Psmg1 | proteasome (prosome, macropain) assembly chaperone 1

GeneMGI:1860263Synonyms: Dscr2

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Embryo Growth/size/body region Nervous system Vision/eye Behavior/neurological Mortality/aging Craniofacial

13 No significant impact

4 Not tested

Gene metrics:11Significant phenotypes
0Associated diseases
Expression examined in:50Adult tissues
0Embryo tissues

Phenotypes

preweaning lethality, complete penetrance3 supporting datasetsPsmg1tm1b(KOMP)WtsihomozygoteEarly adultN/A * 
abnormal visceral yolk sac morphology1 supporting datasetPsmg1tm1b(KOMP)WtsiheterozygoteE9.5N/A * 
abnormal neural tube closure1 supporting datasetPsmg1tm1b(KOMP)WtsiheterozygoteE9.5N/A * 
abnormal pharyngeal arch morphology1 supporting datasetPsmg1tm1b(KOMP)WtsiheterozygoteE9.5N/A * 
cornea opacity1 supporting datasetPsmg1tm1b(KOMP)WtsiheterozygoteEarly adult9.85x10-6 
abnormal embryo turning1 supporting datasetPsmg1tm1b(KOMP)WtsiheterozygoteE9.5N/A * 
hyperactivity1 supporting datasetPsmg1tm1b(KOMP)WtsiheterozygoteEarly adult9.73x10-5 
abnormal embryo size1 supporting datasetPsmg1tm1b(KOMP)WtsiheterozygoteE9.5N/A * 
abnormal neural tube morphology1 supporting datasetPsmg1tm1b(KOMP)WtsiheterozygoteE9.5N/A * 
embryonic growth retardation1 supporting datasetPsmg1tm1b(KOMP)WtsiheterozygoteE9.5N/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

adrenal glandheterozygoten/a0% (0/2)0.7% (4/570)
aortaheterozygoten/a0% (0/2)0.19% (1/533)
boneheterozygoten/a0% (0/2)0% (0/394)
brainheterozygoteWholemount images
100% (2/2)0.86% (5/579)
brainstemheterozygoteWholemount images
100% (2/2)0.41% (2/490)
brown adipose tissueheterozygoten/a0% (0/2)0% (0/588)
cartilage tissueheterozygoteWholemount images
100% (2/2)0.22% (1/454)
cerebellumheterozygoteWholemount images
100% (2/2)0.56% (3/532)
cerebral cortexheterozygoteWholemount images
100% (2/2)0.41% (2/491)
esophagusheterozygoten/a0% (0/2)1.67% (7/419)
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Histopathology

IMPC related publications

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Psmg1tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Psmg1tm1a(KOMP)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
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Psmg1tm1b(KOMP)WtsiReporter-tagged deletion allele (with selection cassette)mouse
Psmg1tm1e(KOMP)WtsiTargeted, non-conditional alleleES Cell

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