Gene Summary
IMPC Data Collections
- Body Weight Measurements
- No Embryo Imaging Data
- Viability Data
The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
decreased total retina thickness | Hibadhtm1b(EUCOMM)Wtsi | HOM | Early adult | 4.23×10-19 | ||
abnormal retina inner nuclear layer morphology | Hibadhtm1b(EUCOMM)Wtsi | HOM | Early adult | 7.33×10-13 | ||
abnormal retina outer nuclear layer morphology | Hibadhtm1b(EUCOMM)Wtsi | HOM | Early adult | 4.50×10-06 | ||
abnormal eye anterior chamber depth | Hibadhtm1b(EUCOMM)Wtsi | HOM | Early adult | 8.18×10-06 | ||
abnormal skin coloration | Hibadhtm1b(EUCOMM)Wtsi | HOM | Early adult | 3.56×10-05 | ||
decreased fasting circulating glucose level | Hibadhtm1b(EUCOMM)Wtsi | HOM | Early adult | 4.63×10-05 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | N/A | heterozygote | 100% (4 of 4) |
Aorta | N/A | heterozygote | 100% (4 of 4) |
Blood vessel | N/A | heterozygote | 0.0% (0 of 2) |
Bone | N/A | heterozygote | 50% (2 of 4) |
Brain | N/A | heterozygote | 100% (4 of 4) |
Brainstem | N/A | heterozygote | 100% (4 of 4) |
Brown adipose tissue | N/A | heterozygote | 100% (4 of 4) |
Cartilage tissue | N/A | heterozygote | 100% (4 of 4) |
Cecum | N/A | heterozygote | Not available |
Cerebellum | N/A | heterozygote | 100% (4 of 4) |
Cerebral cortex | N/A | heterozygote | 100% (4 of 4) |
Esophagus | N/A | heterozygote | 100% (2 of 2) |
Eye | N/A | heterozygote | 0.0% (0 of 4) |
Gall bladder | N/A | heterozygote | 100% (4 of 4) |
Heart | N/A | heterozygote | 100% (4 of 4) |
Hippocampus | N/A | heterozygote | 100% (4 of 4) |
Hypothalamus | N/A | heterozygote | 100% (4 of 4) |
Kidney | N/A | heterozygote | 100% (4 of 4) |
Large intestine | N/A | heterozygote | 100% (4 of 4) |
Liver | N/A | heterozygote | 100% (4 of 4) |
Lower urinary tract | N/A | heterozygote | 100% (4 of 4) |
Lung | N/A | heterozygote | 100% (4 of 4) |
Lymph node | N/A | heterozygote | 0.0% (0 of 4) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 4) |
Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 2) |
Esophagus | N/A | heterozygote | 100% (2 of 2) |
Olfactory lobe | N/A | heterozygote | 100% (4 of 4) |
Oral epithelium | N/A | heterozygote | 0.0% (0 of 2) |
Ovary | N/A | heterozygote | 50% (2 of 4) |
Oviduct | N/A | heterozygote | 50% (2 of 4) |
Pancreas | N/A | heterozygote | 100% (4 of 4) |
Parathyroid gland | N/A | heterozygote | 100% (4 of 4) |
Peripheral nervous system | N/A | heterozygote | 100% (4 of 4) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
Peyer's patch | N/A | heterozygote | 0.0% (0 of 2) |
Pituitary gland | N/A | heterozygote | 75% (3 of 4) |
Prostate gland | N/A | heterozygote | 50% (2 of 4) |
Skeletal muscle tissue | N/A | heterozygote | 100% (2 of 2) |
Skeletal muscle | N/A | heterozygote | 100% (2 of 2) |
Skin | N/A | heterozygote | 100% (4 of 4) |
Small intestine | N/A | heterozygote | 50% (2 of 4) |
Spinal cord | N/A | heterozygote | 100% (4 of 4) |
Spleen | N/A | heterozygote | 0.0% (0 of 4) |
Stomach | N/A | heterozygote | 100% (4 of 4) |
Striatum | N/A | heterozygote | 100% (4 of 4) |
Testis | N/A | heterozygote | 50% (2 of 4) |
Thymus | N/A | heterozygote | 100% (4 of 4) |
Thyroid gland | N/A | heterozygote | 50% (2 of 4) |
Trachea | N/A | heterozygote | 100% (4 of 4) |
Trigeminal V nerve | N/A | heterozygote | 100% (2 of 2) |
Urinary bladder | N/A | heterozygote | 100% (2 of 2) |
Uterus | N/A | heterozygote | 50% (2 of 4) |
Vas deferens | N/A | heterozygote | 50% (1 of 2) |
Vascular system | N/A | heterozygote | 100% (2 of 2) |
White adipose tissue | N/A | heterozygote | 0.0% (0 of 4) |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.0% |
aorta | 0.0% |
blood vessel | |
bone | 0.0% |
brain | 0.0% |
brainstem | 0.0% |
brown adipose tissue | 0.0% |
cartilage tissue | 0.0% |
cecum | 0.0% |
cerebellum | 0.0% |
cerebral cortex | 0.0% |
esophagus | 0.0% |
eye | 0.0% |
gall bladder | 0.0% |
heart | 0.0% |
hippocampus | 0.0% |
hypothalamus | 0.0% |
kidney | 0.0% |
large intestine | 0.0% |
liver | 0.0% |
lower urinary tract | 0.0% |
lung | 0.0% |
lymph node | 0.0% |
mammary gland | 0.0% |
mesenteric lymph node | |
oesophagus | |
olfactory lobe | 0.0% |
oral epithelium | 0.0% |
ovary | 0.0% |
oviduct | 0.0% |
pancreas | 0.0% |
parathyroid gland | 0.0% |
peripheral nervous system | 0.0% |
peyer's patch | |
peyers patch | 0.0% |
pituitary gland | 0.0% |
prostate gland | 0.0% |
skeletal muscle | 0.0% |
skeletal muscle tissue | |
skin | 0.0% |
small intestine | 0.0% |
spinal cord | 0.0% |
spleen | 0.0% |
stomach | 0.0% |
striatum | 0.0% |
testis | 0.0% |
thymus | 0.0% |
thyroid gland | 0.0% |
trachea | 0.0% |
trigeminal v nerve | 0.0% |
urinary bladder | |
uterus | 0.0% |
vas deferens | Unavailable |
vascular system | 0.0% |
white adipose tissue | 0.0% |
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Hibadh by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Retinal Dysplasia, Primary | Retinal dysplasia, Falciform retinal fold | OMIM:312550 | |
Deafness, Cataract, Retinitis Pigmentosa, And Sperm Abnormalities | Cataract, Abnormality of skin pigmentation, Rod-cone dystrophy | OMIM:300719 | |
Homocarnosinosis | Abnormality of retinal pigmentation, Abnormality of skin pigmentation | OMIM:236130 | |
Vitreoretinal Degeneration, Snowflake Type | Corneal guttata, Cataract, Retinal dots, Optically empty vitreous, Retinal detachment, Snowflake ... | OMIM:193230 | |
Retinitis Pigmentosa 13 | Attenuation of retinal blood vessels, Asteroid hyalosis, Cystoid macular edema, Retinal degenerat... | OMIM:600059 | |
Ectopia Lentis Et Pupillae | Cataract, Ectopia lentis, Ectopia pupillae, Retinal detachment, Iris transillumination defect, Pe... | OMIM:225200 | |
Reese Retinal Dysplasia | Retinal dysplasia, Remnants of the hyaloid vascular system | OMIM:266400 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Hibadh.
There are 7 publications which use IMPC produced mice or data.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
MGI Allele | Allele Type | Produced |
---|---|---|
Hibadhtm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | ES Cells |
Hibadhtm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Mice, Targeting vectors, ES Cells |
Hibadhtm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | Mice |
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