Gene: Rnf10

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Phenotype System Allele Zyg Sex Life Stage P Value
decreased lean body mass Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.77×10-14
abnormal tibia morphology Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.93×10-05
decreased startle reflex Rnf10em1(IMPC)J HOM Early adult 3.04×10-09
hyperactivity Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.93×10-12
decreased lean body mass Rnf10em1(IMPC)Bay HOM Early adult 4.95×10-06
enlarged heart Rnf10tm1b(KOMP)Wtsi HET Early adult 0.00
increased fluid intake Rnf10tm1b(KOMP)Wtsi HOM Early adult 5.76×10-07
abnormal behavioral response to light Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.30×10-06
increased lean body mass Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.75×10-06
hypoactivity Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.90×10-06
abnormal spleen morphology Rnf10tm1b(KOMP)Wtsi HOM Early adult 0.00
decreased circulating HDL cholesterol level Rnf10tm1b(KOMP)Wtsi HOM Early adult 3.69×10-09
preweaning lethality, incomplete penetrance Rnf10tm1b(KOMP)Wtsi HOM Early adult 0.00
increased bone mineral content Rnf10em1(IMPC)J HOM Early adult 4.84×10-06
decreased cornea thickness Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.26×10-05
abnormal kidney morphology Rnf10em1(IMPC)Mbp HOM Early adult 0.00
decreased total body fat amount Rnf10tm1b(KOMP)Wtsi HOM Early adult 5.45×10-09
decreased circulating total protein level Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.51×10-06
abnormal lens morphology Rnf10tm1b(KOMP)Wtsi HET Early adult 4.01×10-10
increased heart weight Rnf10tm1b(KOMP)Wtsi HET Early adult 4.06×10-06
decreased hemoglobin content Rnf10tm1b(KOMP)Wtsi HOM Early adult 8.80×10-06
increased circulating triglyceride level Rnf10tm1a(KOMP)Wtsi HOM Early adult 9.97×10-05
thin ventricular wall Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.30×10-06
increased or absent threshold for auditory brainstem response Rnf10tm1b(KOMP)Wtsi HOM Early adult 8.92×10-05
decreased startle reflex Rnf10tm1b(KOMP)Wtsi HOM Early adult 4.32×10-14
convulsive seizures Rnf10tm1b(KOMP)Wtsi HOM Early adult 4.05×10-05
decreased circulating serum albumin level Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.50×10-06
abnormal bone structure Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.71×10-05
abnormal gait Rnf10tm1b(KOMP)Wtsi HOM Early adult 6.68×10-06
increased circulating cholesterol level Rnf10tm1a(KOMP)Wtsi HOM Early adult 4.86×10-05
decreased grip strength Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.35×10-09
decreased prepulse inhibition Rnf10em1(IMPC)Bay HOM Early adult 7.65×10-06
increased circulating creatinine level Rnf10tm1b(KOMP)Wtsi HOM Early adult 4.45×10-06
increased heart left ventricle size Rnf10em1(IMPC)Bay HOM Early adult 2.53×10-05
decreased circulating cholesterol level Rnf10tm1b(KOMP)Wtsi HOM Early adult 3.88×10-09
limb grasping Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.35×10-06
increased circulating chloride level Rnf10tm1b(KOMP)Wtsi HOM Early adult 6.12×10-05
abnormal behavior Rnf10tm1b(KOMP)Wtsi HOM Early adult 8.36×10-14
decreased bone mineral content Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.06×10-05
decreased circulating cholesterol level Rnf10tm1a(KOMP)Wtsi HOM Early adult 4.86×10-05
cataract Rnf10tm1b(KOMP)Wtsi HET Early adult 7.66×10-09
decreased circulating triglyceride level Rnf10tm1b(KOMP)Wtsi HET Early adult 3.35×10-08
increased body weight Rnf10tm1a(KOMP)Wtsi HOM Early adult 4.22×10-06
increased circulating HDL cholesterol level Rnf10tm1a(KOMP)Wtsi HOM Early adult 5.62×10-06
increased cardiac muscle contractility Rnf10tm1b(KOMP)Wtsi HET Early adult 7.32×10-05
decreased body weight Rnf10tm1a(KOMP)Wtsi HOM Early adult 4.22×10-06
increased KLRG1-positive NK cell number Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.33×10-05
decreased total retina thickness Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.65×10-09
absent pinna reflex Rnf10tm1b(KOMP)Wtsi HOM Early adult 4.24×10-06
decreased prepulse inhibition Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.17×10-05
limb grasping Rnf10em1(IMPC)J HOM Early adult 5.58×10-05
decreased circulating glucose level Rnf10tm1b(KOMP)Wtsi HOM Early adult 4.29×10-09
increased red blood cell distribution width Rnf10tm1b(KOMP)Wtsi HOM Early adult 3.31×10-05
decreased startle reflex Rnf10em1(IMPC)Bay HOM Early adult 1.65×10-07
decreased circulating LDL cholesterol level Rnf10tm1b(KOMP)Wtsi HOM Early adult 8.62×10-05
decreased circulating HDL cholesterol level Rnf10tm1a(KOMP)Wtsi HOM Early adult 5.62×10-06
increased bone mineral content Rnf10tm1b(KOMP)Wtsi HOM Early adult 5.77×10-07
improved glucose tolerance Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.07×10-05
abnormal retinal blood vessel morphology Rnf10tm1b(KOMP)Wtsi HET Early adult 6.22×10-06
increased circulating sodium level Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.41×10-07
abnormal sleep behavior Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.08×10-10
increased NK cell number Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.33×10-05
decreased bone mineral density Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.76×10-06
decreased body length Rnf10tm1b(KOMP)Wtsi HOM Early adult 5.21×10-09
decreased circulating creatinine level Rnf10tm1b(KOMP)Wtsi HET Early adult 6.01×10-05
decreased circulating alkaline phosphatase level Rnf10tm1b(KOMP)Wtsi HOM Early adult 8.77×10-07
abnormal retinal blood vessel morphology Rnf10em1(IMPC)Bay HOM Early adult 9.26×10-07
abnormal bone structure Rnf10em1(IMPC)J HOM Early adult 6.68×10-05
decreased effector memory CD8-positive, alpha-beta T cell number Rnf10tm1a(KOMP)Wtsi HOM Early adult 6.77×10-05
increased vertical activity Rnf10tm1b(KOMP)Wtsi HOM Early adult 1.67×10-06
decreased mean corpuscular hemoglobin concentration Rnf10tm1b(KOMP)Wtsi HOM Early adult 2.70×10-05

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 Expression

IMPC lacZ Expression Data

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens HOM Images? WT Expr Mutant Expr Images
Adrenal gland 22 Yes  (2/584)  (18/24)  Wholemount images  Section images
Aorta 22 Yes  (16/24)  Wholemount images  Section images
Blood 6 No N/A
Blood vessel 4 No  (4/4) N/A
Bone 14 Yes  (2/16)  Wholemount images
Bone marrow 6 No N/A
Brain 22 Yes  (21/24)  Wholemount images  Section images
Brainstem 22 No  (15/24)  Wholemount images
Brown adipose tissue 22 Yes  (16/24)  Wholemount images  Section images
Cartilage tissue 22 No  (11/24)  Wholemount images
Cecum 12 Yes  (12/379)  (10/14)  Wholemount images  Section images
Cerebellum 22 No  (19/24)  Wholemount images  Section images
Cerebral cortex 22 No  (15/24)  Wholemount images
Chest bone 10 Yes  (10/12)  Wholemount images
Colon 10 No  (12/127)  (10/12)  Section images
Cranium 6 No N/A
Diaphragm 10 Yes  (10/12)  Wholemount images  Section images
Duodenum 8 Yes  (2/127)  (8/10)  Wholemount images  Section images
Epididymis 12 Yes  (18/134)  (3/14)  Wholemount images  Section images
Esophagus 18 Yes  (7/415)  (16/20)  Wholemount images  Section images
Eye 22 Yes  (5/24)  Wholemount images  Section images
Gall bladder 18 Yes  (10/20)  Wholemount images
Gonadal fat pad 8 Yes  (7/10)  Wholemount images  Section images
Harderian gland 10 Yes  (10/12)  Wholemount images  Section images
Heart 22 Yes  (19/24)  Wholemount images
Hindlimb 10 Yes  (6/12)  Wholemount images
Hippocampus 22 No  (15/24)  Wholemount images
Hypothalamus 22 No  (15/24)  Wholemount images
Ileum 8 Yes  (14/127)  (9/10)  Wholemount images  Section images
Jejunum 8 Yes  (6/127)  (8/10)  Wholemount images  Section images
Kidney 22 Yes  (18/584)  (23/24)  Wholemount images  Section images
Large intestine 22 Yes  (10/584)  (17/24)  Wholemount images
Liver 22 Yes  (13/24)  Wholemount images  Section images
Lower urinary tract 22 No  (15/24)  Wholemount images
Lung 22 Yes  (18/24)  Wholemount images  Section images
Lymph node 22 Yes  Wholemount images
Main olfactory bulb 6 Yes  (6/8)  Wholemount images
Mammary gland 22 Yes  (4/24)  Wholemount images  Section images
Mesenteric adipose tissue 8 Yes  (8/10)  Wholemount images  Section images
Mesenteric lymph node 10 Yes  Wholemount images
Midbrain 10 No  (11/12)  Wholemount images  Section images
Esophagus 4 No  (4/4) N/A
Olfactory lobe 22 No  (17/24)  Wholemount images
Oral epithelium 10 No N/A
Ovary 22 Yes  (1/584)  (10/24)  Wholemount images  Section images
Oviduct 22 Yes  (10/24)  Wholemount images  Section images
Pancreas 22 Yes  (5/584)  (9/24)  Wholemount images
Parathyroid gland 18 Yes  (16/20)  Wholemount images
Parotid gland 10 Yes  (1/12)  Wholemount images  Section images
Penis 10 Yes  (5/12)  Wholemount images  Section images
Peripheral nervous system 22 No  (15/24)  Wholemount images
Peyer's patch 4 No N/A
Peyer's patch 18 No N/A
Pituitary gland 22 Yes  (17/24)  Wholemount images  Section images
Prostate gland 22 Yes  (12/584)  (8/24)  Wholemount images
Quadriceps 8 Yes  (10/10)  Wholemount images  Section images
Sciatic nerve 10 Yes  (4/12)  Wholemount images
Skeletal muscle 18 No  (15/20)  Wholemount images
Skeletal muscle tissue 4 No  (4/4) N/A
Skin 22 Yes  (16/24)  Wholemount images  Section images
Small intestine 22 No  (9/584)  (15/24)  Wholemount images
Spinal cord 22 Yes  (22/24)  Wholemount images  Section images
Spleen 22 Yes  (2/584)  (11/24)  Wholemount images
Stomach 22 Yes  (12/584)  (17/24)  Wholemount images  Section images
Stomach pyloric region 10 No N/A
Striatum 22 No  (15/24)  Wholemount images
Sublingual gland 10 Yes  (1/12)  Wholemount images  Section images
Submandibular gland 12 Yes  (2/132)  (3/14)  Wholemount images
Testis 22 Yes  (2/584)  (12/24)  Wholemount images  Section images
Thalamus 6 No  (7/8) N/A
Thymus 22 Yes  (1/24)  Wholemount images
Thyroid gland 22 Yes  (15/584)  (7/24)  Wholemount images
Tongue 10 Yes  (5/127)  (10/12)  Wholemount images  Section images
Trachea 22 Yes  (21/24)  Wholemount images  Section images
Trigeminal V nerve 12 Yes  (10/14)  Wholemount images  Section images
Urinary bladder 12 Yes  (11/14)  Wholemount images  Section images
Uterus 22 Yes  (10/24)  Wholemount images  Section images
Vagina 10 Yes  (3/12)  Wholemount images
Vas deferens 12 No  (15/388)  (2/14)  Section images
Vascular system 18 No  (9/20)  Wholemount images
Vesicular gland 12 Yes  (3/14)  Wholemount images  Section images
White adipose tissue 22 Yes  (6/24)  Wholemount images
LacZ Section Images

View all 43 images

View all 29 images

View all 9 images

View all 7 images

 Expression  No Expression  Ambiguous  No Tissue Available
Anatomy #HET Specimens WT Expr Mutant Expr Images
Heart atrium 2  (1/57) N/A
Axial skeleton 2  (1/61) N/A
Brain 9  (6/504)  (8/12) N/A
Central nervous system ganglion 2  (1/70) N/A
Dorsal root ganglion 3  (1/57) N/A
Ear 9  (1/504)  (7/12) N/A
Embryo 9  (1/505)  (11/12)  Wholemount images
Outer ear 2  (1/66)  (2/2) N/A
Eye 9  (1/504)  (10/12)  Wholemount images
Foot 9  (1/504)  (4/12) N/A
Forearm 5  (1/297)  (5/5) N/A
Forebrain 9  (1/504)  (8/12)  Wholemount images
Forelimb 9  (1/504)  (11/12)  Wholemount images
Fronto-nasal process 3  (1/58)  (2/3) N/A
Gut 2  (1/56)  (2/2) N/A
Hand 9  (1/503)  (4/12) N/A
Head 9  (5/504)  (9/12)  Wholemount images
Head mesenchyme 2  (1/57) N/A
Heart 9  (1/504)  (4/12)  Wholemount images
Heart ventricle 2  (1/57) N/A
Hindbrain 9  (6/504)  (8/12) N/A
Hindlimb 9  (1/503)  (11/12)  Wholemount images
Intestine 2  (1/55)  (2/2) N/A
Liver 9  (1/504)  (2/12)  Wholemount images
Lower leg 5  (1/297)  (5/5) N/A
Lung 9  (1/500)  (2/12) N/A
Mandibular process 9  (1/504)  (8/12)  Wholemount images
Maxillary process 9  (1/504)  (8/12)  Wholemount images
Meckel's cartilage 2 N/A
Midbrain 9  (1/504)  (7/12)  Wholemount images
Nasal septum 2  (1/57) N/A
Nose 3  (1/70)  (3/3) N/A
Notochord 2  (1/57)  (2/2) N/A
Oral cavity 9  (1/504)  (3/12) N/A
Outflow tract 2  (1/57) N/A
Pericardium 1  (1/52) N/A
Pharynx 2  (1/52)  (2/2) N/A
2  (7/37) N/A
Radius-ulna pre-cartilage condensation 2  (1/61)  (2/2) N/A
Rib pre-cartilage condensation 2  (1/54) N/A
Skeleton 2  (1/70) N/A
Skin 9  (1/504)  (4/12) N/A
Spinal cord 3  (1/69)  (1/3) N/A
Tail 9  (1/504)  (11/12)  Wholemount images
Tail somite 9  (1/504)  (8/12) N/A
Thoracic vertebral cartilage condensation 2  (1/52) N/A
Tongue 2  (1/52) N/A
Trachea 1  (1/56) N/A
Trunk mesenchyme 2  (1/57) N/A
Upper arm 5  (1/297)  (3/5) N/A
Upper leg 5  (1/297)  (3/5) N/A
Vibrissa 2  (1/66)  (2/2) N/A

 Associated Images

X-ray: XRay Images Whole Body Dorso Ventral
167 Images
X-ray: XRay Images Whole Body Lateral Orientation
139 Images
Embryo LacZ: LacZ images wholemount
87 Images
X-ray: XRay Images Forepaw
44 Images
X-ray: XRay Images Skull Lateral Orientation
56 Images
X-ray: XRay Images Skull Dorso Ventral Orientation
72 Images
Sleep Wake: Wake state (bmp file)
9 Images
Combined SHIRPA and Dysmorphology
10 Images
Eye Morphology: Images Ophthalmoscopy
14 Images
Adult LacZ: LacZ Images Wholemount
547 Images
Legacy Phenotype Associated Images

View all 155 images

View all 9 images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Histopathology

Phenotype Allele Zygosity Sex Life Stage
Liver - glycogen deposition Rnf10tm1b(KOMP)Wtsi HOM Early adult

 Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Rnf10em1(IMPC)Mbp Indel causing a Frameshift Mutation Mice, Tissue
Rnf10em1(IMPC)Bay Exon Deletion Mice, Tissue
Rnf10tm1b(KOMP)Wtsi Reporter-tagged deletion allele (post-Cre) Mice, Tissue
Rnf10tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Rnf10em1(IMPC)J Exon Deletion Mice
Rnf10tm303169(L1L2_Bact_P) Targeting vectors