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Gene: Olig2 MGI:1355331

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

oligodendrocyte transcription factor 2

Synonyms:

Bhlhb1, bHLHe19, RK17, Olg-2

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Olig2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Olig2 (0 diseases)
Human diseases predicted to be associated with Olig2 (210 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Olig2 by phenotypic similarity.

Disease	Matching phenotypes	Source
Spastic Paraplegia 25, Autosomal Recessive	Spastic paraplegia, Spinal cord compression	OMIM:608220
Hereditary Liability to Pressure Palsies (HNPP)	Motor conduction block, Abnormal motor neuron morphology	DECIPHER:31
Dystonia 31	Leg dystonia, Generalized dystonia, Writer's cramp, Dysphagia, Abnormal posturing, Arm dystonia, ...	OMIM:619565
Primary Lateral Sclerosis, Adult, 1	Spastic dysarthria, Abnormal upper motor neuron morphology, Dysphagia, Spastic gait, Spastic tetr...	OMIM:611637
Lissencephaly 1	Gray matter heterotopia, Pachygyria, Axial hypotonia, Agyria, Spastic tetraparesis, Lissencephaly...	OMIM:607432
Craniofacial Conodysplasia	Spinal cord compression, Hydrocephalus	ORPHA:85168
Cortical Dysplasia, Complex, With Other Brain Malformations 3	Spastic tetraplegia, Gray matter heterotopia, Pachygyria, Agyria, Lissencephaly, Subcortical band...	OMIM:615411
Isolated Lissencephaly Type 1 Without Known Genetic Defects	Spasticity, Gray matter heterotopia, Neonatal hypotonia, Pachygyria, Agyria, Axial hypotonia	ORPHA:1084
Lissencephaly, X-Linked, 1	Spasticity, Death in infancy, Gray matter heterotopia, Pachygyria, Agyria, Axial hypotonia, Lisse...	OMIM:300067
Spinal Muscular Atrophy, Segmental	Abnormal anterior horn cell morphology	OMIM:183020
Charcot-Marie-Tooth syndrome type 1A (CMT1A)	Decreased motor nerve conduction velocity, Abnormal motor neuron morphology	DECIPHER:29
Periventricular Heterotopia With Microcephaly, Autosomal Recessive	Hypotonia, Generalized hypotonia, Periventricular nodular heterotopia, Periventricular heterotopia	OMIM:608097
Neurodevelopmental Disorder With Nonspecific Brain Abnormalities And With Or Without Seizures	Hypotonia, Attention deficit hyperactivity disorder, Abnormality of neuronal migration, Hydroceph...	OMIM:618709
Juvenile Primary Lateral Sclerosis	Spasticity, Spastic gait, Spastic dysarthria, Abnormal upper motor neuron morphology, Dysphagia, ...	ORPHA:247604
Lissencephaly 3	Spastic tetraplegia, Polymicrogyria, Hypotonia, Generalized hypotonia, Gray matter heterotopia, P...	OMIM:611603
Microlissencephaly	Polymicrogyria, Simplified gyral pattern, Subcortical heterotopia, Pachygyria, Lissencephaly, Hyp...	ORPHA:1083
Chiari Malformation Type Ii	Syringomyelia, Cervical myelopathy, Spina bifida, Hydrocephalus, Hypotonia, Myelomeningocele, Gen...	OMIM:207950
Cortical Dysplasia, Complex, With Other Brain Malformations 10	Spastic tetraplegia, Hypotonia, Lissencephaly, Hypertonia, Periventricular ribbonlike heterotopia	OMIM:618677
Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations	Polymicrogyria, Hyperactivity, Simplified gyral pattern, Gray matter heterotopia, Pachygyria, Spa...	OMIM:604317
Primary Lateral Sclerosis, Juvenile	Spastic gait, Spastic dysarthria, Pseudobulbar paralysis, Spasticity of pharyngeal muscles, Abnor...	OMIM:606353
Sub-Cortical Nodular Heterotopia	Spasticity, Polymicrogyria, Abnormality of neuronal migration, Subcortical heterotopia	ORPHA:101029
Dystonia 1, Torsion, Autosomal Dominant	Torticollis, Blepharospasm, Hypotonia, Generalized hypotonia, Generalized dystonia, Writer's cram...	OMIM:128100
Neuronopathy, Distal Hereditary Motor, Type Viib	Abnormal lower motor neuron morphology	OMIM:607641
Mohr-Tranebjaerg Syndrome	Spasticity, Tremor, Dysphagia, Abnormal posturing, Dystonia	OMIM:304700
Acalvaria	Holoprosencephaly, Hydrocephalus, Abnormality of neuronal migration, Spina bifida	ORPHA:945
Nodular Neuronal Heterotopia	Abnormality of neuronal migration	ORPHA:2149
Primary Lateral Sclerosis	Spasticity, Spastic dysarthria, Atrophy of the spinal cord, Abnormal lower motor neuron morpholog...	ORPHA:35689
Chudley-Mccullough Syndrome	Gray matter heterotopia, Polymicrogyria, Hydrocephalus	OMIM:604213
Spinocerebellar Ataxia Type 2	Spinal cord posterior columns myelin loss, Abnormal cortical gyration, Kinetic tremor, Postural t...	ORPHA:98756
Lissencephaly 5	Type II lissencephaly, Hydrocephalus, Hypotonia, Occipital encephalocele, Gray matter heterotopia...	OMIM:615191
Amyotrophic Lateral Sclerosis 2, Juvenile	Spasticity, Spastic gait, Retrocollis, Lower limb spasticity, Spastic dysarthria, Abnormal lower ...	OMIM:205100
Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia	Amyotrophic lateral sclerosis	OMIM:616208
Ossification Of The Posterior Longitudinal Ligament Of Spine	Spinal cord compression, Myelopathy	OMIM:602475
Congenital Arthrogryposis With Anterior Horn Cell Disease	Abnormal anterior horn cell morphology, Paucity of anterior horn motor neurons, Generalized hypot...	OMIM:611890
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4	Disinhibition, Abnormal lower motor neuron morphology, Dysphagia, Amyotrophic lateral sclerosis	OMIM:616439
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 3	Disinhibition, Abnormal lower motor neuron morphology, Dysphagia, Amyotrophic lateral sclerosis	OMIM:616437
Maternal Hyperthermia-Induced Birth Defects	Hypotonia, Hypertonia, Abnormality of neuronal migration	ORPHA:2216
Cobblestone Lissencephaly Without Muscular Or Ocular Involvement	Type II lissencephaly, Hydrocephalus, Occipital encephalocele, Gray matter heterotopia, Dysgyria	ORPHA:352682
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis	OMIM:105500
Amyotrophic Lateral Sclerosis 23	Degeneration of anterior horn cells, Amyotrophic lateral sclerosis	OMIM:617839
Band Heterotopia	Spasticity, Polymicrogyria, Hydrocephalus, Gray matter heterotopia, Subcortical band heterotopia	OMIM:600348
Amyotrophic Lateral Sclerosis, Susceptibility To, 25	Amyotrophic lateral sclerosis	OMIM:617921
Symmetrical Thalamic Calcifications	Spasticity, Hypertonia, Abnormality of neuronal migration	ORPHA:1314
Amyotrophic Lateral Sclerosis 15 With Or Without Frontotemporal Dementia	Dysphagia, Amyotrophic lateral sclerosis, Dystonia, Athetosis	OMIM:300857
Amyotrophic Lateral Sclerosis 4, Juvenile	Atrophy of the spinal cord, Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis...	OMIM:602433
Developmental Delay, Behavioral Abnormalities, And Neuropsychiatric Disorders	Hypotonia, Attention deficit hyperactivity disorder, Periventricular nodular heterotopia	OMIM:620065
Classic Pantothenate Kinase-Associated Neurodegeneration	Spasticity, Attention deficit hyperactivity disorder, Generalized dystonia, Dysphagia, Opisthoton...	ORPHA:216866
Sporadic Infantile Bilateral Striatal Necrosis	Infantile muscular hypotonia, Titubation, Infantile axial hypotonia, Dysphagia, Abnormal posturin...	ORPHA:225147
Polymicrogyria Due To Tubb2B Mutation	Polymicrogyria, Infantile muscular hypotonia, Attention deficit hyperactivity disorder, Gray matt...	ORPHA:300573
Spastic Paralysis, Infantile-Onset Ascending	Dysphagia, Spastic paraplegia, Spastic tetraplegia, Abnormal lower motor neuron morphology	OMIM:607225
Spinal Muscular Atrophy, Distal, Autosomal Recessive, 4	Respiratory insufficiency due to muscle weakness, Abnormal lower motor neuron morphology	OMIM:611067
Autosomal Recessive Cerebellar Ataxia-Movement Disorder Syndrome	Abnormal lower motor neuron morphology	ORPHA:95434
Polyglucosan Body Neuropathy, Adult Form	Abnormal upper motor neuron morphology, Orthostatic hypotension, Neurogenic bladder	OMIM:263570
Congenital Muscular Dystrophy Without Intellectual Disability	Neonatal hypotonia, Generalized hypotonia, Pachygyria, Gray matter heterotopia	ORPHA:370980
Cerebral Palsy, Spastic Quadriplegic, 3	Spasticity, Spastic tetraplegia, Spastic diplegia, Gray matter heterotopia, Dysphagia	OMIM:617008
Bilateral Striopallidodentate Calcinosis	Abnormality of neuronal migration	ORPHA:1980
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia	Spasticity, Spastic paraplegia, Abnormal spinal cord morphology, Progressive spastic paraplegia	ORPHA:139578
Amyotrophic Lateral Sclerosis 5, Juvenile	Respiratory insufficiency due to muscle weakness, Abnormal lower motor neuron morphology, Amyotro...	OMIM:602099
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 6	Spasticity, Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Dysphagia, Low...	OMIM:613954
Muscular Dystrophy-Dystroglycanopathy (Congenital With Impaired Intellectual Development), Type B, 6	Hypotonia, Generalized hypotonia, Pachygyria, Abnormality of neuronal migration	OMIM:608840
Huntington Disease-Like 1	Generalized hypotonia, Abnormal posturing, Restlessness	ORPHA:157941
Leber Congenital Amaurosis	Encephalocele, Hypotonia, Abnormality of neuronal migration	ORPHA:65
Boucher-Neuhauser Syndrome	Spasticity, Intention tremor, Abnormal upper motor neuron morphology	OMIM:215470
Hemimegalencephaly	Polymicrogyria, Pachygyria, Abnormal neuron morphology, Gray matter heterotopia	ORPHA:99802
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2A2	Postural tremor, Abnormal spinal cord morphology, Hand tremor, Hydrocephalus	ORPHA:99947
Subependymal Nodular Heterotopia	Polymicrogyria, Myelomeningocele, Meningocele, Occipital encephalocele, Nasofrontal encephalocele...	ORPHA:101030
Mismatch Repair Cancer Syndrome 4	Gray matter heterotopia	OMIM:619101
Lissencephaly 6 With Microcephaly	Spasticity, Polymicrogyria, Limb hypertonia, Microlissencephaly, Simplified gyral pattern, Pachyg...	OMIM:616212
Spinal Muscular Atrophy-Progressive Myoclonic Epilepsy Syndrome	Tremor, Abnormal lower motor neuron morphology, Dysphagia	ORPHA:2590
Lissencephaly Syndrome, Norman-Roberts Type	4-layered lissencephaly, Abnormal muscle tone, Microlissencephaly, Dysphagia, Abnormality of neur...	ORPHA:89844
Neurocutaneous Melanocytosis	Syringomyelia, Meningocele, Death in infancy, Abnormality of neuronal migration	ORPHA:2481
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 7	Encephalocele, Type II lissencephaly, Polymicrogyria, Death in childhood, Hydrocephalus, Hypotoni...	OMIM:614643
Frontotemporal Dementia With Motor Neuron Disease	Disinhibition, Abnormal lower motor neuron morphology, Abnormal upper motor neuron morphology, Dy...	ORPHA:275872
Glutathionuria	Tremor, Action tremor, Gray matter heterotopia	OMIM:231950
Brain Small Vessel Disease 2	Spastic tetraplegia, Polymicrogyria, Subcortical heterotopia	OMIM:614483
Lethal Congenital Contracture Syndrome 1	Neonatal death, Paucity of anterior horn motor neurons	OMIM:253310
3-Hydroxyisobutyric Aciduria	Abnormality of neuronal migration	OMIM:236795
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis	OMIM:105550
Thanatophoric Dysplasia Type 2	Encephalocele, Hydrocephalus, Hypotonia, Holoprosencephaly, Abnormality of neuronal migration	ORPHA:93274
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Spasticity, Abnormal upper motor neuron morphology, Disinhibition	OMIM:221770
Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations	Simplified gyral pattern, Generalized hypotonia, Periventricular heterotopia	OMIM:618273
Amyotrophic Lateral Sclerosis 21	Abnormal lower motor neuron morphology, Abnormal upper motor neuron morphology, Amyotrophic later...	OMIM:606070
Methylmalonic Aciduria And Homocystinuria, Cblj Type	Hypotonia, Abnormal posturing	OMIM:614857
Intellectual Developmental Disorder, X-Linked 12	Tremor, Hypotonia, Spasticity, Abnormality of neuronal migration	OMIM:300957
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Cranial nerve compression, Amyotrophic lateral sclerosis, Abnormal motor neuron morphology	ORPHA:52430
Poretti-Boltshauser Syndrome	Hypotonia, Generalized hypotonia, Gray matter heterotopia	OMIM:615960
Periventricular Nodular Heterotopia 7	Polymicrogyria, Periventricular nodular heterotopia, Hypotonia, Gray matter heterotopia, Axial hy...	OMIM:617201
Edinburgh Malformation Syndrome	Hypertonia, Abnormality of neuronal migration, Hydrocephalus	ORPHA:1895
Peroxisome Biogenesis Disorder 13A (Zellweger)	Polymicrogyria, Hypotonia, Generalized hypotonia, Gray matter heterotopia, Neonatal death, Axial ...	OMIM:614887
Microcephaly And Chorioretinopathy, Autosomal Recessive, 2	Simplified gyral pattern, Periventricular heterotopia	OMIM:616171
Walker-Warburg Syndrome	Abnormal cortical gyration, Polymicrogyria, Macrogyria, Hydrocephalus, Hypotonia, Pachygyria, Lis...	ORPHA:899
Infantile-Onset X-Linked Spinal Muscular Atrophy	Abnormal anterior horn cell morphology, Infantile muscular hypotonia, Degeneration of anterior ho...	ORPHA:1145
Joubert Syndrome	Encephalocele, Polymicrogyria, Hydrocephalus, Hypotonia, Tremor, Abnormality of neuronal migration	ORPHA:475
Dysplastic Cortical Hyperostosis, Kozlowski-Tsuruta Type	Abnormality of neuronal migration	ORPHA:2204
Keratoderma Hereditarium Mutilans	Abnormal spinal cord morphology	ORPHA:494
Posterior Column Ataxia-Retinitis Pigmentosa Syndrome	Truncal titubation, Abnormal spinal cord morphology, Generalized hypotonia	ORPHA:88628
Unilateral Polymicrogyria	Spastic tetraplegia, Pseudobulbar paralysis, Appendicular hypotonia, Abnormal posturing, Axial hy...	ORPHA:268943
Neonatal Adrenoleukodystrophy	Hypotonia, Abnormality of neuronal migration	ORPHA:44
Machado-Joseph Disease Type 3	Spasticity, Abnormal lower motor neuron morphology, Spinocerebellar tract degeneration, Dysphagia...	ORPHA:276244
Joubert Syndrome 30	Hypotonia, Gray matter heterotopia	OMIM:617622
Autosomal Recessive Primary Microcephaly	Pachygyria, Gray matter heterotopia	ORPHA:2512
Periventricular Nodular Heterotopia 1	Abnormality of neuronal migration, Gray matter heterotopia	OMIM:300049
Sandifer Syndrome	Torticollis, Abnormal posturing	ORPHA:71272
Desmosterolosis	Spasticity, Abnormal cortical gyration, Polymicrogyria, Macrogyria, Hydrocephalus, Rigidity, Pach...	ORPHA:35107
Spastic Paraplegia 9A, Autosomal Dominant	Abnormal upper motor neuron morphology, Spastic paraplegia, Resting tremor, Spastic gait, Lower l...	OMIM:601162
Laryngotracheoesophageal Cleft Type 4	Respiratory insufficiency, Abnormal lower motor neuron morphology	ORPHA:93941
Thanatophoric Dysplasia	Hypotonia, Gray matter heterotopia, Hydrocephalus	ORPHA:2655
Man1B1-Cdg	Polyphagia, Infantile muscular hypotonia, Resting tremor, Periventricular heterotopia	ORPHA:397941
Developmental Delay With Variable Neurologic And Brain Abnormalities	Spasticity, Gray matter heterotopia	OMIM:619694
Galloway-Mowat Syndrome	Hypotonia, Aqueductal stenosis, Pachygyria, Hypertonia, Abnormality of neuronal migration	ORPHA:2065
Thanatophoric Dysplasia, Type I	Hypotonia, Gray matter heterotopia, Neonatal death, Hydrocephalus	OMIM:187600
Cntnap2-Related Developmental And Epileptic Encephalopathy	Hyperactivity, Abnormal neuron morphology, Hypotonia, Abnormality of neuronal migration, Lower li...	ORPHA:163681
Neurodegeneration With Brain Iron Accumulation 4	Spasticity, Abnormal lower motor neuron morphology, Generalized dystonia, Tremor, Oromandibular d...	OMIM:614298
9Q21.13 Microdeletion Syndrome	Syringomyelia, Gray matter heterotopia	ORPHA:531151
Hydrocephalus, Congenital, 2, With Or Without Brain Or Eye Anomalies	Hydrocephalus, Communicating hydrocephalus, Hypotonia, Simplified gyral pattern, Gray matter hete...	OMIM:615219
Neu-Laxova Syndrome	Abnormal cortical gyration, Polymicrogyria, Macrogyria, Spina bifida, Opisthotonus, Pachygyria, L...	ORPHA:2671
Alg11-Cdg	Infantile muscular hypotonia, Limb hypertonia, Gray matter heterotopia, Opisthotonus, Axial hypot...	ORPHA:280071
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 13	Spasticity, Type II lissencephaly, Hydrocephalus, Hydromyelia, Hypotonia, Communicating hydroceph...	OMIM:615287
Spinal Arteriovenous Metameric Syndrome	Abnormal spinal cord morphology, Spinal arteriovenous malformation	ORPHA:53721
Neurodevelopmental Disorder With Seizures, Microcephaly, And Brain Abnormalities	Spastic tetraplegia, Frontal polymicrogyria, Hypotonia, Gray matter heterotopia, Neonatal death, ...	OMIM:620024
Radio-Tartaglia Syndrome	Hypotonia, Attention deficit hyperactivity disorder, Gray matter heterotopia, Tremor, Dysphagia, ...	OMIM:619312
Li-Ghorbani-Weisz-Hubshman Syndrome	Attention deficit hyperactivity disorder, Periventricular heterotopia	OMIM:618974
Oculocerebrocutaneous Syndrome	Orbital encephalocele, Gray matter heterotopia	OMIM:164180
Congenital Osteogenesis Imperfecta-Microcephaly-Cataracts Syndrome	Abnormality of neuronal migration	ORPHA:2772
Hypertelorism-Hypospadias-Polysyndactyly Syndrome	Encephalocele, Abnormal cortical gyration, Polymicrogyria, Macrogyria, Exencephaly, Pachygyria, L...	ORPHA:2211
Joubert Syndrome With Oculorenal Defect	Encephalocele, Hypotonia, Abnormality of neuronal migration, Hydrocephalus	ORPHA:2318
Vici Syndrome	Dysphagia, Hypotonia, Abnormal posturing, Gray matter heterotopia	OMIM:242840
Hypomelanosis Of Ito	Gray matter heterotopia	OMIM:300337
Congenital Muscular Dystrophy With Cerebellar Involvement	Type II lissencephaly, Polymicrogyria, Hydrocephalus, Occipital encephalocele, Gray matter hetero...	ORPHA:370959
3C Syndrome	Hypotonia, Death in infancy, Abnormality of neuronal migration, Hydrocephalus	ORPHA:7
Fragile X Syndrome	Hyperactivity, Periventricular heterotopia	OMIM:300624
Solitary Bone Cyst	Abnormal spinal cord morphology	ORPHA:83468
X-Linked Cerebral Adrenoleukodystrophy	Hyperactivity, Myelopathy, Dysphagia, Abnormal spinal cord morphology, Spastic tetraparesis, Lowe...	ORPHA:139396
Tetrasomy 18P	Abnormality of neuronal migration	ORPHA:3307
Methylmalonate Semialdehyde Dehydrogenase Deficiency	Hypotonia, Dystonia, Periventricular heterotopia	OMIM:614105
Congenital Disorder Of Deglycosylation 2	Dysphagia, Hypotonia, Polymicrogyria, Gray matter heterotopia	OMIM:619775
Vici Syndrome	Hypotonia, Death in infancy, Gray matter heterotopia	ORPHA:1493
Pyruvate Dehydrogenase E1-Beta Deficiency	Hypotonia, Pachygyria, Periventricular heterotopia	ORPHA:255138
Joubert Syndrome With Hepatic Defect	Hydrocephalus, Hypotonia, Occipital encephalocele, Tremor, Abnormality of neuronal migration	ORPHA:1454
Alkuraya-Kucinskas Syndrome	Lissencephaly, Gray matter heterotopia, Generalized hypotonia, Hydrocephalus	OMIM:617822
Bilateral Perisylvian Polymicrogyria	Spasticity, Spastic tetraplegia, Infantile muscular hypotonia, Limb hypertonia, Pseudobulbar para...	ORPHA:98889
Van Maldergem Syndrome 1	Periventricular nodular heterotopia, Hypotonia, Simplified gyral pattern, Generalized hypotonia, ...	OMIM:601390
Thanatophoric Dysplasia Type 1	Hypotonia, Gray matter heterotopia, Hydrocephalus	ORPHA:1860
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal	Polymicrogyria, Hypotonia, Death in infancy, Neonatal hypotonia, Abnormality of neuronal migration	OMIM:608836
Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome	Hypertonia, Abnormality of neuronal migration	ORPHA:2518
Pseudo-Torch Syndrome 2	Polymicrogyria, Generalized hypotonia, Gray matter heterotopia	OMIM:617397
Holoprosencephaly	Spasticity, Encephalocele, Spinal dysraphism, Hydrocephalus, Hypotonia, Holoprosencephaly, Spinal...	ORPHA:2162
Neurodevelopmental Disorder With Neuromuscular And Skeletal Abnormalities	Periventricular heterotopia, Hypotonia, Hydrocephalus	OMIM:619833
Coffin-Lowry Syndrome	Death in early adulthood, Progressive spasticity, Hypotonia, Hypertonia, Abnormality of neuronal ...	ORPHA:192
Holoprosencephaly 14	Hydrocephalus, Aqueductal stenosis, Generalized hypotonia, Holoprosencephaly, Alobar holoprosence...	OMIM:619895
Midface Hypoplasia, Obesity, Developmental Delay, And Neonatal Hypotonia	Neonatal hypotonia, Generalized hypotonia, Gray matter heterotopia	OMIM:608624
Neurodevelopmental Disorder With Hypotonia, Neonatal Respiratory Insufficiency, And Thermodysregulation	Spasticity, Hypotonia, Gray matter heterotopia	OMIM:618797
Carnitine Palmitoyl Transferase Ii Deficiency, Neonatal Form	Polymicrogyria, Hydrocephalus, Generalized hypotonia, Pachygyria, Abnormality of neuronal migration	ORPHA:228308
Japanese Encephalitis	Hyperintensity of MRI T2 signal of the spinal cord, Paucity of anterior horn motor neurons, Cogwh...	ORPHA:79139
Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome	Axial hypotonia, Attention deficit hyperactivity disorder, Periventricular heterotopia, Impulsivity	OMIM:618929
Skeletal Dysplasia, Mild, With Joint Laxity And Advanced Bone Age	Hypotonia, Attention deficit hyperactivity disorder, Periventricular heterotopia	OMIM:618870
Orofaciodigital Syndrome Xvi	Hypotonia, Gray matter heterotopia	OMIM:617563
Carnitine Palmitoyltransferase Ii Deficiency	Polymicrogyria, Pachygyria, Abnormality of neuronal migration, Hydrocephalus	ORPHA:157
Peroxisome Biogenesis Disorder 1A (Zellweger)	Death in childhood, Polymicrogyria, Hypotonia, Generalized hypotonia, Gray matter heterotopia, Dy...	OMIM:214100
16P13.11 Microdeletion Syndrome	Hypertonia, Holoprosencephaly, Abnormality of neuronal migration	ORPHA:261236
Pagod Syndrome	Encephalocele, Spina bifida, Meningocele, Death in infancy, Abnormality of neuronal migration	ORPHA:991
Multiple Acyl-Coa Dehydrogenase Deficiency	Dysphagia, Hypotonia, Gray matter heterotopia	ORPHA:26791
Orofaciodigital Syndrome Type 6	Tremor, Hypotonia, Generalized hypotonia, Abnormality of neuronal migration	ORPHA:2754
Adrenomyeloneuropathy	Spasticity, Spastic gait, Atrophy of the spinal cord, Abnormal spinal cord morphology, Dorsal col...	ORPHA:139399
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis	Spasticity, Spastic tetraplegia, Hydrocephalus, Rigidity, Periventricular heterotopia	OMIM:618476
Aicardi Syndrome	Polymicrogyria, Spina bifida, Hypotonia, Generalized hypotonia, Gray matter heterotopia, Pachygyria	OMIM:304050
Miller-Dieker Lissencephaly Syndrome	Infantile muscular hypotonia, Progressive spastic paraplegia, Gray matter heterotopia, Pachygyria...	OMIM:247200
Progressive Non-Fluent Aphasia	Abnormal lower motor neuron morphology, Restlessness	ORPHA:100070
Opitz-Kaveggia Syndrome	Spasticity, Hydrocephalus, Hypotonia, Attention deficit hyperactivity disorder, Gray matter heter...	OMIM:305450
Periventricular Nodular Heterotopia	Periventricular heterotopia	ORPHA:98892
Ventriculomegaly With Cystic Kidney Disease	Gray matter heterotopia, Hydrocephalus	OMIM:219730
Splenogonadal Fusion-Limb Defects-Micrognathia Syndrome	Abnormality of neuronal migration	ORPHA:2063
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome	Syringomyelia, Hypotonia, Gray matter heterotopia	ORPHA:453499
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency	Spasticity, Polymicrogyria, Simplified gyral pattern, Lobar holoprosencephaly, Infantile axial hy...	ORPHA:468631
Van Maldergem Syndrome 2	Hypotonia, Periventricular nodular heterotopia, Subcortical band heterotopia, Gray matter heterot...	OMIM:615546
Koolen-De Vries Syndrome	Gray matter heterotopia, Generalized hypotonia, Hyperactivity, Impulsivity	OMIM:610443
Bohring-Opitz Syndrome	Hypotonia, Gray matter heterotopia	OMIM:605039
Acute Disseminated Encephalomyelitis	Abnormal spinal cord morphology, Myelitis	ORPHA:83597
6Q Terminal Deletion Syndrome	Polymicrogyria, Infantile muscular hypotonia, Gray matter heterotopia, Abnormality of neuronal mi...	ORPHA:75857
Arima Syndrome	Hypotonia, Generalized hypotonia, Gray matter heterotopia, Occipital meningocele, Polydipsia	OMIM:243910
Cerebrofacioarticular Syndrome	Infantile muscular hypotonia, Gray matter heterotopia	ORPHA:314679
Superficial Siderosis	Atrophy of the spinal cord, Dysgyria, Abnormal spinal cord morphology	ORPHA:247245
Mosaic Trisomy 20	Hypotonia, Infantile muscular hypotonia, Abnormal spinal cord morphology	ORPHA:1724
16Q24.3 Microdeletion Syndrome	Dysphagia, Periventricular heterotopia	ORPHA:261250
Neuromuscular Oculoauditory Syndrome	Generalized hypotonia, Periventricular heterotopia	OMIM:618733
Tetrasomy 9P	Polymicrogyria, Hyperactivity, Hydrocephalus, Generalized hypotonia, Abnormal spinal cord morphol...	ORPHA:3310
Periventricular Nodular Heterotopia 9	Polymicrogyria, Attention deficit hyperactivity disorder, Periventricular nodular heterotopia, Gr...	OMIM:618918
Limb Body Wall Complex	Encephalocele, Hydrocephalus, Spina bifida, Myelomeningocele, Anencephaly, Spina bifida occulta, ...	ORPHA:2369
Acromelic Frontonasal Dysostosis	Encephalocele, Periventricular nodular heterotopia, Gray matter heterotopia	OMIM:603671
Intellectual Disability Syndrome Due To A Dyrk1A Point Mutation	Attention deficit hyperactivity disorder, Abnormality of neuronal migration	ORPHA:464311
Microcephalic Osteodysplastic Primordial Dwarfism, Type I	Death in childhood, Abnormal cortical gyration, Polymicrogyria, Hydrocephalus, Microlissencephaly...	OMIM:210710
Orofaciodigital Syndrome I	Abnormal cortical gyration, Myelomeningocele, Gray matter heterotopia, Hydrocephalus	OMIM:311200
Genitourinary And/Or Brain Malformation Syndrome	Polymicrogyria, Attention deficit hyperactivity disorder, Holoprosencephaly, Gray matter heterotopia	OMIM:618820
Fontaine Progeroid Syndrome	Hydrocephalus, Generalized hypotonia, Death in infancy, Gray matter heterotopia, Neonatal death, ...	OMIM:612289
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome	Holoprosencephaly, Abnormality of neuronal migration	ORPHA:3186
Amoebiasis Due To Free-Living Amoebae	Abnormal spinal cord morphology, Restlessness	ORPHA:68
Hydrolethalus Syndrome 1	Abnormal cortical gyration, Gray matter heterotopia, Anencephaly, Stillbirth, Severe hydrocephalu...	OMIM:236680
Smith-Lemli-Opitz Syndrome	Hyperactivity, Hydrocephalus, Hypotonia, Generalized hypotonia, Holoprosencephaly, Death in infan...	OMIM:270400
Nijmegen Breakage Syndrome	Attention deficit hyperactivity disorder, Abnormality of neuronal migration	ORPHA:647
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation	Hypotonia, Gray matter heterotopia	ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion	Hypotonia, Gray matter heterotopia	ORPHA:352665
Orofaciodigital Syndrome Xiv	Polymicrogyria, Simplified gyral pattern, Generalized hypotonia, Holoprosencephaly, Occipital enc...	OMIM:615948
Mismatch Repair Cancer Syndrome 1	Gray matter heterotopia	OMIM:276300
Genitopatellar Syndrome	Hypotonia, Generalized hypotonia, Dysphagia, Pachygyria, Periventricular heterotopia	OMIM:606170
Primary Sjögren Syndrome	Abnormal spinal cord morphology	ORPHA:289390
Orofaciodigital Syndrome Type 14	Hypotonia, Periventricular heterotopia	ORPHA:434179
Proteus Syndrome	Gray matter heterotopia	ORPHA:744
Mowat-Wilson Syndrome Due To Monosomy 2Q22	Spasticity, Polymicrogyria, Infantile muscular hypotonia, Dysphagia, Periventricular heterotopia	ORPHA:261537
Mowat-Wilson Syndrome	Spasticity, Polymicrogyria, Hypotonia, Dysphagia, Periventricular heterotopia	ORPHA:2152
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation	Spasticity, Polymicrogyria, Infantile muscular hypotonia, Dysphagia, Periventricular heterotopia	ORPHA:261552

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Olig2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Olig2.

No publications found that use IMPC mice or data for Olig2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Olig2^em1(IMPC)Ics	Deletion	Mice
Olig2^{tm270519(L1L2_Bact_P)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Olig2^{tm1e(EUCOMM)Hmgu}	Targeted, non-conditional allele	ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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