Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
interleukin 19
Synonyms:
N/A

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Il19 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Il19 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Immunodeficiency, Common Variable, 11
Failure to thrive, Crohn's disease, Decreased circulating IgG level, Mucoid diarrhea, Inflammatio... OMIM:615767
Autoimmune Disease, Multisystem, Infantile-Onset, 2
Decreased specific pneumococcal antibody level, Colitis, Minimal change glomerulonephritis OMIM:617006
Immunodeficiency 37
Colitis, Decreased circulating antibody level, Infectious encephalitis OMIM:616098
Immunodeficiency 70
Colitis, Decreased circulating total IgA, Decreased circulating total IgM, Recurrent sinusitis, D... OMIM:618969
Lymphoproliferative Syndrome, X-Linked, 2
Colitis, Folliculitis, Recurrent skin infections, Inflammation of the large intestine, Hepatitis,... OMIM:300635
Inflammatory Bowel Disease 29
Crohn's disease, Ulcerative colitis OMIM:618077
Masp2 Deficiency
Recurrent pneumonia, Ulcerative colitis OMIM:613791
Immunodeficiency 57 With Autoinflammation
Failure to thrive, Gastritis, Skin rash, Diarrhea, Inflammation of the large intestine, Decreased... OMIM:618108
Immunodeficiency 14B, Autosomal Recessive
Decreased circulating IgA level, Colitis, Decreased circulating IgG level, Decreased circulating ... OMIM:619281
Diarrhea 8, Secretory Sodium, Congenital
Secretory diarrhea, Abdominal distention, Inflammation of the large intestine, Elevated fecal sodium OMIM:616868
Leukoencephalopathy, Arthritis, Colitis, And Hypogammaglobulinema
Chronic gastritis, Failure to thrive, Colitis, Decreased circulating IgG level, Eczema, Diarrhea,... OMIM:608809
Inflammatory Bowel Disease 21
Ulcerative colitis OMIM:612354
Inflammatory Bowel Disease 3
Ulcerative colitis OMIM:604519
Immunodeficiency 60 And Autoimmunity
Crohn's disease, Decreased circulating IgA level, Colitis, Decreased circulating IgG level, Bronc... OMIM:618394
Cutaneous Photosensitivity And Colitis, Lethal
Diarrhea, Colitis OMIM:219095
Inflammatory Bowel Disease (Infantile Ulcerative Colitis) 31, Autosomal Recessive
Bloody diarrhea, Ulcerative colitis OMIM:619398
Vulvovaginal Gingival Syndrome
Abnormality of tumor necrosis factor secretion ORPHA:83453
Inflammatory Bowel Disease (Crohn Disease) 1
Crohn's disease, Abdominal pain, Diarrhea, Inflammation of the large intestine, Intestinal obstru... OMIM:266600
Inflammatory Bowel Disease 28, Autosomal Recessive
Crohn's disease, Colitis, Enterocolitis, Folliculitis, Pyoderma, Hematochezia, Perianal abscess OMIM:613148
Ficolin 3 Deficiency
Necrotizing enterocolitis OMIM:613860
Inflammatory Bowel Disease (Crohn Disease) 30
Bloody diarrhea, Ileitis, Gastritis, Abdominal pain, Pancolitis, Vomiting, Protein-losing enterop... OMIM:619079
5-Oxoprolinase Deficiency
Vomiting, Diarrhea, Enterocolitis, Abdominal pain OMIM:260005
Inflammatory Bowel Disease (Crohn Disease) 19
Inflammation of the large intestine OMIM:612278
Inflammatory Bowel Disease 13
Inflammation of the large intestine OMIM:612244
Bare Lymphocyte Syndrome, Type Ii
Failure to thrive, Malabsorption, Colitis, Viral hepatitis, Panhypogammaglobulinemia, Villous atr... OMIM:209920
Adult Acute Respiratory Distress Syndrome
Abnormality of tumor necrosis factor secretion, Increased circulating interleukin 6 concentration... ORPHA:70578
Acute Lung Injury
Abnormality of tumor necrosis factor secretion, Increased circulating interleukin 6 concentration... ORPHA:178320
Hirschsprung Disease, Susceptibility To, 1
Abdominal distention, Enterocolitis, Constipation, Vomiting, Abnormality of enteric ganglion morp... OMIM:142623
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
Recurrent sinusitis, Colitis, Decreased circulating antibody level OMIM:613101
Pigmentary Disorder, Reticulate, With Systemic Manifestations, X-Linked
Increased circulating interleukin 8 concentration, Colitis, Reduced circulating interferon gamma,... OMIM:301220
Autoinflammation, Antibody Deficiency, And Immune Dysregulation
Decreased circulating IgA level, Enterocolitis, Interstitial pneumonitis, Decreased circulating t... OMIM:614878
Autoinflammatory Syndrome, Familial, X-Linked, Behcet-Like 2
Chronic gastritis, Increased circulating interleukin 6 concentration, Colitis, Abdominal pain, Sk... OMIM:301074
Familial Hemophagocytic Lymphohistiocytosis
Abnormality of tumor necrosis factor secretion, Increased circulating interleukin 6 concentration... ORPHA:540
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
Obesity, Colitis ORPHA:88643
Visceral Myopathy 2
Gastroesophageal reflux, Hiatus hernia, Barrett esophagus, Intestinal malrotation, Necrotizing en... OMIM:619350
Dyskeratosis Congenita, Autosomal Recessive 5
Colitis, Decreased circulating antibody level, Esophageal stenosis OMIM:615190
Inflammatory Bowel Disease 25, Autosomal Recessive
Enterocolitis, Folliculitis, Pancolitis, Perianal abscess, Rectovaginal fistula, Enterocutaneous ... OMIM:612567
Proton-Pump Inhibitor-Responsive Esophageal Eosinophilia
Eosinophilic microabscess formation in the esophagus, Vomiting, Lactose intolerance, Feeding diff... ORPHA:411696
Inflammatory Bowel Disease 11
Abdominal pain, Diarrhea, Inflammation of the large intestine, Hematochezia, Weight loss OMIM:191390
Gastrointestinal Defects And Immunodeficiency Syndrome 1
Duodenal atresia, Bloody diarrhea, Intestinal atresia, Enterocolitis, Intestinal malrotation, Pso... OMIM:243150
Secondary Short Bowel Syndrome
Failure to thrive, Malabsorption, Constipation, Enterocolitis, Intestinal atresia, Steatorrhea, S... ORPHA:95427
Granulomatous Disease, Chronic, Autosomal Recessive, 3
Colitis, Diarrhea, Perioral eczema, Recurrent sinusitis, Recurrent aphthous stomatitis OMIM:613960
Sweet Syndrome
Abnormality of tumor necrosis factor secretion, Increased circulating interleukin 6 concentration... ORPHA:3243
Macrophage Activation Syndrome
Abnormality of tumor necrosis factor secretion, Increased circulating interleukin 6 concentration... ORPHA:158061
Epidermolysis Bullosa Acquisita
Abdominal pain, Inflammation of the large intestine ORPHA:46487
Immunodeficiency 58
Failure to thrive, Bronchiectasis, Colitis, Seborrheic dermatitis, Eczema, Chronic otitis media, ... OMIM:618131
Immunodeficiency, Common Variable, 8, With Autoimmunity
Failure to thrive, Decreased circulating IgA level, Colitis, Decreased circulating IgG level, Rec... OMIM:614700
Pseudomyxoma Peritonei
Constipation, Abdominal pain, Inflammation of the large intestine, Intestinal obstruction, Weight... ORPHA:26790
Pyoderma Gangrenosum
Increased circulating antibody level, Pustule, Rheumatoid arthritis, Myositis, Inflammation of th... ORPHA:48104
Enterocolitis
Ulcerative colitis, Abdominal distention, Enterocolitis, Hematochezia OMIM:226150
Immunodeficiency 76
Colitis, Recurrent pneumonia, Chronic diarrhea OMIM:619164
Trichohepatoenteric Syndrome 2
Failure to thrive, Bloody diarrhea, Colitis, Small for gestational age, Chronic hepatitis, Diarrh... OMIM:614602
Autoinflammatory Syndrome, Familial, Behcet-Like 1
Ileal ulcer, Colitis, Skin rash, Anterior uveitis OMIM:616744
Pyogenic Sterile Arthritis, Pyoderma Gangrenosum, And Acne
Cystic acne, Colitis, Arthritis, Acne, Sterile arthritis OMIM:604416
Autoimmune Hepatitis
Increased circulating antibody level, Viral hepatitis, Abdominal pain, Hepatocellular carcinoma, ... ORPHA:2137
Immunodeficiency 97 With Autoinflammation
Decreased circulating IgA level, Colitis, Decreased circulating IgG level, Enterocolitis, Abdomin... OMIM:619802
Immune Dysregulation-Polyendocrinopathy-Enteropathy-X-Linked Syndrome
Recurrent gastroenteritis, Gastritis, Eczema, Vomiting, Pneumonia, Failure to thrive in infancy, ... ORPHA:37042
Autoinflammation With Infantile Enterocolitis
Failure to thrive, Enterocolitis, Skin rash, Episodic vomiting, Feeding difficulties in infancy, ... OMIM:616050
Linear Iga Dermatosis
Inflammation of the large intestine ORPHA:46488
Iga Pemphigus
Increased circulating IgA level, Pustule, Monoclonal elevation of circulating IgA, Ulcerative col... ORPHA:555905
Car T Cell Therapy-Associated Cytokine Release Syndrome
Abnormality of interleukin secretion, Increased circulating interleukin 6 concentration, Skin ras... ORPHA:542323
Hyperphosphatasia With Mental Retardation Syndrome 6
High palate, Abdominal pain, Feeding difficulties, Necrotizing enterocolitis, Vomiting OMIM:616809
Infection-Related Hemolytic Uremic Syndrome
Abdominal cramps, Acute colitis, Increased circulating interleukin 6 concentration, Bloody diarrh... ORPHA:544482
Sepsis In Premature Infants
Increased circulating interleukin 6 concentration, Decreased liver function, Decreased body weigh... ORPHA:90051
Psoriasis-Related Juvenile Idiopathic Arthritis
Abnormality of tumor necrosis factor secretion, Iridocyclitis, Oligoarthritis, Skin rash, Iritis,... ORPHA:85436
Thymoma
Rheumatoid arthritis, Neoplasm of the gastrointestinal tract, Myositis, Decreased circulating ant... ORPHA:99867
Congenital Disorder Of Glycosylation, Type Iil
Decreased specific anti-polysaccharide antibody level, Failure to thrive, Inflammation of the lar... OMIM:614576
Combined Immunodeficiency Due To Zap70 Deficiency
Failure to thrive, Recurrent bacterial skin infections, Colitis, Recurrent infection of the gastr... ORPHA:911
Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy
Failure to thrive, Bloody diarrhea, Eosinophilic infiltration of the esophagus, Pancolitis, Incre... OMIM:618213
Immunodeficiency 82 With Systemic Inflammation
Gastritis, Diarrhea, Vomiting, Pneumonia, Weight loss, Colitis, Osteomyelitis, Decreased circulat... OMIM:619381
Autoimmune Enteropathy And Endocrinopathy-Susceptibility To Chronic Infections Syndrome
Thyroiditis, Inflammatory abnormality of the skin, Enterocolitis, Eczema, Diarrhea, Esophageal ca... ORPHA:391487
Shigellosis
Abdominal cramps, Paralytic ileus, Acute colitis, Bloody mucoid diarrhea, Bloody diarrhea, Abdomi... ORPHA:810
Chronic Nonbacterial Osteomyelitis/Chronic Recurrent Multifocal Osteomyelitis
Osteomyelitis, Skin rash, Palmoplantar pustulosis, Inflammation of the large intestine, Arthritis... ORPHA:324964
Autoimmune Lymphoproliferative Syndrome
Decreased specific anti-polysaccharide antibody level, Increased circulating antibody level, Coli... ORPHA:3261
Amoebiasis Due To Entamoeba Histolytica
Acute colitis, Bloody diarrhea, Abdominal pain, Diarrhea, Constrictive pericarditis, Intestinal o... ORPHA:67
Autoinflammation, Immune Dysregulation, And Eosinophilia
Failure to thrive, Eosinophilic liver infiltration, Atopic dermatitis, Membranous nephropathy, Co... OMIM:618999
Cyclic Neutropenia
Periodontitis, Sinusitis, Enterocolitis, Abdominal pain, Otitis media, Recurrent skin infections,... ORPHA:2686
Immunodeficiency 92
Decreased circulating IgA level, Osteomyelitis, Decreased circulating IgG level, Sclerosing chola... OMIM:619652
Esophagitis, Eosinophilic, 1
Dysphagia, Failure to thrive, Vomiting, Esophagitis OMIM:610247
Esophagitis, Eosinophilic, 2
Dysphagia, Failure to thrive, Vomiting, Esophagitis OMIM:613412
Granulomatous Disease, Chronic, Autosomal Recessive, 5
Crohn's disease, Eczema, Lymphadenitis, Acute pancreatitis, Perianal abscess, Recurrent pneumonia... OMIM:618935
Primary Biliary Cholangitis/Primary Sclerosing Cholangitis And Autoimmune Hepatitis Overlap Syndrome
Sclerosing cholangitis, Increased circulating IgG level, Inflammation of the large intestine, Inc... ORPHA:562639
Zygomycosis
Melena, Gastritis, Unusual gastrointestinal infection, Pancreatitis, Diarrhea, Vomiting, Acute in... ORPHA:73263
Wiskott-Aldrich Syndrome, Autosomal Dominant
Decreased specific anti-polysaccharide antibody level, Sinusitis, Increased circulating IgA level... OMIM:600903
Syndromic Diarrhea
Bloody diarrhea, Colitis, Gastritis, Hepatoblastoma, Dependency on intravenous nutrition, Small f... ORPHA:84064
Gastroesophageal Reflux
Esophagitis, Esophageal neoplasm, Gastroesophageal reflux, Barrett esophagus OMIM:109350
Hermansky-Pudlak Syndrome 1
Colitis, Abdominal pain, Inflammation of the large intestine, Hematochezia OMIM:203300
Sapho Syndrome
Malabsorption, Osteomyelitis, Pustule, Abdominal pain, Steatorrhea, Recurrent skin infections, Sk... ORPHA:793
Shiga Toxin-Associated Hemolytic Uremic Syndrome
Acute colitis, Bloody diarrhea, Pancreatitis, Intussusception, Abdominal pain, Peritonitis, Diarr... ORPHA:90038
Parenteral Nutrition-Associated Cholestasis
Abdominal pain, Hepatic failure, Small for gestational age, Villous atrophy, Abnormality of cytok... ORPHA:567983
X-Linked Lymphoproliferative Disease
Decreased liver function, Decreased circulating IgA level, Colitis, Decreased circulating IgG lev... ORPHA:2442
Pancreatic Triacylglycerol Lipase Deficiency
Exocrine pancreatic insufficiency, Colitis, Abdominal distention, Abdominal pain, Steatorrhea, Di... ORPHA:309031
Primary Sclerosing Cholangitis
Thyroiditis, Cholangiocarcinoma, Adenocarcinoma of the large intestine, Pancreatitis, Abdominal p... ORPHA:171
Hyperlipoproteinemia, Type Id
Failure to thrive, Colitis, Pancreatitis, Recurrent pancreatitis OMIM:615947
Spondyloarthropathy, Susceptibility To, 1
Oligoarthritis, Inflammation of the large intestine, Anterior uveitis, Hip osteoarthritis, Sacroi... OMIM:106300
Wiskott-Aldrich Syndrome
Decreased specific anti-polysaccharide antibody level, Melena, Recurrent otitis media, Increased ... OMIM:301000
Aregenerative Anemia
Abnormality of interleukin secretion ORPHA:101096
Acyl-Coa Dehydrogenase, Very Long-Chain, Deficiency Of
Necrotizing enterocolitis, Episodic vomiting, Gastroesophageal reflux OMIM:201475
Immunodeficiency 71 With Inflammatory Disease And Congenital Thrombocytopenia
Failure to thrive, Inflammation of the large intestine OMIM:617718
Polyglucosan Body Myopathy 1 With Or Without Immunodeficiency
Failure to thrive, Abdominal pain, Eczema, Lymphadenitis, Inflammation of the large intestine, He... OMIM:615895
Idiopathic Hypereosinophilic Syndrome
Failure to thrive, Malabsorption, Colitis, Pancreatitis, Inflammatory abnormality of the skin, Ab... ORPHA:3260
Kindler Epidermolysis Bullosa
Cheilitis, Colitis, Periodontitis, Recurrent skin infections, Inflammation of the large intestine... ORPHA:2908
Reactive Arthritis
Osteomyelitis, Pustule, Abdominal pain, Diarrhea, Inflammation of the large intestine, Pericardit... ORPHA:29207
Gastrointestinal Defects And Immunodeficiency Syndrome 2
Intestinal atresia, Inflammation of the large intestine, Bronchiectasis, Dysphagia, Absent uvula,... OMIM:619708
Sarcoidosis, Susceptibility To, 1
Increased circulating antibody level, Iridocyclitis, Anorexia, Inflammation of the large intestin... OMIM:181000
Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ib
Failure to thrive, Periodontitis, Pancreatitis, Enterocolitis, Hepatocellular carcinoma, Diarrhea... ORPHA:79259
Visceral Myopathy 1
Pancreatitis, Constipation, Abdominal pain, Abdominal distention, Diarrhea, Vomiting, Dysphagia, ... OMIM:155310
Cocaine Intoxication
Bloody diarrhea, Colitis, Abdominal pain, Vomiting, Tubulointerstitial nephritis, Nausea, Glomeru... ORPHA:90068
Congenital Factor Xiii Deficiency
Inflammation of the large intestine, Hepatic failure ORPHA:331
Plague
Bloody diarrhea, Enterocolitis, Hematemesis, Abdominal pain, Anorexia, Skin rash, Lymphadenitis, ... ORPHA:707
Glycogen Storage Disease Ib
Pancreatitis, Hepatocellular carcinoma, Gout, Inflammation of the large intestine, Protuberant ab... OMIM:232220
Wiskott-Aldrich Syndrome
Keratitis, Blepharitis, Sinusitis, Hematemesis, Otitis media, Eczema, Chronic otitis media, Infla... ORPHA:906
Immunodeficiency 87 And Autoimmunity
Increased fecal calprotectin level, Cleft palate, Small for gestational age, Necrotizing enteroco... OMIM:619573
Frontometaphyseal Dysplasia 2
High palate, Gastroesophageal reflux, Cleft palate, Bifid uvula, Pyloric stenosis, Feeding diffic... OMIM:617137
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome
Abdominal distention, Intestinal malrotation, Abnormality of the gastrointestinal tract, Hypoperi... ORPHA:2241
Chronic Thromboembolic Pulmonary Hypertension
Obesity, Osteomyelitis, Inflammation of the large intestine ORPHA:70591
Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 5
Intestinal malrotation, Microcolon, Hepatic failure OMIM:619431
Turner Syndrome Due To Structural X Chromosome Anomalies
High palate, High, narrow palate, Inflammation of the large intestine, Failure to thrive in infan... ORPHA:99413
Turner Syndrome
High palate, High, narrow palate, Inflammation of the large intestine, Failure to thrive in infan... ORPHA:881
Mosaic Monosomy X
High palate, High, narrow palate, Inflammation of the large intestine, Failure to thrive in infan... ORPHA:99228
Monosomy X
High palate, High, narrow palate, Inflammation of the large intestine, Failure to thrive in infan... ORPHA:99226
Mowat-Wilson Syndrome
Decreased body weight, Constipation, Enterocolitis, Cleft palate, Dependency on intravenous nutri... ORPHA:2152
Meconium Ileus
Meconium ileus, Microcolon OMIM:614665

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Il19

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Il19.

No publications found that use IMPC mice or data for Il19.

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MGI Allele Allele Type Produced
Il19tm2a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Il19tm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) ES Cells
Il19tm2e(EUCOMM)Hmgu Targeted, non-conditional allele Mice, ES Cells
Il19tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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