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Gene: Olig2 MGI:1355331

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

oligodendrocyte transcription factor 2

Synonyms:

Bhlhb1, bHLHe19, RK17, Olg-2

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Olig2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Olig2 (0 diseases)
Human diseases predicted to be associated with Olig2 (216 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Olig2 by phenotypic similarity.

Disease	Matching phenotypes	Source
Spastic Paraplegia 25, Autosomal Recessive	Spastic paraplegia, Spinal cord compression	OMIM:608220
Dystonia 31	Arm dystonia, Abnormal posturing, Generalized dystonia, Leg dystonia, Craniofacial dystonia, Writ...	OMIM:619565
Hereditary Liability to Pressure Palsies (HNPP)	Motor conduction block, Abnormal motor neuron morphology	DECIPHER:31
Primary Lateral Sclerosis, Adult, 1	Abnormal upper motor neuron morphology, Spastic gait, Spastic tetraparesis, Spastic dysarthria, D...	OMIM:611637
Lissencephaly 1	Lissencephaly, Pachygyria, Spastic tetraparesis, Agyria, Gray matter heterotopia, Subcortical ban...	OMIM:607432
Craniofacial Conodysplasia	Hydrocephalus, Spinal cord compression	ORPHA:85168
Cortical Dysplasia, Complex, With Other Brain Malformations 3	Spastic tetraplegia, Pachygyria, Agyria, Gray matter heterotopia, Subcortical band heterotopia, L...	OMIM:615411
Isolated Lissencephaly Type 1 Without Known Genetic Defects	Spasticity, Neonatal hypotonia, Pachygyria, Agyria, Gray matter heterotopia, Axial hypotonia	ORPHA:1084
Neurodevelopmental Disorder With Nonspecific Brain Abnormalities And With Or Without Seizures	Hypotonia, Abnormality of neuronal migration, Attention deficit hyperactivity disorder, Hydroceph...	OMIM:618709
Lissencephaly, X-Linked, 1	Lissencephaly, Spasticity, Death in infancy, Pachygyria, Agyria, Gray matter heterotopia, Axial h...	OMIM:300067
Spinal Muscular Atrophy, Segmental	Abnormal anterior horn cell morphology	OMIM:183020
Charcot-Marie-Tooth syndrome type 1A (CMT1A)	Decreased motor nerve conduction velocity, Abnormal motor neuron morphology	DECIPHER:29
Periventricular Heterotopia With Microcephaly, Autosomal Recessive	Periventricular nodular heterotopia, Hypotonia, Periventricular heterotopia, Generalized hypotonia	OMIM:608097
Juvenile Primary Lateral Sclerosis	Spasticity, Abnormal upper motor neuron morphology, Spastic gait, Spastic tetraparesis, Spastic d...	ORPHA:247604
Lissencephaly 3	Polymicrogyria, Generalized hypotonia, Periventricular laminar heterotopia, Hypotonia, Pachygyria...	OMIM:611603
Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations	Lissencephaly, Polymicrogyria, Self-mutilation, Abnormality of neuronal migration, Aggressive beh...	OMIM:604317
Microlissencephaly	Polymicrogyria, Periventricular heterotopia, Hypertonia, Pachygyria, Subcortical heterotopia, Lis...	ORPHA:1083
Cortical Dysplasia, Complex, With Other Brain Malformations 10	Hypotonia, Hypertonia, Periventricular ribbonlike heterotopia, Spastic tetraplegia, Lissencephaly	OMIM:618677
Chiari Malformation Type Ii	Cervical myelopathy, Generalized hypotonia, Myelomeningocele, Hypotonia, Syringomyelia, Opisthoto...	OMIM:207950
Primary Lateral Sclerosis, Juvenile	Pseudobulbar paralysis, Abnormal upper motor neuron morphology, Appendicular spasticity, Spastici...	OMIM:606353
Dystonia 1, Torsion, Autosomal Dominant	Blepharospasm, Abnormal posturing, Generalized dystonia, Generalized hypotonia, Hypotonia, Tremor...	OMIM:128100
Sub-Cortical Nodular Heterotopia	Abnormality of neuronal migration, Subcortical heterotopia, Spasticity, Polymicrogyria	ORPHA:101029
Neuronopathy, Distal Hereditary Motor, Autosomal Dominant 14	Abnormal lower motor neuron morphology	OMIM:607641
Mohr-Tranebjaerg Syndrome	Spasticity, Abnormal posturing, Tremor, Dystonia, Dysphagia	OMIM:304700
Maternal Hyperthermia-Induced Birth Defects	Abnormality of neuronal migration, Hypotonia, Hypertonia	ORPHA:2216
Nodular Neuronal Heterotopia	Abnormality of neuronal migration	ORPHA:2149
Acalvaria	Abnormality of neuronal migration, Hydrocephalus, Holoprosencephaly, Spina bifida	ORPHA:945
Spinocerebellar Ataxia Type 2	Abnormal cortical gyration, Spinal cord posterior columns myelin loss, Generalized hypotonia, Abn...	ORPHA:98756
Chudley-Mccullough Syndrome	Gray matter heterotopia, Hydrocephalus, Polymicrogyria	OMIM:604213
Primary Lateral Sclerosis	Spasticity, Progressive spastic paraparesis, Abnormal upper motor neuron morphology, Cervical spi...	ORPHA:35689
Amyotrophic Lateral Sclerosis 11	Decreased nerve conduction velocity, Amyotrophic lateral sclerosis	OMIM:612577
Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia	Amyotrophic lateral sclerosis	OMIM:616208
Lissencephaly 5	Spastic paraplegia, Occipital encephalocele, Type II lissencephaly, Hypotonia, Hydrocephalus, Gra...	OMIM:615191
Amyotrophic Lateral Sclerosis 2, Juvenile	Spasticity, Arm dystonia, Amyotrophic lateral sclerosis, Generalized dystonia, Abnormal upper mot...	OMIM:205100
Ossification Of The Posterior Longitudinal Ligament Of Spine	Myelopathy, Spinal cord compression	OMIM:602475
Developmental Delay, Behavioral Abnormalities, And Neuropsychiatric Disorders	Periventricular nodular heterotopia, Hypotonia, Attention deficit hyperactivity disorder, Motor s...	OMIM:620065
Congenital Arthrogryposis With Anterior Horn Cell Disease	Abnormal anterior horn cell morphology, Generalized hypotonia, Neonatal death, Paucity of anterio...	OMIM:611890
Amyotrophic Lateral Sclerosis 23	Degeneration of anterior horn cells, Amyotrophic lateral sclerosis	OMIM:617839
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis	OMIM:105500
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4	Abnormal lower motor neuron morphology, Dysphagia, Amyotrophic lateral sclerosis, Disinhibition	OMIM:616439
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 3	Abnormal lower motor neuron morphology, Dysphagia, Amyotrophic lateral sclerosis, Disinhibition	OMIM:616437
Cobblestone Lissencephaly Without Muscular Or Ocular Involvement	Occipital encephalocele, Type II lissencephaly, Dysgyria, Hydrocephalus, Gray matter heterotopia	ORPHA:352682
Band Heterotopia	Spasticity, Polymicrogyria, Hydrocephalus, Gray matter heterotopia, Subcortical band heterotopia	OMIM:600348
Amyotrophic Lateral Sclerosis, Susceptibility To, 25	Amyotrophic lateral sclerosis	OMIM:617921
Symmetrical Thalamic Calcifications	Abnormality of neuronal migration, Spasticity, Hypertonia	ORPHA:1314
Amyotrophic Lateral Sclerosis 15 With Or Without Frontotemporal Dementia	Dystonia, Athetosis, Dysphagia, Amyotrophic lateral sclerosis	OMIM:300857
Polymicrogyria Due To Tubb2B Mutation	Abnormal temper tantrums, Polymicrogyria, Attention deficit hyperactivity disorder, Infantile mus...	ORPHA:300573
Classic Pantothenate Kinase-Associated Neurodegeneration	Spasticity, Abnormal posturing, Generalized dystonia, Opisthotonus, Attention deficit hyperactivi...	ORPHA:216866
Amyotrophic Lateral Sclerosis 4, Juvenile	Amyotrophic lateral sclerosis, Decreased compound muscle action potential amplitude, Abnormal low...	OMIM:602433
Sporadic Infantile Bilateral Striatal Necrosis	Abnormal posturing, Progressive extrapyramidal muscular rigidity, Resting tremor, Infantile axial...	ORPHA:225147
Spastic Paralysis, Infantile-Onset Ascending	Abnormal lower motor neuron morphology, Spastic paraplegia, Dysphagia, Spastic tetraplegia	OMIM:607225
Autosomal Recessive Cerebellar Ataxia-Movement Disorder Syndrome	Abnormal lower motor neuron morphology	ORPHA:95434
Neuronopathy, Distal Hereditary Motor, Autosomal Recessive 4	Abnormal lower motor neuron morphology	OMIM:611067
Polyglucosan Body Neuropathy, Adult Form	Abnormal upper motor neuron morphology, Neurogenic bladder, Orthostatic hypotension	OMIM:263570
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2A2	Hand tremor, Postural tremor, Restless legs, Hydrocephalus, Abnormal spinal cord morphology	ORPHA:99947
Cerebral Palsy, Spastic Quadriplegic, 3	Spasticity, Gray matter heterotopia, Dysphagia, Spastic tetraplegia, Spastic diplegia	OMIM:617008
Autosomal Dominant Spastic Paraplegia Type 41	Spinal cord lesion, Spastic gait, Lower limb spasticity, Progressive spastic paraplegia	ORPHA:320355
Bilateral Striopallidodentate Calcinosis	Abnormality of neuronal migration	ORPHA:1980
Spinal Muscular Atrophy-Progressive Myoclonic Epilepsy Syndrome	Abnormal lower motor neuron morphology, Dysphagia, Tremor	ORPHA:2590
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia	Spastic paraplegia, Spasticity, Abnormal spinal cord morphology, Progressive spastic paraplegia	ORPHA:139578
Amyotrophic Lateral Sclerosis 5, Juvenile	Abnormal lower motor neuron morphology, Spasticity, Amyotrophic lateral sclerosis	OMIM:602099
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 6	Spasticity, Amyotrophic lateral sclerosis, Abnormal lower motor neuron morphology, Lower limb spa...	OMIM:613954
Muscular Dystrophy-Dystroglycanopathy (Congenital With Impaired Intellectual Development), Type B, 6	Abnormality of neuronal migration, Hypotonia, Pachygyria, Generalized hypotonia	OMIM:608840
Boucher-Neuhauser Syndrome	Abnormal upper motor neuron morphology, Spasticity, Intention tremor	OMIM:215470
Leber Congenital Amaurosis	Abnormality of neuronal migration, Hypotonia, Encephalocele	ORPHA:65
Huntington Disease-Like 1	Restlessness, Abnormal posturing, Generalized hypotonia	ORPHA:157941
Frontotemporal Dementia With Motor Neuron Disease	Abnormal upper motor neuron morphology, Disinhibition, Abnormal lower motor neuron morphology, Ab...	ORPHA:275872
Lissencephaly 6 With Microcephaly	Spasticity, Polymicrogyria, Periventricular heterotopia, Microlissencephaly, Limb hypertonia, Pac...	OMIM:616212
Hemimegalencephaly	Pachygyria, Gray matter heterotopia, Abnormal neuron morphology, Polymicrogyria	ORPHA:99802
Lissencephaly Syndrome, Norman-Roberts Type	Abnormal muscle tone, Abnormality of neuronal migration, Microlissencephaly, Dysphagia, 4-layered...	ORPHA:89844
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Spasticity, Inappropriate behavior, Abnormal upper motor neuron morphology, Disinhibition, Aggres...	OMIM:221770
Subependymal Nodular Heterotopia	Occipital encephalocele, Polymicrogyria, Myelomeningocele, Abnormality of neuronal migration, Nas...	ORPHA:101030
Mismatch Repair Cancer Syndrome 4	Gray matter heterotopia	OMIM:619101
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 7	Generalized hypotonia, Type II lissencephaly, Polymicrogyria, Hypotonia, Encephalocele, Death in ...	OMIM:614643
Neurocutaneous Melanocytosis	Syringomyelia, Meningocele, Abnormality of neuronal migration, Death in infancy	ORPHA:2481
Lethal Congenital Contracture Syndrome 1	Paucity of anterior horn motor neurons, Neonatal death	OMIM:253310
Congenital Muscular Dystrophy Without Intellectual Disability	Pachygyria, Gray matter heterotopia, Neonatal hypotonia, Generalized hypotonia	ORPHA:370980
Brain Small Vessel Disease 2	Subcortical heterotopia, Spastic tetraplegia, Polymicrogyria	OMIM:614483
Keratoderma Hereditarium Mutilans	Self-injurious behavior, Abnormal spinal cord morphology	ORPHA:494
Cntnap2-Related Developmental And Epileptic Encephalopathy	Abnormal temper tantrums, Hypotonia, Self-mutilation, Stereotypical hand wringing, Abnormality of...	ORPHA:163681
Glutathionuria	Gray matter heterotopia, Action tremor, Tremor	OMIM:231950
Progressive Non-Fluent Aphasia	Abnormal lower motor neuron morphology, Restlessness	ORPHA:100070
3-Hydroxyisobutyric Aciduria	Abnormality of neuronal migration	OMIM:236795
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis	OMIM:105550
Intellectual Developmental Disorder, X-Linked 12	Abnormality of neuronal migration, Hypotonia, Spasticity, Tremor	OMIM:300957
Amyotrophic Lateral Sclerosis 21	Abnormal lower motor neuron morphology, Decreased nerve conduction velocity, Abnormal upper motor...	OMIM:606070
Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations	Simplified gyral pattern, Periventricular heterotopia, Generalized hypotonia	OMIM:618273
Methylmalonic Aciduria And Homocystinuria, Cblj Type	Hypotonia, Abnormal posturing	OMIM:614857
Thanatophoric Dysplasia Type 2	Hypotonia, Encephalocele, Abnormality of neuronal migration, Hydrocephalus, Holoprosencephaly	ORPHA:93274
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Abnormal motor neuron morphology, Amyotrophic lateral sclerosis, Cranial nerve compression	ORPHA:52430
Poretti-Boltshauser Syndrome	Gray matter heterotopia, Hypotonia, Generalized hypotonia	OMIM:615960
Periventricular Nodular Heterotopia 7	Polymicrogyria, Periventricular nodular heterotopia, Hypotonia, Gray matter heterotopia, Axial hy...	OMIM:617201
Joubert Syndrome 30	Gray matter heterotopia, Hypotonia, Polymicrogyria	OMIM:617622
Microcephaly And Chorioretinopathy, Autosomal Recessive, 2	Periventricular heterotopia, Simplified gyral pattern	OMIM:616171
Edinburgh Malformation Syndrome	Abnormality of neuronal migration, Hydrocephalus, Hypertonia	ORPHA:1895
Peroxisome Biogenesis Disorder 13A (Zellweger)	Polymicrogyria, Generalized hypotonia, Hypotonia, Neonatal death, Gray matter heterotopia, Axial ...	OMIM:614887
Infantile-Onset X-Linked Spinal Muscular Atrophy	Infantile muscular hypotonia, Abnormal anterior horn cell morphology, Degeneration of anterior ho...	ORPHA:1145
Dysplastic Cortical Hyperostosis, Kozlowski-Tsuruta Type	Abnormality of neuronal migration	ORPHA:2204
Joubert Syndrome	Polymicrogyria, Hypotonia, Encephalocele, Tremor, Abnormality of neuronal migration, Hydrocephalus	ORPHA:475
Unilateral Polymicrogyria	Abnormal posturing, Pseudobulbar paralysis, Appendicular hypotonia, Spastic tetraplegia, Axial hy...	ORPHA:268943
Machado-Joseph Disease Type 3	Spasticity, Spinocerebellar tract degeneration, Abnormal lower motor neuron morphology, Dystonia,...	ORPHA:276244
Posterior Column Ataxia-Retinitis Pigmentosa Syndrome	Truncal titubation, Abnormal spinal cord morphology, Generalized hypotonia	ORPHA:88628
Neonatal Adrenoleukodystrophy	Abnormality of neuronal migration, Hypotonia	ORPHA:44
Autosomal Recessive Primary Microcephaly	Gray matter heterotopia, Pachygyria	ORPHA:2512
Walker-Warburg Syndrome	Abnormal cortical gyration, Polymicrogyria, Hypotonia, Abnormality of neuronal migration, Hydroce...	ORPHA:899
Sandifer Syndrome	Abnormal posturing, Torticollis	ORPHA:71272
Fragile X Syndrome	Periventricular heterotopia, Recurrent hand flapping, Hyperactivity, Self-biting	OMIM:300624
Periventricular Nodular Heterotopia 1	Abnormality of neuronal migration, Gray matter heterotopia	OMIM:300049
Spastic Paraplegia 9A, Autosomal Dominant	Spastic paraplegia, Resting tremor, Abnormal upper motor neuron morphology, Lower limb spasticity...	OMIM:601162
Man1B1-Cdg	Polyphagia, Periventricular heterotopia, Resting tremor, Infantile muscular hypotonia	ORPHA:397941
Developmental Delay With Variable Neurologic And Brain Abnormalities	Gray matter heterotopia, Spasticity	OMIM:619694
Radio-Tartaglia Syndrome	Hypotonia, Tremor, Aggressive behavior, Attention deficit hyperactivity disorder, Dysphagia, Gray...	OMIM:619312
Galloway-Mowat Syndrome	Hypotonia, Abnormality of neuronal migration, Hypertonia, Pachygyria, Aqueductal stenosis	ORPHA:2065
Thanatophoric Dysplasia	Gray matter heterotopia, Hypotonia, Hydrocephalus	ORPHA:2655
Hydrocephalus, Congenital, 2, With Or Without Brain Or Eye Anomalies	Hypotonia, Hydrocephalus, Gray matter heterotopia, Communicating hydrocephalus, Lissencephaly, Si...	OMIM:615219
Thanatophoric Dysplasia, Type I	Gray matter heterotopia, Hypotonia, Hydrocephalus, Neonatal death	OMIM:187600
9Q21.13 Microdeletion Syndrome	Syringomyelia, Gray matter heterotopia	ORPHA:531151
Neurodegeneration With Brain Iron Accumulation 4	Spasticity, Generalized dystonia, Tremor, Abnormal lower motor neuron morphology, Oromandibular d...	OMIM:614298
Alg11-Cdg	Opisthotonus, Limb hypertonia, Infantile muscular hypotonia, Hypertonia, Gray matter heterotopia,...	ORPHA:280071
Desmosterolosis	Spasticity, Abnormal cortical gyration, Polymicrogyria, Rigidity, Abnormality of neuronal migrati...	ORPHA:35107
Spinal Arteriovenous Metameric Syndrome	Spinal arteriovenous malformation, Abnormal spinal cord morphology	ORPHA:53721
Neurodevelopmental Disorder With Seizures, Microcephaly, And Brain Abnormalities	Hypotonia, Neonatal death, Frontal polymicrogyria, Hypertonia, Pachygyria, Dystonia, Gray matter ...	OMIM:620024
Neu-Laxova Syndrome	Abnormal cortical gyration, Polymicrogyria, Abnormality of neuronal migration, Opisthotonus, Spin...	ORPHA:2671
Spinal Cord Injury	Syringomyelia, Spinal cord lesion, Spasticity, Allodynia	ORPHA:90058
Laryngotracheoesophageal Cleft Type 4	Abnormal lower motor neuron morphology	ORPHA:93941
Oculocerebrocutaneous Syndrome	Gray matter heterotopia, Orbital encephalocele	OMIM:164180
Vici Syndrome	Gray matter heterotopia, Hypotonia, Dysphagia, Abnormal posturing	OMIM:242840
Li-Ghorbani-Weisz-Hubshman Syndrome	Attention deficit hyperactivity disorder, Periventricular heterotopia	OMIM:618974
Congenital Osteogenesis Imperfecta-Microcephaly-Cataracts Syndrome	Abnormality of neuronal migration	ORPHA:2772
Hypomelanosis Of Ito	Gray matter heterotopia	OMIM:300337
Congenital Muscular Dystrophy With Cerebellar Involvement	Occipital encephalocele, Polymicrogyria, Type II lissencephaly, Hydrocephalus, Gray matter hetero...	ORPHA:370959
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 13	Spasticity, Hydromyelia, Occipital encephalocele, Type II lissencephaly, Hypotonia, Severe muscul...	OMIM:615287
Joubert Syndrome With Oculorenal Defect	Abnormality of neuronal migration, Hydrocephalus, Hypotonia, Encephalocele	ORPHA:2318
Neurodevelopmental Disorder With Neuromuscular And Skeletal Abnormalities	Self-injurious behavior, Hypotonia, Periventricular heterotopia, Aggressive behavior, Hydrocephalus	OMIM:619833
Solitary Bone Cyst	Abnormal spinal cord morphology	ORPHA:83468
3C Syndrome	Abnormality of neuronal migration, Hypotonia, Hydrocephalus, Death in infancy	ORPHA:7
X-Linked Cerebral Adrenoleukodystrophy	Myelopathy, Lower limb spasticity, Abnormal spinal cord morphology, Hyperactivity, Spastic tetrap...	ORPHA:139396
Tetrasomy 18P	Abnormality of neuronal migration	ORPHA:3307
16P13.11 Microdeletion Syndrome	Self-injurious behavior, Abnormality of neuronal migration, Hypertonia, Compulsive behaviors, Hol...	ORPHA:261236
Methylmalonate Semialdehyde Dehydrogenase Deficiency	Hypotonia, Dystonia, Periventricular heterotopia	OMIM:614105
Congenital Disorder Of Deglycosylation 2	Gray matter heterotopia, Hypotonia, Dysphagia, Polymicrogyria	OMIM:619775
Japanese Encephalitis	Pill-rolling tremor, Cogwheel rigidity, Tremor, Opisthotonus, Hypertonia, Anorexia, Paucity of an...	ORPHA:79139
Coffin-Lowry Syndrome	Self-injurious behavior, Hypotonia, Death in early adulthood, Abnormality of neuronal migration, ...	ORPHA:192
Vici Syndrome	Gray matter heterotopia, Hypotonia, Death in infancy	ORPHA:1493
Bilateral Perisylvian Polymicrogyria	Spasticity, Bilateral perisylvian polymicrogyria, Perisylvian predominant thick cortex pachygyria...	ORPHA:98889
Pyruvate Dehydrogenase E1-Beta Deficiency	Pachygyria, Hypotonia, Periventricular heterotopia	ORPHA:255138
Hypertelorism-Hypospadias-Polysyndactyly Syndrome	Abnormal cortical gyration, Polymicrogyria, Encephalocele, Exencephaly, Abnormality of neuronal m...	ORPHA:2211
Joubert Syndrome With Hepatic Defect	Occipital encephalocele, Hypotonia, Tremor, Abnormality of neuronal migration, Hydrocephalus	ORPHA:1454
Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome	Self-injurious behavior, Periventricular heterotopia, Impulsivity, Attention deficit hyperactivit...	OMIM:618929
Van Maldergem Syndrome 1	Generalized hypotonia, Periventricular nodular heterotopia, Hypotonia, Pachygyria, Gray matter he...	OMIM:601390
Alkuraya-Kucinskas Syndrome	Gray matter heterotopia, Hydrocephalus, Lissencephaly, Generalized hypotonia	OMIM:617822
Pseudo-Torch Syndrome 2	Gray matter heterotopia, Polymicrogyria, Generalized hypotonia	OMIM:617397
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal	Neonatal hypotonia, Polymicrogyria, Hypotonia, Death in infancy, Abnormality of neuronal migration	OMIM:608836
Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome	Abnormality of neuronal migration, Hypertonia	ORPHA:2518
Thanatophoric Dysplasia Type 1	Gray matter heterotopia, Hypotonia, Hydrocephalus	ORPHA:1860
Midface Hypoplasia, Obesity, Developmental Delay, And Neonatal Hypotonia	Gray matter heterotopia, Neonatal hypotonia, Generalized hypotonia	OMIM:608624
Holoprosencephaly	Spasticity, Spinal dysraphism, Hypotonia, Encephalocele, Abnormality of neuronal migration, Hydro...	ORPHA:2162
Galloway-Mowat Syndrome 1	Spasticity, Hypotonia, Abnormality of neuronal migration, Pachygyria, Dystonia, Spastic tetrapleg...	OMIM:251300
Carnitine Palmitoyl Transferase Ii Deficiency, Neonatal Form	Polymicrogyria, Generalized hypotonia, Abnormality of neuronal migration, Hydrocephalus, Pachygyria	ORPHA:228308
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis	Spasticity, Inappropriate laughter, Periventricular heterotopia, Rigidity, Hydrocephalus, Spastic...	OMIM:618476
Neurodevelopmental Disorder With Hypotonia, Neonatal Respiratory Insufficiency, And Thermodysregulation	Gray matter heterotopia, Hypotonia, Spasticity	OMIM:618797
Skeletal Dysplasia, Mild, With Joint Laxity And Advanced Bone Age	Hypotonia, Attention deficit hyperactivity disorder, Periventricular heterotopia	OMIM:618870
Holoprosencephaly 14	Alobar holoprosencephaly, Generalized hypotonia, Periventricular heterotopia, Hydrocephalus, Gray...	OMIM:619895
Carnitine Palmitoyltransferase Ii Deficiency	Abnormality of neuronal migration, Hydrocephalus, Pachygyria, Polymicrogyria	ORPHA:157
Orofaciodigital Syndrome Xvi	Gray matter heterotopia, Hypotonia	OMIM:617563
Peroxisome Biogenesis Disorder 1A (Zellweger)	Polymicrogyria, Generalized hypotonia, Hypotonia, Death in childhood, Gray matter heterotopia, Dy...	OMIM:214100
Multiple Acyl-Coa Dehydrogenase Deficiency	Gray matter heterotopia, Hypotonia, Dysphagia	ORPHA:26791
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency	Self-injurious behavior, Spasticity, Polymicrogyria, Infantile axial hypotonia, Periventricular h...	ORPHA:468631
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome	Syringomyelia, Bruxism, Hypotonia, Gray matter heterotopia	ORPHA:453499
Pagod Syndrome	Encephalocele, Death in infancy, Abnormality of neuronal migration, Spina bifida, Meningocele	ORPHA:991
Orofaciodigital Syndrome Type 6	Abnormality of neuronal migration, Hypotonia, Tremor, Generalized hypotonia	ORPHA:2754
Adrenomyeloneuropathy	Spasticity, Progressive spastic paraparesis, Dorsal column degeneration, Atrophy of the spinal co...	ORPHA:139399
Miller-Dieker Lissencephaly Syndrome	Progressive spastic paraplegia, Pachygyria, Infantile muscular hypotonia, Gray matter heterotopia...	OMIM:247200
Aicardi Syndrome	Polymicrogyria, Generalized hypotonia, Hypotonia, Spina bifida, Pachygyria, Gray matter heterotopia	OMIM:304050
Acute Disseminated Encephalomyelitis	Aggressive behavior, Myelitis, Abnormal spinal cord morphology	ORPHA:83597
Periventricular Nodular Heterotopia	Periventricular heterotopia	ORPHA:98892
Opitz-Kaveggia Syndrome	Spasticity, Neonatal hypotonia, Hypotonia, Attention deficit hyperactivity disorder, Hydrocephalu...	OMIM:305450
Splenogonadal Fusion-Limb Defects-Micrognathia Syndrome	Abnormality of neuronal migration	ORPHA:2063
Ventriculomegaly With Cystic Kidney Disease	Gray matter heterotopia, Hydrocephalus	OMIM:219730
Thrombocytopenia 8, With Dysmorphic Features And Developmental Delay	Gray matter heterotopia, Lower limb spasticity	OMIM:620475
Koolen-De Vries Syndrome	Gray matter heterotopia, Hyperactivity, Impulsivity, Generalized hypotonia	OMIM:610443
Cerebrofacioarticular Syndrome	Self-injurious behavior, Gray matter heterotopia, Infantile muscular hypotonia	ORPHA:314679
Van Maldergem Syndrome 2	Gray matter heterotopia, Periventricular nodular heterotopia, Hypotonia, Subcortical band heterot...	OMIM:615546
6Q Terminal Deletion Syndrome	Polymicrogyria, Periventricular heterotopia, Abnormality of neuronal migration, Infantile muscula...	ORPHA:75857
Bohring-Opitz Syndrome	Gray matter heterotopia, Hypotonia	OMIM:605039
Arima Syndrome	Polydipsia, Generalized hypotonia, Hypotonia, Gray matter heterotopia, Occipital meningocele	OMIM:243910
Superficial Siderosis	Atrophy of the spinal cord, Abnormal spinal cord morphology, Dysgyria	ORPHA:247245
Periventricular Nodular Heterotopia 9	Polymicrogyria, Periventricular nodular heterotopia, Attention deficit hyperactivity disorder, Co...	OMIM:618918
Tetrasomy 9P	Inappropriate behavior, Generalized hypotonia, Polymicrogyria, Pachygyria, Hydrocephalus, Abnorma...	ORPHA:3310
Mosaic Trisomy 20	Hypotonia, Abnormal spinal cord morphology, Infantile muscular hypotonia	ORPHA:1724
Thrombocytopenia 11 With Multiple Congenital Anomalies And Dysmorphic Facies	Gray matter heterotopia, Hypotonia	OMIM:620654
16Q24.3 Microdeletion Syndrome	Periventricular heterotopia, Dysphagia	ORPHA:261250
Neuromuscular Oculoauditory Syndrome	Periventricular heterotopia, Generalized hypotonia	OMIM:618733
Intellectual Disability Syndrome Due To A Dyrk1A Point Mutation	Abnormality of neuronal migration, Attention deficit hyperactivity disorder, Motor stereotypy	ORPHA:464311
Limb Body Wall Complex	Myelomeningocele, Encephalocele, Abnormal spinal cord morphology, Spina bifida, Hydrocephalus, Sp...	ORPHA:2369
Microcephalic Osteodysplastic Primordial Dwarfism, Type I	Abnormal cortical gyration, Polymicrogyria, Pachygyria, Death in childhood, Death in infancy, Mic...	OMIM:210710
Orofaciodigital Syndrome I	Myelomeningocele, Abnormal cortical gyration, Gray matter heterotopia, Hydrocephalus	OMIM:311200
Fontaine Progeroid Syndrome	Generalized hypotonia, Periventricular heterotopia, Death in infancy, Neonatal death, Hydrocephal...	OMIM:612289
Smith-Lemli-Opitz Syndrome	Generalized hypotonia, Hypotonia, Periventricular heterotopia, Self-mutilation, Death in infancy,...	OMIM:270400
Genitourinary And/Or Brain Malformation Syndrome	Gray matter heterotopia, Attention deficit hyperactivity disorder, Holoprosencephaly, Polymicrogyria	OMIM:618820
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation	Gray matter heterotopia, Bruxism, Hypotonia	ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion	Gray matter heterotopia, Bruxism, Hypotonia	ORPHA:352665
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome	Abnormality of neuronal migration, Holoprosencephaly	ORPHA:3186
Amoebiasis Due To Free-Living Amoebae	Restlessness, Abnormal spinal cord morphology	ORPHA:68
Nijmegen Breakage Syndrome	Abnormality of neuronal migration, Attention deficit hyperactivity disorder	ORPHA:647
Hydrolethalus Syndrome 1	Abnormal cortical gyration, Stillbirth, Gray matter heterotopia, Anencephaly, Severe hydrocephalus	OMIM:236680
Orofaciodigital Syndrome Xiv	Occipital encephalocele, Polymicrogyria, Generalized hypotonia, Periventricular heterotopia, Holo...	OMIM:615948
Acromelic Frontonasal Dysostosis	Gray matter heterotopia, Periventricular nodular heterotopia, Encephalocele	OMIM:603671
Mismatch Repair Cancer Syndrome 1	Gray matter heterotopia	OMIM:276300
Genitopatellar Syndrome	Generalized hypotonia, Hypotonia, Periventricular heterotopia, Pachygyria, Dysphagia	OMIM:606170
Primary Sjögren Syndrome	Abnormal spinal cord morphology	ORPHA:289390
Orofaciodigital Syndrome Type 14	Hypotonia, Periventricular heterotopia	ORPHA:434179
Proteus Syndrome	Gray matter heterotopia	ORPHA:744
Mowat-Wilson Syndrome Due To Monosomy 2Q22	Spasticity, Polymicrogyria, Bruxism, Periventricular heterotopia, Dysphagia, Infantile muscular h...	ORPHA:261537
Mowat-Wilson Syndrome	Spasticity, Polymicrogyria, Bruxism, Hypotonia, Periventricular heterotopia, Dysphagia, Motor ste...	ORPHA:2152
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation	Spasticity, Polymicrogyria, Bruxism, Periventricular heterotopia, Dysphagia, Infantile muscular h...	ORPHA:261552

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Olig2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Olig2.

No publications found that use IMPC mice or data for Olig2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Olig2^em1(IMPC)Ics	Deletion	Mice
Olig2^{tm270519(L1L2_Bact_P)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Olig2^{tm1e(EUCOMM)Hmgu}	Targeted, non-conditional allele	ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

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