Gene: Rnf10

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Phenotype System Allele Zyg Sex Life Stage P Value
abnormal auditory brainstem response Rnf10tm1b(KOMP)Wtsi HOM   Early adult 2.36×10-05
decreased spleen weight Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.76×10-05
preweaning lethality, incomplete penetrance Rnf10tm1b(KOMP)Wtsi HOM   Early adult 0.00
decreased total body fat amount Rnf10tm1b(KOMP)Wtsi HET Early adult 4.79×10-06
abnormal kidney morphology Rnf10em1(IMPC)Mbp HOM Early adult 0.00
improved glucose tolerance Rnf10tm1b(KOMP)Wtsi HOM Early adult 4.96×10-05
increased erythrocyte cell number Rnf10tm1b(KOMP)Wtsi HET   Early adult 1.62×10-05
increased bone mineral density Rnf10tm1a(KOMP)Wtsi HOM Early adult 1.67×10-08
increased bone mineral content Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.95×10-11
increased grip strength Rnf10tm1b(KOMP)Wtsi HET Early adult 2.52×10-05
abnormal tibia morphology Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.90×10-05
decreased hematocrit Rnf10tm1b(KOMP)Wtsi HOM Early adult 5.60×10-05
decreased circulating aspartate transaminase level Rnf10tm1a(KOMP)Wtsi HOM Early adult 2.62×10-05
increased bone mineral content Rnf10tm1a(KOMP)Wtsi HOM Early adult 5.33×10-05
increased bone mineral content Rnf10em1(IMPC)J HOM Early adult 1.31×10-06
enlarged heart Rnf10tm1b(KOMP)Wtsi HET Early adult 0.00
anophthalmia Rnf10em1(IMPC)Mbp HOM Early adult 0.00
increased red blood cell distribution width Rnf10tm1b(KOMP)Wtsi HOM   Early adult 3.22×10-05
decreased circulating HDL cholesterol level Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.78×10-05
shortened ST segment Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.92×10-05
increased mean platelet volume Rnf10tm1b(KOMP)Wtsi HOM Early adult 4.01×10-05
increased lean body mass Rnf10tm1b(KOMP)Wtsi HOM Early adult 3.11×10-10
abnormal retinal blood vessel morphology Rnf10tm1b(KOMP)Wtsi HET   Early adult 1.13×10-05
decreased prepulse inhibition Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.59×10-06
decreased circulating iron level Rnf10tm1b(KOMP)Wtsi HET Early adult 1.46×10-06
decreased lean body mass Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.24×10-06
increased liver weight Rnf10tm1b(KOMP)Wtsi HET   Early adult 9.20×10-07
increased circulating creatinine level Rnf10tm1b(KOMP)Wtsi HOM Early adult 9.75×10-07
increased exploration in new environment Rnf10tm1b(KOMP)Wtsi HOM Early adult 5.59×10-06
decreased mean corpuscular hemoglobin Rnf10tm1b(KOMP)Wtsi HOM   Early adult 3.30×10-05
abnormal retinal vasculature morphology Rnf10tm1b(KOMP)Wtsi HOM   Early adult 6.48×10-05
decreased circulating serum albumin level Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.44×10-09
decreased prepulse inhibition Rnf10em1(IMPC)Bay HOM Early adult 9.70×10-07
abnormal QT variability Rnf10em1(IMPC)J HOM   Late adult 2.36×10-05
abnormal bone structure Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.56×10-05
increased heart rate Rnf10tm1b(KOMP)Wtsi HOM Early adult 3.40×10-05
decreased startle reflex Rnf10tm1b(KOMP)Wtsi HOM Early adult 8.39×10-29
increased vertical activity Rnf10em1(IMPC)J HOM Early adult 3.39×10-10
increased heart left ventricle size Rnf10em1(IMPC)Bay HOM   Early adult 2.10×10-05
decreased grip strength Rnf10tm1b(KOMP)Wtsi HOM Early adult 3.98×10-09
thin ventricular wall Rnf10tm1b(KOMP)Wtsi HOM Early adult 3.40×10-06
convulsive seizures Rnf10tm1b(KOMP)Wtsi HOM   Early adult 3.88×10-05
abnormal retinal inner nuclear layer morphology Rnf10tm1b(KOMP)Wtsi HOM   Early adult 9.84×10-05
abnormal gait Rnf10tm1b(KOMP)Wtsi HOM   Early adult 6.02×10-06
absent pinna reflex Rnf10tm1b(KOMP)Wtsi HOM   Early adult 3.54×10-06
increased total body fat amount Rnf10em1(IMPC)J HOM Late adult 6.73×10-05
decreased circulating total protein level Rnf10tm1b(KOMP)Wtsi HOM   Early adult 1.95×10-08
decreased circulating alkaline phosphatase level Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.55×10-07
decreased spleen weight Rnf10tm1b(KOMP)Wtsi HET   Early adult 5.91×10-07
decreased total body fat amount Rnf10tm1b(KOMP)Wtsi HOM Early adult 6.06×10-10
abnormal retinal outer nuclear layer morphology Rnf10em1(IMPC)Bay HOM Early adult 1.58×10-06
increased circulating unsaturated transferrin level Rnf10tm1b(KOMP)Wtsi HET Early adult 1.29×10-05
abnormal bone structure Rnf10em1(IMPC)J HOM Early adult 4.24×10-05
cataract Rnf10tm1b(KOMP)Wtsi HET Early adult 1.87×10-08
decreased total body fat amount Rnf10tm1a(KOMP)Wtsi HOM Early adult 1.88×10-06
increased circulating sodium level Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.47×10-16
prolonged PQ interval Rnf10em1(IMPC)J HOM Late adult 1.56×10-05
decreased circulating serum albumin level Rnf10tm1b(KOMP)Wtsi HET Early adult 4.09×10-05
abnormal sleep behavior Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.47×10-05
increased monocyte cell number Rnf10tm1b(KOMP)Wtsi HOM Early adult 7.65×10-05
decreased exploration in new environment Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.22×10-05
decreased circulating creatinine level Rnf10tm1b(KOMP)Wtsi HET   Early adult 6.32×10-05
abnormal behavior Rnf10tm1b(KOMP)Wtsi HOM Early adult 5.85×10-14
decreased lymphocyte cell number Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.74×10-05
increased circulating triglyceride level Rnf10tm1b(KOMP)Wtsi HOM Early adult 8.38×10-05
increased body length Rnf10tm1a(KOMP)Wtsi HOM Early adult 5.03×10-06
increased circulating chloride level Rnf10tm1b(KOMP)Wtsi HOM Early adult 4.28×10-08
increased liver weight Rnf10em1(IMPC)Mbp HOM   Early adult 8.84×10-08
increased vertical activity Rnf10em1(IMPC)Bay HOM Early adult 4.13×10-05
abnormal retinal inner nuclear layer morphology Rnf10em1(IMPC)Bay HOM Early adult 5.57×10-05
decreased circulating triglyceride level Rnf10tm1b(KOMP)Wtsi HET Early adult 1.65×10-15
decreased startle reflex Rnf10em1(IMPC)Bay HOM Early adult 4.91×10-11
decreased circulating cholesterol level Rnf10tm1b(KOMP)Wtsi HOM   Early adult 3.25×10-06
increased heart weight Rnf10tm1b(KOMP)Wtsi HET Early adult 2.68×10-05
limb grasping Rnf10em1(IMPC)J HOM Early adult 5.54×10-05
decreased circulating glucose level Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.41×10-11
decreased mean corpuscular hemoglobin Rnf10em1(IMPC)J HOM Late adult 1.94×10-05
abnormal spleen morphology Rnf10tm1b(KOMP)Wtsi HOM Early adult 0.00
abnormal retinal blood vessel morphology Rnf10tm1b(KOMP)Wtsi HOM   Early adult 5.61×10-05
increased lean body mass Rnf10tm1a(KOMP)Wtsi HOM Early adult 3.60×10-08
limb grasping Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.12×10-06
hypoactivity Rnf10tm1b(KOMP)Wtsi HOM   Early adult 2.36×10-06
increased total body fat amount Rnf10tm1b(KOMP)Wtsi HOM Early adult 5.53×10-06
hyperactivity Rnf10tm1b(KOMP)Wtsi HOM   Early adult 1.68×10-10
increased large unstained cell number Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.84×10-05
decreased total retina thickness Rnf10em1(IMPC)Bay HOM   Early adult 8.85×10-11
abnormal lens morphology Rnf10tm1b(KOMP)Wtsi HET Early adult 1.01×10-09
abnormal retinal blood vessel morphology Rnf10em1(IMPC)Bay HOM Early adult 1.66×10-05
decreased thigmotaxis Rnf10tm1b(KOMP)Wtsi HOM Early adult 7.36×10-05
abnormal eye morphology Rnf10em1(IMPC)Mbp HOM Early adult 0.00
decreased mean corpuscular hemoglobin concentration Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.39×10-05
decreased body length Rnf10tm1b(KOMP)Wtsi HOM Early adult 8.59×10-09
increased vertical activity Rnf10tm1b(KOMP)Wtsi HOM   Early adult 5.04×10-06

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
21 Yes  (4/583)  (18/23)  Wholemount images  Section images
21 Yes  (1/583)  (16/23)  Wholemount images  Section images
6 No N/A
4 No  (4/4) N/A
14 Yes  (2/16)  Wholemount images
6 No N/A
21 Yes  (4/583)  (21/23)  Wholemount images  Section images
21 No  (2/583)  (15/23)  Wholemount images
21 Yes  (16/23)  Wholemount images  Section images
21 No  (1/583)  (11/23)  Wholemount images  Section images
12 Yes  (12/371)  (10/14)  Wholemount images  Section images
21 No  (3/583)  (19/23)  Wholemount images  Section images
21 No  (2/583)  (15/23)  Wholemount images
10 Yes  (10/12)  Wholemount images
10 No  (12/127)  (10/12)  Section images
6 No N/A
10 Yes  (10/12)  Wholemount images  Section images
8 Yes  (2/127)  (8/10)  Wholemount images  Section images
11 Yes  (18/132)  (3/13)  Wholemount images  Section images
17 Yes  (7/407)  (16/19)  Wholemount images  Section images
21 Yes  (5/23)  Wholemount images  Section images
18 Yes  (10/20)  Wholemount images
8 Yes  (7/10)  Wholemount images  Section images
10 Yes  (10/12)  Wholemount images  Section images
21 Yes  (2/583)  (19/23)  Wholemount images
10 Yes  (6/12)  Wholemount images
21 No  (3/583)  (15/23)  Wholemount images
21 No  (2/583)  (15/23)  Wholemount images  Section images
8 Yes  (14/127)  (9/10)  Wholemount images  Section images
8 Yes  (6/127)  (8/10)  Wholemount images  Section images
21 Yes  (21/583)  (23/23)  Wholemount images  Section images
21 Yes  (10/583)  (17/23)  Wholemount images
21 Yes  (13/23)  Wholemount images  Section images
21 No  (1/583)  (15/23)  Wholemount images
21 Yes  (2/583)  (18/23)  Wholemount images  Section images
21 Yes  (1/583)  Wholemount images
6 Yes  (6/8)  Wholemount images
21 Yes  (4/23)  Wholemount images  Section images
8 Yes  (8/10)  Wholemount images  Section images
10 Yes  Wholemount images
9 No  (11/11)  Wholemount images  Section images
4 No  (4/4) N/A
21 No  (2/583)  (17/23)  Wholemount images
10 No N/A
21 Yes  (1/583)  (10/23)  Wholemount images  Section images
21 Yes  (10/23)  Wholemount images  Section images
21 Yes  (5/583)  (9/23)  Wholemount images
18 Yes  (1/563)  (16/20)  Wholemount images
10 Yes  (1/12)  Wholemount images  Section images
10 Yes  (5/12)  Wholemount images  Section images
21 No  (2/583)  (15/23)  Wholemount images  Section images
4 No  (1/176) N/A
17 No N/A
21 Yes  (1/583)  (17/23)  Wholemount images  Section images
21 Yes  (12/583)  (8/23)  Wholemount images
8 Yes  (10/10)  Wholemount images  Section images
10 Yes  (4/12)  Wholemount images
17 No  (15/19)  Wholemount images  Section images
4 No  (4/4) N/A
21 Yes  (1/583)  (16/23)  Wholemount images  Section images
21 No  (9/583)  (15/23)  Wholemount images
21 Yes  (3/583)  (22/23)  Wholemount images  Section images
21 Yes  (3/583)  (11/23)  Wholemount images
21 Yes  (13/583)  (17/23)  Wholemount images  Section images
10 No N/A
21 No  (3/583)  (15/23)  Wholemount images  Section images
10 Yes  (1/12)  Wholemount images  Section images
11 Yes  (2/130)  (3/13)  Wholemount images  Section images
21 Yes  (6/583)  (12/23)  Wholemount images  Section images
5 No  (7/7) N/A
21 Yes  (1/583)  (1/23)  Wholemount images
21 Yes  (17/583)  (7/23)  Wholemount images  Section images
10 Yes  (5/127)  (10/12)  Wholemount images  Section images
21 Yes  (3/583)  (21/23)  Wholemount images  Section images
12 Yes  (10/14)  Wholemount images  Section images
11 Yes  (11/13)  Wholemount images  Section images
21 Yes  (10/23)  Wholemount images  Section images
10 Yes  (3/12)  Wholemount images
12 No  (15/382)  (2/14)  Section images
17 No  (9/19)  Wholemount images  Section images
11 Yes  (3/13)  Wholemount images  Section images
21 Yes  (6/23)  Wholemount images
LacZ Section Images

View all 43 images

View all 29 images

View all 9 images

View all 7 images

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
2  (1/60) N/A
2  (1/64) N/A
9  (6/505)  (8/12) N/A
2  (1/73) N/A
3  (1/60) N/A
9  (1/505)  (7/12) N/A
9  (1/506)  (11/12)  Wholemount images
2  (1/71)  (2/2) N/A
9  (1/505)  (10/12)  Wholemount images
9  (1/505)  (4/12) N/A
5  (1/302)  (5/5) N/A
9  (1/505)  (8/12)  Wholemount images
9  (1/505)  (11/12)  Wholemount images
3  (1/61)  (2/3) N/A
2  (1/59)  (2/2) N/A
9  (1/505)  (4/12) N/A
9  (5/505)  (9/12)  Wholemount images
2  (1/60) N/A
9  (1/505)  (4/12)  Wholemount images
2  (1/60) N/A
9  (6/505)  (8/12) N/A
9  (1/505)  (11/12)  Wholemount images
2  (1/58)  (2/2) N/A
9  (1/503)  (2/12)  Wholemount images
5  (1/302)  (5/5) N/A
9  (1/503)  (2/12) N/A
9  (1/505)  (8/12)  Wholemount images
9  (1/505)  (8/12)  Wholemount images
2 N/A
9  (1/505)  (7/12)  Wholemount images
2  (1/60) N/A
3  (1/75)  (3/3) N/A
2  (1/60)  (2/2) N/A
9  (1/503)  (3/12) N/A
2  (1/60) N/A
1  (1/55) N/A
2  (1/56)  (2/2) N/A
2  (7/39) N/A
2  (1/64)  (2/2) N/A
2  (1/57) N/A
2  (1/75) N/A
9  (1/505)  (4/12) N/A
3  (1/72)  (1/3) N/A
9  (1/505)  (11/12)  Wholemount images
9  (1/505)  (8/12) N/A
2  (1/55) N/A
2  (1/55) N/A
1  (1/59) N/A
2  (1/60) N/A
5  (1/302)  (3/5) N/A
5  (1/302)  (3/5) N/A
2  (1/71)  (2/2) N/A

 Associated Images

Adult LacZ: LacZ Images Wholemount
547 Images
Original Image
Adult LacZ: LacZ Images Section
176 Images
X-ray: XRay Images Skull Lateral Orientation
69 Images
X-ray: XRay Images Whole Body Dorso Ventral
119 Images
Embryo LacZ: LacZ images wholemount
87 Images
X-ray: XRay Images Whole Body Lateral Orientation
125 Images
Sleep Wake: Wake state (bmp file)
19 Images
X-ray: XRay Images Hind Leg and Hip
10 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
85 Images
X-ray: XRay Images Forepaw
57 Images
Legacy Phenotype Associated Images

View all 155 images

View all 9 images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Liver - glycogen deposition Rnf10tm1b(KOMP)Wtsi HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Rnf10tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Rnf10tm303169(L1L2_Bact_P) Targeting vectors
Rnf10tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Rnf10em1(IMPC)Bay Exon Deletion Mice, Tissue
Rnf10em1(IMPC)J Exon Deletion Mice
Rnf10em1(IMPC)Mbp Indel causing a Frameshift Mutation Mice, Tissue