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Gene: Dnal4 MGI:1859217

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Gene Summary

Name:
dynein, axonemal, light chain 4
Synonyms:
Dnalc4,  D15Ertd424e

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
tremors Dnal4tm1b(EUCOMM)Wtsi HET   Early adult 7.93×10-05
preweaning lethality, incomplete penetrance Dnal4tm1b(EUCOMM)Wtsi HOM   Early adult 0.00
decreased exploration in new environment Dnal4tm1b(EUCOMM)Wtsi HET Early adult 9.60×10-07

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

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FCS thumbnail FCS
Immunophenotyping

Panel A FCS file(s)

6 Images

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FCS thumbnail FCS
Immunophenotyping

Panel B FCS file(s)

6 Images

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Human diseases caused by Dnal4 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Dnal4 by orthology or direct annotation.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Familial Congenital Mirror Movements
Poor fine motor coordination, Clumsiness, Cerebral palsy ORPHA:238722
Mirror Movements 3
OMIM:616059

The table below shows human diseases predicted to be associated to Dnal4 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Primary Orthostatic Tremor
Abnormality of extrapyramidal motor function, Tremor ORPHA:238606
X-Linked Spinocerebellar Ataxia Type 4
Abnormal pyramidal sign, Postural tremor, Dementia, Progressive cerebellar ataxia, Memory impairment ORPHA:85292
Tremor, Hereditary Essential, 6
Vocal tremor, Head tremor, Kinetic tremor, Postural tremor OMIM:618866
Tremor, Hereditary Essential, 5
Kinetic tremor, Tongue tremor, Postural tremor, Intention tremor OMIM:616736
Tremor, Hereditary Essential, 1
Hand tremor, Action tremor, Postural tremor OMIM:190300
Cerebellar Ataxia, Impaired Intellectual Development, And Dysequilibrium Syndrome 3
Cerebellar ataxia associated with quadrupedal gait, Slurred speech, Tremor, Ataxia OMIM:613227
Optic Atrophy 2
Tremor, Dysdiadochokinesis, Babinski sign OMIM:311050
Parkinson Disease 24, Autosomal Dominant, Susceptibility To
Rigidity, Parkinsonism with favorable response to dopaminergic medication, Resting tremor OMIM:619491
Dystonia 27
Postural tremor, Writer's cramp, Limb dystonia, Torticollis, Action tremor, Oromandibular dystoni... OMIM:616411
Spinocerebellar Ataxia Type 15/16
Gait ataxia, Tremor by anatomical site, Upper limb postural tremor, Ataxia, Head tremor, Action t... ORPHA:98769
Episodic Ataxia, Type 1
Spastic gait, Episodic ataxia, Incoordination, Babinski sign, Slurred speech, Tremor OMIM:160120
Primary Dystonia, Dyt27 Type
Writer's cramp, Limb dystonia, Upper limb postural tremor, Focal dystonia, Axial dystonia, Action... ORPHA:464440
Huntington Disease-Like Syndrome Due To C9Orf72 Expansions
Chorea, Cognitive impairment, Parkinsonism, Rigidity, Myoclonus, Upper motor neuron dysfunction, ... ORPHA:401901
Tremor, Hereditary Essential, 4
Action tremor, Postural tremor OMIM:614782
Dystonia 3, Torsion, X-Linked
Chorea, Myoclonus, Parkinsonism with favorable response to dopaminergic medication, Torsion dysto... OMIM:314250
Leukoencephalopathy, Brain Calcifications, And Cysts
Spasticity, Abnormal pyramidal sign, Abnormality of extrapyramidal motor function, Ataxia, Hemipl... OMIM:614561
Dystonia 11, Myoclonic
Anxiety, Writer's cramp, Torticollis, Myoclonus, Tremor, Panic attack, Agoraphobia OMIM:159900
Episodic Ataxia With Slurred Speech
Gait ataxia, Slurred speech, Tremor ORPHA:401953
Leukoencephalopathy With Brainstem And Spinal Cord Involvement And Lactate Elevation
Spasticity, Cognitive impairment, Ataxia, Babinski sign, Tremor OMIM:611105
Adult Neuronal Ceroid Lipofuscinosis
Spasticity, Abnormal pyramidal sign, Cognitive impairment, Motor deterioration, Clumsiness, Abnor... ORPHA:79262
Autosomal Recessive Spastic Paraplegia Type 71
Progressive spastic paraplegia, Spastic gait, Hand tremor, Babinski sign, Lower limb spasticity ORPHA:401840
Progressive Myoclonic Epilepsy Type 1
Myoclonus, Limb ataxia, Morning myoclonic jerks, Ataxia, Dementia, Intention tremor ORPHA:308
Spinocerebellar Ataxia 20
Gait ataxia, Abnormal pyramidal sign, Postural tremor, Palatal tremor, Limb ataxia, Action tremor OMIM:608687
Mental Retardation With Spastic Paraplegia And Palmoplantar Hyperkeratosis
Tremor, Spastic paraplegia OMIM:309560
Intellectual Developmental Disorder, Autosomal Recessive 6
Postural tremor, Torticollis, Myoclonus, Kinetic tremor, Involuntary movements OMIM:611092
Parkinson Disease 13, Autosomal Dominant, Susceptibility To
Rigidity, Tremor, Parkinsonism with favorable response to dopaminergic medication, Bradykinesia OMIM:610297
Myoclonus, Familial, 1
Myoclonus, Ataxia, Action tremor, Frequent falls, Action myoclonus OMIM:614937
Huntington Disease-Like 2
Chorea, Inertia, Anxiety, Rigidity, Apathy, Dementia, Dystonia, Action tremor, Subcortical dement... OMIM:606438
Sandhoff Disease, Adult Form
Gait ataxia, Spasticity, Anxiety, Focal dystonia, Tremor, Mental deterioration, Dystonia, Fascicu... ORPHA:309169
Episodic Kinesigenic Dyskinesia 2
Chorea, Paroxysmal dyskinesia, Dystonia, Involuntary movements OMIM:611031
Primary Dystonia, Dyt13 Type
Postural tremor, Limb dystonia, Torticollis, Focal dystonia, Torsion dystonia, Action tremor, Cra... ORPHA:98807
Autosomal Spastic Paraplegia Type 72
Rigidity, Memory impairment, Spastic gait, Postural tremor ORPHA:401849
Brunner Syndrome
Low frustration tolerance, Aggressive behavior, Self-injurious behavior, Kinetic tremor OMIM:300615
Parkinsonism With Spasticity, X-Linked
Spasticity, Resting tremor, Parkinsonism, Babinski sign, Cogwheel rigidity, Bradykinesia OMIM:300911
Parkinson Disease 11, Autosomal Dominant, Susceptibility To
Rigidity, Bradykinesia, Parkinsonism with favorable response to dopaminergic medication, Resting ... OMIM:607688
Epilepsy, Progressive Myoclonic 7
Myoclonus, Tremor, Ataxia, Mental deterioration OMIM:616187
Cerebellar Hypoplasia/Atrophy, Epilepsy, And Global Developmental Delay
Tremor, Ataxia OMIM:213000
Parkinson Disease 6, Autosomal Recessive Early-Onset
Resting tremor, Parkinsonism, Rigidity, Dementia, Anxiety, Dystonia, Bradykinesia OMIM:605909
Atypical Pantothenate Kinase-Associated Neurodegeneration
Chorea, Spasticity, Abnormal pyramidal sign, Cognitive impairment, Inertia, Parkinsonism, Rigidit... ORPHA:216873
Tremor, Hereditary Essential, 2
Upper limb postural tremor, Kinetic tremor OMIM:602134
Tremor Of Intention, Ataxia, And Lipofuscinosis
Intention tremor, Ataxia OMIM:190200
Parkinson Disease 7, Autosomal Recessive Early-Onset
Blepharospasm, Resting tremor, Postural tremor, Rigidity, Parkinsonism with favorable response to... OMIM:606324
Spinocerebellar Ataxia Type 28
Gait ataxia, Spasticity, Cognitive impairment, Parkinsonism, Rigidity, Limb dystonia, Limb ataxia... ORPHA:101109
Neuronopathy, Distal Hereditary Motor, Type Viia
Vocal cord paresis, Tremor, Vocal cord paralysis OMIM:158580
Intellectual Developmental Disorder, Autosomal Recessive 77
Head tremor, Self-biting OMIM:619988
Parkinson Disease 15, Autosomal Recessive Early-Onset
Parkinsonism, Rigidity, Abnormality of extrapyramidal motor function, Parkinsonism with favorable... OMIM:260300
Spinocerebellar Ataxia 12
Dysdiadochokinesis, Parkinsonism, Dementia, Dysmetria, Head tremor, Axial dystonia, Action tremor... OMIM:604326
Spinocerebellar Ataxia 40
Gait ataxia, Ankle clonus, Dysdiadochokinesis, Ataxia, Spastic paraparesis, Dysmetria, Tremor, In... OMIM:616053
Neurodevelopmental Disorder With Impaired Speech And Hyperkinetic Movements
Chorea, Torticollis, Ataxia, Tremor, Hyperkinetic movements, Dystonia OMIM:618425
Corticobasal Syndrome
Limb myoclonus, Speech apraxia, Parkinsonism, Limb dystonia, Limb apraxia, Myoclonus, Dementia, T... ORPHA:454887
Segawa Syndrome, Autosomal Recessive
Gait ataxia, Parkinsonism, Rigidity, Abnormality of extrapyramidal motor function, Myoclonus, Lim... OMIM:605407
Spinocerebellar Ataxia Type 12
Poor fine motor coordination, Abnormal pyramidal sign, Cognitive impairment, Tremor by anatomical... ORPHA:98762
Spinocerebellar Ataxia 43
Gait ataxia, Rigidity, Limb ataxia, Ataxia, Tremor OMIM:617018
Spinocerebellar Ataxia, X-Linked 5
Action tremor, Ataxia OMIM:300703
Spinocerebellar Ataxia Type 31
Gait ataxia, Spasticity, Tremor ORPHA:217012
Spinocerebellar Ataxia, Autosomal Recessive 16
Spasticity, Ankle clonus, Cognitive impairment, Truncal ataxia, Limb ataxia, Babinski sign, Tremor OMIM:615768
Dystonia 12
Parkinsonism, Torticollis, Emotional lability, Tremor, Anxiety, Dystonia, Bradykinesia OMIM:128235
Dyskinesia, Limb And Orofacial, Infantile-Onset
Chorea, Hemiballismus, Tremor, Frequent falls, Hyperkinetic movements OMIM:616921
Spinocerebellar Ataxia Type 20
Gait ataxia, Abnormal pyramidal sign, Tremor by anatomical site, Upper limb postural tremor, Atax... ORPHA:101110
Epilepsy, Progressive Myoclonic, 1B
Myoclonus, Ataxia, Babinski sign, Dysmetria, Tremor OMIM:612437
Dystonia 13, Torsion, Autosomal Dominant
Blepharospasm, Writer's cramp, Limb dystonia, Torticollis, Torsion dystonia, Tremor, Oromandibula... OMIM:607671
Spinocerebellar Ataxia 37
Tremor, Frequent falls, Ataxia OMIM:615945
Paroxysmal Exertion-Induced Dyskinesia
Chorea, Aggressive behavior, Choreoathetosis, Ataxia, Torsion dystonia, Paroxysmal dyskinesia, Lo... ORPHA:98811
Tremor, Hereditary Essential, And Idiopathic Normal Pressure Hydrocephalus
Tremor, Kinetic tremor OMIM:611808
Atp13A2-Related Juvenile Neuronal Ceroid Lipofuscinosis
Cognitive impairment, Postural tremor, Rigidity, Myoclonus, Parkinsonism with favorable response ... ORPHA:314632
Migraine, Familial Hemiplegic, 1
Hemiparesis, Ataxia, Hemiplegia, Tremor, Anxiety OMIM:141500
Dystonia 24
Blepharospasm, Torticollis, Head tremor, Oromandibular dystonia, Limb tremor, Arm dystonia OMIM:615034
Spastic Ataxia 2, Autosomal Recessive
Gait ataxia, Spasticity, Spastic ataxia, Babinski sign, Dysmetria, Tremor, Frequent falls, Head t... OMIM:611302
Spastic Paraparesis And Deafness
Spastic paraparesis, Tremor OMIM:312910
Hyperphenylalaninemia, Bh4-Deficient, C
Myoclonus, Choreoathetosis, Tremor, Progressive neurologic deterioration, Hypertonia, Irritabilit... OMIM:261630
Ceroid Lipofuscinosis, Neuronal, 13 (Kufs Type)
Gait ataxia, Abnormality of extrapyramidal motor function, Myoclonus, Emotional lability, Babinsk... OMIM:615362
Urocanase Deficiency
Gait ataxia, Aggressive behavior, Truncal ataxia, Ataxia, Dysmetria, Action tremor OMIM:276880
Dyskinesia With Orofacial Involvement, Autosomal Recessive
Myoclonus, Tremor, Dystonia, Frequent falls OMIM:619647
Dystonia 23
Writer's cramp, Limb dystonia, Torticollis, Myoclonus, Head tremor, Axial dystonia OMIM:614860
Hyperphenylalaninemia, Bh4-Deficient, D
Tremor, Hypertonia OMIM:264070
Primary Dystonia, Dyt2 Type
Blepharospasm, Limb dystonia, Torticollis, Torsion dystonia, Tremor, Involuntary movements, Gener... ORPHA:99657
Encephalopathy, Progressive, With Or Without Lipodystrophy
Spasticity, Abnormal pyramidal sign, Myoclonus, Ataxia, Tremor, Tetraparesis, Mental deterioratio... OMIM:615924
Basal Ganglia Calcification, Idiopathic, 1
Chorea, Abnormal pyramidal sign, Dysdiadochokinesis, Parkinsonism, Rigidity, Tremor, Dystonia, Me... OMIM:213600
Spinocerebellar Ataxia 48
Gait ataxia, Chorea, Anxiety, Parkinsonism, Ataxia, Babinski sign, Dysmetria, Tremor, Mental dete... OMIM:618093
Spinocerebellar Ataxia Type 14
Gait ataxia, Cognitive impairment, Rigidity, Myoclonus, Limb ataxia, Tremor, Progressive cerebell... ORPHA:98763
Dystonia, Dopa-Responsive
Gait ataxia, Spasticity, Dysdiadochokinesis, Postural tremor, Writer's cramp, Resting tremor, Tor... OMIM:128230
Parkinson Disease 17
Resting tremor, Parkinsonism, Rigidity, Tremor, Bradykinesia OMIM:614203
Parkinson Disease 2, Autosomal Recessive Juvenile
Parkinsonism, Rigidity, Tremor, Dystonia, Bradykinesia OMIM:600116
Progressive Supranuclear Palsy-Parkinsonism Syndrome
Anxiety, Rigidity, Apathy, Parkinsonism with favorable response to dopaminergic medication, Tremo... ORPHA:240085
Infantile-Onset Generalized Dyskinesia With Orofacial Involvement
Chorea, Tremor, Hemiballismus, Frequent falls ORPHA:494526
Dystonia 28, Childhood-Onset
Retrocollis, Spasticity, Cognitive impairment, Torticollis, Myoclonus, Tremor, Craniofacial dysto... OMIM:617284
Rapid-Onset Dystonia-Parkinsonism
Gait ataxia, Resting tremor, Parkinsonism, Limb dystonia, Torticollis, Emotional lability, Cranio... ORPHA:71517
Parkinson Disease 22, Autosomal Dominant
Bradykinesia, Tremor, Resting tremor OMIM:616710
Parkinson-Dementia Syndrome
Abnormal pyramidal sign, Parkinsonism, Rigidity, Dementia, Tremor OMIM:260540
Dystonia 16
Abnormal pyramidal sign, Postural tremor, Parkinsonism, Limb dystonia, Torticollis, Bradykinesia ORPHA:210571
Spinocerebellar Ataxia 38
Gait ataxia, Myoclonus, Limb ataxia, Ataxia, Tremor OMIM:615957
Neurodevelopmental Disorder With Hyperkinetic Movements And Dyskinesia
Myoclonus, Tremor, Dystonia, Anxiety OMIM:619651
Cranio-Cervical Dystonia With Laryngeal And Upper-Limb Involvement
Blepharospasm, Limb dystonia, Torticollis, Myoclonus, Hand tremor, Upper limb postural tremor, Or... ORPHA:420485
Cerebral Amyloid Angiopathy, Itm2B-Related, 1
Spasticity, Rigidity, Dementia, Tremor, Progressive neurologic deterioration, Hypertonia OMIM:176500
Progressive Supranuclear Palsy-Corticobasal Syndrome
Limb myoclonus, Abnormal pyramidal sign, Involuntary movements, Rigidity, Limb apraxia, Apraxia, ... ORPHA:240103
Neurodegeneration With Brain Iron Accumulation 3
Chorea, Spasticity, Blepharospasm, Parkinsonism, Writer's cramp, Rigidity, Choreoathetosis, Emoti... OMIM:606159
Spinocerebellar Ataxia, Autosomal Recessive 4
Gait ataxia, Spasticity, Abnormal pyramidal sign, Torticollis, Myoclonus, Ataxia, Babinski sign, ... OMIM:607317
Spinal Muscular Atrophy, Late-Onset, Finkel Type
Tremor, Fasciculations OMIM:182980
Lichtenstein-Knorr Syndrome
Gait ataxia, Dysdiadochokinesis, Limb ataxia, Ataxia, Dysmetria, Action tremor OMIM:616291
Parkinson Disease 19A, Juvenile-Onset
Spasticity, Abnormal pyramidal sign, Cognitive impairment, Limb hypertonia, Parkinsonism, Rigidit... OMIM:615528
Spinocerebellar Ataxia Type 38
Gait ataxia, Tremor ORPHA:423296
Neurodegeneration With Ataxia, Dystonia, And Gaze Palsy, Childhood-Onset
Gait ataxia, Abnormal pyramidal sign, Cognitive impairment, Dysdiadochokinesis, Oculomotor apraxi... OMIM:617145
X-Linked Non Progressive Cerebellar Ataxia
Truncal ataxia, Clumsiness, Spastic dysarthria, Babinski sign, Intention tremor, Action tremor, F... ORPHA:314978
Spinocerebellar Ataxia 50
Chorea, Postural tremor, Apraxia, Myoclonus, Ataxia, Head tremor, Action tremor, Memory impairment OMIM:620158
Optic Atrophy 3, Autosomal Dominant
Abnormality of extrapyramidal motor function, Tremor OMIM:165300
Autosomal Dominant Spastic Ataxia Type 1
Spastic ataxia, Spastic gait, Spastic dysarthria, Limb ataxia, Babinski sign, Spastic paraplegia,... ORPHA:251282
Spinocerebellar Ataxia 7
Chorea, Spasticity, Abnormality of extrapyramidal motor function, Babinski sign, Dysmetria, Tremo... OMIM:164500
Dystonia 7, Torsion
Blepharospasm, Writer's cramp, Clumsiness, Torticollis, Hand tremor, Torsion dystonia, Oromandibu... OMIM:602124
Epilepsy, Familial Adult Myoclonic, 4
Myoclonus, Tremor OMIM:615127
Dystonia 16
Retrocollis, Abnormal pyramidal sign, Cognitive impairment, Postural tremor, Parkinsonism, Limb d... OMIM:612067
Intellectual Developmental Disorder, Autosomal Recessive 48
Tremor, Aggressive behavior, Self-mutilation, Emotional lability OMIM:616269
Dystonia 2, Torsion, Autosomal Recessive
Torticollis, Blepharospasm, Torsion dystonia, Tremor OMIM:224500
Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency
Spasticity, Aggressive behavior, Oculomotor apraxia, Choreoathetosis, Ataxia, Tremor, Dystonia OMIM:612716
Spinocerebellar Ataxia 18
Dysdiadochokinesis, Progressive gait ataxia, Babinski sign, Dysmetria, Tremor OMIM:607458
Dyskinesia With Orofacial Involvement, Autosomal Dominant
Chorea, Resting tremor, Limb hypertonia, Involuntary movements, Myoclonus, Choreoathetosis, Parox... OMIM:606703
Parkinsonism With Polyneuropathy
Resting tremor, Rigidity, Parkinsonism with favorable response to dopaminergic medication, Anxiet... OMIM:619279
Spinocerebellar Ataxia 19
Gait ataxia, Cognitive impairment, Postural tremor, Truncal ataxia, Myoclonus, Limb ataxia, Cogwh... OMIM:607346
Cyanide-Induced Parkinsonism-Dystonia
Resting tremor, Parkinsonism, Rigidity, Apathy, Bradykinesia ORPHA:306692
Epilepsy, Familial Adult Myoclonic, 5
Myoclonus, Tremor OMIM:615400
Dystonia-Parkinsonism-Hypermanganesemia Syndrome
Spasticity, Ankle clonus, Parkinsonism, Babinski sign, Scissor gait, Tremor, Oromandibular dyston... ORPHA:521406
Perry Syndrome
Parkinsonism, Abnormality of extrapyramidal motor function, Apathy, Dementia, Tremor ORPHA:178509
Beta-Propeller Protein-Associated Neurodegeneration
Aggressive behavior, Parkinsonism, Rigidity, Dementia, Spastic paraparesis, Tremor, Dystonia, Bra... ORPHA:329284
Spinal Muscular Atrophy, Jokela Type
Tremor, Fasciculations OMIM:615048
Spastic Paraplegia 78, Autosomal Recessive
Gait ataxia, Aggressive behavior, Abnormal pyramidal sign, Spastic tetraplegia, Resting tremor, P... OMIM:617225
Parkinsonism-Dystonia 3, Childhood-Onset
Chorea, Aggressive behavior, Parkinsonism, Ataxia, Tremor, Action tremor, Hypertonia, Anxiety, Hy... OMIM:619738
Parkinsonism-Dystonia 1, Infantile-Onset
Chorea, Abnormal pyramidal sign, Parkinsonism, Rigidity, Limb dystonia, Oculogyric crisis, Tremor... OMIM:613135
Spinocerebellar Ataxia Type 37
Dysdiadochokinesis, Truncal ataxia, Myoclonus, Tremor, Cogwheel rigidity, Limb dysmetria ORPHA:363710
Gerstmann-Straussler Disease
Gait ataxia, Spasticity, Aggressive behavior, Parkinsonism, Truncal ataxia, Rigidity, Apraxia, My... OMIM:137440
Spastic Paraplegia 6, Autosomal Dominant
Spastic gait, Babinski sign, Spastic paraplegia, Tremor, Lower limb spasticity, Clonus OMIM:600363
Hyperphenylalaninemia, Bh4-Deficient, B
Limb hypertonia, Rigidity, Choreoathetosis, Tremor, Progressive neurologic deterioration, Hyperki... OMIM:233910
Spinocerebellar Ataxia Type 21
Gait ataxia, Cognitive impairment, Rigidity, Abnormality of extrapyramidal motor function, Tremor... ORPHA:98773
Mitochondrial Complex Iii Deficiency, Nuclear Type 2
Gait ataxia, Diminished motivation, Aggressive behavior, Cognitive impairment, Gait apraxia, Dysd... OMIM:615157
Infantile Neuronal Ceroid Lipofuscinosis
Poor fine motor coordination, Chorea, Spasticity, Cognitive impairment, Motor deterioration, Clum... ORPHA:79263
Monomelic Amyotrophy
Tremor, Fasciculations ORPHA:65684
Epilepsy, Progressive Myoclonic, 6
Myoclonus, Tremor, Memory impairment, Ataxia OMIM:614018
Glut1 Deficiency Syndrome 2
Choreoathetosis, Ataxia, Tremor, Irritability, Dystonia OMIM:612126
Epilepsy, Familial Adult Myoclonic, 2
Blepharospasm, Cognitive impairment, Myoclonus, Ataxia, Dementia, Tremor OMIM:607876
Hyperphenylalaninemia, Bh4-Deficient, A
Limb hypertonia, Parkinsonism, Rigidity, Choreoathetosis, Ataxia, Tremor, Progressive neurologic ... OMIM:261640
Parkinson Disease 21
Rigidity, Tremor, Bradykinesia, Parkinsonism OMIM:616361
Parkinson Disease 14, Autosomal Recessive
Frontotemporal dementia, Aggressive behavior, Spasticity, Ankle clonus, Resting tremor, Parkinson... OMIM:612953
Dentatorubral Pallidoluysian Atrophy
Gait ataxia, Blepharospasm, Cognitive impairment, Dysdiadochokinesis, Truncal ataxia, Myoclonus, ... ORPHA:101
Parkinson Disease 8, Autosomal Dominant
Resting tremor, Parkinsonism, Rigidity, Parkinsonism with favorable response to dopaminergic medi... OMIM:607060
Sneddon Syndrome
Chorea, Hemiparesis, Dementia, Tremor, Mental deterioration, Memory impairment ORPHA:820
Anemia, Sideroblastic, And Spinocerebellar Ataxia
Dysdiadochokinesis, Babinski sign, Intention tremor, Dysmetria, Clonus, Nonprogressive cerebellar... OMIM:301310
Familial Dyskinesia And Facial Myokymia
Chorea, Limb hypertonia, Resting tremor, Myoclonus, Dystonia ORPHA:324588
Spinocerebellar Ataxia 23
Gait ataxia, Limb ataxia, Babinski sign, Dysmetria, Tremor OMIM:610245
Cerebral Creatine Deficiency Syndrome 2
Aggressive behavior, Rigidity, Paraparesis, Myoclonus, Ataxia, Tremor, Progressive extrapyramidal... OMIM:612736
Atypical Progressive Supranuclear Palsy Syndrome
Blepharospasm, Abnormal pyramidal sign, Tremor by anatomical site, Parkinsonism, Rigidity, Oculom... ORPHA:99750
Epilepsy, Familial Adult Myoclonic, 1
Tremor OMIM:601068
Spinocerebellar Ataxia 21
Gait ataxia, Aggressive behavior, Cognitive impairment, Postural tremor, Parkinsonism, Abnormalit... OMIM:607454
Leukoencephalopathy With Calcifications And Cysts
Spasticity, Abnormal pyramidal sign, Cognitive impairment, Emotional lability, Ataxia, Tremor, Me... ORPHA:542310
Epilepsy, Familial Adult Myoclonic, 3
Myoclonus, Tremor OMIM:613608
X-Linked Parkinsonism-Spasticity Syndrome
Spasticity, Ankle clonus, Resting tremor, Babinski sign, Spastic paraparesis, Scissor gait, Cogwh... ORPHA:363654
Spinocerebellar Ataxia Type 27
Gait ataxia, Aggressive behavior, Truncal ataxia, Limb ataxia, Hand tremor, Tremor, Memory impair... ORPHA:98764
Inherited Creutzfeldt-Jakob Disease
Gait ataxia, Chorea, Bradykinesia, Abnormal pyramidal sign, Spastic dysarthria, Clumsiness, Myocl... ORPHA:282166
Neurodevelopmental Disorder With Or Without Variable Movement Or Behavioral Abnormalities
Chorea, Anxiety, Resting tremor, Parkinsonism, Myoclonus, Ataxia, Cogwheel rigidity, Panic attack... OMIM:619725
Neurodegeneration With Brain Iron Accumulation 8
Dysmetria, Tremor, Ataxia OMIM:617917
Neurodegeneration With Brain Iron Accumulation 5
Aggressive behavior, Anxiety, Parkinsonism, Rigidity, Dementia, Spastic paraparesis, Tremor, Ment... OMIM:300894
Parkinson Disease 18, Autosomal Dominant, Susceptibility To
Rigidity, Bradykinesia, Resting tremor, Parkinsonism OMIM:614251
Kufor-Rakeb Syndrome
Spasticity, Aggressive behavior, Parkinsonism, Rigidity, Torticollis, Paraparesis, Parkinsonism w... OMIM:606693
Intellectual Developmental Disorder With Speech Delay And Axonal Peripheral Neuropathy
Tremor, Ataxia OMIM:619099
Autosomal Recessive Cerebelloparenchymal Disorder Type 3
Gait ataxia, Spasticity, Cognitive impairment, Oculomotor apraxia, Poor motor coordination, Ataxi... ORPHA:1170
X-Linked Dystonia-Parkinsonism
Chorea, Blepharospasm, Resting tremor, Limb dystonia, Myoclonus, Parkinsonism with favorable resp... ORPHA:53351
Autosomal Spastic Paraplegia Type 58
Gait ataxia, Chorea, Erratic myoclonus, Spasticity, Abnormal pyramidal sign, Spastic ataxia, Titu... ORPHA:397946
Spinocerebellar Ataxia 15
Gait ataxia, Postural tremor, Truncal ataxia, Limb ataxia, Action tremor OMIM:606658
X-Linked Intellectual Disability-Psychosis-Macroorchidism Syndrome
Abnormal fear/anxiety-related behavior, Aggressive behavior, Resting tremor, Abnormal aggressive,... ORPHA:3077
Crigler-Najjar Syndrome Type 1
Tremor, Memory impairment ORPHA:79234
Dopa-Responsive Dystonia Due To Sepiapterin Reductase Deficiency
Cognitive impairment, Cerebral palsy, Limb hypertonia, Rigidity, Oculogyric crisis, Tremor, Dysto... ORPHA:70594
Spinocerebellar Ataxia 42
Abnormal pyramidal sign, Cognitive impairment, Spastic ataxia, Spastic gait, Ataxia, Babinski sig... OMIM:616795
Coenzyme Q10 Deficiency, Primary, 9
Myoclonus, Ataxia, Dysmetria, Tremor, Lower limb spasticity OMIM:619028
Intellectual Developmental Disorder, X-Linked 104
Spasticity, Aggressive behavior, Ataxia, Tremor OMIM:300983
Dopa-Responsive Dystonia
Generalized dystonia, Anxiety, Parkinsonism, Rigidity, Poor coordination, Oculogyric crisis, Abno... ORPHA:255
Adult-Onset Cervical Dystonia, Dyt23 Type
Writer's cramp, Torticollis, Myoclonus, Focal dystonia, Head tremor, Axial dystonia, Craniofacial... ORPHA:420492
Parkinson Disease 23, Autosomal Recessive Early-Onset
Spasticity, Abnormal pyramidal sign, Resting tremor, Parkinsonism, Rigidity, Limb dystonia, Demen... OMIM:616840
Intellectual Developmental Disorder, Autosomal Dominant 60, With Seizures
Gait ataxia, Chorea, Truncal ataxia, Myoclonus, Tremor OMIM:618587
Charcot-Marie-Tooth Disease, Axonal, Autosomal Dominant, Type 2A2A
Spasticity, Babinski sign, Tremor, Hypertonia, Mental deterioration OMIM:609260
Developmental Delay And Seizures With Or Without Movement Abnormalities
Rigidity, Ataxia, Tremor, Dystonia, Bradykinesia OMIM:617836
Neurodevelopmental Disorder With Motor And Speech Delay And Behavioral Abnormalities
Spastic tetraparesis, Tremor, Aggressive behavior OMIM:619470
Cataract-Ataxia-Deafness Syndrome
Tremor, Ataxia, Hypertonia ORPHA:1368
Urocanic Aciduria
Gait ataxia, Action tremor, Truncal ataxia, Ataxia ORPHA:210128
Neuroferritinopathy
Chorea, Blepharospasm, Cognitive impairment, Resting tremor, Frontal lobe dementia, Writer's cram... ORPHA:157846
Saccharopinuria
Gait ataxia, Cognitive impairment, Spastic diplegia, Tremor, Mental deterioration ORPHA:3124
Waisman Syndrome
Resting tremor, Parkinsonism, Rigidity, Parkinsonism with favorable response to dopaminergic medi... OMIM:311510
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia
Gait ataxia, Chorea, Cognitive impairment, Truncal ataxia, Oculomotor apraxia, Limb ataxia, Demen... OMIM:208920
Xeroderma Pigmentosum, Complementation Group G
Spasticity, Tremor, Ataxia OMIM:278780
Fragile X Tremor/Ataxia Syndrome
Poor fine motor coordination, Gait ataxia, Dysdiadochokinesis, Postural tremor, Resting tremor, P... OMIM:300623
Spinal Muscular Atrophy With Progressive Myoclonic Epilepsy
Myoclonus, Dementia, Tremor, Frequent falls, Tongue fasciculations OMIM:159950
Myoclonic-Atonic Epilepsy
Eyelid myoclonus, Tremor, Ataxia OMIM:616421
Aicardi-Goutieres Syndrome 6
Rigidity, Tremor, Irritability, Dystonia OMIM:615010
Neuronal Intranuclear Inclusion Disease
Cognitive impairment, Rigidity, Ataxia, Dementia, Tremor OMIM:603472
Pseudohyperkalemia, Familial, 2, Due To Red Cell Leak
Periodic paralysis, Hand tremor OMIM:609153
Classic Phenylketonuria
Self-injurious behavior, Motor deterioration, Hemiplegia, Paraplegia, Tremor, Hypertonia, Mental ... ORPHA:79254
Parkinsonism-Dystonia 2, Infantile-Onset
Dysdiadochokinesis, Parkinsonism, Oculogyric crisis, Incoordination, Ataxia, Tremor, Dystonia OMIM:618049
Developmental And Epileptic Encephalopathy 32
Myoclonus, Tremor, Ataxia OMIM:616366
Leukodystrophy, Hypomyelinating, 11
Ataxia, Spasticity, Tremor, Myoclonus OMIM:616494
Autosomal Recessive Ataxia Due To Ubiquinone Deficiency
Abnormal pyramidal sign, Myoclonus, Tremor, Progressive cerebellar ataxia, Dystonia ORPHA:139485
Hemiparkinsonism-Hemiatrophy Syndrome
Parkinsonism, Hemiparesis, Tremor, Dystonia, Bradykinesia ORPHA:306669
Ataxia With Vitamin E Deficiency
Abnormal pyramidal sign, Dysdiadochokinesis, Hemiplegia/hemiparesis, Ataxia, Dysmetria, Tremor, H... ORPHA:96
Hypermanganesemia With Dystonia 2
Spasticity, Ankle clonus, Generalized dystonia, Parkinsonism, Limb dystonia, Clumsiness, Babinski... OMIM:617013
Brain Dopamine-Serotonin Vesicular Transport Disease
Cognitive impairment, Dysdiadochokinesis, Parkinsonism, Limb dystonia, Oculogyric crisis, Ataxia,... ORPHA:352649
Autosomal Dominant Cerebellar Ataxia
Pseudobulbar paralysis, Choreoathetosis, Upper motor neuron dysfunction, Action tremor, Spasticit... ORPHA:99
Spinocerebellar Ataxia, Autosomal Recessive 2
Gait ataxia, Spasticity, Limb ataxia, Incoordination, Ataxia, Dysmetria, Tremor OMIM:213200
Spinal Muscular Atrophy-Progressive Myoclonic Epilepsy Syndrome
Limb myoclonus, Eyelid myoclonus, Clumsiness, Myoclonus, Tremor, Frequent falls, Mental deteriora... ORPHA:2590
Multiple System Atrophy, Parkinsonian Type
Gait ataxia, Abnormal pyramidal sign, Postural tremor, Resting tremor, Parkinsonism, Rigidity, Ap... ORPHA:98933
Tremor, Nystagmus, And Duodenal Ulcer
Tremor, Kinetic tremor OMIM:190310
Sensorineural Hearing Loss-Early Graying-Essential Tremor Syndrome
Tremor ORPHA:66633
Neurodegeneration With Brain Iron Accumulation 7
Ataxia, Dysmetria, Tremor, Lower limb spasticity, Dystonia OMIM:617916
Leukoencephalopathy, Developmental Delay, And Episodic Neurologic Regression Syndrome
Gait ataxia, Spasticity, Hemiballismus, Parkinsonism, Truncal ataxia, Rigidity, Myoclonus, Choreo... OMIM:618877
Thiamine Metabolism Dysfunction Syndrome 2 (Biotin- Or Thiamine-Responsive Type)
Gait ataxia, Chorea, Abnormal pyramidal sign, Rigidity, Paraparesis, Babinski sign, Truncal titub... OMIM:607483
Spinocerebellar Ataxia 2
Spasticity, Dysdiadochokinesis, Postural tremor, Parkinsonism, Oculomotor apraxia, Rigidity, Myoc... OMIM:183090
Intellectual Developmental Disorder, Autosomal Dominant 55, With Seizures
Gait ataxia, Tremor, Ataxia OMIM:617831
Pelizaeus-Merzbacher Disease
Abnormal pyramidal sign, Cognitive impairment, Writer's cramp, Choreoathetosis, Apathy, Psychomot... OMIM:312080
Classic Progressive Supranuclear Palsy Syndrome
Blepharospasm, Social and occupational deterioration, Abnormal pyramidal sign, Parkinsonism, Park... ORPHA:240071
Severe Neurodegenerative Syndrome With Lipodystrophy
Gait ataxia, Spasticity, Abnormal pyramidal sign, Cognitive impairment, Limb dystonia, Myoclonus,... ORPHA:363400
Trisomy X
Tremor, Cognitive impairment, Anxiety ORPHA:3375
4H Leukodystrophy
Dysdiadochokinesis, Progressive gait ataxia, Abnormality of extrapyramidal motor function, Upper ... ORPHA:289494
Oculopharyngeal Myopathy With Leukoencephalopathy 1
Tremor, Ataxia OMIM:618637
Mohr-Tranebjaerg Syndrome
Spasticity, Tremor, Dystonia, Mental deterioration OMIM:304700
Leukodystrophy, Hypomyelinating, 6
Spasticity, Rigidity, Oculomotor apraxia, Choreoathetosis, Ataxia, Tremor, Dystonia OMIM:612438
Generalized Epilepsy With Febrile Seizures-Plus
Poor fine motor coordination, Cognitive impairment, Incoordination, Ataxia, Tremor, Anxiety, Brad... ORPHA:36387
Cln5 Disease
Spasticity, Aggressive behavior, Anxiety, Dysdiadochokinesis, Truncal ataxia, Clumsiness, Ataxia,... ORPHA:228360
Perry Syndrome
Frontotemporal dementia, Suicidal ideation, Parkinsonism, Rigidity, Apathy, Tremor, Anxiety, Dyst... OMIM:168605
Intellectual Developmental Disorder, X-Linked, Syndromic 13
Spastic tetraplegia, Spastic gait, Resting tremor, Parkinsonism, Apraxia, Choreoathetosis, Emotio... OMIM:300055
Late-Infantile/Juvenile Krabbe Disease
Tetraplegia, Spastic diplegia, Clumsiness, Upper motor neuron dysfunction, Emotional lability, He... ORPHA:206443
Glutathionuria
Tremor, Action tremor, Dysdiadochokinesis OMIM:231950
Alpha-Methylacyl-Coa Racemase Deficiency
Spasticity, Hemiparesis, Ataxia, Tremor, Intention tremor OMIM:614307
Spinocerebellar Ataxia 8
Spasticity, Abnormal pyramidal sign, Incoordination, Tremor, Progressive cerebellar ataxia OMIM:608768
Spinocerebellar Ataxia, Autosomal Recessive 21
Gait ataxia, Spasticity, Limb ataxia, Tremor, Frequent falls OMIM:616719
Lopes-Maciel-Rodan Syndrome
Spasticity, Ankle clonus, Abnormal pyramidal sign, Tremor, Hypertonia, Dystonia, Bradykinesia OMIM:617435
Parkinson Disease, Late-Onset
Resting tremor, Parkinsonism, Rigidity, Dementia, Tremor, Dystonia, Bradykinesia OMIM:168600
Developmental And Epileptic Encephalopathy 42
Ataxia, Tremor, Athetosis, Hypertonia OMIM:617106
Spinocerebellar Ataxia, Autosomal Recessive 30
Titubation, Dysmetria, Tremor, Ataxia OMIM:619405
Atypical Rett Syndrome
Gait ataxia, Spasticity, Limb myoclonus, Involuntary movements, Apraxia, Tremor, Hand apraxia, Pa... ORPHA:3095
Mohr-Tranebjaerg Syndrome
Ankle clonus, Abnormal pyramidal sign, Apraxia, Dementia, Babinski sign, Focal dystonia, Tremor, ... ORPHA:52368
Parkinson Disease 20, Early-Onset
Parkinsonism, Rigidity, Eyelid apraxia, Involuntary movements, Tremor, Mental deterioration, Dyst... OMIM:615530
Sporadic Adult-Onset Ataxia Of Unknown Etiology
Gait ataxia, Spasticity, Dysdiadochokinesis, Resting tremor, Parkinsonism, Rigidity, Dementia, Ba... ORPHA:247234
Caribbean Parkinsonism
Frontal lobe dementia, Parkinsonism, Rigidity, Myoclonus, Apraxia, Progressive gait ataxia, Demen... ORPHA:97355
Neurodegeneration With Brain Iron Accumulation 4
Spasticity, Abnormal pyramidal sign, Parkinsonism, Abnormality of extrapyramidal motor function, ... OMIM:614298
Young-Onset Parkinson Disease
Spasticity, Cognitive impairment, Frontal lobe dementia, Rigidity, Apathy, Dementia, Tremor, Anxi... ORPHA:2828
Dystonia 1, Torsion, Autosomal Dominant
Blepharospasm, Writer's cramp, Torticollis, Babinski sign, Torsion dystonia, Tremor, Hypertonia, ... OMIM:128100
Cystathioninuria
Tremor ORPHA:212
Progressive Supranuclear Palsy
Blepharospasm, Cognitive impairment, Rigidity, Dementia, Tremor, Dystonia, Memory impairment, Bra... ORPHA:683
Leukoencephalopathy With Brain Stem And Spinal Cord Involvement-High Lactate Syndrome
Poor fine motor coordination, Spastic ataxia, Progressive spasticity, Truncal ataxia, Clumsiness,... ORPHA:137898
Hypermanganesemia With Dystonia 1
Poor fine motor coordination, Parkinsonism, Rigidity, Abnormality of extrapyramidal motor functio... OMIM:613280
Adult-Onset Dystonia-Parkinsonism
Spasticity, Frontotemporal dementia, Rigidity, Eyelid apraxia, Clumsiness, Parkinsonism with favo... ORPHA:199351
Progressive Supranuclear Palsy-Pure Akinesia With Gait Freezing Syndrome
Blepharospasm, Rigidity, Oculomotor apraxia, Spastic dysarthria, Dementia, Tremor, Bradykinesia ORPHA:240094
Pterin-4 Alpha-Carbinolamine Dehydratase Deficiency
Cerebral palsy, Parkinsonism, Oculogyric crisis, Tremor, Hypertonia, Irritability ORPHA:1578
Aceruloplasminemia
Gait ataxia, Chorea, Blepharospasm, Cognitive impairment, Parkinsonism, Rigidity, Torticollis, Ap... ORPHA:48818
Behr Syndrome
Progressive spasticity, Truncal ataxia, Ataxia, Babinski sign, Dysmetria, Tremor, Frequent falls OMIM:210000
Leukodystrophy, Hypomyelinating, 7, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism
Spasticity, Postural tremor, Ataxia, Babinski sign, Dysmetria, Tremor, Dystonia OMIM:607694
Spinal And Bulbar Muscular Atrophy, X-Linked 1
Tremor, Fasciculations OMIM:313200
Parkinson Disease 1, Autosomal Dominant
Resting tremor, Parkinsonism, Rigidity, Myoclonus, Dementia, Mental deterioration, Dystonia, Brad... OMIM:168601
Neurodevelopmental Disorder, Mitochondrial, With Abnormal Movements And Lactic Acidosis, With Or Without Seizures
Aggressive behavior, Spastic tetraplegia, Limb hypertonia, Ataxia, Dysmetria, Tremor, Hypertonia,... OMIM:617710
Adult-Onset Distal Myopathy Due To Vcp Mutation
Parkinsonism, Dementia, Tremor, Frequent falls, Progressive neurologic deterioration, Anxiety, Fa... ORPHA:329478
Intellectual Developmental Disorder With Or Without Epilepsy Or Cerebellar Ataxia
Abnormal pyramidal sign, Eyelid myoclonus, Oculomotor apraxia, Incoordination, Ataxia, Tremor OMIM:618060
Leukodystrophy, Hypomyelinating, 8, With Or Without Oligodontia And/Or Hypogonadotropic Hypogonadism
Gait ataxia, Spasticity, Abnormal pyramidal sign, Dysdiadochokinesis, Ataxia, Dysmetria, Tremor, ... OMIM:614381
Adult-Onset Autosomal Dominant Leukodystrophy
Gait ataxia, Spasticity, Abnormal pyramidal sign, Cognitive impairment, Spastic gait, Dysdiadocho... ORPHA:99027
Amyloidosis, Hereditary, Transthyretin-Related
Spasticity, Hemiparesis, Ataxia, Dementia, Paraplegia, Tremor OMIM:105210
Migraine, Familial Hemiplegic, 2
Gait ataxia, Hemiparesis, Apraxia, Episodic ataxia, Hemiplegia, Dysmetria, Tremor OMIM:602481
Glutaryl-Coa Dehydrogenase Deficiency
Chorea, Cognitive impairment, Rigidity, Limb dystonia, Poor motor coordination, Dementia, Ataxia,... ORPHA:25
Spastic Paraplegia 9B, Autosomal Recessive
Spasticity, Pseudobulbar paralysis, Babinski sign, Spastic paraplegia, Tremor, Tetraplegia OMIM:616586
Supranuclear Palsy, Progressive, 1
Retrocollis, Frontolimbic dementia, Parkinsonism, Rigidity, Limb dystonia, Eyelid apraxia, Apathy... OMIM:601104
Autosomal Dominant Spastic Paraplegia Type 9A
Abnormal pyramidal sign, Spastic gait, Spastic dysarthria, Dementia, Babinski sign, Tremor, Memor... ORPHA:447753
Serotonin Syndrome
Anxiety, Rigidity, Myoclonus, Tremor, Hypertonia, Clonus, Mental deterioration, Irritability ORPHA:43116
Multiple System Atrophy 1, Susceptibility To
Cognitive impairment, Parkinsonism, Rigidity, Ataxia, Babinski sign, Tremor, Bradykinesia OMIM:146500
Tay-Sachs Disease
Poor fine motor coordination, Exaggerated startle response, Ankle clonus, Progressive spasticity,... ORPHA:845
Congenital Bile Acid Synthesis Defect Type 4
Tremor, Memory impairment, Ataxia, Mental deterioration ORPHA:79095
Thyrotoxic Periodic Paralysis, Susceptibility To, 2
Periodic paralysis, Tremor OMIM:613239
O'Sullivan-Mcleod Syndrome
Tremor, Fasciculations ORPHA:99965
Niemann-Pick Disease Type C
Limb dystonia, Cataplexy, Upper motor neuron dysfunction, Axial dystonia, Frequent falls, Aggress... ORPHA:646
Ichthyotic Keratoderma, Spasticity, Hypomyelination, And Dysmorphic Facial Features
Spasticity, Ataxia, Babinski sign, Spastic paraplegia, Dysmetria, Tremor OMIM:618527
Neurodegeneration With Brain Iron Accumulation 1
Spasticity, Blepharospasm, Abnormal pyramidal sign, Parkinsonism, Rigidity, Eyelid apraxia, Abnor... OMIM:234200
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 2
Gait ataxia, Chorea, Abnormal pyramidal sign, Progressive gait ataxia, Oculomotor apraxia, Limb a... OMIM:606002
Metachromatic Leukodystrophy
Progressive spasticity, Incoordination, Emotional lability, Ataxia, Dementia, Tremor, Frequent fa... ORPHA:512
Familial Congenital Mirror Movements
Poor fine motor coordination, Clumsiness, Cerebral palsy ORPHA:238722
Mirror Movements 3
OMIM:616059

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Dnal4

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Dnal4.

No publications found that use IMPC mice or data for Dnal4.

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MGI Allele Allele Type Produced
Dnal4tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Dnal4tm1b(EUCOMM)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice
Dnal4tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Dnal4tm1e(EUCOMM)Wtsi Targeted, non-conditional allele ES Cells

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