Gene Summary

Name:
5-hydroxytryptamine (serotonin) receptor 3B
Synonyms:
5-HT3B,  5-HT3 receptor subunit B

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased grip strength Htr3btm1.1(KOMP)Vlcg HET   Early adult 2.88×10-05
abnormal bone structure Htr3btm1.1(KOMP)Vlcg HOM Early adult 5.09×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland  Section images heterozygote 100% (2 of 2)
Kidney  Section images heterozygote 100% (2 of 2)
Large intestine  Section images heterozygote 100% (2 of 2)
Ovary  Section images heterozygote 50% (1 of 2)
Oviduct  Section images heterozygote Not available
Peripheral nervous system  Section images heterozygote 100% (2 of 2)
Small intestine  Section images heterozygote 100% (2 of 2)
Spinal cord  Section images heterozygote 100% (2 of 2)
Stomach  Section images heterozygote 100% (2 of 2)
Uterus  Section images heterozygote 50% (1 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Brain N/A heterozygote 0.0% (0 of 2)
Brainstem N/A heterozygote 0.0% (0 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 0.0% (0 of 2)
Cerebral cortex N/A heterozygote 0.0% (0 of 2)
Epididymis N/A heterozygote 0.0% (0 of 2)
Esophagus N/A heterozygote 0.0% (0 of 2)
Eye N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote 50% (1 of 2)
Hippocampus N/A heterozygote 0.0% (0 of 2)
Hypothalamus N/A heterozygote 0.0% (0 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote Not available
Lung N/A heterozygote 0.0% (0 of 2)
Lymph node N/A heterozygote 0.0% (0 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 2)
Midbrain N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 0.0% (0 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A heterozygote Not available
Skeletal muscle N/A heterozygote 0.0% (0 of 2)
Skin N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote 0.0% (0 of 2)
Submandibular gland N/A heterozygote 0.0% (0 of 2)
Testis N/A heterozygote 0.0% (0 of 2)
Thalamus N/A heterozygote 0.0% (0 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Trachea N/A heterozygote 0.0% (0 of 2)
Urinary bladder N/A heterozygote 0.0% (0 of 2)
Vascular system N/A heterozygote 0.0% (0 of 2)
Vesicular gland N/A heterozygote Not available
White adipose tissue N/A heterozygote 0.0% (0 of 2)

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Embryo N/A heterozygote 100% (2 of 2)
Embryo N/A homozygote Ambiguous
Brain N/A heterozygote 50% (1 of 2)
Brain N/A homozygote Ambiguous
Central nervous system ganglion N/A heterozygote 100% (1 of 1)
N/A Ambiguous
Dorsal root ganglion N/A heterozygote 0.0% (0 of 1)
Dorsal root ganglion N/A homozygote Ambiguous
Ear N/A heterozygote 0.0% (0 of 2)
Ear N/A homozygote Ambiguous
Eye N/A heterozygote 0.0% (0 of 2)
Eye N/A homozygote Ambiguous
Footplate N/A heterozygote 0.0% (0 of 2)
Footplate N/A homozygote Ambiguous
Forebrain N/A heterozygote 0.0% (0 of 2)
Forebrain N/A homozygote Ambiguous
Forelimb N/A heterozygote 0.0% (0 of 2)
Forelimb N/A homozygote Ambiguous
Fronto-nasal process N/A heterozygote 100% (2 of 2)
Fronto-nasal process N/A homozygote Ambiguous
Handplate N/A heterozygote 0.0% (0 of 2)
Handplate N/A homozygote Ambiguous
Head N/A heterozygote 100% (2 of 2)
Head N/A homozygote Ambiguous
Heart N/A heterozygote 0.0% (0 of 2)
Heart N/A homozygote Ambiguous
Hindbrain N/A heterozygote 50% (1 of 2)
Hindbrain N/A homozygote Ambiguous
Hindlimb N/A heterozygote 0.0% (0 of 2)
Hindlimb N/A homozygote Ambiguous
Liver N/A heterozygote 0.0% (0 of 2)
Liver N/A homozygote Ambiguous
Lung N/A heterozygote 0.0% (0 of 2)
Lung N/A homozygote Ambiguous
Mandibular process N/A heterozygote 0.0% (0 of 2)
Mandibular process N/A homozygote Ambiguous
Maxillary process N/A heterozygote 0.0% (0 of 2)
Maxillary process N/A homozygote Ambiguous
Metanephros N/A heterozygote 100% (1 of 1)
N/A Ambiguous
Midbrain N/A heterozygote 0.0% (0 of 2)
Midbrain N/A homozygote Ambiguous
Nasal septum N/A heterozygote 100% (1 of 1)
N/A Ambiguous
Nose N/A heterozygote 100% (2 of 2)
Nose N/A homozygote Ambiguous
Oral cavity N/A heterozygote 0.0% (0 of 2)
Oral cavity N/A homozygote Ambiguous
Skin N/A heterozygote 0.0% (0 of 2)
Skin N/A homozygote Ambiguous
Spinal cord N/A heterozygote 50% (1 of 2)
Spinal cord N/A homozygote Ambiguous
Tail somite N/A heterozygote 0.0% (0 of 2)
Tail somite N/A homozygote Ambiguous
Tail N/A heterozygote 0.0% (0 of 2)
Tail N/A homozygote Ambiguous

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.83% (4 of 484)
aorta 0.21% (1 of 483)
brain 0.82% (4 of 485)
brainstem 0.41% (2 of 488)
brown adipose tissue 0.0%
cartilage tissue 0.2% (1 of 490)
cerebellum 0.63% (3 of 478)
cerebral cortex 0.41% (2 of 485)
epididymis 11.43% (12 of 105)
esophagus 1.8% (6 of 333)
eye 0.0%
heart 0.2% (1 of 494)
hippocampus 0.62% (3 of 486)
hypothalamus 0.41% (2 of 482)
kidney 3.31% (16 of 483)
large intestine 1.7% (8 of 470)
liver 0.0%
lower urinary tract 0.21% (1 of 480)
lung 0.21% (1 of 483)
lymph node 0.2% (1 of 488)
mammary gland 0.0%
midbrain 0.0%
olfactory lobe 0.41% (2 of 482)
ovary 0.21% (1 of 484)
oviduct 0.0%
pancreas 0.82% (4 of 490)
peripheral nervous system 0.42% (2 of 472)
peyers patch 0.0%
pituitary gland 0.21% (1 of 468)
prostate gland 2.02% (10 of 494)
skeletal muscle 0.0%
skin 0.21% (1 of 481)
small intestine 1.63% (8 of 490)
spinal cord 0.42% (2 of 471)
spleen 0.63% (3 of 477)
stomach 1.82% (9 of 494)
striatum 0.62% (3 of 486)
submandibular gland 0.97% (1 of 103)
testis 1.21% (6 of 495)
thalamus 0.0%
thymus 0.0%
thyroid gland 3.28% (16 of 488)
trachea 0.62% (3 of 481)
urinary bladder 0.0%
uterus 0.0%
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
brain 1.2% (3 of 251)
central nervous system ganglion 3.03% (1 of 33)
dorsal root ganglion 3.45% (1 of 29)
ear 0.41% (1 of 241)
embryo 0.0%
eye 0.0%
footplate 0.0%
forebrain 0.41% (1 of 241)
forelimb 0.0%
fronto-nasal process 3.45% (1 of 29)
handplate 0.0%
head 1.26% (3 of 239)
heart 0.43% (1 of 234)
hindbrain 0.84% (2 of 237)
hindlimb 0.45% (1 of 223)
liver 0.45% (1 of 221)
lung 0.4% (1 of 251)
mandibular process 0.0%
maxillary process 0.0%
metanephros 3.33% (1 of 30)
midbrain 0.0%
nasal septum 3.12% (1 of 32)
nose 0.0%
oral cavity 0.4% (1 of 247)
skin 0.4% (1 of 252)
spinal cord 0.0%
tail 0.0%
tail somite group 0.41% (1 of 241)

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

27 Images

X-ray

XRay Images Forepaw

26 Images

Sleep Wake

Wake state (bmp file)

26 Images

Eye Morphology

Images Slit Lamp

8 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

27 Images

X-ray

XRay Images Skull Lateral Orientation

27 Images

X-ray

XRay Images Whole Body Dorso Ventral

27 Images

Eye Morphology

Images Ophthalmoscopy

5 Images

Embryo LacZ

LacZ images wholemount

12 Images

Adult LacZ

LacZ Images Section

10 Images

Combined SHIRPA and Dysmorphology

Images

3 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

15 Images

Electroretinography

Cone waveform (pdf format)

9 Images

Electroretinography

Rod waveform (pdf format)

9 Images

Human diseases caused by Htr3b mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Htr3b by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Cystic Angiomatosis Of Bone, Diffuse
Cystic angiomatosis of bone OMIM:123880
Superior Transverse Scapular Ligament, Calcification Of, Familial
Ectopic ossification in ligament tissue OMIM:601708
Distal Osteosclerosis
Diaphyseal sclerosis, Hyperostosis, Craniofacial osteosclerosis OMIM:126250
Melorheostosis, Isolated
Hyperostosis, Increased bone mineral density OMIM:155950

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Htr3b

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Htr3b.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program. PloS one (July 2017) Htr3btm1.1(KOMP)Vlcg PMC5503261
High-throughput discovery of novel developmental phenotypes. Nature (September 2016) Htr3btm1.1(KOMP)Vlcg PMC5295821
The perfect host: a mouse host embryo facilitating more efficient germ line transmission of genetically modified embryonic stem cells. PloS one (July 2013) Htr3btm1(KOMP)Vlcg PMC3699516

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MGI Allele Allele Type Produced
Htr3btm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Htr3btm240909(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors
Htr3btm1(KOMP)Vlcg Reporter-tagged deletion allele (with selection cassette) Mice, ES Cells
Htr3btm1.1(KOMP)Vlcg Reporter-tagged deletion allele (post Cre, with no selection cassette) Mice
Htr3btm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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