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Genes Phenotypes Help, News, Blog

Gene: Wdr7 MGI:1860197

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
WD repeat domain 7
Synonyms:
TGF-beta resistance associated gene,  TRAG

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Wdr7 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.
No human diseases associated to this gene by phenotypic similarity.

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Wdr7

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Wdr7.

There are 3 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
WDR72 regulates vesicle trafficking in ameloblasts. Scientific reports (February 2022) Wdr72tm1a(KOMP)Wtsi PMC8857301
WDR76 is a RAS binding protein that functions as a tumor suppressor via RAS degradation. Nature communications (January 2019) Wdr76tm1a(EUCOMM)Hmgu PMC6336889
WDR72 models of structure and function: a stage-specific regulator of enamel mineralization. Matrix biology : journal of the International Society for Matrix Biology (July 2014) Wdr72tm1a(KOMP)Wtsi PMC4185229

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Wdr7tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Wdr7tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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