Genes Phenotypes

Gene: Laptm4b

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Name
lysosomal-associated protein transmembrane 4B
MGI ID
MGI:1890494
Synonyms
C330023P13Rik
Viability
Homozygous - Subviable
View
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (10) Measurements chart (222) All data table (455)
Expression & images (30) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased startle reflex Laptm4btm1e.1(KOMP)Wtsi HET postnatal 6.06×10-05
abnormal craniofacial morphology Laptm4btm1e.1(KOMP)Wtsi HOM embryonic day 15.5 0.00
abnormal eye morphology Laptm4btm1e.1(KOMP)Wtsi HOM embryonic day 12.5 0.00
abnormal hindbrain morphology Laptm4btm1e.1(KOMP)Wtsi HOM embryonic day 12.5 0.00
preweaning lethality, incomplete penetrance Laptm4btm1e.1(KOMP)Wtsi HOM n/a 0.00
abnormal midbrain morphology Laptm4btm1e.1(KOMP)Wtsi HOM embryonic day 12.5 0.00
edema Laptm4btm1e.1(KOMP)Wtsi HOM embryonic day 15.5 0.00
abnormal neural tube closure Laptm4btm1e.1(KOMP)Wtsi HOM embryonic day 12.5 0.00
abnormal embryo size Laptm4btm1e.1(KOMP)Wtsi HOM embryonic day 12.5 0.00
decreased prepulse inhibition Laptm4btm1e.1(KOMP)Wtsi HET postnatal 5.52×10-09

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Viewing: all phenotypes
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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 0  (1/51) N/A
Brain 3  (6/485) N/A
Central nervous system ganglion 0  (1/51) N/A
Ear 3  (1/485) N/A
Embryo 3  (1/485) N/A
Eye 3  (1/485) N/A
Foot 3  (1/485) N/A
Forebrain 3  (1/485) N/A
Forelimb 3  (1/485) N/A
Gut 0  (1/50) N/A
Hand 3  (1/485) N/A
Head 3  (5/485) N/A
Heart 3  (1/485)  (2/8) N/A
Hindbrain 3  (6/485) N/A
Hindlimb 3  (1/485) N/A
Liver 3  (1/485)  (2/8) N/A
Lung 3  (1/485) N/A
Mandibular process 3  (1/485) N/A
Maxillary process 3  (1/485) N/A
Midbrain 3  (1/485) N/A
Nose 0  (1/51) N/A
Oral cavity 3  (1/485) N/A
0  (7/25)  (2/2) N/A
Skeleton 0  (1/51) N/A
Skin 3  (1/485) N/A
Spinal cord 0  (1/50) N/A
Tail 3  (1/485) N/A
Tail somite 3  (1/485) N/A
Trachea 0  (1/50) N/A
Urinary system 0  (1/50)  (2/2) N/A

 Associated Images

Gross Morphology Embryo E14.5-E15.5
8 Images
Embryo LacZ: LacZ images wholemount
24 Images
Gross Pathology and Tissue Collection
8 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Dorso Ventral
10 Images
X-ray: XRay Images Lateral Orientation
10 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Laptm4btm1e(KOMP)Wtsi Targeted, non-conditional allele Mice
Laptm4btm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Laptm4btm1e.1(KOMP)Wtsi Mice, Tissue

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