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Gene: Arhgef7 MGI:1860493

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Gene Summary

Name:
Rho guanine nucleotide exchange factor
Synonyms:
betaPix-b,  betaPix,  Pak interacting exchange factor,  betaPix-c,  PIX,  Cool,  cool-1,  p85SPR

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
preweaning lethality, complete penetrance Arhgef7tm1a(EUCOMM)Wtsi HOM   Early adult 0.00

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Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

15 Images

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X-ray

XRay Images Forepaw

13 Images

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X-ray

XRay Images Whole Body Dorso Ventral

15 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

15 Images

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X-ray

XRay Images Whole Body Lateral Orientation

15 Images

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Legacy Phenotype Associated Images
Arhgef7tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Arhgef7tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Arhgef7tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Arhgef7tm1a(EUCOMM)Wtsi
WT, Female, WTSI
Arhgef7tm1a(EUCOMM)Wtsi
WT, Female, WTSI

View all 112 images

Arhgef7tm1a(EUCOMM)Wtsi
right eye, HET, Male, WTSI
Arhgef7tm1a(EUCOMM)Wtsi
back skin, HET, Female, WTSI

Human diseases caused by Arhgef7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Arhgef7 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 10
Type II lissencephaly, Neural tube defect OMIM:615041

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Arhgef7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Arhgef7.

There are 10 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
Muscarinic receptor agonist-induced βPix binding to β-catenin promotes colon neoplasia. Scientific reports (October 2023) Arhgef7tm1c(EUCOMM)Wtsi PMC10560271
Genetics of mirror movements identifies a multifunctional complex required for Netrin-1 guidance and lateralization of motor control. Science advances (May 2023) Arhgef7tm1c(EUCOMM)Wtsi Arhgef7tm1b(EUCOMM)Wtsi PMC10181192
Targeted intestinal deletion of Rho guanine nucleotide exchange factor 7, βPIX, impairs enterocyte proliferation, villus maturation, and mucosal defenses in mice. American journal of physiology. Gastrointestinal and liver physiology (February 2021) Arhgef7tm1a(EUCOMM)Wtsi PMC8238171
β-Pix-dependent cellular protrusions propel collective mesoderm migration in the mouse embryo. Nature communications (November 2020) Arhgef7tm1a(EUCOMM)Wtsi PMC7695707
A Genome-Wide Screen in Mice To Identify Cell-Extrinsic Regulators of Pulmonary Metastatic Colonisation. G3 (Bethesda, Md.) (June 2020) Arhgef7tm1a(EUCOMM)Wtsi PMC7263671
ARHGEF7 (β-PIX) Is Required for the Maintenance of Podocyte Architecture and Glomerular Function. Journal of the American Society of Nephrology : JASN (March 2020) Arhgef7tm1c(EUCOMM)Wtsi PMC7217415
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis. Nature communications (August 2019) Arhgef7tm1a(EUCOMM)Wtsi PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss. PLoS biology (April 2019) Arhgef7tm1a(EUCOMM)Wtsi PMC6459510
Genome wide in vivo mouse screen data from studies to assess host regulation of metastatic colonisation. Scientific data (September 2017) Arhgef7tm1a(EUCOMM)Wtsi PMC5827107
β-Pix directs collective migration of anterior visceral endoderm cells in the early mouse embryo. Genes & development (December 2014) Arhgef7tm1a(EUCOMM)Wtsi PMC4265679

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All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Arhgef7tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells
Arhgef7tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Arhgef7tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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