Adar | adenosine deaminase, RNA-specific
Physiological systems
22 / 24 physiological systems tested
6 Significantly impacted by the knock-out
Homeostasis/metabolism Integument Embryo Growth/size/body region Nervous system Mortality/aging
16 No significant impact
2 Not tested
Data collections
Gene metrics:7Significant phenotypes
5Associated diseases
Expression examined in:55Adult tissues
50Embryo tissues
decreased circulating glucose level | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.73x10-5 | ||
abnormal neural tube closure | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
pale yolk sac | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
abnormal embryo size | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
abnormal placenta size | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
pallor | 1 supporting dataset | Adartm1b(EUCOMM)Wtsi | homozygote | E12.5 | N/A * | ||
preweaning lethality, complete penetrance | 1 supporting dataset | Adartm1a(EUCOMM)Wtsi | homozygote | Early adult | N/A * |
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External links
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Adartm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector ES Cell mouse |
Adartm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |