Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
midnolin
Synonyms:
3000003C15Rik

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Midn mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Midn by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Orofacial Cleft 11
Cleft lip, Cleft palate OMIM:600625
Syngnathia
Cleft palate OMIM:119550
Ankyloblepharon Filiforme Adnatum-Imperforate Anus Syndrome
Non-midline cleft lip, Cleft palate, Tooth agenesis, Cryptorchidism ORPHA:1074
Van Der Woude Syndrome 2
Cleft upper lip, Cleft palate, Anodontia OMIM:606713
Premature Ovarian Failure 5
Secondary amenorrhea, Streak ovary, Hypoplasia of the ovary, Primary amenorrhea, Premature ovaria... OMIM:611548
Orofacial Cleft 6, Susceptibility To
Cleft upper lip, Cleft palate OMIM:608864
Orofacial Cleft 1
Cleft upper lip, Cleft palate OMIM:119530
Orofacial Cleft 5
Cleft upper lip, Cleft palate OMIM:608874
Orofacial Cleft 10
Unilateral cleft lip, Unilateral cleft palate OMIM:613705
Palatopharyngeal Incompetence
Cleft palate, Velopharyngeal insufficiency OMIM:167500
Ankyloblepharon Filiforme Adnatum And Cleft Palate
Cleft upper lip, Cleft palate OMIM:106250
Congenital Laryngomalacia
Non-midline cleft lip, Cleft palate ORPHA:2373
Hypergonadotropic Hypogonadism And Partial Alopecia
Streak ovary, Hypergonadotropic hypogonadism OMIM:241090
Pierre Robin Syndrome And Oligodactyly
Cleft palate, Pierre-Robin sequence OMIM:172880
Diffuse Gastric And Lobular Breast Cancer Syndrome
Cleft upper lip, Cleft palate, Stomach cancer OMIM:137215
Perrault Syndrome 6
Secondary amenorrhea, Streak ovary, Primary amenorrhea, Premature ovarian insufficiency, Irregula... OMIM:617565
Van Der Woude Syndrome 1
Hypodontia, Cleft palate, Cleft upper lip, Lower lip pit, Bifid uvula OMIM:119300
Hypogonadotropic Hypogonadism 5 With Or Without Anosmia
Cleft lip, Hypogonadotropic hypogonadism, Cleft palate, Cryptorchidism OMIM:612370
Premature Ovarian Failure 18
Secondary amenorrhea, Decreased antimullerian hormone level, Elevated circulating follicle stimul... OMIM:619203
Cleft Palate, Isolated
Increased overbite, Cleft palate, Gingival overgrowth, Anterior open-bite malocclusion OMIM:119540
Omphalocele-Cleft Palate Syndrome, Lethal
Bicornuate uterus, Cleft palate, Bifid uvula OMIM:258320
Premature Ovarian Failure 10
Elevated circulating follicle stimulating hormone level, Azoospermia, Hypoplasia of the ovary, Pr... OMIM:612885
Perrault Syndrome 2
Amenorrhea, Streak ovary OMIM:614926
Ovarian Dysgenesis 9
Decreased antimullerian hormone level, Elevated circulating follicle stimulating hormone level, H... OMIM:619665
Premature Ovarian Failure 6
Secondary amenorrhea, Streak ovary, Elevated circulating follicle stimulating hormone level, Fema... OMIM:612310
Cleft Palate-Lateral Synechia Syndrome
Cleft palate, Narrow mouth, Everted lower lip vermilion, Oral synechia ORPHA:2016
Pierre Robin Syndrome
Cleft palate, Pierre-Robin sequence, Glossoptosis OMIM:261800
Ring Chromosome Y Syndrome
Hypospadias, Unilateral cryptorchidism, Bifid scrotum, Streak ovary, Abnormality of the male geni... ORPHA:261529
Isolated Pierre Robin Syndrome
Cleft palate, Glossoptosis ORPHA:718
Premature Ovarian Failure 2A
Secondary amenorrhea, Premature ovarian insufficiency OMIM:300511
Ectrodactyly-Cleft Palate Syndrome
Cleft palate OMIM:129830
2q33.1 deletion syndrome
Cleft palate, High palate DECIPHER:51
Hypogonadotropic Hypogonadism 12 With Or Without Anosmia
Hypogonadotropic hypogonadism, Hypoplasia of the ovary, Decreased serum estradiol, Micropenis, Hy... OMIM:614841
Cleft Palate With Or Without Ankyloglossia, X-Linked
Ankyloglossia, Cleft palate, Bifid uvula OMIM:303400
Hypogonadotropic Hypogonadism 15 With Or Without Anosmia
Cleft palate, Small pituitary gland, Micropenis, Primary amenorrhea, Cryptorchidism, Decreased te... OMIM:614880
Perrault Syndrome 4
Secondary amenorrhea, Cleft palate, Oligomenorrhea, Hypoplasia of the ovary, Increased circulatin... OMIM:615300
Hypogonadotropic Hypogonadism 25 With Anosmia
Hypoplasia of the ovary, Decreased serum estradiol, Micropenis, Hypothalamic gonadotropin-releasi... OMIM:618841
Van Der Woude Syndrome
Abnormal salivary gland morphology, Hypodontia, Cleft palate, Cleft upper lip, Lower lip pit, Lip... ORPHA:888
Cleft Soft Palate
Cleft soft palate OMIM:119570
Uvula, Bifid
Bifid uvula OMIM:192100
Osteosclerosis With Ichthyosis And Premature Ovarian Failure
Hypoplasia of the ovary, Premature ovarian insufficiency OMIM:609993
Familial Hyperprolactinemia
Menorrhagia, Hemorrhagic ovarian cyst, Infertility, Oligomenorrhea, Amenorrhea, Female hypogonadism ORPHA:397685
46,Xy Sex Reversal 7
Gonadal dysgenesis, male, Sex reversal, Streak ovary, Gonadoblastoma, Hypoplasia of the fallopian... OMIM:233420
46,Xy Gonadal Dysgenesis-Motor And Sensory Neuropathy Syndrome
Testicular dysgenesis, Gonadal dysgenesis with female appearance, male, Abnormal vagina morpholog... ORPHA:168563
Cleft Lip With Or Without Cleft Palate
Non-midline cleft palate, Non-midline cleft lip, Submucous cleft of soft and hard palate ORPHA:1991
Normosmic Congenital Hypogonadotropic Hypogonadism
Secondary amenorrhea, Cleft palate, Micropenis, Breast hypoplasia, Hypogonadotropic hypogonadism,... ORPHA:432
Trochlea Of The Humerus, Aplasia Of
Cleft palate OMIM:191000
Weaver-Williams Syndrome
Cleft palate, Narrow mouth ORPHA:3448
Epidermolysis Bullosa, Late-Onset Localized Junctional, With Mental Retardation
Cleft palate, Short philtrum, Thick upper lip vermilion, Thin upper lip vermilion, Abnormality of... OMIM:226440
Wilms Tumor, Aniridia, Genitourinary Anomalies, And Mental Retardation Syndrome
Hypospadias, Abnormal vagina morphology, Streak ovary, Gonadoblastoma, Abnormality of the uterus,... OMIM:194072
Radius, Aplasia Of, With Cleft Lip/Palate
Cleft upper lip, Cleft palate OMIM:179400
Hypogonadotropic Hypogonadism 9 With Or Without Anosmia
Cleft palate, Hypogonadotropic hypogonadism, Cleft lip, Micropenis, Decreased testicular size OMIM:614838
Hypogonadotropic Hypogonadism-Retinitis Pigmentosa Syndrome
Hypogonadotropic hypogonadism, Secondary growth hormone deficiency, Absence of secondary sex char... ORPHA:2235
Premature Ovarian Failure 16
Reduced antral follicle count, Premature ovarian insufficiency, Elevated circulating follicle sti... OMIM:618723
Premature Ovarian Failure 3
Secondary amenorrhea, Premature ovarian insufficiency, Hypoplasia of the uterus OMIM:608996
Holzgreve Syndrome
Cleft upper lip, Cleft palate OMIM:236110
46,Xy Partial Gonadal Dysgenesis
Hypospadias, Adrenal insufficiency, Elevated circulating follicle stimulating hormone level, Urog... ORPHA:251510
Microphthalmia, Syndromic 11
Cleft upper lip, Agenesis of pineal gland, Cleft palate OMIM:614402
Frasier Syndrome
Gonadal dysgenesis with female appearance, male, Streak ovary, Gonadoblastoma, Increased circulat... ORPHA:347
Lethal Omphalocele-Cleft Palate Syndrome
Cleft palate, Bifid uterus, Cleft soft palate, Bifid uvula, Unilateral cleft lip ORPHA:2736
Chromosome 15Q14 Deletion Syndrome
Cleft palate, Short philtrum, Tented upper lip vermilion, Cleft lip, Everted lower lip vermilion OMIM:616898
Bifid Uvula
Cleft lip, Bifid uvula, Submucous cleft soft palate ORPHA:99771
Cleft Lip/Palate
Peg-shaped maxillary lateral incisors, Cleft palate, Agenesis of lateral incisor, Palate fistula,... ORPHA:199306
Premature Ovarian Failure 8
Ovarian neoplasm, Primary amenorrhea, Premature ovarian insufficiency, Increased circulating gona... OMIM:615723
Leydig Cell Hypoplasia
Hypospadias, Secondary amenorrhea, Aplasia of the uterus, Abnormal external genitalia, Micropenis... ORPHA:755
Isolated Follicle Stimulating Hormone Deficiency
Oligospermia, Abnormal sperm morphology, Testicular atrophy, Oligomenorrhea, Azoospermia, Hypogon... ORPHA:52901
Obesity Due To Congenital Leptin Deficiency
Insulin-resistant diabetes mellitus, Pituitary hypothyroidism, Hypoplasia of the ovary, Absence o... ORPHA:66628
46,Xx Gonadal Dysgenesis
Secondary amenorrhea, Aplasia/hypoplasia of the uterus, Streak ovary, Decreased serum estradiol, ... ORPHA:243
Ankyloblepharon Filiforme Adnatum-Cleft Palate Syndrome
Non-midline cleft lip, Cleft palate, Lip pit ORPHA:1072
Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate
Cleft palate, Thyroid agenesis OMIM:241850
Obesity Due To Leptin Receptor Gene Deficiency
Insulin-resistant diabetes mellitus, Pituitary hypothyroidism, Hypoplasia of the ovary, Absence o... ORPHA:179494
Anencephaly 2
Median cleft palate, Median cleft lip, Cleft of alveolar ridge of maxilla OMIM:619452
Microphthalmia, Syndromic 8
Cleft palate, Cleft upper lip, Widely-spaced maxillary central incisors, Cryptorchidism, Oral cleft OMIM:601349
Contractures, Congenital, Torticollis, And Malignant Hyperthermia
Natal tooth, Cleft palate OMIM:217150
Hypogonadotropic Hypogonadism 3 With Or Without Anosmia
Cleft palate, Cleft upper lip, Hypogonadotropic hypogonadism, Micropenis, Primary amenorrhea, Cry... OMIM:244200
Bamforth-Lazarus Syndrome
Cleft palate, Congenital hypothyroidism, Thyroid agenesis ORPHA:1226
Arrhinia-Choanal Atresia-Microphthalmia Syndrome
Cleft palate, Hypogonadotropic hypogonadism, High palate, Tooth agenesis ORPHA:1135
Facial Clefting, Oblique, 1
Cleft upper lip, Cleft palate OMIM:600251
Satoyoshi Syndrome
Abnormality of the ovary, Amenorrhea, Hypoplasia of the ovary, Abnormality of the uterus, Nephrog... ORPHA:3130
Genitopalatocardiac Syndrome
Cleft upper lip, Cleft palate, Hypospadias, Gonadal dysgenesis, male OMIM:231060
Orofaciodigital Syndrome V
Aganglionic megacolon, Cleft palate, Bifid uvula, Lobulated tongue, Median cleft lip OMIM:174300
Primary Hypergonadotropic Hypogonadism-Partial Alopecia Syndrome
Infertility, Aplasia/hypoplasia of the uterus, Streak ovary, Hypergonadotropic hypogonadism, Abse... ORPHA:2232
Hypogonadotropic Hypogonadism 2 With Or Without Anosmia
Cleft palate, Cleft upper lip, Hypogonadotropic hypogonadism, Micropenis, Primary amenorrhea, Cry... OMIM:147950
Non-Syndromic Posterior Hypospadias
Ventral shortening of foreskin, Cleft palate, Bifid scrotum, Androgen insufficiency, Abnormality ... ORPHA:95706
Culler-Jones Syndrome
Cleft palate, Diabetes insipidus, Cleft upper lip, Hypogonadism, Micropenis, Anterior pituitary h... OMIM:615849
Microcephaly-Cleft Palate-Abnormal Retinal Pigmentation Syndrome
Submucous cleft hard palate, Cleft palate, Bifid uvula ORPHA:2521
45,X/46,Xy Mixed Gonadal Dysgenesis
Hypospadias, Bifid scrotum, Ambiguous genitalia, female, Urogenital sinus anomaly, Ambiguous geni... ORPHA:1772
Woodhouse-Sakati Syndrome
Streak ovary, Insulin-resistant diabetes mellitus, Hypoplasia of the fallopian tube, Decreased se... ORPHA:3464
Bardet-Biedl Syndrome
Hypogonadism, Cryptorchidism, Hypoplasia of penis, Hypoplasia of the ovary ORPHA:110
Blepharophimosis-Ptosis-Epicanthus Inversus Syndrome Plus
Secondary amenorrhea, Lacrimal gland aplasia, Oligomenorrhea, Short philtrum, Elevated circulatin... ORPHA:572333
Popliteal Pterygium Syndrome
Hypoplastic labia majora, Cleft palate, Bifid scrotum, Cleft upper lip, Lower lip pit, Hypoplasia... OMIM:119500
Leopard Syndrome 1
Hypospadias, Cleft palate, Hypoplasia of the ovary, Aplasia of the ovary, Micropenis, Cryptorchid... OMIM:151100
Genitourinary And/Or Brain Malformation Syndrome
Hypospadias, Streak ovary, Long philtrum, Chordee, Ileal atresia, Uterus didelphys, Jejunal atres... OMIM:618820
Growth Restriction, Hypoplastic Kidneys, Alopecia, And Distinctive Facies
Smooth philtrum, Cleft soft palate, Hypoplasia of the ovary, Intestinal malrotation, Micropenis, ... OMIM:619321
Alg9-Cdg
Smooth philtrum, Villous atrophy, Wide mouth, Hypoplastic nipples, Long philtrum, Bifid uvula, Hy... ORPHA:79328
Schinzel-Giedion Syndrome
Hypospadias, Central hypothyroidism, Aganglionic megacolon, High palate, Wide mouth, Short philtr... ORPHA:798

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Midn

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Midn.

No publications found that use IMPC mice or data for Midn.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Midnem1(IMPC)Bay Exon Deletion Mice
Midntm381490(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter