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Gene: Ctnnal1 MGI:1859649

Gene Summary

Name:

catenin (cadherin associated protein), alpha-like 1

Synonyms:

Catnal1, ACRP

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype	System	Allele	Zyg	Sex	Life Stage	P Value
increased circulating bilirubin level		Ctnnal1^{tm1e(EUCOMM)Wtsi}	HOM		Early adult	4.95×10^-05

Download data as: TSV XLS

Select physiological systems to view:

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Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Legacy Phenotype Associated Images

Ctnnal1^{tm1e(EUCOMM)Wtsi}
head, WT, Female, WTSI

Ctnnal1^{tm1e(EUCOMM)Wtsi}
forearm, WT, Female, WTSI

Ctnnal1^{tm1e(EUCOMM)Wtsi}
body, HOM, Female, WTSI

Ctnnal1^{tm1e(EUCOMM)Wtsi}
body, WT, Female, WTSI

View all 144 images

Ctnnal1^{tm1e(EUCOMM)Wtsi}
tail skin, HOM, Female, WTSI

Ctnnal1^{tm1e(EUCOMM)Wtsi}
tail skin, WT, Female, WTSI

Ctnnal1^{tm1e(EUCOMM)Wtsi}
tail skin, HOM, Female, WTSI

Human diseases caused by Ctnnal1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Ctnnal1 (0 diseases)
Human diseases predicted to be associated with Ctnnal1 (154 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Ctnnal1 by phenotypic similarity.

Disease	Matching phenotypes	Source
Crigler-Najjar Syndrome Type 2	Neonatal hyperbilirubinemia, Unconjugated hyperbilirubinemia	ORPHA:79235
Hyperbilirubinemia, Transient Familial Neonatal	Neonatal unconjugated hyperbilirubinemia	OMIM:237900
Jaundice, Familial Obstructive, Of Infancy	Neonatal hyperbilirubinemia	OMIM:308600
Crigler-Najjar Syndrome, Type Ii	Unconjugated hyperbilirubinemia	OMIM:606785
Hyperbilirubinemia, Conjugated, Type Iii	Conjugated hyperbilirubinemia	OMIM:237550
Cysteine Peptiduria	Abnormal circulating cysteine concentration, Abnormal circulating glycine concentration	OMIM:219550
Maple Syrup Urine Disease, Mild Variant	Hyperleucinemia, Hyperisoleucinemia	OMIM:615135
Sarcosinemia	Hypersarcosinemia	OMIM:268900
Schizophrenia 4	Hyperprolinemia	OMIM:600850
Glutathione Peroxidase Deficiency	Neonatal hyperbilirubinemia	OMIM:614164
Hemolytic Anemia Due To Glutathione Reductase Deficiency	Hyperbilirubinemia	OMIM:618660
Hyperbilirubinemia, Rotor Type	Conjugated hyperbilirubinemia	OMIM:237450
Dubin-Johnson Syndrome	Conjugated hyperbilirubinemia	OMIM:237500
Crigler-Najjar Syndrome, Type I	Unconjugated hyperbilirubinemia	OMIM:218800
Hypercholanemia, Familial, 2	Unconjugated hyperbilirubinemia, Increased serum bile acid concentration	OMIM:619256
Cholestasis, Progressive Familial Intrahepatic, 11	Increased serum bile acid concentration, Abnormal circulating bilirubin concentration	OMIM:619874
Red Cell Phospholipid Defect With Hemolysis	Hyperbilirubinemia	OMIM:179700
Rotor Syndrome	Conjugated hyperbilirubinemia, Hyperbilirubinemia	ORPHA:3111
Gilbert Syndrome	Unconjugated hyperbilirubinemia	OMIM:143500
Citrullinemia, Type Ii, Neonatal-Onset	Hyperbilirubinemia, Decreased HDL cholesterol concentration, Hypermethioninemia, Hypertriglycerid...	OMIM:605814
Cholestasis, Progressive Familial Intrahepatic, 12	Conjugated hyperbilirubinemia, Hyperbilirubinemia, Increased serum bile acid concentration	OMIM:620010
Crigler-Najjar Syndrome Type 1	Neonatal hyperbilirubinemia, Unconjugated hyperbilirubinemia	ORPHA:79234
Edinburgh Malformation Syndrome	Neonatal hyperbilirubinemia	OMIM:129850
Cholestasis, Progressive Familial Intrahepatic, 10	Increased total bilirubin, Conjugated hyperbilirubinemia, Hypoalbuminemia, Hypercholesterolemia, ...	OMIM:619868
Hyperbilirubinemia, Shunt, Primary	Hyperbilirubinemia	OMIM:237800
Malaria	Elevated circulating C-reactive protein concentration, Hyperbilirubinemia	ORPHA:673
Polycystic Liver Disease 1 With Or Without Kidney Cysts	Increased total bilirubin	OMIM:174050
Cholestasis, Benign Recurrent Intrahepatic, 1	Conjugated hyperbilirubinemia, Increased serum bile acid concentration	OMIM:243300
Biliary Atresia, Extrahepatic	Increased total bilirubin, Hyperbilirubinemia, Unconjugated hyperbilirubinemia	OMIM:210500
Megaloblastic Anemia, Folate-Responsive	Increased circulating ferritin concentration, Hyperbilirubinemia, Hyperhomocystinemia	OMIM:601775
Rh-Null, Regulator Type	Unconjugated hyperbilirubinemia	OMIM:268150
Elliptocytosis 2	Neonatal hyperbilirubinemia	OMIM:130600
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair	Hyperbilirubinemia	OMIM:609734
Adenosine Deaminase, Elevated, Hemolytic Anemia Due To	Hyperbilirubinemia	OMIM:301083
Bile Acid Synthesis Defect, Congenital, 5	Increased total iron binding capacity, Hyperbilirubinemia, Increased serum bile acid concentration	OMIM:616278
Isolated Polycystic Liver Disease	Increased total bilirubin	ORPHA:2924
Bile Acid Conjugation Defect 1	Conjugated hyperbilirubinemia	OMIM:619232
Hepatic Veno-Occlusive Disease	Increased total bilirubin	ORPHA:890
Spherocytosis, Type 4	Hyperbilirubinemia	OMIM:612653
Cholestasis-Lymphedema Syndrome	Hyperlipidemia, Conjugated hyperbilirubinemia	OMIM:214900
Hypermethioninemia Due To Adenosine Kinase Deficiency	Hypermethioninemia, Hyperbilirubinemia	OMIM:614300
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency	Increased circulating ferritin concentration, Elevated transferrin saturation, Unconjugated hyper...	ORPHA:766
Mitochondrial Dna Depletion Syndrome 16 (Hepatic Type)	Increased total bilirubin	OMIM:618528
Lipoyltransferase 1 Deficiency	Increased total bilirubin	OMIM:616299
Neonatal Intrahepatic Cholestasis Due To Citrin Deficiency	Hyperlysinemia, Hyperbilirubinemia, Increased LDL cholesterol concentration, Abnormal circulating...	ORPHA:247598
Cholestasis, Benign Recurrent Intrahepatic, 2	Conjugated hyperbilirubinemia	OMIM:605479
Spherocytosis, Type 1	Hyperbilirubinemia	OMIM:182900
Spherocytosis, Type 2	Hyperbilirubinemia	OMIM:616649
Autosomal Dominant Spastic Paraplegia Type 29	Hyperbilirubinemia	ORPHA:101009
Bile Acid Synthesis Defect, Congenital, 4	Hyperbilirubinemia	OMIM:214950
Overhydrated Hereditary Stomatocytosis	Hyperbilirubinemia	OMIM:185000
Harderoporphyria	Increased circulating ferritin concentration, Neonatal hyperbilirubinemia	OMIM:618892
Glycogen Storage Disease Vii	Increased total bilirubin, Hyperuricemia	OMIM:232800
Congenital Hypothyroidism Due To Transplacental Passage Of Tsh-Binding Inhibitory Antibodies	Conjugated hyperbilirubinemia, Abnormal circulating thyroglobulin level	ORPHA:95715
Idiopathic Congenital Hypothyroidism	Neonatal hyperbilirubinemia	ORPHA:95717
Hemolytic Anemia, Nonspherocytic, Due To Hexokinase Deficiency	Hyperbilirubinemia	OMIM:235700
Acquired Hemophagocytic Lymphohistiocytosis Associated With Malignant Disease	Increased circulating ferritin concentration, Hypertriglyceridemia, Elevated circulating C-reacti...	ORPHA:158057
Drug-Induced Autoimmune Hemolytic Anemia	Increased total bilirubin	ORPHA:90037
Dubin-Johnson Syndrome	Conjugated hyperbilirubinemia	ORPHA:234
Cholestasis, Progressive Familial Intrahepatic, 6	Conjugated hyperbilirubinemia	OMIM:619484
Infantile Sialic Acid Storage Disease	Conjugated hyperbilirubinemia	OMIM:269920
Bile Acid Synthesis Defect, Congenital, 2	Hyperbilirubinemia	OMIM:235555
Congenital Dyserythropoietic Anemia Type Iii	Increased total iron binding capacity, Hyperbilirubinemia, Increased serum iron	ORPHA:98870
Congenital Bile Acid Synthesis Defect Type 2	Conjugated hyperbilirubinemia, Abnormal serum bile acid concentration, Hyperbilirubinemia	ORPHA:79303
Anemia, Sideroblastic, 3, Pyridoxine-Refractory	Increased circulating ferritin concentration, Conjugated hyperbilirubinemia, Elevated hepatic iro...	OMIM:616860
Neurodevelopmental Disorder With Microcephaly, Seizures, And Neonatal Cholestasis	Hyperbilirubinemia, Increased serum bile acid concentration	OMIM:619685
Dehydrated Hereditary Stomatocytosis 2	Hyperbilirubinemia	OMIM:616689
Hypermanganesemia With Dystonia 1	Increased total iron binding capacity, Hypermanganesemia, Unconjugated hyperbilirubinemia	OMIM:613280
Congenital Bile Acid Synthesis Defect Type 3	Hyperbilirubinemia	ORPHA:79302
Glycogen Storage Disease Due To Phosphoglycerate Kinase 1 Deficiency	Hyperbilirubinemia	ORPHA:713
Cholestasis, Progressive Familial Intrahepatic, 5	Elevated alpha-fetoprotein, Conjugated hyperbilirubinemia, Hyperammonemia	OMIM:617049
Hemophagocytic Lymphohistiocytosis, Familial, 1	Increased circulating ferritin concentration, Hypoproteinemia, Increased LDL cholesterol concentr...	OMIM:267700
Bile Acid Synthesis Defect, Congenital, 1	Hypocholesterolemia, Hyperbilirubinemia	OMIM:607765
Liver Failure, Infantile, Transient	Hyperbilirubinemia, Hypoalbuminemia	OMIM:613070
Solute carrier family 4 (anion exchanger), member 1	Hyperbilirubinemia	OMIM:109270
Mixed-Type Autoimmune Hemolytic Anemia	Increased total bilirubin	ORPHA:90036
Cholestasis, Progressive Familial Intrahepatic, 8	Elevated alpha-fetoprotein, Conjugated hyperbilirubinemia, Increased serum bile acid concentratio...	OMIM:619662
Familial Thyroid Dyshormonogenesis	Neonatal hyperbilirubinemia, Abnormal circulating thyroglobulin level	ORPHA:95716
Mitochondrial Dna Depletion Syndrome 3 (Hepatocerebral Type)	Hyperbilirubinemia, Hypoalbuminemia	OMIM:251880
Peroxisome Biogenesis Disorder 12A (Zellweger)	Hyperbilirubinemia, Elevated circulating long chain fatty acid concentration	OMIM:614886
Bachmann-Bupp Syndrome	Hyperbilirubinemia	OMIM:619075
Cholestasis, Progressive Familial Intrahepatic, 2	Conjugated hyperbilirubinemia	OMIM:601847
Intrahepatic Cholestasis Of Pregnancy	Hyperbilirubinemia, Increased serum bile acid concentration	ORPHA:69665
Pyruvate Kinase Deficiency Of Red Cells	Unconjugated hyperbilirubinemia, Reduced haptoglobin level	OMIM:266200
Hepatoportal Sclerosis	Hyperbilirubinemia, Hypoalbuminemia	ORPHA:64743
Wolcott-Rallison Syndrome	Hypoalbuminemia, Hyperbilirubinemia, Hyponatremia, Hyperammonemia	ORPHA:1667
Car T Cell Therapy-Associated Cytokine Release Syndrome	Elevated circulating creatinine concentration, Hyperbilirubinemia	ORPHA:542323
Cholestasis, Progressive Familial Intrahepatic, 1	Conjugated hyperbilirubinemia	OMIM:211600
Hereditary Elliptocytosis	Neonatal hyperbilirubinemia, Hyperbilirubinemia	ORPHA:288
Spastic Paraplegia 29, Autosomal Dominant	Neonatal hyperbilirubinemia	OMIM:609727
Dehydrated Hereditary Stomatocytosis	Increased circulating ferritin concentration, Increased total bilirubin, Neonatal hyperbilirubine...	ORPHA:3202
Relapsing Fever	Increased total bilirubin, Elevated circulating creatinine concentration, Elevated circulating C-...	ORPHA:91547
Chronic Bilirubin Encephalopathy	Neonatal hyperbilirubinemia, Hypoalbuminemia, Hypernatremia	ORPHA:529808
Acute Bilirubin Encephalopathy	Neonatal hyperbilirubinemia, Hypoalbuminemia, Hypernatremia	ORPHA:529799
Tyrosinosis	Hypertyrosinemia	OMIM:276800
Pyruvate Carboxylase Deficiency	Hyperlysinemia, Hyperammonemia, Increased serum pyruvate, Hyperprolinemia, Hypertaurinemia, Hyper...	ORPHA:3008
Sickle Cell Anemia	Elevated circulating creatinine concentration, Unconjugated hyperbilirubinemia	ORPHA:232
Growth Delay Due To Insulin-Like Growth Factor Type 1 Deficiency	Neonatal hyperbilirubinemia	ORPHA:73272
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal	Elevated circulating long chain fatty acid concentration, Hyperammonemia, Elevated circulating cr...	OMIM:608836
Anemia, Congenital Dyserythropoietic, Type Iv	Hyperbilirubinemia, Reduced haptoglobin level, Unconjugated hyperbilirubinemia	OMIM:613673
Fumarase Deficiency	Hyperbilirubinemia	OMIM:606812
Arthrogryposis, Renal Dysfunction, And Cholestasis 2	Conjugated hyperbilirubinemia	OMIM:613404
Fructose-1,6-Bisphosphatase Deficiency	Neonatal hyperbilirubinemia, Hyperalaninemia, Hyperuricemia	ORPHA:348
Anemia, Nonspherocytic Hemolytic, Due To G6Pd Deficiency	Decreased glucose-6-phosphate dehydrogenase level in blood, Unconjugated hyperbilirubinemia	OMIM:300908
Mitchell-Riley Syndrome	Hyperbilirubinemia	OMIM:615710
Hemophagocytic Lymphohistiocytosis, Familial, 2	Increased circulating ferritin concentration, Hypoproteinemia, Hypertriglyceridemia, Increased to...	OMIM:603553
Distal Xq28 Microduplication Syndrome	Neonatal hyperbilirubinemia	ORPHA:293939
Rh Deficiency Syndrome	Hyperbilirubinemia, Reduced haptoglobin level	ORPHA:71275
Glycogen Storage Disease Xii	Elevated circulating creatine kinase concentration, Hyperbilirubinemia, Reduced haptoglobin level	OMIM:611881
Anemia, Congenital Dyserythropoietic, Type Ia	Hyperbilirubinemia	OMIM:224120
Arthrogryposis, Renal Dysfunction, And Cholestasis 1	Conjugated hyperbilirubinemia	OMIM:208085
Abetalipoproteinemia	Abnormal circulating apolipoprotein concentration, Hyperbilirubinemia, Decreased HDL cholesterol ...	ORPHA:14
Cystic Echinococcosis	Hyperbilirubinemia	ORPHA:400
Hereditary Spherocytosis	Hyperbilirubinemia	ORPHA:822
Lissencephaly Due To Lis1 Mutation	Neonatal hyperbilirubinemia	ORPHA:95232
Graft Versus Host Disease	Hyperbilirubinemia	ORPHA:39812
Hypothyroidism Due To Tsh Receptor Mutations	Neonatal hyperbilirubinemia, Increased circulating thyroglobulin level	ORPHA:90673
Wilson Disease	Increased circulating copper concentration, Hyperbilirubinemia, Hypouricemia, Hypoalbuminemia, De...	OMIM:277900
Osteopetrosis, Autosomal Recessive 5	Hypocalcemia, Hyperbilirubinemia	OMIM:259720
Autoimmune Hepatitis	Increased total bilirubin	ORPHA:2137
Mirizzi Syndrome	Hyperbilirubinemia	ORPHA:521219
Reynolds Syndrome	Calcinosis, Hyperbilirubinemia	OMIM:613471
Primary Biliary Cholangitis	Conjugated hyperbilirubinemia, Hypoalbuminemia, Abnormal circulating lipid concentration	ORPHA:186
Parenteral Nutrition-Associated Cholestasis	Hyperlipidemia, Abnormal circulating fatty-acid concentration, Conjugated hyperbilirubinemia	ORPHA:567983
Isolated Thyroid-Stimulating Hormone Deficiency	Neonatal hyperbilirubinemia, Hypercholesterolemia, Abnormal circulating thyroglobulin level	ORPHA:90674
Caroli Syndrome	Conjugated hyperbilirubinemia, Hyperbilirubinemia	ORPHA:480520
Hepatocellular Carcinoma	Hypokalemia, Hyperbilirubinemia, Hypoalbuminemia, Hypercalcemia, Hyponatremia	ORPHA:88673
Lathosterolosis	Abnormal circulating cholesterol concentration, Hyperbilirubinemia	OMIM:607330
Fructose Intolerance, Hereditary	Bicarbonaturia, Hypophosphatemia, Hyperbilirubinemia, Hyperuricemia	OMIM:229600
Shiga Toxin-Associated Hemolytic Uremic Syndrome	Elevated circulating creatinine concentration, Unconjugated hyperbilirubinemia, Hyponatremia, Hyp...	ORPHA:90038
X-Linked Intellectual Disability-Craniofacioskeletal Syndrome	Hypocalcemia, Hyperbilirubinemia	ORPHA:163979
Multifocal Lymphangioendotheliomatosis-Thrombocytopenia Syndrome	Hyperbilirubinemia	ORPHA:464321
Hypothyroidism, Congenital, Nongoitrous, 2	Hyperbilirubinemia, Increased circulating thyroglobulin level	OMIM:218700
Primary Biliary Cholangitis/Primary Sclerosing Cholangitis And Autoimmune Hepatitis Overlap Syndrome	Hyperbilirubinemia	ORPHA:562639
Pearson Marrow-Pancreas Syndrome	Hyperbilirubinemia	OMIM:557000
Caroli Disease	Conjugated hyperbilirubinemia	ORPHA:53035
Hereditary Cryohydrocytosis With Reduced Stomatin	Conjugated hyperbilirubinemia	ORPHA:168577
Cranioectodermal Dysplasia 2	Hyperbilirubinemia	OMIM:613610
Ogden Syndrome	Hyperbilirubinemia	OMIM:300855
Isolated Biliary Atresia	Conjugated hyperbilirubinemia	ORPHA:30391
Developmental Delay, Impaired Speech, And Behavioral Abnormalities	Hyperbilirubinemia	OMIM:619475
X-Linked Intellectual Disability, Nascimento Type	Neonatal hyperbilirubinemia	ORPHA:163956
Liver Disease, Severe Congenital	Increased circulating ferritin concentration, Hypocalcemia, Hyperbilirubinemia, Hypoproteinemia, ...	OMIM:619991
Degcags Syndrome	Hyperbilirubinemia	OMIM:619488
Short-Rib Thoracic Dysplasia 1 With Or Without Polydactyly	Conjugated hyperbilirubinemia	OMIM:208500
Senior-Boichis Syndrome	Increased total bilirubin	ORPHA:84081
Fibrosis, Neurodegeneration, And Cerebral Angiomatosis	Unconjugated hyperbilirubinemia	OMIM:618278
Hardikar Syndrome	Hyperbilirubinemia	OMIM:301068
Congenital Erythropoietic Porphyria	Abnormal circulating porphyrin concentration, Increased erythrocyte protoporphyrin concentration,...	ORPHA:79277
Yellow Fever	Elevated circulating creatine kinase concentration, Elevated circulating creatinine concentration...	ORPHA:99829
Rajab Interstitial Lung Disease With Brain Calcifications 1	Hypocalcemia, Unconjugated hyperbilirubinemia, Hypoalbuminemia	OMIM:613658
Biliary, Renal, Neurologic, And Skeletal Syndrome	Increased circulating ferritin concentration, Hyperbilirubinemia, Conjugated hyperbilirubinemia, ...	OMIM:619534
Paroxysmal Nocturnal Hemoglobinuria	Increased blood urea nitrogen, Unconjugated hyperbilirubinemia, Reduced haptoglobin level, Decrea...	ORPHA:447
Congenital Disorder Of Glycosylation, Type Iim	Neonatal hyperbilirubinemia	OMIM:300896

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Ctnnal1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Ctnnal1.

There are 3 publications which use IMPC produced mice or data.

Title	Journal	IMPC Allele	PubMed ID
Large-scale neuroanatomical study uncovers 198 gene associations in mouse brain morphogenesis.	Nature communications (August 2019)	Ctnnal1^{tm1e(EUCOMM)Wtsi}	PMC6671969
Mouse screen reveals multiple new genes underlying mouse and human hearing loss.	PLoS biology (April 2019)	Ctnnal1^{tm1a(EUCOMM)Wtsi}	PMC6459510
A gene expression resource generated by genome-wide lacZ profiling in the mouse.	Disease models & mechanisms (August 2015)	Ctnnal1^{tm1e(EUCOMM)Wtsi}	PMC4631787

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MGI Allele	Allele Type	Produced
Ctnnal1^{tm1a(EUCOMM)Wtsi}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors, ES Cells
Ctnnal1^{tm1e(EUCOMM)Wtsi}	Targeted, non-conditional allele	Mice, ES Cells
Ctnnal1^{tm36202(L1L2_gt0)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors

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