Gene: Rnf10 MGI:1859162

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Gene Summary

Name:
ring finger protein 10
Synonyms:
N/A

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal eye morphology Rnf10em1(IMPC)Mbp HOM Early adult 0.00
hypoactivity Rnf10tm1b(KOMP)Wtsi HOM   Early adult 4.71×10-06
increased vertical activity Rnf10em1(IMPC)J HOM Early adult 2.53×10-10
decreased exploration in new environment Rnf10em1(IMPC)J HOM Late adult 3.91×10-05
decreased anxiety-related response Rnf10tm1b(KOMP)Wtsi HOM Early adult 9.89×10-06
abnormal retinal blood vessel morphology Rnf10tm1b(KOMP)Wtsi HET   Early adult 1.16×10-05
abnormal spleen morphology Rnf10tm1b(KOMP)Wtsi HOM Early adult 0.00
increased body length Rnf10tm1a(KOMP)Wtsi HOM Early adult 9.76×10-06
decreased total body fat amount Rnf10tm1a(KOMP)Wtsi HOM Early adult 3.79×10-06
increased vertical activity Rnf10tm1b(KOMP)Wtsi HOM Early adult 3.96×10-07
increased lean body mass Rnf10tm1a(KOMP)Wtsi HOM Early adult 3.72×10-07
shortened QT interval Rnf10tm1b(KOMP)Wtsi HOM Early adult 6.89×10-05
abnormal retinal blood vessel morphology Rnf10em1(IMPC)Bay HOM Early adult 1.66×10-05
decreased circulating alkaline phosphatase level Rnf10tm1b(KOMP)Wtsi HOM Early adult 3.02×10-09
increased large unstained cell number Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.82×10-08
decreased bone mineral density Rnf10tm1b(KOMP)Wtsi HOM Early adult 3.73×10-06
decreased circulating serum albumin level Rnf10tm1b(KOMP)Wtsi HOM   Early adult 2.14×10-05
decreased lymphocyte cell number Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.53×10-05
increased leukocyte cell number Rnf10tm1a(KOMP)Wtsi HOM Early adult 4.52×10-05
decreased total body fat amount Rnf10tm1b(KOMP)Wtsi HET Early adult 4.79×10-06
convulsive seizures Rnf10tm1b(KOMP)Wtsi HOM Early adult 6.45×10-05
decreased mean corpuscular volume Rnf10em1(IMPC)J HOM Late adult 2.61×10-05
abnormal bone structure Rnf10em1(IMPC)J HOM Early adult 4.15×10-05
increased circulating triglyceride level Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.03×10-05
increased circulating total protein level Rnf10tm1b(KOMP)Wtsi HET   Early adult 7.26×10-05
decreased exploration in new environment Rnf10tm1b(KOMP)Wtsi HOM Early adult 5.51×10-15
increased monocyte cell number Rnf10tm1b(KOMP)Wtsi HOM Early adult 5.51×10-05
hyperactivity Rnf10tm1b(KOMP)Wtsi HOM   Early adult 6.82×10-15
increased bone mineral content Rnf10tm1b(KOMP)Wtsi HOM Early adult 3.12×10-05
decreased circulating serum albumin level Rnf10tm1b(KOMP)Wtsi HET Early adult 5.25×10-07
decreased circulating total protein level Rnf10tm1b(KOMP)Wtsi HOM   Early adult 2.04×10-05
absent pinna reflex Rnf10tm1b(KOMP)Wtsi HOM   Early adult 3.54×10-06
decreased prepulse inhibition Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.82×10-13
limb grasping Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.09×10-06
preweaning lethality, incomplete penetrance Rnf10tm1b(KOMP)Wtsi HOM   Early adult 0.00
increased grip strength Rnf10tm1b(KOMP)Wtsi HET Early adult 3.09×10-06
increased anxiety-related response Rnf10tm1b(KOMP)Wtsi HOM   Early adult 3.77×10-05
decreased mean corpuscular hemoglobin Rnf10em1(IMPC)J HOM Late adult 6.84×10-06
abnormal auditory brainstem response Rnf10tm1b(KOMP)Wtsi HOM   Early adult 2.36×10-05
decreased circulating cholesterol level Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.03×10-06
decreased circulating triglyceride level Rnf10tm1b(KOMP)Wtsi HET Early adult 1.48×10-15
increased vertical activity Rnf10em1(IMPC)Bay HOM Early adult 2.14×10-10
decreased mean corpuscular hemoglobin Rnf10tm1b(KOMP)Wtsi HOM   Early adult 2.94×10-09
decreased mean corpuscular volume Rnf10tm1a(KOMP)Wtsi HOM Early adult 3.70×10-08
decreased prepulse inhibition Rnf10em1(IMPC)Bay HOM Early adult 7.16×10-07
decreased hemoglobin content Rnf10tm1b(KOMP)Wtsi HOM   Early adult 3.28×10-06
increased red blood cell distribution width Rnf10tm1b(KOMP)Wtsi HOM   Early adult 2.38×10-05
decreased hematocrit Rnf10tm1a(KOMP)Wtsi HOM Early adult 6.22×10-05
decreased thigmotaxis Rnf10tm1b(KOMP)Wtsi HOM   Early adult 7.44×10-06
increased heart weight Rnf10tm1b(KOMP)Wtsi HET Early adult 2.68×10-05
decreased total retina thickness Rnf10em1(IMPC)Bay HOM Early adult 5.94×10-06
abnormal freezing behavior Rnf10tm1b(KOMP)Wtsi HOM   Early adult 3.33×10-05
increased bone mineral density Rnf10tm1a(KOMP)Wtsi HOM Early adult 4.57×10-08
shortened ST segment Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.41×10-05
abnormal lens morphology Rnf10tm1b(KOMP)Wtsi HET Early adult 1.11×10-09
decreased vertical activity Rnf10tm1b(KOMP)Wtsi HOM Early adult 4.81×10-06
decreased mean corpuscular volume Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.11×10-05
decreased mean corpuscular hemoglobin concentration Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.04×10-05
increased circulating alanine transaminase level Rnf10em1(IMPC)Mbp HOM Early adult 1.46×10-30
increased circulating aspartate transaminase level Rnf10em1(IMPC)Mbp HOM Early adult 2.13×10-14
decreased body length Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.96×10-05
abnormal gait Rnf10tm1b(KOMP)Wtsi HOM   Early adult 6.20×10-06
decreased grip strength Rnf10tm1b(KOMP)Wtsi HOM   Early adult 1.70×10-08
decreased fasting circulating glucose level Rnf10tm1b(KOMP)Wtsi HOM Early adult 9.35×10-06
abnormal behavior Rnf10tm1b(KOMP)Wtsi HOM   Early adult 5.58×10-14
cataract Rnf10tm1b(KOMP)Wtsi HET Early adult 1.69×10-08
increased circulating creatinine level Rnf10tm1b(KOMP)Wtsi HOM   Early adult 2.82×10-07
abnormal tibia morphology Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.90×10-05
prolonged PQ interval Rnf10em1(IMPC)J HOM Late adult 1.53×10-05
improved glucose tolerance Rnf10tm1b(KOMP)Wtsi HOM Early adult 8.93×10-05
hyperactivity Rnf10em1(IMPC)Mbp HOM   Early adult 5.72×10-05
decreased total retina thickness Rnf10tm1b(KOMP)Wtsi HOM Early adult 6.88×10-10
abnormal kidney morphology Rnf10em1(IMPC)Mbp HOM Early adult 0.00
increased lean body mass Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.77×10-05
increased bone mineral content Rnf10em1(IMPC)J HOM Early adult 6.59×10-05
decreased circulating HDL cholesterol level Rnf10tm1b(KOMP)Wtsi HOM   Early adult 1.43×10-05
enlarged heart Rnf10tm1b(KOMP)Wtsi HET Early adult 0.00
anophthalmia Rnf10em1(IMPC)Mbp HOM Early adult 0.00
limb grasping Rnf10em1(IMPC)J HOM Early adult 5.21×10-05

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Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Adrenal gland  Wholemount images  Section images heterozygote 72.73% (16 of 22)
Adrenal gland  Wholemount images homozygote 100% (2 of 2)
Aorta  Wholemount images  Section images heterozygote 63.64% (14 of 22)
Aorta  Wholemount images homozygote 100% (2 of 2)
Bone  Wholemount images heterozygote 14.29% (2 of 14)
Bone  Wholemount images homozygote Ambiguous
Brain  Wholemount images  Section images heterozygote 86.36% (19 of 22)
Brain  Wholemount images homozygote 100% (2 of 2)
Brainstem  Wholemount images heterozygote 59.09% (13 of 22)
Brown adipose tissue  Wholemount images  Section images heterozygote 63.64% (14 of 22)
Brown adipose tissue  Wholemount images homozygote 100% (2 of 2)
Cartilage tissue  Wholemount images  Section images heterozygote 50% (11 of 22)
Cecum  Wholemount images  Section images heterozygote 66.67% (8 of 12)
Cecum  Wholemount images homozygote 100% (2 of 2)
Cerebellum  Wholemount images  Section images heterozygote 77.27% (17 of 22)
Cerebral cortex  Wholemount images heterozygote 59.09% (13 of 22)
Chest bone  Wholemount images heterozygote 80% (8 of 10)
Chest bone  Wholemount images homozygote 100% (2 of 2)
Colon  Section images heterozygote 80% (8 of 10)
Diaphragm  Wholemount images  Section images heterozygote 80% (8 of 10)
Diaphragm  Wholemount images homozygote 100% (2 of 2)
Duodenum  Wholemount images  Section images heterozygote 75% (6 of 8)
Duodenum  Wholemount images homozygote 100% (2 of 2)
Epididymis  Wholemount images  Section images heterozygote 25% (3 of 12)
Epididymis  Wholemount images homozygote Not available
Esophagus  Wholemount images  Section images heterozygote 77.78% (14 of 18)
Esophagus  Wholemount images homozygote 100% (2 of 2)
Eye  Wholemount images  Section images heterozygote 13.64% (3 of 22)
Eye  Wholemount images homozygote 100% (2 of 2)
Gall bladder  Wholemount images heterozygote 44.44% (8 of 18)
Gall bladder  Wholemount images homozygote 100% (2 of 2)
Gonadal fat pad  Wholemount images  Section images heterozygote 62.5% (5 of 8)
Gonadal fat pad  Wholemount images homozygote 100% (2 of 2)
Harderian gland  Wholemount images  Section images heterozygote 80% (8 of 10)
Harderian gland  Wholemount images homozygote 100% (2 of 2)
Heart  Wholemount images heterozygote 77.27% (17 of 22)
Heart  Wholemount images homozygote 100% (2 of 2)
Hindlimb  Wholemount images heterozygote 40% (4 of 10)
Hindlimb  Wholemount images homozygote 100% (2 of 2)
Hippocampus  Wholemount images heterozygote 59.09% (13 of 22)
Hypothalamus  Wholemount images  Section images heterozygote 59.09% (13 of 22)
Ileum  Wholemount images  Section images heterozygote 87.5% (7 of 8)
Ileum  Wholemount images homozygote 100% (2 of 2)
Jejunum  Wholemount images  Section images heterozygote 75% (6 of 8)
Jejunum  Wholemount images homozygote 100% (2 of 2)
Kidney  Wholemount images  Section images heterozygote 95.45% (21 of 22)
Kidney  Wholemount images homozygote 100% (2 of 2)
Large intestine  Wholemount images heterozygote 68.18% (15 of 22)
Large intestine  Wholemount images homozygote 100% (2 of 2)
Liver  Wholemount images  Section images heterozygote 50% (11 of 22)
Liver  Wholemount images homozygote 100% (2 of 2)
Lower urinary tract  Wholemount images heterozygote 59.09% (13 of 22)
Lung  Wholemount images  Section images heterozygote 72.73% (16 of 22)
Lung  Wholemount images homozygote 100% (2 of 2)
Lymph node  Wholemount images heterozygote 0.0% (0 of 22)
Lymph node  Wholemount images homozygote Ambiguous
Main olfactory bulb  Wholemount images heterozygote 66.67% (4 of 6)
Main olfactory bulb  Wholemount images homozygote 100% (2 of 2)
Mammary gland  Wholemount images  Section images heterozygote 13.64% (3 of 22)
Mammary gland  Wholemount images homozygote 50% (1 of 2)
Mesenteric adipose tissue  Wholemount images  Section images heterozygote 75% (6 of 8)
Mesenteric adipose tissue  Wholemount images homozygote 100% (2 of 2)
Mesenteric lymph node  Wholemount images heterozygote 0.0% (0 of 10)
Mesenteric lymph node  Wholemount images homozygote Ambiguous
Midbrain  Wholemount images  Section images heterozygote 90% (9 of 10)
Olfactory lobe  Wholemount images heterozygote 68.18% (15 of 22)
Ovary  Wholemount images  Section images heterozygote 40.91% (9 of 22)
Ovary  Wholemount images homozygote 50% (1 of 2)
Oviduct  Wholemount images  Section images heterozygote 40.91% (9 of 22)
Oviduct  Wholemount images homozygote 50% (1 of 2)
Pancreas  Wholemount images heterozygote 31.82% (7 of 22)
Pancreas  Wholemount images homozygote 100% (2 of 2)
Parathyroid gland  Wholemount images heterozygote 77.78% (14 of 18)
Parathyroid gland  Wholemount images homozygote 100% (2 of 2)
Parotid gland  Wholemount images  Section images heterozygote 10% (1 of 10)
Parotid gland  Wholemount images homozygote Ambiguous
Penis  Wholemount images  Section images heterozygote 40% (4 of 10)
Penis  Wholemount images homozygote 50% (1 of 2)
Peripheral nervous system  Wholemount images  Section images heterozygote 59.09% (13 of 22)
Pituitary gland  Wholemount images  Section images heterozygote 68.18% (15 of 22)
Pituitary gland  Wholemount images homozygote 100% (2 of 2)
Prostate gland  Wholemount images heterozygote 31.82% (7 of 22)
Prostate gland  Wholemount images homozygote 50% (1 of 2)
Quadriceps  Wholemount images  Section images heterozygote 100% (8 of 8)
Quadriceps  Wholemount images homozygote 100% (2 of 2)
Sciatic nerve  Wholemount images heterozygote 20% (2 of 10)
Sciatic nerve  Wholemount images homozygote 100% (2 of 2)
Skeletal muscle  Wholemount images  Section images heterozygote 72.22% (13 of 18)
Skin  Wholemount images  Section images heterozygote 63.64% (14 of 22)
Skin  Wholemount images homozygote 100% (2 of 2)
Small intestine  Wholemount images heterozygote 59.09% (13 of 22)
Spinal cord  Wholemount images  Section images heterozygote 90.91% (20 of 22)
Spinal cord  Wholemount images homozygote 100% (2 of 2)
Spleen  Wholemount images heterozygote 40.91% (9 of 22)
Spleen  Wholemount images homozygote 100% (2 of 2)
Stomach  Wholemount images  Section images heterozygote 68.18% (15 of 22)
Stomach  Wholemount images homozygote 100% (2 of 2)
Striatum  Wholemount images  Section images heterozygote 59.09% (13 of 22)
Sublingual gland  Wholemount images  Section images heterozygote 10% (1 of 10)
Sublingual gland  Wholemount images homozygote Ambiguous
Submandibular gland  Wholemount images  Section images heterozygote 25% (3 of 12)
Submandibular gland  Wholemount images homozygote Ambiguous
Testis  Wholemount images  Section images heterozygote 50% (11 of 22)
Testis  Wholemount images homozygote 50% (1 of 2)
Thymus  Wholemount images heterozygote 4.55% (1 of 22)
Thymus  Wholemount images homozygote Ambiguous
Thyroid gland  Wholemount images  Section images heterozygote 31.82% (7 of 22)
Thyroid gland  Wholemount images homozygote Ambiguous
Tongue  Wholemount images  Section images heterozygote 80% (8 of 10)
Tongue  Wholemount images homozygote 100% (2 of 2)
Trachea  Wholemount images  Section images heterozygote 86.36% (19 of 22)
Trachea  Wholemount images homozygote 100% (2 of 2)
Trigeminal V nerve  Wholemount images  Section images heterozygote 66.67% (8 of 12)
Trigeminal V nerve  Wholemount images homozygote 100% (2 of 2)
Urinary bladder  Wholemount images  Section images heterozygote 75% (9 of 12)
Urinary bladder  Wholemount images homozygote 100% (2 of 2)
Uterus  Wholemount images  Section images heterozygote 40.91% (9 of 22)
Uterus  Wholemount images homozygote 50% (1 of 2)
Vagina  Wholemount images heterozygote 20% (2 of 10)
Vagina  Wholemount images homozygote 50% (1 of 2)
Vas deferens  Section images heterozygote 16.67% (2 of 12)
Vascular system  Wholemount images  Section images heterozygote 38.89% (7 of 18)
Vesicular gland  Wholemount images  Section images heterozygote 16.67% (2 of 12)
Vesicular gland  Wholemount images homozygote 50% (1 of 2)
White adipose tissue  Wholemount images heterozygote 18.18% (4 of 22)
White adipose tissue  Wholemount images homozygote 100% (2 of 2)
Blood vessel N/A heterozygote 100% (4 of 4)
N/A Ambiguous
Blood N/A heterozygote 0.0% (0 of 6)
N/A Ambiguous
Bone marrow N/A heterozygote 0.0% (0 of 6)
N/A Ambiguous
Brainstem N/A homozygote 100% (2 of 2)
Cartilage tissue N/A homozygote Ambiguous
Cerebellum N/A homozygote 100% (2 of 2)
Cerebral cortex N/A homozygote 100% (2 of 2)
Colon N/A homozygote 100% (2 of 2)
Cranium N/A heterozygote 0.0% (0 of 6)
Cranium N/A homozygote Ambiguous
Hippocampus N/A homozygote 100% (2 of 2)
Hypothalamus N/A homozygote 100% (2 of 2)
Lower urinary tract N/A homozygote 100% (2 of 2)
Midbrain N/A homozygote 100% (2 of 2)
Esophagus N/A heterozygote 100% (4 of 4)
N/A Ambiguous
Olfactory lobe N/A homozygote 100% (2 of 2)
Oral epithelium N/A heterozygote 0.0% (0 of 10)
Oral epithelium N/A homozygote 0.0% (0 of 2)
Peripheral nervous system N/A homozygote 100% (2 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 4)
N/A Ambiguous
Peyer's patch N/A heterozygote 0.0% (0 of 18)
Peyer's patch N/A homozygote 0.0% (0 of 2)
Skeletal muscle tissue N/A heterozygote 100% (4 of 4)
N/A Ambiguous
Skeletal muscle N/A homozygote 100% (2 of 2)
Small intestine N/A homozygote 100% (2 of 2)
Stomach pyloric region N/A heterozygote 0.0% (0 of 10)
Stomach pyloric region N/A homozygote 0.0% (0 of 2)
Striatum N/A homozygote 100% (2 of 2)
Thalamus N/A heterozygote 83.33% (5 of 6)
Thalamus N/A homozygote 100% (2 of 2)
Vas deferens N/A homozygote Not available
Vascular system N/A homozygote 100% (2 of 2)

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
N/A heterozygote 100% (9 of 9)
N/A homozygote 66.67% (2 of 3)
N/A heterozygote 100% (9 of 9)
N/A heterozygote 77.78% (7 of 9)
N/A heterozygote 100% (9 of 9)
N/A heterozygote 77.78% (7 of 9)
N/A heterozygote 33.33% (3 of 9)
N/A heterozygote 100% (9 of 9)
N/A heterozygote 11.11% (1 of 9)
N/A heterozygote 77.78% (7 of 9)
N/A heterozygote 77.78% (7 of 9)
N/A heterozygote 66.67% (6 of 9)
N/A heterozygote 100% (9 of 9)
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A heterozygote 77.78% (7 of 9)
N/A homozygote 33.33% (1 of 3)
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A heterozygote 0.0% (0 of 3)
N/A Ambiguous
N/A heterozygote 66.67% (6 of 9)
N/A homozygote 33.33% (1 of 3)
N/A heterozygote 100% (2 of 2)
N/A Ambiguous
N/A homozygote 33.33% (1 of 3)
N/A heterozygote 44.44% (4 of 9)
N/A homozygote Ambiguous
N/A heterozygote 100% (5 of 5)
N/A Ambiguous
N/A homozygote 33.33% (1 of 3)
N/A homozygote 66.67% (2 of 3)
N/A heterozygote 66.67% (2 of 3)
N/A Ambiguous
N/A heterozygote 100% (2 of 2)
N/A Ambiguous
N/A heterozygote 44.44% (4 of 9)
N/A homozygote Ambiguous
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A homozygote 66.67% (2 of 3)
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A homozygote 33.33% (1 of 3)
N/A heterozygote 77.78% (7 of 9)
N/A homozygote 33.33% (1 of 3)
N/A homozygote 66.67% (2 of 3)
N/A heterozygote 100% (2 of 2)
N/A Ambiguous
N/A homozygote 33.33% (1 of 3)
N/A heterozygote 100% (5 of 5)
N/A Ambiguous
N/A heterozygote 11.11% (1 of 9)
N/A homozygote 33.33% (1 of 3)
N/A homozygote 33.33% (1 of 3)
N/A homozygote 33.33% (1 of 3)
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A homozygote 33.33% (1 of 3)
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A heterozygote 100% (3 of 3)
N/A Ambiguous
N/A heterozygote 100% (2 of 2)
N/A Ambiguous
N/A heterozygote 22.22% (2 of 9)
N/A homozygote 33.33% (1 of 3)
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A heterozygote 0.0% (0 of 1)
N/A Ambiguous
N/A heterozygote 100% (2 of 2)
N/A Ambiguous
N/A heterozygote Not available
N/A Ambiguous
N/A heterozygote 100% (2 of 2)
N/A Ambiguous
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A heterozygote 33.33% (3 of 9)
N/A homozygote 33.33% (1 of 3)
N/A heterozygote 33.33% (1 of 3)
N/A Ambiguous
N/A heterozygote 66.67% (6 of 9)
N/A homozygote 66.67% (2 of 3)
N/A homozygote 66.67% (2 of 3)
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A heterozygote 0.0% (0 of 1)
N/A Ambiguous
N/A heterozygote 0.0% (0 of 2)
N/A Ambiguous
N/A heterozygote 60% (3 of 5)
N/A Ambiguous
N/A heterozygote 60% (3 of 5)
N/A Ambiguous
N/A heterozygote 100% (2 of 2)
N/A Ambiguous

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.68% (4 of 584)
aorta 0.17% (1 of 584)
blood 0.0%
blood vessel 0.0%
bone 0.0%
bone marrow 0.0%
brain 0.68% (4 of 584)
brainstem 0.34% (2 of 584)
brown adipose tissue 0.0%
cartilage tissue 0.17% (1 of 584)
cecum 2.97% (11 of 370)
cerebellum 0.51% (3 of 584)
cerebral cortex 0.34% (2 of 584)
chest bone Unavailable
colon 8.73% (11 of 126)
cranium
diaphragm 0.0%
duodenum 0.79% (1 of 126)
epididymis 12.78% (17 of 133)
esophagus 1.72% (7 of 408)
eye 0.0%
gall bladder 0.0%
gonadal fat pad 0.0%
harderian gland 0.0%
heart 0.34% (2 of 584)
hindlimb 0.0%
hippocampus 0.51% (3 of 584)
hypothalamus 0.34% (2 of 584)
ileum 10.32% (13 of 126)
jejunum 3.97% (5 of 126)
kidney 3.6% (21 of 584)
large intestine 1.71% (10 of 584)
liver 0.0%
lower urinary tract 0.17% (1 of 584)
lung 0.34% (2 of 584)
lymph node 0.17% (1 of 584)
main olfactory bulb 0.0%
mammary gland 0.0%
mesenteric adipose tissue 0.0%
mesenteric lymph node 0.0%
midbrain 0.0%
oesophagus 0.0%
olfactory lobe 0.34% (2 of 584)
oral epithelium 0.0%
ovary 0.17% (1 of 584)
oviduct 0.0%
pancreas 0.86% (5 of 584)
parathyroid gland 0.18% (1 of 562)
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.34% (2 of 584)
peyer's patch 0.57% (1 of 176)
peyers patch 0.0%
pituitary gland 0.17% (1 of 584)
prostate gland 2.05% (12 of 584)
quadriceps 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skeletal muscle tissue 0.0%
skin 0.17% (1 of 584)
small intestine 1.54% (9 of 584)
spinal cord 0.51% (3 of 584)
spleen 0.51% (3 of 584)
stomach 2.05% (12 of 584)
stomach pyloric region 0.0%
striatum 0.51% (3 of 584)
sublingual gland 0.0%
submandibular gland 1.53% (2 of 131)
testis 1.03% (6 of 584)
thalamus 0.0%
thymus 0.17% (1 of 584)
thyroid gland 2.74% (16 of 584)
tongue 3.97% (5 of 126)
trachea 0.51% (3 of 584)
trigeminal v nerve 0.0%
urinary bladder 0.0%
uterus 0.0%
vagina 0.0%
vas deferens 3.67% (14 of 381)
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
atrium 1.69% (1 of 59)
axial skeleton 1.59% (1 of 63)
brain 1.18% (6 of 507)
central nervous system ganglion 1.39% (1 of 72)
dorsal root ganglion 1.69% (1 of 59)
ear 0.2% (1 of 507)
embryo 0.2% (1 of 508)
external ear 1.37% (1 of 73)
eye 0.2% (1 of 507)
footplate 0.2% (1 of 507)
forearm 0.33% (1 of 304)
forebrain 0.2% (1 of 507)
forelimb 0.2% (1 of 507)
fronto-nasal process 1.67% (1 of 60)
gut 1.72% (1 of 58)
handplate 0.2% (1 of 507)
head 0.99% (5 of 507)
head mesenchyme 1.69% (1 of 59)
heart 0.2% (1 of 507)
heart ventricle 1.69% (1 of 59)
hindbrain 1.18% (6 of 507)
hindlimb 0.2% (1 of 507)
intestine 1.75% (1 of 57)
liver 0.2% (1 of 502)
lower leg 0.33% (1 of 304)
lung 0.2% (1 of 502)
mandibular process 0.2% (1 of 507)
maxillary process 0.2% (1 of 507)
meckel's cartilage 0.0%
midbrain 0.2% (1 of 507)
nasal septum 1.69% (1 of 59)
nose 1.3% (1 of 77)
notochord 1.69% (1 of 59)
oral cavity 0.2% (1 of 502)
outflow tract 1.69% (1 of 59)
pericardium 1.85% (1 of 54)
pharynx 1.82% (1 of 55)
placenta 16.67% (7 of 42)
radius-ulna pre cartilage condensation 1.59% (1 of 63)
rib pre-cartilage condensation 1.79% (1 of 56)
skeleton 1.3% (1 of 77)
skin 0.2% (1 of 507)
spinal cord 1.41% (1 of 71)
tail 0.2% (1 of 507)
tail somite group 0.2% (1 of 507)
thoracic vertebral cartilage condensation 1.85% (1 of 54)
tongue 1.85% (1 of 54)
trachea 1.72% (1 of 58)
trunk mesenchyme 1.69% (1 of 59)
upper arm 0.33% (1 of 304)
upper leg 0.33% (1 of 304)
vibrissa 1.37% (1 of 73)

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

75 Images

Adult LacZ

LacZ Images Section

176 Images

Adult LacZ

LacZ Images Wholemount

547 Images

X-ray

XRay Images Whole Body Dorso Ventral

119 Images

X-ray

XRay Images Whole Body Lateral Orientation

119 Images

Combined SHIRPA and Dysmorphology

Images

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

85 Images

X-ray

XRay Images Forepaw

57 Images

X-ray

XRay Images Hind Leg and Hip

16 Images

Embryo LacZ

LacZ images wholemount

87 Images

Echo

M-Mode Images

32 Images

Eye Morphology

Images Ophthalmoscopy

12 Images

Sleep Wake

Wake state (bmp file)

19 Images

Gross Pathology and Tissue Collection

Images

14 Images

Histopathology

Images

1 Images

Eye Morphology

Images Slit Lamp

7 Images

Immunophenotyping

Panel B FCS file(s)

18 Images

Immunophenotyping

Panel A FCS file(s)

18 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

Legacy Phenotype Associated Images

View all 155 images

View all 9 images

Human diseases caused by Rnf10 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Rnf10 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Retinal Dysplasia, Primary
OMIM:312550
Hemoglobin-Delta locus
OMIM:142000
Hemoglobin E-Beta-Thalassemia Syndrome
ORPHA:231249
Thalassemia, Beta+, Silent Allele
OMIM:187550
Fetal Hemoglobin Quantitative Trait Locus 1
OMIM:141749
Pentosuria
ORPHA:2843
Buschke-Ollendorff Syndrome
OMIM:166700
Acetophenetidin Sensitivity
OMIM:200300
Hemophagocytic Lymphohistiocytosis, Familial, 1
OMIM:267700
Delta-Beta-Thalassemia
ORPHA:231237
Hemoglobin H Disease
OMIM:613978
Hemoglobin C-Beta-Thalassemia Syndrome
ORPHA:231242
Attention Deficit-Hyperactivity Disorder
OMIM:143465
Citrullinemia Type Ii
ORPHA:247585
Hemophagocytic Lymphohistiocytosis, Familial, 2
OMIM:603553
Microphthalmia-Ankyloblepharon-Intellectual Disability Syndrome
ORPHA:85275
Obesity-Colitis-Hypothyroidism-Cardiac Hypertrophy-Developmental Delay Syndrome
ORPHA:88643
Methemoglobinemia, Beta Type
OMIM:617971
Methemoglobinemia, Alpha Type
OMIM:617973
Mental Retardation, Autosomal Dominant 45
OMIM:617600
Beta-Thalassemia-X-Linked Thrombocytopenia Syndrome
ORPHA:231393
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
OMIM:301008
Cataract 20, Multiple Types
OMIM:116100
Encephalopathy, Progressive, With Or Without Lipodystrophy
OMIM:615924
Microphthalmia, Isolated 1
OMIM:251600
Coronary Artery Disease, Autosomal Dominant 2
OMIM:610947
Ch├ędiak-Higashi Syndrome
ORPHA:167
Melorheostosis With Osteopoikilosis
ORPHA:1879
Alpha-N-Acetylgalactosaminidase Deficiency Type 3
ORPHA:79281
Hereditary Persistence Of Fetal Hemoglobin-Beta-Thalassemia Syndrome
ORPHA:46532
Analbuminemia
OMIM:616000
Acquired Aneurysmal Subarachnoid Hemorrhage
ORPHA:90065
Alpha-Thalassemia Myelodysplasia Syndrome
OMIM:300448
Genetic Hyperferritinemia Without Iron Overload
ORPHA:254704
Monosomy 7 Myelodysplasia And Leukemia Syndrome 1
OMIM:252270
Deafness, Cataract, Retinitis Pigmentosa, And Sperm Abnormalities
OMIM:300719
Refractory Celiac Disease
ORPHA:398063
Immunodeficiency 27A
OMIM:209950
Ghosal Hematodiaphyseal Dysplasia
OMIM:231095
Mental Retardation, Autosomal Recessive 54
OMIM:617028
Schizophrenia 15
OMIM:613950
Dengue Fever
ORPHA:99828
Dominant Beta-Thalassemia
ORPHA:231226
Hypertrophic Neuropathy And Cataract
OMIM:239900
Triokinase And Fmn Cyclase Deficiency Syndrome
OMIM:618805
Ethanolaminosis
OMIM:227150
Spinocerebellar Ataxia, Autosomal Recessive, With Axonal Neuropathy 1
OMIM:607250
Alpha-Thalassemia
ORPHA:846
Diamond-Blackfan Anemia 3
OMIM:610629
Neutral Lipid Storage Disease With Myopathy
OMIM:610717
Omenn Syndrome
OMIM:603554
Nephrotic Syndrome, Type 14
OMIM:617575
Hemophagocytic Lymphohistiocytosis, Familial, 4
OMIM:603552
Severe Neurodegenerative Syndrome With Lipodystrophy
ORPHA:363400
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
DECIPHER:20
Mental Retardation, Autosomal Recessive 3
OMIM:608443
Long Qt Syndrome 10
OMIM:611819
Maternal Uniparental Disomy Of Chromosome 4
ORPHA:96180
Dentin Dysplasia
ORPHA:1653
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
DECIPHER:19
Focal Segmental Glomerulosclerosis 1
OMIM:603278
Hereditary Hyperferritinemia-Cataract Syndrome
ORPHA:163
Cataract 35
OMIM:609376
Cataract 36
OMIM:613887
Cataract 29
OMIM:115800
Cataract 18
OMIM:610019
Microphthalmia, Isolated, With Coloboma 10
OMIM:616428
Diarrhea 7, Protein-Losing Enteropathy Type
OMIM:615863
Aplasia Cutis Congenita-Intestinal Lymphangiectasia Syndrome
ORPHA:1116
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
ORPHA:26793
Incessant Infant Ventricular Tachycardia
ORPHA:45453
Body Mass Index Quantitative Trait Locus 20
OMIM:618406
Spinocerebellar Ataxia With Axonal Neuropathy Type 1
ORPHA:94124
Thumb, Hypoplastic, With Choroid Coloboma, Poorly Developed Antihelix, And Deafness
OMIM:274205
Nephrotic Syndrome, Type 2
OMIM:600995
Cataract And Congenital Ichthyosis
OMIM:212400
Hemolytic Anemia Due To Red Cell Pyruvate Kinase Deficiency
ORPHA:766
Mental Retardation, Autosomal Dominant 52
OMIM:617796
Congenital Disorder Of Glycosylation, Type Ij
OMIM:608093
Microphthalmia, Isolated, With Coloboma 5
OMIM:611638
Ossification Of The Posterior Longitudinal Ligament Of Spine
OMIM:602475
Ataxia, Early-Onset, With Oculomotor Apraxia And Hypoalbuminemia
OMIM:208920
Arrhythmogenic Right Ventricular Dysplasia, Familial, 12
OMIM:611528
Autoinflammation With Infantile Enterocolitis
OMIM:616050
Metaphyseal Modeling Abnormality, Skin Lesions, And Spastic Paraplegia
OMIM:250500
Aniridia 3
OMIM:617142
12q14 microdeletion syndrome
DECIPHER:76
X-Linked Retinoschisis
ORPHA:792
Glycosylphosphatidylinositol Biosynthesis Defect 17
OMIM:618010
Melorheostosis
ORPHA:2485
Osteomesopyknosis
OMIM:166450
Foveal Hypoplasia-Presenile Cataract Syndrome
ORPHA:2253
Enteropathy, Familial, With Villous Edema And Immunoglobulin G2 Deficiency
OMIM:600351
Lymphangiectasia, Intestinal
OMIM:152800
Brugada Syndrome
ORPHA:130
Niemann-Pick Disease, Type B
OMIM:607616
Recessive Mitochondrial Ataxia Syndrome
ORPHA:94125
Pyknoachondrogenesis
OMIM:265880
Spastic Tetraplegia, Thin Corpus Callosum, And Progressive Microcephaly
OMIM:616657
Congenital Amegakaryocytic Thrombocytopenia
ORPHA:3319
Mucopolysaccharidosis-Plus Syndrome
OMIM:617303
Immunodeficiency 8
OMIM:615401
Exudative Vitreoretinopathy 2, X-Linked
OMIM:305390
Familial Pseudohyperkalemia
ORPHA:90044
Emery-Dreifuss Muscular Dystrophy 3, Autosomal Recessive
OMIM:616516
Wolcott-Rallison Syndrome
ORPHA:1667
Monosomy 7 Myelodysplasia And Leukemia Syndrome 2
OMIM:619041
Primary Intestinal Lymphangiectasia
ORPHA:90362
Dehydrated Hereditary Stomatocytosis 2
OMIM:616689
Galactosemia Iv
OMIM:618881
Smith-Magenis Syndrome
OMIM:182290
Idiopathic Neonatal Atrial Flutter
ORPHA:45452
Congenital Enterovirus Infection
ORPHA:292
Morbid Obesity And Spermatogenic Failure
OMIM:615703
Hemophagocytic Lymphohistiocytosis, Familial, 3
OMIM:608898
Rajab Interstitial Lung Disease With Brain Calcifications 2
OMIM:619013
Landau-Kleffner Syndrome
ORPHA:98818
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
ORPHA:356996
Ras-Associated Autoimmune Leukoproliferative Disorder
OMIM:614470
Leishmaniasis
ORPHA:507
Intermediate Osteopetrosis
ORPHA:210110
Cyanosis, Transient Neonatal
OMIM:613977
Glycogen Storage Disease Vi
OMIM:232700
Sclerosteosis
ORPHA:3152
Abetalipoproteinemia
ORPHA:14
Chylomicron Retention Disease
OMIM:246700
Lipodystrophy, Familial Partial, Type 7
OMIM:606721
Hemophagocytic Lymphohistiocytosis, Familial, 5, With Or Without Microvillus Inclusion Disease
OMIM:613101
Sickle Cell Anemia
ORPHA:232
Osteosclerosis-Ichthyosis-Premature Ovarian Failure Syndrome
ORPHA:75325
Mental Retardation, Autosomal Recessive 37
OMIM:615493
Anemia, Sideroblastic, 3, Pyridoxine-Refractory
OMIM:616860
Inflammatory Bowel Disease (Infantile Ulcerative Colitis) 31, Autosomal Recessive
OMIM:619398
Ceroid Lipofuscinosis, Neuronal, 3
OMIM:204200
Retinal Vasculopathy With Cerebral Leukoencephalopathy And Systemic Manifestations
ORPHA:247691
Intrinsic Factor Deficiency
OMIM:261000
Osteomesopyknosis
ORPHA:2777
Birdshot Chorioretinopathy
ORPHA:179
Central Retinal Vein Occlusion
ORPHA:411527
Schnitzler Syndrome
ORPHA:37748
Pseudohypoparathyroidism Type 1B
ORPHA:94089
Congenital Disorder Of Glycosylation, Type Ih
OMIM:608104
Complement Hyperactivation, Angiopathic Thrombosis, And Protein-Losing Enteropathy
OMIM:226300
Osteopetrosis, Autosomal Recessive 8
OMIM:615085
Multiple Endocrine Neoplasia Type 1
ORPHA:652
Autoimmune Hypoparathyroidism
ORPHA:36913
Hyperprolinemia, Type I
OMIM:239500
Proteasome-Associated Autoinflammatory Syndrome 5
OMIM:619175
Galactosemia Ii
OMIM:230200