Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
isoprenylcysteine carboxyl methyltransferase
Synonyms:
HSTE14,  protein-S isoprenylcysteine O-methyltransferase,  prenylated protein carboxyl methyltransferase,  prenylcysteine carboxyl methyltransferase,  STE14,  pcCMT,  1700008E11Rik,  Gm13095

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Icmt mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Icmt by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
Persistence of hemoglobin F, Hepatomegaly, Anemia, Splenomegaly, Pallor ORPHA:46532
Retinohepatoendocrinologic Syndrome
Degenerative liver disease, Pallor OMIM:268040
Anemia, Hypochromic Microcytic, With Iron Overload 2
Hypochromia, Hepatomegaly, Anemia, Splenomegaly, Decreased mean corpuscular volume, Pallor, Poiki... OMIM:615234
Anemia, Congenital Dyserythropoietic, Type Ib
Reticulocytosis, Erythroid hyperplasia, Hepatomegaly, Jaundice, Anisocytosis, Anemia of inadequat... OMIM:615631
Autoimmune Hemolytic Anemia, Cold Type
Abnormal leukocyte morphology, Hemolytic anemia, Pallor, Splenomegaly ORPHA:228312
X-Linked Sideroblastic Anemia
Pallor, Elevated hepatic transaminase, Anemia, Splenomegaly ORPHA:75563
Retinitis Pigmentosa 42
Pallor OMIM:612943
Beta-Thalassemia
Microcytic anemia, Cholelithiasis, Hepatomegaly, Thrombocytopenia, Hepatitis, Anemia, Splenomegal... ORPHA:848
Acquired Idiopathic Sideroblastic Anemia
Hypochromic anemia, Thrombocytosis, Leukocytosis, Erythroid hyperplasia, Neutropenia, Hyposegment... ORPHA:75564
Megaloblastic Anemia Due To Dihydrofolate Reductase Deficiency
Megaloblastic anemia, Hepatomegaly, Jaundice, Thrombocytopenia, Pancytopenia, Pallor OMIM:613839
Retinitis Pigmentosa 81
Pallor OMIM:617871
Retinitis Pigmentosa 60
Pallor OMIM:613983
Acute Myelomonocytic Leukemia
Leukocytosis, Thrombocytopenia, Anemia, Pallor, Eosinophilia ORPHA:517
Primary Myelofibrosis
Ecchymosis, Thrombocytosis, Purpura, Leukocytosis, Extramedullary hematopoiesis, Hepatomegaly, Pa... ORPHA:824
Beta-Thalassemia Intermedia
Cirrhosis, Persistence of hemoglobin F, Leukocytosis, Hepatocellular carcinoma, Extramedullary he... ORPHA:231222
Leishmaniasis
Elevated hepatic transaminase, Abnormal macrophage morphology, Hepatomegaly, Pancytopenia, Thromb... ORPHA:507
Optic Atrophy 9
Pallor OMIM:616289
Elliptocytosis 1
Hemolytic anemia, Elliptocytosis, Jaundice, Splenomegaly, Pallor OMIM:611804
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema
Increased mean corpuscular hemoglobin concentration, Reticulocytosis, Increased red cell hemolysi... OMIM:194380
Hb Bart'S Hydrops Fetalis
Hepatomegaly, Anemia, Splenomegaly, Abnormal hemoglobin, Pallor ORPHA:163596
Breath-Holding Spells
Iron deficiency anemia, Pallor OMIM:607578
Methylmalonic Acidemia With Homocystinuria, Type Cbld
Pallor ORPHA:79283
Evans Syndrome
Autoimmune thrombocytopenia, Autoimmune hemolytic anemia, Neutropenia in presence of anti-neutrop... ORPHA:1959
Peripheral Cone Dystrophy
Pallor OMIM:609021
Acute Peripheral Arterial Occlusion
Leukocytosis, Pallor ORPHA:90064
Cold Agglutinin Disease
Hepatomegaly, Hemolytic anemia, Pallor, Splenomegaly ORPHA:56425
Cone-Rod Dystrophy 11
Pallor OMIM:610381
Hereditary Spherocytosis
Increased mean corpuscular hemoglobin concentration, Reticulocytosis, Extramedullary hematopoiesi... ORPHA:822
Senior-Loken Syndrome 8
Hepatic cysts, Pancreatic cysts, Pallor OMIM:616307
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency
Fava bean-induced hemolytic anemia, Reticulocytosis, Leukocytosis, Prolonged neonatal jaundice, A... OMIM:300908
Renal Tubular Acidosis, Distal, 4, With Hemolytic Anemia
Hemolytic anemia, Reticulocytosis, Decreased mean corpuscular volume, Hepatosplenomegaly, Pallor OMIM:611590
Auditory Neuropathy And Optic Atrophy
Pallor OMIM:617717
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Hepatomegaly, Focal pancreatic islet hyperplasia, Pallor, Diffuse pancreatic islet hyperplasia ORPHA:276575
Optic Atrophy 1
Pallor OMIM:165500
Hyperinsulinism Due To Ucp2 Deficiency
Hepatomegaly, Pallor, Diffuse pancreatic islet hyperplasia ORPHA:276556
Dermatitis, Atopic
Pallor, Facial erythema, Dry skin OMIM:603165
Non-Insulinoma Pancreatogenous Hypoglycemia Syndrome
Pallor, Pancreatic islet-cell hyperplasia ORPHA:276608
Retinitis Pigmentosa 70
Pallor OMIM:615922
Irida Syndrome
Intrahepatic cholestasis, Pallor ORPHA:209981
Benign Paroxysmal Torticollis Of Infancy
Pallor ORPHA:71518
Deafness-Lymphedema-Leukemia Syndrome
Leukocytosis, Hepatomegaly, Thrombocytopenia, Abnormal neutrophil count, Splenomegaly, Myeloproli... ORPHA:3226
Dominant Beta-Thalassemia
Hypochromic microcytic anemia, Cirrhosis, Persistence of hemoglobin F, Decreased mean corpuscular... ORPHA:231226
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Hepatomegaly, Pallor, Diffuse pancreatic islet hyperplasia ORPHA:276580
Myopathy, Lactic Acidosis, And Sideroblastic Anemia 1
Hypochromic anemia, Pappenheimer bodies, Microcytic anemia, Erythroid hyperplasia, Sideroblastic ... OMIM:600462
Severe Congenital Hypochromic Anemia With Ringed Sideroblasts
Elevated hepatic transaminase, Reticulocytopenia, Anisopoikilocytosis, Dysplastic erythropoesis, ... ORPHA:300298
Osteoporosis-Oculocutaneous Hypopigmentation Syndrome
Pallor ORPHA:2786
Congenital Dyserythropoietic Anemia Type Iii
Elevated hepatic transaminase, Abnormal erythrocyte morphology, Anisocytosis, Anemia, Increased m... ORPHA:98870
Myelofibrosis
Purpura, Myeloproliferative disorder, Pallor, Splenomegaly OMIM:254450
Beta-Thalassemia Major
Hypochromic microcytic anemia, Cirrhosis, Persistence of hemoglobin F, Decreased mean corpuscular... ORPHA:231214
Letterer-Siwe Disease
Neutropenia, Thrombocytopenia, Jaundice, Anemia, Hepatosplenomegaly, Pallor OMIM:246400
Retinitis Pigmentosa 27
Pallor OMIM:613750
Hyperinsulinism Due To Hnf1A Deficiency
Hepatomegaly, Pallor ORPHA:324575
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Elevated hepatic transaminase, Autoimmune hemolytic anemia, Decreased proportion of CD3-positive ... ORPHA:331206
Autoimmune Hemolytic Anemia
Abnormal leukocyte morphology, Hemolytic anemia, Pallor, Splenomegaly ORPHA:98375
Retinitis Pigmentosa 73
Pallor OMIM:616544
Autoimmune Hemolytic Anemia, Warm Type
Autoimmune hemolytic anemia, Chronic lymphatic leukemia, Jaundice, Splenomegaly, Pallor ORPHA:90033
Drug-Induced Autoimmune Hemolytic Anemia
Autoimmune hemolytic anemia, Pallor, Splenomegaly ORPHA:90037
Leber Congenital Amaurosis 14
Pallor OMIM:613341
Primary Lateral Sclerosis, Juvenile
Pallor OMIM:606353
Thiamine-Responsive Megaloblastic Anemia Syndrome
Megaloblastic anemia, Thrombocytopenia, Pallor ORPHA:49827
3-Hydroxy-3-Methylglutaryl-Coa Lyase Deficiency
Hepatomegaly, Pallor, Anemia OMIM:246450
Hyperinsulinism Due To Hnf4A Deficiency
Elevated hepatic transaminase, Hepatomegaly, Pallor, Increased hepatic glycogen content, Pancreat... ORPHA:263455
Optic Atrophy 7 With Or Without Auditory Neuropathy
Pallor OMIM:612989
American Trypanosomiasis
Hepatomegaly, Pallor, Splenomegaly ORPHA:3386
Systemic Mastocytosis With Associated Hematologic Neoplasm
Myeloid leukemia, Leukocytosis, Chronic lymphatic leukemia, Normocytic anemia, Hepatomegaly, Abno... ORPHA:98849
Familial Focal Epilepsy With Variable Foci
Pallor ORPHA:98820
Fumarase Deficiency
Polycythemia, Pallor, Hepatic failure, Cholestasis OMIM:606812
Muscular Dystrophy, Limb-Girdle, Autosomal Dominant 2
Pallor OMIM:608423
Spontaneous Periodic Hypothermia
Pallor ORPHA:29822
Sepsis In Premature Infants
Purpura, Leukocytosis, Neutropenia, Hepatomegaly, Jaundice, Thrombocytopenia, Decreased liver fun... ORPHA:90051
Cyclic Vomiting Syndrome
Pallor OMIM:500007
3-Hydroxy-3-Methylglutaric Aciduria
Thrombocytosis, Elevated hepatic transaminase, Leukocytosis, Acute pancreatitis, Hepatomegaly, Ja... ORPHA:20
Fructose-1,6-Bisphosphatase Deficiency
Hepatomegaly, Hepatic steatosis, Pallor, Elevated hepatic transaminase ORPHA:348
Retinitis Pigmentosa And Erythrocytic Microcytosis
Elliptocytosis, Anisocytosis, Anemia, Decreased mean corpuscular volume, Pallor, Poikilocytosis OMIM:616959
Myopathic Ehlers-Danlos Syndrome
Pallor ORPHA:536516
Waldenström Macroglobulinemia
Purpura, Abnormality of neutrophils, Normocytic anemia, Hepatomegaly, Splenomegaly, Leukemia, Pallor ORPHA:33226
Beta-Ketothiolase Deficiency
Hepatomegaly, Thrombocytosis, Pallor, Leukocytosis ORPHA:134
Aregenerative Anemia
Erythroid hypoplasia, Decreased proportion of CD4-positive helper T cells, Neutropenia, Reticuloc... ORPHA:101096
Mixed-Type Autoimmune Hemolytic Anemia
Autoimmune hemolytic anemia, Pallor ORPHA:90036
Retinitis Pigmentosa 51
Pallor OMIM:613464
Hereditary Folate Malabsorption
Megaloblastic anemia, Pancytopenia, Thrombocytopenia, Pallor, Eosinophilia ORPHA:90045
Fanconi Anemia, Complementation Group I
Intrauterine growth retardation, Pallor, Neutropenia OMIM:609053
Myoclonus, Intractable, Neonatal
Pallor OMIM:617235
Non-Functioning Paraganglioma
Pallor ORPHA:94080
Plummer-Vinson Syndrome
Iron deficiency anemia, Hypochromic microcytic anemia, Pallor ORPHA:54028
Dravet Syndrome
Pallor ORPHA:33069
Kcnq2-Related Epileptic Encephalopathy
Pallor, Facial erythema ORPHA:439218
Idiopathic Hypereosinophilic Syndrome
Thrombocytosis, Elevated hepatic transaminase, Leukocytosis, Thrombocytopenia, Chronic hepatitis,... ORPHA:3260
Retinitis Pigmentosa 75
Pallor OMIM:617023
Paroxysmal Nocturnal Hemoglobinuria
Hemolytic anemia, Pancytopenia, Acute myeloid leukemia, Hypoplastic anemia, Aplastic anemia, Pallor ORPHA:447
Refractory Anemia With Excess Blasts
Anemic pallor, Leukocytosis, Thrombocytopenia, Acute myeloid leukemia, Anemia of inadequate produ... ORPHA:86839
Rheumatic Fever
Pallor, Erythema ORPHA:3099
6-Pyruvoyl-Tetrahydropterin Synthase Deficiency
Pallor ORPHA:13
Fanconi Anemia, Complementation Group D2
Anemic pallor, Patent ductus arteriosus, Neutropenia, Reticulocytopenia, Pancytopenia, Thrombocyt... OMIM:227646
Cone-Rod Dystrophy 8
Pallor OMIM:605549
Tay-Sachs Disease
Pallor OMIM:272800
Non-Functioning Pituitary Adenoma
Pallor, Anemia of inadequate production ORPHA:91349
Blackfan-Diamond Anemia
Elevated red cell adenosine deaminase level, Erythroid hypoplasia, Pure red cell aplasia, Thrombo... ORPHA:124
Myopathy, Mitochondrial, And Ataxia
Pallor OMIM:617675
Sporadic Pheochromocytoma/Secreting Paraganglioma
Pallor ORPHA:276621
Fanconi Anemia, Complementation Group C
Anemic pallor, Neutropenia, Reticulocytopenia, Thrombocytopenia, Pancytopenia, Anemia, Intrauteri... OMIM:227645
Adenohypophysitis
Normochromic anemia, Pallor ORPHA:95512
Pituitary Apoplexy
Normochromic anemia, Pallor ORPHA:95613
Fanconi Anemia, Complementation Group E
Anemic pallor, Neutropenia, Reticulocytopenia, Pancytopenia, Thrombocytopenia, Anemia, Leukemia OMIM:600901
Sheehan Syndrome
Normochromic anemia, Pallor, Dry skin ORPHA:91355
Fanconi Anemia, Complementation Group A
Anemic pallor, Neutropenia, Reticulocytopenia, Pancytopenia, Thrombocytopenia, Anemia, Leukemia OMIM:227650
Panhypophysitis
Normochromic anemia, Pallor ORPHA:95513
Childhood Absence Epilepsy
Pallor ORPHA:64280
Rare Circulatory System Disease
Pallor ORPHA:98028
Von Hippel-Lindau Disease
Pancreatic cysts, Polycythemia, Neoplasm of the pancreas, Pallor, Pancreatic islet cell adenoma ORPHA:892
Incontinentia Pigmenti
Leukocytosis, Pallor, Eosinophilia, Erythema OMIM:308300
Diamond-Blackfan Anemia 1
Elevated red cell adenosine deaminase level, Thrombocytosis, Congenital hypoplastic anemia, Neutr... OMIM:105650
Multiple Endocrine Neoplasia Type 2
Pallor, Neoplasm of the liver ORPHA:653
Autosomal Recessive Malignant Osteopetrosis
Hepatomegaly, Pallor, Anemia, Splenomegaly ORPHA:667
Histiocytoid Cardiomyopathy
Hepatomegaly, Pallor ORPHA:137675
Generalized Juvenile Polyposis/Juvenile Polyposis Coli
Anemic pallor, Anemia ORPHA:329971
Infection-Related Hemolytic Uremic Syndrome
Hemolytic anemia, Leukocytosis, Thrombocytopenia, Pancreatitis, Pallor ORPHA:544482
Prolactinoma
Pallor ORPHA:2965
Hereditary Pheochromocytoma-Paraganglioma
Pallor ORPHA:29072
Alternating Hemiplegia Of Childhood
Pallor ORPHA:2131
Tsh-Secreting Pituitary Adenoma
Pallor ORPHA:91347
Esophageal Atresia
Pallor ORPHA:1199
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 3
Pallor OMIM:253280
Congenital Total Pulmonary Venous Return Anomaly
Hepatomegaly, Pallor, Patent ductus arteriosus ORPHA:99125
Goodpasture Syndrome
Pallor, Anemia OMIM:233450

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Icmt

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Icmt.

No publications found that use IMPC mice or data for Icmt.

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MGI Allele Allele Type Produced
Icmttm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Icmttm210401(L1L2_Bact_P) Targeting vectors

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