Genes Phenotypes

Gene: Brd4

Name
bromodomain containing 4
MGI ID
MGI:1888520
Synonyms
MCAP HUNK1 WI-11513
Viability
Homozygous - Lethal
Other links
MGI   Ensembl  
Significant phenotypes (5) All measurements (698) Expression & images (113) Disease models (0) Order (3)
View data by physiological system
Significant
Not Significant
Not tested
Body weight
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal cranium morphology Brd4tm1b(EUCOMM)Wtsi HET postnatal 1.18×10-05
hypoactivity Brd4tm1b(EUCOMM)Wtsi HET postnatal 1.35×10-08
short tibia Brd4tm1b(EUCOMM)Wtsi HET postnatal 4.07×10-10
embryonic lethality prior to organogenesis Brd4tm1b(EUCOMM)Wtsi HOM embryonic day 9.5 0.00
preweaning lethality, complete penetrance Brd4tm1b(EUCOMM)Wtsi HOM n/a 0.00

Download data as:  TSV  XLS

Filtered by: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (2/584)  (2/2) N/A
Aorta 2 No  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (2/2)  Wholemount images
Brainstem 2 No  (2/2)  Wholemount images
Brown adipose tissue 2 No  (1/2)  Wholemount images
Cartilage tissue 2 No  (2/2)  Wholemount images
Cecum 2 No  (12/383)  (2/2) N/A
Cerebellum 2 No  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (2/2)  Wholemount images
Hippocampus 2 No  (2/2)  Wholemount images
Hypothalamus 2 No  (2/2)  Wholemount images
Kidney 2 No  (18/584)  (2/2)  Wholemount images
Large intestine 2 No  (10/584)  (2/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (2/2)  Wholemount images
Lung 2 No  (2/2) N/A
Lymph node 2 No N/A
Mammary gland 2 No N/A
Mesenteric lymph node 2 No N/A
Olfactory lobe 2 No  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/584)  (1/2) N/A
Oviduct 2 No  (1/2) N/A
Pancreas 2 No  (5/584)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2) N/A
Peripheral nervous system 2 No  (2/2) N/A
Peyer's patch 2 No  (1/2)  Wholemount images
Pituitary gland 2 No N/A
Prostate gland 2 No  (12/584)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2) N/A
Small intestine 2 No  (9/584) N/A
Spinal cord 2 No N/A
Spleen 2 No  (2/584) N/A
Stomach 2 No  (12/584)  (2/2)  Wholemount images
Striatum 2 No  (2/2)  Wholemount images
Testis 2 No  (2/584)  (1/2) N/A
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (15/584)  (2/2) N/A
Trachea 2 No  (2/2) N/A
Trigeminal V nerve 2 No  (2/2) N/A
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2) N/A
Vas deferens 2 No  (15/388)  (1/2)  Wholemount images
Vascular system 2 No  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
adipose tissue (1)
Brown adipose tissue expression
MA:0000057
cardiovascular system (3)
Heart expression
Aorta expression
MA:0000072
MA:0000062
digestive system (4)
Large Intestine expression
MA:0000333
exocrine system (1)
Lower Urinary Tract expression
Vas Deferens expression
Prostate gland expression
MA:0002636
MA:0000413
MA:0000404
immune system (3)
Peyers Patch expression
MA:0000137
musculoskeletal system (1)
Vascular System no expression
Cartilage tissue expression
Bone expression
MA:0002718
MA:0000104
MA:0001459
nervous system (1)
Cerebral Cortex expression
Brain expression
Striatum expression
Hippocampus expression
Hypothalamus expression
Cerebellum expression
Brainstem expression
Olfactory Lobe expression
MA:0000185
MA:0000168
MA:0000891
MA:0000191
MA:0000173
MA:0000198
MA:0000169
MA:0002413
postnatal mouse (14)
Brown adipose tissue expression
MA:0000057
reproductive system (1)
Lower Urinary Tract expression
Vas Deferens expression
Prostate gland expression
MA:0002636
MA:0000413
MA:0000404
set of connective tissues (2)
Brown adipose tissue expression
MA:0000057
trunk (11)
Heart expression
Aorta expression
MA:0000072
MA:0000062
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/47) N/A
Axial skeleton 2  (1/51) N/A
Brain 2  (6/485) N/A
Central nervous system ganglion 2  (1/51) N/A
Cranium 2  (1/46) N/A
Dorsal root ganglion 2  (1/47) N/A
Ear 2  (1/485) N/A
Embryo 2  (1/485) N/A
Outer ear 2  (1/47) N/A
Eye 2  (1/485) N/A
Femur pre-cartilage condensation 2  (1/46) N/A
Foot 2  (1/485) N/A
Forearm 2  (1/282) N/A
Forebrain 2  (1/485) N/A
Forelimb 2  (1/485) N/A
Fronto-nasal process 2  (1/48) N/A
Gut 2  (1/50) N/A
Hand 2  (1/485) N/A
Head 2  (5/485) N/A
Head mesenchyme 2  (1/47) N/A
Heart 2  (1/485) N/A
Heart ventricle 2  (1/47) N/A
Hindbrain 2  (6/485) N/A
Hindlimb 2  (1/485) N/A
Humerus pre-cartilage condensation 2  (1/46) N/A
Inner ear 2  (1/46) N/A
Intestine 2  (1/47) N/A
Liver 2  (1/485) N/A
Lower leg 2  (1/282) N/A
Lung 2  (1/485) N/A
Mandibular process 2  (1/485) N/A
Maxillary process 2  (1/485) N/A
Mesonephros of female 2  (1/46) N/A
Mesonephros of male 2  (1/46) N/A
Metanephros 2  (1/46) N/A
Midbrain 2  (1/485) N/A
Nasal septum 2  (1/47) N/A
Nose 2  (1/51) N/A
Notochord 2  (1/47) N/A
Oral cavity 2  (1/485) N/A
Outflow tract 2  (1/47) N/A
Pancreas 2  (1/46) N/A
Pericardium 2  (1/46) N/A
Pharynx 2  (1/46) N/A
Radius-ulna pre-cartilage condensation 2  (1/46) N/A
Rib pre-cartilage condensation 2  (1/46) N/A
Skeleton 2  (1/51) N/A
Skin 2  (1/485) N/A
Spinal cord 2  (1/50) N/A
Stomach 2  (1/46) N/A
Tail 2  (1/485) N/A
Tail somite 2  (1/485) N/A
Thoracic vertebral cartilage condensation 2  (1/46) N/A
Tongue 2  (1/46) N/A
Trachea 2  (1/50) N/A
Trunk mesenchyme 2  (1/47) N/A
Umbilical artery embryonic part 2  (1/47) N/A
Umbilical vein embryonic part 2  (1/47) N/A
Upper arm 2  (1/282) N/A
Upper leg 2  (1/282) N/A
Urinary system 2  (1/50) N/A
Vibrissa 2  (1/47) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
14 Images
Eye Morphology: VIP of left fundus
2 Images

 Disease Models

No associations by disease annotation and gene orthology found.
Please visit the desktop version to see this section

 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Brd4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Brd4tm48673(L1L2_gt0) Targeting vectors
Brd4tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue

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