Genes Phenotypes

Gene: Brd4

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Name
bromodomain containing 4
MGI ID
MGI:1888520
Synonyms
MCAP HUNK1 WI-11513
Viability
Homozygous - Lethal
Embryo viewer
N/A
Other links
MGI   Ensembl  
Significant phenotypes (11) Measurements chart (190) All data table (485)
Expression & images (113) Disease models (0) Order (3)
Significant
Not Significant
Not tested
View body weight measurements
Phenotype System Allele Zyg Sex Life Stage P Value
abnormal neural tube closure Brd4tm1b(EUCOMM)Wtsi HET E9.5 0.00
abnormal embryo size Brd4tm1b(EUCOMM)Wtsi HET E9.5 0.00
abnormal tibia morphology Brd4tm1b(EUCOMM)Wtsi HET Early adult 1.12×10-06
abnormal eye anterior chamber depth Brd4tm1b(EUCOMM)Wtsi HET Early adult 9.25×10-05
preweaning lethality, complete penetrance Brd4tm1b(EUCOMM)Wtsi HOM Early adult 0.00
embryonic lethality prior to organogenesis Brd4tm1b(EUCOMM)Wtsi HOM E9.5 0.00
short tibia Brd4tm1b(EUCOMM)Wtsi HET Early adult 3.02×10-05
abnormal cranium morphology Brd4tm1b(EUCOMM)Wtsi HET Early adult 2.50×10-10
abnormal embryo turning Brd4tm1b(EUCOMM)Wtsi HET E9.5 0.00
abnormal retinal blood vessel morphology Brd4tm1b(EUCOMM)Wtsi HET Early adult 1.71×10-06
abnormal QRS complex Brd4tm1b(EUCOMM)Wtsi HET Early adult 7.82×10-05

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Viewing: all phenotypes

 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 2 No  (3/589)  (2/2)  Wholemount images
Aorta 2 No  (1/589)  (2/2)  Wholemount images
Bone 2 No  (2/2)  Wholemount images
Brain 2 No  (3/589)  (2/2)  Wholemount images
Brainstem 2 No  (2/589)  (2/2)  Wholemount images
Brown adipose tissue 2 No  (1/2)  Wholemount images
Cartilage tissue 2 No  (2/2)  Wholemount images
Cecum 2 No  (12/379)  (2/2) N/A
Cerebellum 2 No  (3/589)  (2/2)  Wholemount images
Cerebral cortex 2 No  (2/589)  (2/2)  Wholemount images
Esophagus 2 No  (7/415)  (2/2)  Wholemount images
Eye 2 No N/A
Gall bladder 2 No  (2/2)  Wholemount images
Heart 2 No  (1/589)  (2/2)  Wholemount images
Hippocampus 2 No  (3/589)  (2/2)  Wholemount images
Hypothalamus 2 No  (2/589)  (2/2)  Wholemount images
Kidney 2 No  (20/589)  (2/2)  Wholemount images
Large intestine 2 No  (10/589)  (2/2)  Wholemount images
Liver 2 No  (2/2)  Wholemount images
Lower urinary tract 2 No  (1/589)  (2/2)  Wholemount images
Lung 2 No  (1/589)  (2/2)  Wholemount images
Lymph node 2 No N/A
Mammary gland 2 No N/A
Mesenteric lymph node 2 No N/A
Olfactory lobe 2 No  (2/589)  (2/2)  Wholemount images
Oral epithelium 2 No N/A
Ovary 2 No  (1/589)  (1/2)  Wholemount images
Oviduct 2 No  (1/2)  Wholemount images
Pancreas 2 No  (5/589)  (2/2)  Wholemount images
Parathyroid gland 2 No  (2/2)  Wholemount images
Peripheral nervous system 2 No  (1/589)  (2/2)  Wholemount images
Peyer's patch 2 No  (1/2)  Wholemount images
Pituitary gland 2 No  (1/589) N/A
Prostate gland 2 No  (12/589)  (1/2)  Wholemount images
Skeletal muscle 2 No N/A
Skin 2 No  (2/2)  Wholemount images
Small intestine 2 No  (9/589) N/A
Spinal cord 2 No  (2/589) N/A
Spleen 2 No  (2/589) N/A
Stomach 2 No  (13/589)  (2/2)  Wholemount images
Striatum 2 No  (3/589)  (2/2)  Wholemount images
Testis 2 No  (5/589)  (1/2)  Wholemount images
Thymus 2 No  (2/2)  Wholemount images
Thyroid gland 2 No  (16/589)  (2/2)  Wholemount images
Trachea 2 No  (2/589)  (2/2)  Wholemount images
Trigeminal V nerve 2 No  (2/2)  Wholemount images
Urinary bladder 2 No  (2/2) N/A
Uterus 2 No  (1/2)  Wholemount images
Vas deferens 2 No  (15/388)  (1/2)  Wholemount images
Vascular system 2 No  Wholemount images
White adipose tissue 2 No N/A
LacZ Wholemount Images
Unassigned Top Level MA (46)
Esophagus expression
Stomach
adipose tissue (2)
Brown adipose tissue expression
MA:0000057
digestive system (3)
Large Intestine expression
MA:0000333
endocrine system (1)
Adrenal gland expression
MA:0000116
immune system (3)
Peyers Patch expression
MA:0000137
integumental system (1)
Skin expression
MA:0000151
postnatal mouse (14)
Adrenal gland expression
MA:0000116
respiratory system (1)
Lung expression
MA:0000415
set of connective tissues (2)
Brown adipose tissue expression
MA:0000057
trunk (11)
Adrenal gland expression
MA:0000116
urinary system (2)
Kidney expression
MA:0000368
LacZ Section Images
 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/61)  (2/2) N/A
Axial skeleton 2  (1/65)  (2/2) N/A
Brain 2  (6/506)  (2/2) N/A
Central nervous system ganglion 2  (1/74)  (2/2) N/A
Cranium 2  (1/65)  (2/2) N/A
Dorsal root ganglion 2  (1/61)  (2/2) N/A
Ear 2  (1/506)  (2/2) N/A
Embryo 2  (1/507)  (2/2) N/A
Outer ear 2  (1/70)  (2/2) N/A
Eye 2  (1/506)  (2/2) N/A
Femur pre-cartilage condensation 2  (1/56)  (2/2) N/A
Foot 2  (1/506)  (2/2) N/A
Forearm 2  (1/301)  (2/2) N/A
Forebrain 2  (1/506)  (2/2) N/A
Forelimb 2  (1/506)  (2/2) N/A
Fronto-nasal process 2  (1/62)  (2/2) N/A
Gut 2  (1/60)  (2/2) N/A
Hand 2  (1/505)  (2/2) N/A
Head 2  (5/506)  (2/2) N/A
Head mesenchyme 2  (1/61)  (2/2) N/A
Heart 2  (1/506)  (2/2) N/A
Heart ventricle 2  (1/61)  (2/2) N/A
Hindbrain 2  (6/506)  (2/2) N/A
Hindlimb 2  (1/505)  (2/2) N/A
Humerus pre-cartilage condensation 2  (1/65)  (2/2) N/A
Inner ear 2  (1/65)  (2/2) N/A
Intestine 2  (1/59)  (2/2) N/A
Liver 2  (1/506)  (2/2) N/A
Lower leg 2  (1/301)  (2/2) N/A
Lung 2  (1/502)  (2/2) N/A
Mandibular process 2  (1/506)  (2/2) N/A
Maxillary process 2  (1/506)  (2/2) N/A
Mesonephros of female 2  (1/56)  (1/2) N/A
Mesonephros of male 2  (1/56)  (1/2) N/A
Metanephros 2  (1/56)  (2/2) N/A
Midbrain 2  (1/506)  (2/2) N/A
Nasal septum 2  (1/61)  (2/2) N/A
Nose 2  (1/74)  (2/2) N/A
Notochord 2  (1/61)  (2/2) N/A
Oral cavity 2  (1/506)  (2/2) N/A
Outflow tract 2  (1/61)  (2/2) N/A
Pancreas 2  (1/56)  (2/2) N/A
Pericardium 2  (1/56)  (2/2) N/A
Pharynx 2  (1/56)  (2/2) N/A
Radius-ulna pre-cartilage condensation 2  (1/65)  (2/2) N/A
Rib pre-cartilage condensation 2  (1/58)  (2/2) N/A
Skeleton 2  (1/74)  (2/2) N/A
Skin 2  (1/506)  (2/2) N/A
Spinal cord 2  (1/73)  (2/2) N/A
Stomach 2  (1/56)  (2/2) N/A
Tail 2  (1/506)  (2/2) N/A
Tail somite 2  (1/506)  (2/2) N/A
Thoracic vertebral cartilage condensation 2  (1/56)  (2/2) N/A
Tongue 2  (1/56)  (2/2) N/A
Trachea 2  (1/60)  (2/2) N/A
Trunk mesenchyme 2  (1/61)  (2/2) N/A
Umbilical artery embryonic part 2  (1/61)  (2/2) N/A
Umbilical vein embryonic part 2  (1/61)  (2/2) N/A
Upper arm 2  (1/301)  (2/2) N/A
Upper leg 2  (1/301)  (2/2) N/A
Urinary system 2  (1/60)  (2/2) N/A
Vibrissa 2  (1/70)  (2/2) N/A

 Associated Images

X-ray: XRay Images Skull Dorso Ventral Orientation
10 Images
X-ray: XRay Images Skull Lateral Orientation
10 Images
X-ray: XRay Images Whole Body Lateral Orientation
10 Images
X-ray: XRay Images Forepaw
10 Images
X-ray: XRay Images Whole Body Dorso Ventral
10 Images
Eye Morphology: VIP of right fundus
16 Images
Eye Morphology: VIP of right eye
16 Images
Eye Morphology: VIP of left fundus
16 Images
Eye Morphology: VIP of left eye
16 Images
Adult LacZ: LacZ Images Wholemount
60 Images

 Disease Models

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 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Brd4tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Brd4tm48673(L1L2_gt0) Targeting vectors
Brd4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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