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Gene: Laptm4b

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Name
lysosomal-associated protein transmembrane 4B
MGI ID
MGI:1890494
Synonyms
C330023P13Rik
Viability
Data available
Embryo viewer
3D Imaging
Other links
MGI   Ensembl  
Significant phenotypes (13) Measurements chart (212) All data table (742)
Expression & images (30) Disease models (0) Histopathology (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
increased grip strength Laptm4btm1e.1(KOMP)Wtsi HET Early adult 6.30×10-05
abnormal midbrain morphology Laptm4btm1e.1(KOMP)Wtsi HOM E12.5 0.00
abnormal craniofacial morphology Laptm4btm1e.1(KOMP)Wtsi HOM E15.5 0.00
abnormal hindbrain morphology Laptm4btm1e.1(KOMP)Wtsi HOM E12.5 0.00
abnormal eye morphology Laptm4btm1e.1(KOMP)Wtsi HOM E12.5 0.00
abnormal neural tube closure Laptm4btm1e.1(KOMP)Wtsi HOM E12.5 0.00
abnormal embryo size Laptm4btm1e.1(KOMP)Wtsi HOM E12.5 0.00
preweaning lethality, complete penetrance Laptm4btm1e.1(KOMP)Wtsi HOM Early adult 0.00
decreased prepulse inhibition Laptm4btm1e.1(KOMP)Wtsi HET Early adult 3.12×10-15
edema Laptm4btm1e.1(KOMP)Wtsi HOM E15.5 0.00
preweaning lethality, incomplete penetrance Laptm4btm1e.1(KOMP)Wtsi HOM   Early adult 0.00
abnormal sinus arrhythmia Laptm4btm1e.1(KOMP)Wtsi HET   Early adult 2.29×10-05
cardiovascular system phenotype Laptm4btm1e.1(KOMP)Wtsi HET   Early adult 3.74×10-05

Download data as:  TSV  XLS

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

No Adult expression data was found for this gene.
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Axial skeleton 0  (1/63) N/A
Brain 3  (6/507) N/A
Central nervous system ganglion 0  (1/72) N/A
Ear 3  (1/507) N/A
Embryo 3  (1/508) N/A
Eye 3  (1/507) N/A
Footplate 3  (1/507) N/A
Forebrain 3  (1/507) N/A
Forelimb 3  (1/507) N/A
Gut 0  (1/58) N/A
Handplate 3  (1/507) N/A
Head 3  (5/507) N/A
Heart 3  (1/507) N/A
Hindbrain 3  (6/507) N/A
Hindlimb 3  (1/507) N/A
Liver 3  (1/502)  (1/8) N/A
Lung 3  (1/502) N/A
Mandibular process 3  (1/507) N/A
Maxillary process 3  (1/507) N/A
Midbrain 3  (1/507) N/A
Nose 0  (1/77) N/A
Oral cavity 3  (1/502) N/A
Placenta 0  (7/42)  (2/2) N/A
Skeleton 0  (1/77) N/A
Skin 3  (1/507) N/A
Spinal cord 0  (1/71) N/A
Tail 3  (1/507) N/A
Tail somite group 3  (1/507) N/A
Trachea 0  (1/58) N/A
Urinary system 0  (1/58)  (1/2) N/A

 Associated Images

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X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
Immunophenotyping: Panel A FCS file(s)
6 Images
Immunophenotyping: Panel B FCS file(s)
6 Images
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X-ray: XRay Images Skull Lateral Orientation
10 Images
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Embryo LacZ: LacZ images wholemount
32 Images
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X-ray: XRay Images Whole Body Dorso Ventral
10 Images
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X-ray: XRay Images Whole Body Lateral Orientation
10 Images
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Gross Morphology Embryo E14.5-E15.5
8 Images
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Gross Pathology and Tissue Collection
8 Images
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X-ray: XRay Images Hind Leg and Hip
1 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Laptm4btm1e(KOMP)Wtsi Targeted, non-conditional allele Mice
Laptm4btm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Laptm4btm1e.1(KOMP)Wtsi Mice, Tissue

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