Adar | adenosine deaminase, RNA-specific

GeneMGI:1889575Synonyms: Adar1p110, mZaADAR, +2 more

Physiological systems

22 / 24 physiological systems tested

6 Significantly impacted by the knock-out

 Homeostasis/metabolism Integument Embryo Growth/size/body region Nervous system Mortality/aging

16 No significant impact

2 Not tested

Gene metrics:7Significant phenotypes
5Associated diseases
Expression examined in:55Adult tissues
50Embryo tissues

Phenotypes

decreased circulating glucose level1 supporting datasetAdartm1b(EUCOMM)WtsiheterozygoteEarly adult1.73x10-5 
abnormal neural tube closure1 supporting datasetAdartm1b(EUCOMM)WtsihomozygoteE12.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetAdartm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
pale yolk sac1 supporting datasetAdartm1b(EUCOMM)WtsihomozygoteE12.5N/A * 
abnormal embryo size1 supporting datasetAdartm1b(EUCOMM)WtsihomozygoteE12.5N/A * 
abnormal placenta size1 supporting datasetAdartm1b(EUCOMM)WtsihomozygoteE12.5N/A * 
pallor1 supporting datasetAdartm1b(EUCOMM)WtsihomozygoteE12.5N/A * 
preweaning lethality, complete penetrance1 supporting datasetAdartm1a(EUCOMM)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Adartm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Adartm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse

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