Foxo3 | forkhead box O3

GeneMGI:1890081Synonyms: FKHRL1, Fkhr2, +3 more

Physiological systems

17 / 24 physiological systems tested

8 Significantly impacted by the knock-out

Homeostasis/metabolism Growth/size/body region Nervous system Vision/eye Hematopoietic system Behavior/neurological Skeleton Cardiovascular system

9 No significant impact

7 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data

Viability data
Body weight measurements
Embryo imaging data

Allele products available

Gene metrics:15Significant phenotypes

0Associated diseases

Expression examined in:49Adult tissues

55Embryo tissues

Phenotypes

Phy. System:



increased mean corpuscular volume	2 supporting datasets	Foxo3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	1.25x10^-26
abnormal sleep behavior	1 supporting dataset	Foxo3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	9.63x10^-5
thrombocytopenia	1 supporting dataset	Foxo3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.22x10^-5
prolonged QRS complex duration	1 supporting dataset	Foxo3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	4.75x10^-5
decreased locomotor activity	6 supporting datasets	Foxo3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.18x10^-7
increased heart weight	1 supporting dataset	Foxo3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	6.95x10^-5
sclerocornea	1 supporting dataset	Foxo3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.26x10^-5
decreased startle reflex	1 supporting dataset	Foxo3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.13x10^-5
increased mean corpuscular hemoglobin	1 supporting dataset	Foxo3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	0
decreased prepulse inhibition	1 supporting dataset	Foxo3^{tm1.1(KOMP)Vlcg}	homozygote	Early adult	2.1x10^-7

* Does not have a P-value assigned because it was manually marked as significant.

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* This parameter was manually assessed for significance.

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lacZ Expression

No adult expression data available for Foxo3.

Associated images

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Histopathology

There is no histopathology data found for Foxo3.

IMPC related publications

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External links

No external links available for Foxo3.

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*Foxo3^{tm1(KOMP)Vlcg}*	Reporter-tagged deletion allele (with selection cassette)	‌	ES Cell mouse
*Foxo3^{tm1.1(KOMP)Vlcg}*	Reporter-tagged deletion allele (post Cre, with no selection cassette)	‌	mouse
*Foxo3^{tm214689(L1L2_Bact_P)}*	Reporter-tagged deletion allele (with selection cassette)	‌	targeting vector

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