiratory system (2)
Oral epithelium ambiguous
MA:0000344
trunk (15)
Adrenal gland no expression
MA:0000116
urinary system (4)
Heart expression
Vascular System no expression
Aorta expression
Kidney expression
MA:0000072
MA:0002718
MA:0000062
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/57)  (2/2) N/A
Axial skeleton 2  (1/61)  (2/2) N/A
Brain 2  (6/504)  (2/2) N/A
Central nervous system ganglion 2  (1/70)  (2/2) N/A
Cranium 2  (1/61)  (2/2) N/A
Dorsal root ganglion 2  (1/57)  (2/2) N/A
Ear 2  (1/504)  (2/2) N/A
Embryo 2  (1/505)  (2/2) N/A
Outer ear 2  (1/66)  (2/2) N/A
Eye 2  (1/504)  (2/2) N/A
Femur pre-cartilage condensation 2  (1/52)  (2/2) N/A
Foot 2  (1/504)  (2/2) N/A
Forearm 2  (1/297)  (2/2) N/A
Forebrain 2  (1/504)  (2/2) N/A
Forelimb 2  (1/504)  (2/2) N/A
Fronto-nasal process 2  (1/58)  (2/2) N/A
Gut 2  (1/56)  (2/2) N/A
Hand 2  (1/503)  (2/2) N/A
Head 2  (5/504)  (2/2) N/A
Head mesenchyme 2  (1/57)  (2/2) N/A
Heart 2  (1/504)  (2/2) N/A
Heart ventricle 2  (1/57)  (2/2) N/A
Hindbrain 2  (6/504)  (2/2) N/A
Hindlimb 2  (1/503)  (2/2) N/A
Humerus pre-cartilage condensation 2  (1/61)  (2/2) N/A
Inner ear 2  (1/61)  (2/2) N/A
Intestine 2  (1/55)  (2/2) N/A
Liver 2  (1/504)  (2/2) N/A
Lower leg 2  (1/297)  (2/2) N/A
Lung 2  (1/500)  (2/2) N/A
Mandibular process 2  (1/504)  (2/2) N/A
Maxillary process 2  (1/504)  (2/2) N/A
Mesonephros of female 2  (1/52)  (2/2) N/A
Mesonephros of male 2  (1/52)  (2/2) N/A
Metanephros 2  (1/52)  (2/2) N/A
Midbrain 2  (1/504)  (2/2) N/A
Nasal septum 2  (1/57)  (2/2) N/A
Nose 2  (1/70)  (2/2) N/A
Notochord 2  (1/57)  (2/2) N/A
Oral cavity 2  (1/504)  (2/2) N/A
Outflow tract 2  (1/57)  (2/2) N/A
Pancreas 2  (1/52)  (2/2) N/A
Pericardium 2  (1/52)  (2/2) N/A
Pharynx 2  (1/52)  (2/2) N/A
Radius-ulna pre-cartilage condensation 2  (1/61)  (2/2) N/A
Rib pre-cartilage condensation 2  (1/54)  (2/2) N/A
Skeleton 2  (1/70)  (2/2) N/A
Skin 2  (1/504)  (2/2) N/A
Spinal cord 2  (1/69)  (2/2) N/A
Stomach 2  (1/52)  (2/2) N/A
Tail 2  (1/504)  (2/2) N/A
Tail somite 2  (1/504)  (2/2) N/A
Thoracic vertebral cartilage condensation 2  (1/52)  (2/2) N/A
Tongue 2  (1/52)  (2/2) N/A
Trachea 2  (1/56)  (2/2) N/A
Trunk mesenchyme 2  (1/57)  (2/2) N/A
Umbilical artery embryonic part 2  (1/57)  (2/2) N/A
Umbilical vein embryonic part 2  (1/57)  (2/2) N/A
Upper arm 2  (1/297)  (2/2) N/A
Upper leg 2  (1/297)  (2/2) N/A
Urinary system 2  (1/56)  (2/2) N/A
Vibrissa 2  (1/66)  (2/2) N/A

 Associated Images

Embryo LacZ: LacZ images wholemount
4 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
4 Images
X-ray: XRay Images Forepaw
4 Images
X-ray: XRay Images Whole Body Dorso Ventral
4 Images
X-ray: XRay Images Whole Body Lateral Orientation
4 Images
X-ray: XRay Images Skull Lateral Orientation
4 Images
Adult LacZ: LacZ Images Wholemount
23 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Vps4atm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Vps4atm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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