Kptn | kaptin

GeneMGI:1890380Synonyms: 2E4, actin-binding protein, +2 more

Physiological systems

20 / 24 physiological systems tested

4 Significantly impacted by the knock-out

 Growth/size/body region Hematopoietic system Behavior/neurological Skeleton

16 No significant impact

4 Not tested

Gene metrics:7Significant phenotypes
2Associated diseases
Expression examined in:45Adult tissues
0Embryo tissues

Phenotypes

abnormal behavior3 supporting datasetsKptntm1a(EUCOMM)WtsihomozygoteEarly adult7.17x10-6 
abnormal tail movements1 supporting datasetKptntm1a(EUCOMM)WtsihomozygoteEarly adult7.74x10-6 
decreased hemoglobin content1 supporting datasetKptntm1a(EUCOMM)WtsihomozygoteEarly adult9.03x10-5 
increased body weight3 supporting datasetsKptntm1a(EUCOMM)WtsihomozygoteEarly adult6.77x10-14 
decreased bone mineral content1 supporting datasetKptntm1a(EUCOMM)WtsihomozygoteEarly adult3.29x10-8 
decreased bone mineral density1 supporting datasetKptntm1a(EUCOMM)WtsihomozygoteEarly adult4.19x10-5 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Kptntm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Kptntm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Kptntm1c(EUCOMM)WtsiWild type floxed exon (post-Flp)mouse
Kptntm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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