Brd4 | bromodomain containing 4
Physiological systems
19 / 24 physiological systems tested
8 Significantly impacted by the knock-out
Limbs/digits/tail Nervous system Vision/eye Behavior/neurological Skeleton Mortality/aging Craniofacial Cardiovascular system
11 No significant impact
5 Not tested
Data collections
Gene metrics:11Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
62Embryo tissues
preweaning lethality, complete penetrance | 3 supporting datasets | Brd4tm1b(EUCOMM)Wtsi | homozygote | Early adult | N/A * | ||
abnormal eye posterior chamber depth | 2 supporting datasets | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 3.52x10-6 | ||
abnormal cranium morphology | 1 supporting dataset | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 9.11x10-6 | ||
abnormal retina blood vessel morphology | 1 supporting dataset | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.39x10-5 | ||
decreased prepulse inhibition | 3 supporting datasets | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 7.88x10-15 | ||
decreased total retina thickness | 2 supporting datasets | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.31x10-22 | ||
abnormal retina outer nuclear layer morphology | 2 supporting datasets | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 5.79x10-39 | ||
short tibia | 1 supporting dataset | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.23x10-6 | ||
embryonic lethality prior to organogenesis | 1 supporting dataset | Brd4tm1b(EUCOMM)Wtsi | homozygote | E9.5 | N/A * | ||
increased grip strength | 1 supporting dataset | Brd4tm1b(EUCOMM)Wtsi | heterozygote | Early adult | 1.57x10-6 |
| | | | | | | | | |
External links
No external links available for Brd4.
All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.
Brd4tm1a(EUCOMM)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector es cell mouse |
Brd4tm1b(EUCOMM)Wtsi | Reporter-tagged deletion allele (with selection cassette) | | mouse |
Brd4tm48673(L1L2_gt0) | KO first allele (reporter-tagged insertion with conditional potential) | | targeting vector |