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Gene: Prc1 MGI:1858961

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Gene Summary

Name:
protein regulator of cytokinesis 1
Synonyms:
D7Ertd348e

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal lens morphology Prc1tm1b(EUCOMM)Hmgu HET Early adult 1.10×10-10
cataract Prc1tm1b(EUCOMM)Hmgu HET Early adult 3.22×10-09
preweaning lethality, complete penetrance Prc1tm1b(EUCOMM)Hmgu HOM   Early adult 5.65×10-05
increased total body fat amount Prc1tm1b(EUCOMM)Hmgu HET Early adult 7.79×10-05

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lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Electrocardiogram (ECG)

Waveform Image

30 Images

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X-ray

XRay Images Whole Body Lateral Orientation

9 Images

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Human diseases caused by Prc1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Prc1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Cataract 20, Multiple Types
Cataract, Membranous cataract OMIM:116100
Hereditary Hyperferritinemia-Cataract Syndrome
Cataract ORPHA:163
Cataract 36
Cataract OMIM:613887
Cataract 18
Cataract OMIM:610019
Cataract 29
Cataract OMIM:115800
Cataract 35
Cataract OMIM:609376
Cataract 4, Multiple Types
Developmental cataract OMIM:115700
Cataract 39, Multiple Types
Developmental cataract OMIM:615188
Cataract 13 With Adult I Phenotype
Developmental cataract OMIM:116700
Cataract 37
Developmental cataract OMIM:614422
Cataract 45
Developmental cataract OMIM:616851
Cataract 38
Developmental cataract OMIM:614691
Cataract And Congenital Ichthyosis
Cataract OMIM:212400
Hypertrophic Neuropathy And Cataract
Cataract OMIM:239900
Cochleosaccular Degeneration With Progressive Cataracts
Progressive cataract OMIM:120040
Cataract 44
Developmental cataract OMIM:616509
Aniridia 3
Cataract OMIM:617142
Corneal Dystrophy, Groenouw Type I
Nodular corneal dystrophy, Granular corneal dystrophy, Cataract, Punctate corneal dystrophy OMIM:121900
Cataract 12, Multiple Types
Developmental cataract, Progressive cataract OMIM:611597
Trichomegaly
Cataract OMIM:190330
Hydrocephaly-Cerebellar Agenesis Syndrome
Cataract ORPHA:1397
Aldh18A1-Related De Barsy Syndrome
Cataract ORPHA:35664
Cataract 7
Developmental cataract OMIM:115660
Spinal Muscular Atrophy-Dandy-Walker Malformation-Cataracts Syndrome
Cataract ORPHA:73245
Pupillary Membrane, Persistence Of
Developmental cataract, Persistent pupillary membrane, Megalocornea OMIM:178900
Cataract 46, Juvenile-Onset, With Or Without Arrhythmic Cardiomyopathy
Juvenile cataract OMIM:212500
Nathalie Syndrome
Cataract ORPHA:2663
Galactosemia Iv
Cataract OMIM:618881
Deafness, Cataract, Retinitis Pigmentosa, And Sperm Abnormalities
Cataract OMIM:300719
Thumb, Hypoplastic, With Choroid Coloboma, Poorly Developed Antihelix, And Deafness
Cataract OMIM:274205
Cataract-Nephropathy-Encephalopathy Syndrome
Cataract ORPHA:1380
Uncombable Hair Syndrome 2
Juvenile cataract OMIM:617251
Cataract-Microcornea Syndrome
Corneal dystrophy, Iris coloboma, Corneal opacity, Cataract, Microcornea ORPHA:1377
Alpha-N-Acetylgalactosaminidase Deficiency Type 3
Cataract ORPHA:79281
Myopathy, Mitochondrial Progressive, With Congenital Cataract And Developmental Delay
Developmental cataract, Cataract OMIM:613076
Foveal Hypoplasia 1
Presenile cataracts OMIM:136520
Chorea, Remitting, With Nystagmus And Cataract
Cataract OMIM:601372
Microphthalmia, Isolated, With Coloboma 3
Cataract, Iris coloboma OMIM:610092
Foveal Hypoplasia-Presenile Cataract Syndrome
Cataract ORPHA:2253
X-Linked Retinoschisis
Cataract ORPHA:792
Aniridia, Microcornea, And Spontaneously Reabsorbed Cataract
Aniridia, Microcornea, Cataract OMIM:106230
Genetic Hyperferritinemia Without Iron Overload
Cataract ORPHA:254704
Galactosemia Ii
Cataract OMIM:230200
Microphthalmia, Isolated, With Cataract 1
Cataract OMIM:156850
Muscular Dystrophy, Congenital, With Infantile Cataract And Hypogonadism
Cataract OMIM:254000
Cataract 42
Developmental cataract OMIM:115900
Iris Pigment Layer, Cleavage Of
Cataract OMIM:147610
Cataract 47
Microcornea, Cataract OMIM:612018
Cataract 1, Multiple Types
Nuclear cataract, Developmental cataract, Posterior subcapsular cataract, Microcornea, Pulverulen... OMIM:116200
Cataract 14, Multiple Types
Zonular cataract OMIM:601885
Cataract 41
Nuclear cataract, Developmental cataract OMIM:116400
Spastic Paraparesis And Deafness
Cataract OMIM:312910
Aniridia 2
Aniridia, Cataract OMIM:617141
Spinocerebellar Ataxia, Autosomal Recessive 24
Cataract OMIM:617133
Cataract 15, Multiple Types
Nuclear cataract, Developmental cataract, Lamellar cataract, Cortical cataract, Cataract OMIM:615274
Cataract 10, Multiple Types
Posterior Y-sutural cataract, Developmental cataract, Zonular cataract OMIM:600881
Cataract 9, Multiple Types
Developmental cataract, Progressive cataract, Iris coloboma, Cataract, Microcornea OMIM:604219
Cataract 8, Multiple Types
Nuclear cataract, Developmental cataract OMIM:115665
Hemolytic Anemia Due To Glutathione Reductase Deficiency
Cataract OMIM:618660
Proximal Myotonic Myopathy
Cataract ORPHA:606
Mental Retardation, Truncal Obesity, Retinal Dystrophy, And Micropenis Syndrome
Cataract OMIM:610156
Cataract 22, Multiple Types
Nuclear cataract, Developmental cataract OMIM:609741
Megalocornea
Decreased corneal thickness, Corneal arcus, Lens subluxation, Iris transillumination defect, Irid... OMIM:309300
Nathalie Syndrome
Cataract OMIM:255990
Anterior Segment Dysgenesis 8
Persistent pupillary membrane, Hypoplasia of the iris, Ectopia lentis, Microphakia, Iris transill... OMIM:617319
Cataract, Microcephaly, Failure To Thrive, Kyphoscoliosis Syndrome
Cataract, Arthrogryposis multiplex congenita OMIM:212540
Encephalopathy, Axonal, With Necrotizing Myopathy, Cardiomyopathy, And Cataracts
Cataract OMIM:225740
Dysequilibrium Syndrome
Cataract ORPHA:1766
Cataract 3, Multiple Types
Sutural cataract, Developmental cataract, Cerulean cataract, Nuclear pulverulent cataract OMIM:601547
Optic Atrophy 3, Autosomal Dominant
Cataract OMIM:165300
Leber Congenital Amaurosis 7
Keratoconus, Cataract OMIM:613829
Kahrizi Syndrome
Knee flexion contracture, Cataract, Elbow flexion contracture, Iris coloboma OMIM:612713
Cortical Dysplasia, Complex, With Other Brain Malformations 4
Cataract OMIM:615412
Bardet-Biedl Syndrome 18
Cataract OMIM:615995
Cataract 43
Subcapsular cataract OMIM:616279
Congenital Varicella Syndrome
Atypical scarring of skin, Cataract ORPHA:291
Exfoliation Syndrome
Mydriasis, Abnormality of the lens, Lens subluxation, Iris hypoperfusion, Phakodonesis, Pseudoexf... OMIM:177650
Cataract 11, Multiple Types
Cataract OMIM:610623
Intellectual Disability-Cataracts-Kyphosis Syndrome
Knee flexion contracture, Cataract, Elbow flexion contracture, Iris coloboma ORPHA:171860
Ectopia Lentis Et Pupillae
Persistent pupillary membrane, Cataract, Ectopia lentis OMIM:225200
Hyperferritinemia With Or Without Cataract
Nuclear cataract, Pulverulent cataract OMIM:600886
Aniridia-Intellectual Disability Syndrome
Aniridia, Cataract, Ectopia lentis ORPHA:1068
Microcornea, Rod-Cone Dystrophy, Cataract, And Posterior Staphyloma 1
Microcornea, Cataract OMIM:619082
Congenital Disorder Of Glycosylation, Type Ii
Cataract OMIM:607906
Retinitis Pigmentosa 84
Cataract OMIM:618220
Cataract 21, Multiple Types
Microcornea, Cerulean cataract, Cortical pulverulent cataract, Iris coloboma OMIM:610202
Stiff Skin Syndrome
Lipodystrophy, Knee flexion contracture, Cataract, Camptodactyly, Elbow flexion contracture OMIM:184900
Anterior Segment Dysgenesis 7
Buphthalmos, Sclerocornea, Cataract, Microcornea, Ocular anterior segment dysgenesis OMIM:269400
Coats Disease
Cataract, Aplasia/Hypoplasia of the iris, Abnormal anterior chamber morphology ORPHA:190
Myopia 17, Autosomal Dominant
Presenile cataracts OMIM:608367
Cataract 17, Multiple Types
Microcornea, Nuclear cataract, Developmental cataract, Pulverulent cataract OMIM:611544
Edict Syndrome
Developmental cataract, Hypoplasia of the iris, Astigmatism, Microcornea, Keratoconus OMIM:614303
Ehlers-Danlos Syndrome, Beasley-Cohen Type
Cigarette-paper scars, Cataract, Inguinal hernia OMIM:608763
Cataract-Aberrant Oral Frenula-Growth Delay Syndrome
Cataract, Umbilical hernia, Inguinal hernia ORPHA:1373
Cataract 5, Multiple Types
Nuclear cataract, Anterior polar cataract, Lamellar cataract, Zonular cataract, Pulverulent cataract OMIM:116800
Peters Anomaly
Opacification of the corneal stroma, Thinning of Descemet membrane, Peters anomaly, Developmental... ORPHA:708
Cataract, Age-Related Nuclear
Nuclear cataract OMIM:601371
Thanatophoric Dysplasia, Glasgow Variant
Cataract OMIM:273680
Aniridia-Ptosis-Intellectual Disability-Familial Obesity Syndrome
Persistent pupillary membrane, Corneal opacity, Cataract, Aplasia/Hypoplasia of the iris ORPHA:1067
Cataract 16, Multiple Types
Posterior polar cataract, Developmental cataract OMIM:613763
Aniridia And Absent Patella
Aniridia, Cataract OMIM:106220
Leber Congenital Amaurosis 6
Keratoconus, Cataract OMIM:613826
Myopia, High, With Cataract And Vitreoretinal Degeneration
Cataract, Lens subluxation OMIM:614292
Anterior Segment Dysgenesis 1
Posterior polar cataract, Peters anomaly, Opacification of the corneal stroma, Microcornea, Ocula... OMIM:107250
Cataract 30, Multiple Types
Posterior polar cataract, Pulverulent cataract, Diffuse nuclear cataract OMIM:116300
Pellagra-Like Syndrome
Cataract OMIM:260650
Autosomal Recessive Spastic Paraplegia Type 69
Cataract ORPHA:401830
Isolated Aniridia
Aniridia, Cataract, Peters anomaly ORPHA:250923
Leber Congenital Amaurosis 8
Cataract, Keratoconus OMIM:613835
Ichthyosis-Intellectual Disability-Dwarfism-Renal Impairment Syndrome
Cataract ORPHA:2278
Stickler Syndrome Type 2
Corneal opacity, Cataract ORPHA:90654
Amoebic Keratitis
Corneal perforation, Decreased corneal sensation, Corneal stromal edema, Iris atrophy, Abnormal c... ORPHA:67043
Muscular Dystrophy, Congenital, With Cataracts And Intellectual Disability
Increased adipose tissue, Cataract OMIM:617404
Kyrle Disease
Posterior subcapsular cataract OMIM:149500
Ectopia Lentis 2, Isolated, Autosomal Recessive
Ectopia lentis OMIM:225100
Ectopia Lentis 1, Isolated, Autosomal Dominant
Ectopia lentis OMIM:129600
Renal Tubular Acidosis, Proximal, With Ocular Abnormalities And Mental Retardation
Band keratopathy, Cataract OMIM:604278
Cochleosaccular Degeneration-Cataract Syndrome
Cataract ORPHA:3233
Glaucoma 3, Primary Congenital, D
Corneal opacity, Primary congenital glaucoma, Ectopia lentis OMIM:613086
Cataract 31, Multiple Types
Nuclear cataract, Posterior subcapsular cataract, Anterior subcapsular cataract OMIM:605387
Congenital Cataract-Hypertrophic Cardiomyopathy-Mitochondrial Myopathy Syndrome
Cataract, Corneal dystrophy ORPHA:1369
Anterior Segment Dysgenesis 2
Anterior segment of eye aplasia, Sclerocornea, Congenital aphakia, Aniridia, Peters anomaly, Post... OMIM:610256
Exudative Vitreoretinopathy 6
Cataract OMIM:616468
Autosomal Dominant Keratitis
Abnormality of the corneal limbus, Aniridia, Hypoplastic iris stroma, Limbal stem cell deficiency... ORPHA:2334
Intellectual Developmental Disorder And Retinitis Pigmentosa
Cataract OMIM:618195
Retinitis Pigmentosa 23
Posterior subcapsular cataract OMIM:300424
Leber Congenital Amaurosis 2
Keratoconus, Cataract OMIM:204100
Retinitis Pigmentosa 4
Cataract OMIM:613731
Hypogonadism-Cataract Syndrome
Cataract OMIM:240950
Absence Deformity Of Leg-Cataract Syndrome
Cataract ORPHA:2310
Split-Hand With Congenital Nystagmus, Fundal Changes, And Cataracts
Cataract OMIM:183800
Coloboma, Ocular, With Or Without Hearing Impairment, Cleft Lip/Palate, And/Or Mental Retardation
Cataract OMIM:120433
X-Linked Endothelial Corneal Dystrophy
Nuclear cataract, Corneal opacity, Abnormal corneal endothelium morphology, Band keratopathy ORPHA:293621
Morm Syndrome
Cataract ORPHA:75858
Cornea Guttata With Anterior Polar Cataracts
Anterior polar cataract OMIM:121390
Cataract 33, Multiple Types
Nuclear cataract, Lamellar cataract, Cortical cataract OMIM:611391
Xeroderma Pigmentosum, Complementation Group G
Cataract OMIM:278780
Leber Congenital Amaurosis 16
Cataract OMIM:614186
Cataract 32, Multiple Types
Anterior polar cataract OMIM:115650
Vitreoretinal Degeneration, Snowflake Type
Corneal guttata, Cataract OMIM:193230
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 6
Cataract, Flexion contracture OMIM:613154
Aniridia-Absent Patella Syndrome
Aniridia, Cataract, Inguinal hernia ORPHA:1069
Retinitis Pigmentosa 2
Cataract OMIM:312600
Cataract 6, Multiple Types
Posterior polar cataract, Developmental cataract OMIM:116600
Martsolf Syndrome 2
Developmental cataract, Cataract, Camptodactyly of finger, Camptodactyly OMIM:619420
Congenital Cataracts, Hearing Loss, And Neurodegeneration
Developmental cataract, Cataract OMIM:614482
Retinitis Pigmentosa 37
Cataract OMIM:611131
Cataract 24
Anterior polar cataract OMIM:601202
Cataract 40
Nuclear cataract, Sutural cataract OMIM:302200
Uveal Coloboma-Cleft Lip And Palate-Intellectual Disability
Corneal opacity, Cataract, Posterior embryotoxon, Iris coloboma ORPHA:1473
Optic Disc Anomalies With Retinal And/Or Macular Dystrophy
Cataract, Iris coloboma OMIM:212550
Retinitis Pigmentosa 9
Cataract OMIM:180104
Autosomal Recessive Palmoplantar Keratoderma And Congenital Alopecia
Atypical scarring of skin, Cataract ORPHA:1366
X-Linked Immunoneurologic Disorder
Cataract ORPHA:2571
Cataract-Intellectual Disability-Anal Atresia-Urinary Defects Syndrome
Cataract, Aplasia/Hypoplasia of the lens ORPHA:1381
Galactose Mutarotase Deficiency
Cataract ORPHA:570422
Usher Syndrome Type 3
Astigmatism, Iris hypopigmentation, Cataract ORPHA:231183
Dermatitis, Atopic
Keratoconus, Cataract, Conjunctivitis OMIM:603165
Oculocerebral Hypopigmentation Syndrome Of Preus
Cataract OMIM:257790
Autoinflammation, Antibody Deficiency, And Immune Dysregulation
Cellulitis, Cataract, Corneal erosion OMIM:614878
Trichothiodystrophy 3, Photosensitive
Cataract, Joint contracture of the hand OMIM:616395
Retinal Dystrophy And Iris Coloboma With Or Without Congenital Cataract
Developmental cataract, Posterior synechiae of the anterior chamber OMIM:616722
Achromatopsia 3
Cataract OMIM:262300
Norrie Disease
Opacification of the corneal stroma, Shallow anterior chamber, Cataract, Hypoplasia of the iris OMIM:310600
Blindness-Scoliosis-Arachnodactyly Syndrome
Microphakia, Cataract, Lens subluxation ORPHA:171844
Peroxisome Biogenesis Disorder 11B
Cataract OMIM:614885
Isolated Ectopia Lentis
Cataract, Ectopia pupillae, Ectopia lentis ORPHA:1885
Cataract 23, Multiple Types
Lamellar cataract OMIM:610425
Hypoparathyroidism, Familial Isolated, 1
Cataract OMIM:146200
Coloboma, Ocular, Autosomal Recessive
Cataract, Lens subluxation, Iris coloboma OMIM:216820
Peroxisome Biogenesis Disorder 9B
Cataract OMIM:614879
Polycystic Kidney, Cataract, And Congenital Blindness
Microcoria, Cataract OMIM:263100
Cataracts, Spastic Paraparesis, And Speech Delay
Cataract OMIM:619338
Woolly Hair
Abnormal pupil morphology, Cataract ORPHA:170
Morning Glory Disc Anomaly
Cataract ORPHA:35737
Cahmr Syndrome
Lamellar cataract OMIM:211770
Keratosis Follicularis Spinulosa Decalvans, Autosomal Dominant
Scarring alopecia of scalp, Keratitis, Enamel hypoplasia, Cataract, Conjunctivitis OMIM:612843
Hereditary Leiomyomatosis And Renal Cell Cancer
Cataract ORPHA:523
Persistent Hyperplastic Primary Vitreous, Autosomal Recessive
Buphthalmos, Persistent pupillary membrane, Shallow anterior chamber, Iris coloboma, Corneal opac... OMIM:221900
Dystonia, Juvenile-Onset
Cataract OMIM:607371
Coloboma-Obesity-Hypogenitalism-Mental Retardation Syndrome
Cataract OMIM:601794
Weill-Marchesani Syndrome
Cataract, Ectopia lentis ORPHA:3449
Peroxisome Biogenesis Disorder 10B
Cataract OMIM:617370
Familial Isolated Hypoparathyroidism
Abnormal dental enamel morphology, Cataract ORPHA:2238
Microphthalmia/Coloboma And Skeletal Dysplasia Syndrome
Sclerocornea, Microcornea, Cataract, Ectopia pupillae OMIM:615877
Ifap Syndrome 2
Keratoconjunctivitis sicca, Cataract, Keratitis OMIM:619016
Alport Syndrome 2, Autosomal Recessive
Cataract, Corneal erosion, Anterior lenticonus OMIM:203780
Aniridia 1
Corneal erosion, Anterior subcapsular cataract, Ectopia lentis, Hypoplasia of the iris, Aniridia,... OMIM:106210
Ectodermal Dysplasia-Blindness Syndrome
Keratoconjunctivitis sicca, Sclerocornea, Corneal dystrophy, Cataract, Microcornea ORPHA:1806
Epidermolysis Bullosa Dystrophica, Autosomal Recessive
Corneal scarring, Atrophic scars, Enamel hypoplasia, Cataract, Flexion contracture, Conjunctivitis OMIM:226600
Persistent Hyperplastic Primary Vitreous
Buphthalmos, Persistent pupillary membrane, Shallow anterior chamber, Developmental cataract, Cor... ORPHA:91495
Oculoauricular Syndrome
Iris cyst, Developmental cataract, Posterior embryotoxon, Microphakia, Sclerocornea, Iris colobom... OMIM:612109
Chondrodysplasia Punctata, Autosomal Dominant
Cataract, Hip contracture, Knee flexion contracture OMIM:118650
Intermediate Uveitis
Band keratopathy, Posterior synechiae of the anterior chamber, Cataract, Macular scar ORPHA:279914
Enhanced S-Cone Syndrome
Cataract OMIM:268100
Craniosynostosis With Ocular Abnormalities And Hallucal Defects
Microcornea, Cataract OMIM:608279
Autosomal Dominant Optic Atrophy And Cataract
Cerulean cataract, Posterior subcapsular cataract, Anterior subcapsular cataract, Posterior corti... ORPHA:67036

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Prc1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Prc1.

No publications found that use IMPC mice or data for Prc1.

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MGI Allele Allele Type Produced
Prc1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Prc1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Prc1tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells

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