Gene Summary

Name:
folate hydrolase 1
Synonyms:
mopsm,  GCP2,  prostate-specific membrane antigen,  glutamate carboxypeptidase II

IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
hyperactivity Folh1tm1b(KOMP)Wtsi HOM   Early adult 6.03×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Brain  Section images heterozygote 100% (2 of 2)
Brainstem  Section images heterozygote 100% (2 of 2)
Epididymis  Section images heterozygote 50% (1 of 2)
Hypothalamus  Section images heterozygote 100% (2 of 2)
Kidney  Section images heterozygote 100% (2 of 2)
Midbrain  Section images heterozygote 100% (2 of 2)
Spinal cord  Section images heterozygote 100% (2 of 2)
Submandibular gland  Section images heterozygote 50% (1 of 2)
Testis  Section images heterozygote 50% (1 of 2)
Adrenal gland N/A heterozygote 0.0% (0 of 2)
Aorta N/A heterozygote 0.0% (0 of 2)
Brown adipose tissue N/A heterozygote 0.0% (0 of 2)
Cartilage tissue N/A heterozygote 0.0% (0 of 2)
Cerebellum N/A heterozygote 0.0% (0 of 2)
Cerebral cortex N/A heterozygote 0.0% (0 of 2)
Esophagus N/A heterozygote 0.0% (0 of 2)
Eye N/A heterozygote 0.0% (0 of 2)
Heart N/A heterozygote 0.0% (0 of 2)
Hippocampus N/A heterozygote 0.0% (0 of 2)
Large intestine N/A heterozygote 0.0% (0 of 2)
Liver N/A heterozygote 0.0% (0 of 2)
Lower urinary tract N/A heterozygote Not available
Lung N/A heterozygote 0.0% (0 of 2)
Lymph node N/A heterozygote 0.0% (0 of 2)
Mammary gland N/A heterozygote 0.0% (0 of 2)
Olfactory lobe N/A heterozygote 0.0% (0 of 2)
Ovary N/A heterozygote Not available
Oviduct N/A heterozygote 0.0% (0 of 2)
Pancreas N/A heterozygote 0.0% (0 of 2)
Peripheral nervous system N/A heterozygote 0.0% (0 of 2)
Peyer's patch N/A heterozygote 0.0% (0 of 2)
Pituitary gland N/A heterozygote 0.0% (0 of 2)
Prostate gland N/A heterozygote Not available
Skeletal muscle N/A heterozygote 0.0% (0 of 2)
Skin N/A heterozygote 0.0% (0 of 2)
Small intestine N/A heterozygote 0.0% (0 of 2)
Spleen N/A heterozygote 0.0% (0 of 2)
Stomach N/A heterozygote 0.0% (0 of 2)
Striatum N/A heterozygote 0.0% (0 of 2)
Thalamus N/A heterozygote 0.0% (0 of 2)
Thymus N/A heterozygote 0.0% (0 of 2)
Thyroid gland N/A heterozygote 0.0% (0 of 2)
Trachea N/A heterozygote 0.0% (0 of 2)
Urinary bladder N/A heterozygote 0.0% (0 of 2)
Uterus N/A heterozygote 0.0% (0 of 2)
Vascular system N/A heterozygote 0.0% (0 of 2)
Vesicular gland N/A heterozygote Not available
White adipose tissue N/A heterozygote 0.0% (0 of 2)

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Brain N/A heterozygote 0.0% (0 of 2)
Brain N/A homozygote 0.0% (0 of 1)
Dorsal root ganglion N/A heterozygote 0.0% (0 of 2)
Dorsal root ganglion N/A homozygote 0.0% (0 of 1)
Ear N/A heterozygote 0.0% (0 of 2)
Ear N/A homozygote 0.0% (0 of 1)
Embryo N/A heterozygote 0.0% (0 of 2)
Embryo N/A homozygote 0.0% (0 of 1)
Eye N/A heterozygote 0.0% (0 of 2)
Eye N/A homozygote 0.0% (0 of 1)
Footplate N/A heterozygote 0.0% (0 of 2)
Footplate N/A homozygote 0.0% (0 of 1)
Forebrain N/A heterozygote 0.0% (0 of 2)
Forebrain N/A homozygote 0.0% (0 of 1)
Forelimb N/A heterozygote 0.0% (0 of 2)
Forelimb N/A homozygote 0.0% (0 of 1)
Fronto-nasal process N/A heterozygote 0.0% (0 of 2)
Fronto-nasal process N/A homozygote 0.0% (0 of 1)
Handplate N/A heterozygote 0.0% (0 of 2)
Handplate N/A homozygote 0.0% (0 of 1)
Head N/A heterozygote 0.0% (0 of 2)
Head N/A homozygote 0.0% (0 of 1)
Heart N/A heterozygote 0.0% (0 of 2)
Heart N/A homozygote 0.0% (0 of 1)
Hindbrain N/A heterozygote 0.0% (0 of 2)
Hindbrain N/A homozygote 0.0% (0 of 1)
Hindlimb N/A heterozygote 0.0% (0 of 2)
Hindlimb N/A homozygote 0.0% (0 of 1)
Liver N/A heterozygote 0.0% (0 of 2)
Liver N/A homozygote 0.0% (0 of 1)
Lung N/A heterozygote 0.0% (0 of 2)
Lung N/A homozygote 0.0% (0 of 1)
Mandibular process N/A heterozygote 0.0% (0 of 2)
Mandibular process N/A homozygote 0.0% (0 of 1)
Maxillary process N/A heterozygote 0.0% (0 of 2)
Maxillary process N/A homozygote 0.0% (0 of 1)
Midbrain N/A heterozygote 0.0% (0 of 2)
Midbrain N/A homozygote 0.0% (0 of 1)
Nose N/A heterozygote 0.0% (0 of 2)
Nose N/A homozygote 0.0% (0 of 1)
Oral cavity N/A heterozygote 0.0% (0 of 2)
Oral cavity N/A homozygote 0.0% (0 of 1)
Skin N/A heterozygote 0.0% (0 of 2)
Skin N/A homozygote 0.0% (0 of 1)
Spinal cord N/A heterozygote 0.0% (0 of 2)
Spinal cord N/A homozygote 0.0% (0 of 1)
Tail somite N/A heterozygote 0.0% (0 of 2)
Tail somite N/A homozygote 0.0% (0 of 1)
Tail N/A heterozygote 0.0% (0 of 2)
Tail N/A homozygote 0.0% (0 of 1)

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.74% (4 of 537)
aorta 0.19% (1 of 528)
brain 0.91% (5 of 547)
brainstem 0.37% (2 of 539)
brown adipose tissue 0.0%
cartilage tissue 0.19% (1 of 529)
cerebellum 0.37% (2 of 542)
cerebral cortex 0.37% (2 of 535)
epididymis 13.64% (18 of 132)
esophagus 1.63% (6 of 367)
eye 0.0%
heart 0.37% (2 of 546)
hippocampus 0.56% (3 of 532)
hypothalamus 0.37% (2 of 535)
kidney 4.3% (23 of 535)
large intestine 5.08% (27 of 532)
liver 0.0%
lower urinary tract 0.19% (1 of 532)
lung 0.37% (2 of 547)
lymph node 0.18% (1 of 544)
mammary gland 0.0%
midbrain 0.0%
olfactory lobe 0.37% (2 of 537)
ovary 0.19% (1 of 539)
oviduct 0.0%
pancreas 0.96% (5 of 522)
peripheral nervous system 0.19% (1 of 520)
peyers patch 0.0%
pituitary gland 0.19% (1 of 529)
prostate gland 2.23% (12 of 539)
skeletal muscle 0.0%
skin 0.18% (1 of 544)
small intestine 5.69% (31 of 545)
spinal cord 0.56% (3 of 534)
spleen 0.56% (3 of 531)
stomach 3.72% (20 of 537)
striatum 0.37% (2 of 535)
submandibular gland 1.54% (2 of 130)
testis 0.95% (5 of 524)
thalamus 0.0%
thymus 0.19% (1 of 535)
thyroid gland 3.22% (17 of 528)
trachea 0.55% (3 of 544)
urinary bladder 0.0%
uterus 0.38% (2 of 527)
vascular system 0.0%
vesicular gland 0.0%
white adipose tissue 0.0%

Background staining occurs in wild type mice and embryos at an incidental rate.

Background staining occurs in wild type embryos at a measurable rate.

Anatomy Background staining in controls(WT)
brain 1.26% (6 of 477)
dorsal root ganglion 1.72% (1 of 58)
ear 0.21% (1 of 480)
embryo 0.42% (2 of 479)
eye 0.21% (1 of 480)
footplate 0.21% (1 of 480)
forebrain 0.21% (1 of 468)
forelimb 0.21% (1 of 468)
fronto-nasal process 1.75% (1 of 57)
handplate 0.21% (1 of 475)
head 1.04% (5 of 479)
heart 0.21% (1 of 471)
hindbrain 1.27% (6 of 471)
hindlimb 0.21% (1 of 479)
liver 0.21% (1 of 474)
lung 0.22% (1 of 462)
mandibular process 0.21% (1 of 479)
maxillary process 0.21% (1 of 470)
midbrain 0.21% (1 of 471)
nose 1.39% (1 of 72)
oral cavity 0.21% (1 of 470)
skin 0.0%
spinal cord 1.47% (1 of 68)
tail 0.21% (1 of 470)
tail somite group 0.0%

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

X-ray

XRay Images Skull Lateral Orientation

10 Images

X-ray

XRay Images Whole Body Lateral Orientation

10 Images

X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

Adult LacZ

LacZ Images Section

9 Images

X-ray

XRay Images Whole Body Dorso Ventral

10 Images

X-ray

XRay Images Forepaw

10 Images

Sleep Wake

Wake state (bmp file)

9 Images

Auditory Brain Stem Response

Click-evoked + 6 to 30kHz tone waveforms (pdf format)

8 Images

Human diseases caused by Folh1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Folh1 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Intellectual Developmental Disorder, Autosomal Recessive 54
Hyperactivity OMIM:617028
Schizophrenia 15
Hyperactivity OMIM:613950
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Attention Deficit-Hyperactivity Disorder 8
Attention deficit hyperactivity disorder OMIM:619957
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Attention Deficit-Hyperactivity Disorder, Susceptibility To, 7
Attention deficit hyperactivity disorder OMIM:613003
Intellectual Developmental Disorder, Autosomal Recessive 3
Hyperactivity OMIM:608443
Autism, Susceptibility To, 20
Attention deficit hyperactivity disorder OMIM:618830
Immunodeficiency 8
Hyperactivity OMIM:615401
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Intellectual Developmental Disorder, Autosomal Recessive 2
Attention deficit hyperactivity disorder OMIM:607417
Pick Disease Of Brain
Apathy, Emotional blunting, Polyphagia, Disinhibition, Inappropriate laughter, Diminished motivat... OMIM:172700
Hyperlysinemia, Type I
Hyperactivity OMIM:238700
Intellectual Developmental Disorder, Autosomal Dominant 33
Hyperactivity OMIM:616311
Frontotemporal Dementia
Apathy, Inappropriate sexual behavior, Polyphagia, Disinhibition, Inappropriate laughter, Diminis... OMIM:600274
Intellectual Developmental Disorder, Autosomal Dominant 69
Attention deficit hyperactivity disorder OMIM:617863
Intellectual Developmental Disorder, Autosomal Recessive 37
Hyperactivity OMIM:615493
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity ORPHA:356996
Intellectual Developmental Disorder, X-Linked 72
Hyperactivity OMIM:300271
Progressive Non-Fluent Aphasia
Temporal cortical atrophy, Senile plaques, Mental deterioration, Memory impairment, Astrocytosis,... ORPHA:100070
Language Delay And Attention Deficit-Hyperactivity Disorder/Cognitive Impairment With Or Without Cardiac Arrhythmia
Attention deficit hyperactivity disorder, Hyperactivity OMIM:617182
Intellectual Disability-Expressive Aphasia-Facial Dysmorphism Syndrome
Hyperactivity ORPHA:436151
Smith-Magenis syndrome
Hyperactivity DECIPHER:8
Obesity Due To Sim1 Deficiency
Hypotension, Polyphagia, Abnormal autonomic nervous system physiology, Postural hypotension with ... ORPHA:369873
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Attention deficit hyperactivity disorder, Hyperactivity OMIM:301008
Huntington Disease
Apathy, Depression, Anxiety, Hostility, Suicidal ideation, Polyphagia, Disinhibition, Aggressive ... ORPHA:399
Severe Early-Onset Obesity-Insulin Resistance Syndrome Due To Sh2B1 Deficiency
Polyphagia, Aggressive behavior ORPHA:329249
Obesity Due To Melanocortin 4 Receptor Deficiency
Hypertension, Polyphagia ORPHA:71529
Early-Onset Schizophrenia
Impairment in personality functioning, Abnormal emotion/affect behavior, Depression, Anxiety, Low... ORPHA:96369
Sporadic Creutzfeldt-Jakob Disease
Neuronal loss in central nervous system, Ataxia, Gliosis, Cerebral atrophy, Cognitive impairment,... ORPHA:204
Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type
Hyperactivity OMIM:301076
Kleine-Levin Hibernation Syndrome
Polyphagia OMIM:148840
Intellectual Developmental Disorder, Autosomal Dominant 39
Polyphagia, Aggressive behavior, Self-mutilation OMIM:616521
Focal Cortical Dysplasia, Type Ii
Astrocytosis, Cognitive impairment OMIM:607341
8p23.1 deletion syndrome
Hyperactivity DECIPHER:39
Angelman Syndrome Due To Imprinting Defect In 15Q11-Q13
Happy demeanor, Polyphagia, Inappropriate laughter ORPHA:411515
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 7
Neuronal loss in central nervous system, Cerebral cortical atrophy, Memory impairment, Astrocytos... OMIM:600795
Intellectual Developmental Disorder, X-Linked 101
Hyperactivity OMIM:300928
Graves Disease, Susceptibility To, 1
Polyphagia, Irritability, Congestive heart failure OMIM:275000
Developmental And Epileptic Encephalopathy 43
Attention deficit hyperactivity disorder, Hyperactivity OMIM:617113
Hyperinsulinism Due To Ucp2 Deficiency
Palpitations, Tachycardia, Syncope, Polyphagia, Hypertrophic cardiomyopathy ORPHA:276556
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Hyperactivity OMIM:619031
Leptin Deficiency Or Dysfunction
Polyphagia, Abnormal eating behavior OMIM:614962
Autosomal Dominant Hyperinsulinism Due To Sur1 Deficiency
Palpitations, Tachycardia, Syncope, Polyphagia, Hypertrophic cardiomyopathy ORPHA:276575
Leptin Receptor Deficiency
Polyphagia, Aggressive behavior, Abnormal eating behavior OMIM:614963
Autosomal Dominant Hyperinsulinism Due To Kir6.2 Deficiency
Palpitations, Tachycardia, Syncope, Polyphagia, Hypertrophic cardiomyopathy ORPHA:276580
Macrosomia Adiposa Congenita
Polyphagia OMIM:248100
Obesity, Hyperphagia, And Developmental Delay
Polyphagia OMIM:613886
Body Mass Index Quantitative Trait Locus 20
Polyphagia OMIM:618406
Morm Syndrome
Hyperactivity ORPHA:75858
Hyperinsulinism Due To Hnf1A Deficiency
Polyphagia, Palpitations, Tachycardia, Syncope ORPHA:324575
Behavioral Variant Of Frontotemporal Dementia
Mental deterioration, Memory impairment, Astrocytosis, Frontotemporal cerebral atrophy, Frontotem... ORPHA:275864
Wilms Tumor, Aniridia, Genitourinary Anomalies, Mental Retardation, And Obesity Syndrome
Anxiety, Polyphagia, Aggressive behavior, Emotional lability, Hypertension, Low frustration toler... OMIM:612469
Type 1 Diabetes Mellitus
Polyphagia, Polydipsia OMIM:222100
Pediatric-Onset Graves Disease
Polydipsia, Sinus tachycardia, Palpitations, Polyphagia, Emotional lability, Hypertension, Atrial... ORPHA:525731
Bardet-Biedl Syndrome 22
Polyphagia OMIM:617119
Intellectual Developmental Disorder, Autosomal Dominant 67
Attention deficit hyperactivity disorder, Hyperactivity OMIM:619927
Renal Glucosuria
Polyphagia, Polydipsia OMIM:233100
2Q23.1 Microdeletion Syndrome
Polyphagia, Self-injurious behavior, Paroxysmal bursts of laughter ORPHA:228402
Hypotonia-Cystinuria Syndrome
Polyphagia ORPHA:163690
Obesity, Early-Onset, With Adrenal Insufficiency And Red Hair
Polyphagia OMIM:609734
Prader-Willi Syndrome Due To Imprinting Mutation
Polyphagia ORPHA:177910
Schaaf-Yang Syndrome
Polyphagia, Impulsivity, Skin-picking OMIM:615547
Obesity Due To Leptin Receptor Gene Deficiency
Orthostatic hypotension due to autonomic dysfunction, Polyphagia, Emotional lability ORPHA:179494
Histidinemia
Hyperactivity ORPHA:2157
Chromosome 22Q13 Duplication Syndrome
Polyphagia, Bipolar affective disorder OMIM:615538
Obesity Due To Prohormone Convertase I Deficiency
Polyphagia ORPHA:71528
Obesity Due To Pro-Opiomelanocortin Deficiency
Polyphagia ORPHA:71526
Insulinoma
Polyphagia, Palpitations, Anxiety ORPHA:97279
Inherited Creutzfeldt-Jakob Disease
Senile plaques, Neuronal loss in central nervous system, Progressive cerebellar ataxia, Progressi... ORPHA:282166
6Q16 Microdeletion Syndrome
Polyphagia ORPHA:171829
Frontotemporal Lobar Degeneration With Tdp43 Inclusions, Grn-Related
Hypersexuality, Polyphagia, Apathy, Disinhibition OMIM:607485
Angelman Syndrome
Happy demeanor, Self-injurious behavior, Anxiety, Optic atrophy, Optic disc pallor, Polyphagia, A... ORPHA:72
Temple Syndrome
Polyphagia ORPHA:254516
Hypotonia-Cystinuria Syndrome
Polyphagia, Facial palsy OMIM:606407
Cebalid Syndrome
Polyphagia OMIM:618774
Bardet-Biedl Syndrome 9
Polyphagia, Polydipsia OMIM:615986
Luscan-Lumish Syndrome
Polyphagia, Anxiety, Aggressive behavior OMIM:616831
Trisomy 18P
Polyphagia, Facial palsy ORPHA:1715
Body Mass Index Quantitative Trait Locus 19
Polyphagia OMIM:617885
Man1B1-Cdg
Polyphagia ORPHA:397941
Obesity Due To Congenital Leptin Deficiency
Orthostatic hypotension due to autonomic dysfunction, Polyphagia ORPHA:66628
Intellectual Developmental Disorder, Autosomal Dominant 1
Self-injurious behavior, Anxiety, Polyphagia, Aggressive behavior, Inappropriate laughter OMIM:156200
Photomyoclonus, Diabetes Mellitus, Deafness, Nephropathy, And Cerebral Dysfunction
Ataxia, Astrocytosis OMIM:172500
Intellectual Developmental Disorder, Autosomal Recessive 71
Attention deficit hyperactivity disorder, Hyperactivity OMIM:618504
7Q11.23 Microduplication Syndrome
Self-injurious behavior, Aortic valve stenosis, Anxiety, Polyphagia, Patent ductus arteriosus, Ag... ORPHA:96121
Paternal Uniparental Disomy Of Chromosome 1
Hypertension, Polyphagia ORPHA:251004
Satb2-Associated Syndrome Due To A Chromosomal Rearrangement
Emotional lability, Polyphagia, Aggressive behavior, Self-mutilation ORPHA:251028
Intellectual Developmental Disorder, X-Linked 107
Attention deficit hyperactivity disorder, Hyperactivity OMIM:301013
Secondary Short Bowel Syndrome
Polyphagia, Aganglionic megacolon ORPHA:95427
Mitochondrial Dna Depletion Syndrome 4A (Alpers Type)
Neuronal loss in central nervous system, Ataxia, Gliosis, Astrocytosis, Cerebellar atrophy, Cereb... OMIM:203700
Pseudohypoparathyroidism Type 1C
Depression, Anxiety, Polyphagia, Prolonged QT interval, Irritability ORPHA:79444
Pseudohypoparathyroidism Type 1A
Depression, Anxiety, Polyphagia, Hypertension, Prolonged QT interval, Irritability ORPHA:79443
Prader-Willi Syndrome Due To Maternal Uniparental Disomy Of Chromosome 15
Polyphagia, Bulimia, Self-injurious behavior, Skin-picking ORPHA:98754
Prader-Willi Syndrome Due To Paternal 15Q11Q13 Deletion
Polyphagia, Bulimia, Self-injurious behavior, Skin-picking ORPHA:98793
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 2
Polyphagia, Bulimia, Self-injurious behavior, Skin-picking ORPHA:177904
Prader-Willi Syndrome Due To Paternal Deletion Of 15Q11Q13 Type 1
Polyphagia, Bulimia, Self-injurious behavior, Skin-picking ORPHA:177901
Magel2-Related Prader-Willi-Like Syndrome
Polyphagia, Impulsivity, Skin-picking ORPHA:398069
Sim1-Related Prader-Willi-Like Syndrome
Polyphagia, Skin-picking ORPHA:398079
Craniopharyngioma
Papilledema, Cerebral ischemia, Optic atrophy, Myocardial infarction, Polyphagia ORPHA:54595
Chromosome Xq26.3 Duplication Syndrome
Polyphagia OMIM:300942
Weaver Syndrome
Polyphagia, Patent ductus arteriosus OMIM:277590
Prader-Willi-Like Syndrome
Polyphagia, Bulimia, Self-injurious behavior, Skin-picking ORPHA:398073
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Hyperactivity ORPHA:85327
Hypomagnesemia, Seizures, And Impaired Intellectual Development 2
Hyperactivity OMIM:618314
Prader-Willi Syndrome
Hypertension, Polyphagia ORPHA:739
Adnp Syndrome
Polyphagia, Anxiety, Aggressive behavior, Oral-pharyngeal dysphagia ORPHA:404448
Prader-Willi Syndrome
Polyphagia, Self-injurious behavior OMIM:176270
Gangliocytoma
Polyphagia ORPHA:251937
Rapid-Onset Childhood Obesity-Hypothalamic Dysfunction-Hypoventilation-Autonomic Dysregulation Syndrome
Polydipsia, Self-injurious behavior, Abnormal autonomic nervous system physiology, Depression, Po... ORPHA:293987
Supranuclear Palsy, Progressive, 1
Frontolimbic dementia, Senile plaques, Neuronal loss in central nervous system, Gliosis, Cerebral... OMIM:601104
Hyperthyroidism, Nonautoimmune
Hyperactivity OMIM:609152
1P36 Deletion Syndrome
Self-injurious behavior, Optic atrophy, Polyphagia, Dilated cardiomyopathy, Patent ductus arterio... ORPHA:1606
Chromosome 1P36 Deletion Syndrome, Distal
Self-mutilation, Optic disc coloboma, Optic atrophy, Optic disc pallor, Polyphagia, Noncompaction... OMIM:607872
X-Linked Acrogigantism
Polyphagia ORPHA:300373
Lipodystrophy, Congenital Generalized, Type 1
Polyphagia, Cardiomyopathy OMIM:608594
Lipodystrophy, Congenital Generalized, Type 2
Polyphagia, Hypertrophic cardiomyopathy OMIM:269700
Alström Syndrome
Abnormal coronary artery physiology, Optic disc pallor, Polyphagia, Dilated cardiomyopathy, Porta... ORPHA:64

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Folh1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Folh1.

No publications found that use IMPC mice or data for Folh1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

This service may be affected by the Covid-19 pandemic. See how

MGI Allele Allele Type Produced
Folh1tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells
Folh1tm1b(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Mice

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter