Brd4 | bromodomain containing 4

GeneMGI:1888520Synonyms: MCAP, WI-11513, +1 more

Physiological systems

19 / 24 physiological systems tested

8 Significantly impacted by the knock-out

 Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging Craniofacial Cardiovascular system

11 No significant impact

5 Not tested

Gene metrics:11Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
62Embryo tissues

Phenotypes

preweaning lethality, complete penetrance3 supporting datasetsBrd4tm1b(EUCOMM)WtsihomozygoteEarly adultN/A * 
abnormal eye posterior chamber depth2 supporting datasetsBrd4tm1b(EUCOMM)WtsiheterozygoteEarly adult3.52x10-6 
abnormal cranium morphology1 supporting datasetBrd4tm1b(EUCOMM)WtsiheterozygoteEarly adult9.11x10-6 
abnormal retina blood vessel morphology1 supporting datasetBrd4tm1b(EUCOMM)WtsiheterozygoteEarly adult1.39x10-5 
decreased prepulse inhibition3 supporting datasetsBrd4tm1b(EUCOMM)WtsiheterozygoteEarly adult7.88x10-15 
decreased total retina thickness2 supporting datasetsBrd4tm1b(EUCOMM)WtsiheterozygoteEarly adult1.31x10-22 
abnormal retina outer nuclear layer morphology2 supporting datasetsBrd4tm1b(EUCOMM)WtsiheterozygoteEarly adult5.79x10-39 
short tibia1 supporting datasetBrd4tm1b(EUCOMM)WtsiheterozygoteEarly adult1.23x10-6 
embryonic lethality prior to organogenesis1 supporting datasetBrd4tm1b(EUCOMM)WtsihomozygoteE9.5N/A * 
increased grip strength1 supporting datasetBrd4tm1b(EUCOMM)WtsiheterozygoteEarly adult1.57x10-6 
* Does not have a P-value assigned because it was manually marked as significant.
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* Does not have a P-value assigned because it was manually marked as significant.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Brd4tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
es cell
mouse
Brd4tm1b(EUCOMM)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Brd4tm48673(L1L2_gt0)KO first allele (reporter-tagged insertion with conditional potential)targeting vector

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