Genes Phenotypes Help, News, Blog

Please enable javascript if you want to log in to follow or stop following this gene.

Gene: Olig2 MGI:1355331

Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:

oligodendrocyte transcription factor 2

Synonyms:

Bhlhb1, bHLHe19, RK17, Olg-2

Order Alleles

IMPC Data Collections

No Body Weight Data
No Embryo Imaging Data
No Viability Data

IMPC Phenotype Summary

Significant

Not Significant

Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Olig2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

Human diseases associated with Olig2 (0 diseases)
Human diseases predicted to be associated with Olig2 (211 diseases)

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Olig2 by phenotypic similarity.

Disease	Matching phenotypes	Source
Spastic Paraplegia 25, Autosomal Recessive	Spinal cord compression, Spastic paraplegia	OMIM:608220
Dystonia 31	Generalized dystonia, Writer's cramp, Leg dystonia, Arm dystonia, Dysphagia, Abnormal posturing, ...	OMIM:619565
Hereditary Liability to Pressure Palsies (HNPP)	Abnormal motor neuron morphology, Motor conduction block	DECIPHER:31
Primary Lateral Sclerosis, Adult, 1	Spastic tetraparesis, Spastic dysarthria, Dysphagia, Abnormal upper motor neuron morphology, Spas...	OMIM:611637
Lissencephaly 1	Axial hypotonia, Spastic tetraparesis, Subcortical band heterotopia, Gray matter heterotopia, Lis...	OMIM:607432
Craniofacial Conodysplasia	Spinal cord compression, Hydrocephalus	ORPHA:85168
Cortical Dysplasia, Complex, With Other Brain Malformations 3	Subcortical band heterotopia, Spastic tetraplegia, Gray matter heterotopia, Lissencephaly, Pachyg...	OMIM:615411
Neurodevelopmental Disorder With Nonspecific Brain Abnormalities And With Or Without Seizures	Hydrocephalus, Hypotonia, Abnormality of neuronal migration, Attention deficit hyperactivity diso...	OMIM:618709
Isolated Lissencephaly Type 1 Without Known Genetic Defects	Axial hypotonia, Gray matter heterotopia, Neonatal hypotonia, Spasticity, Pachygyria, Agyria	ORPHA:1084
Lissencephaly, X-Linked, 1	Death in infancy, Axial hypotonia, Gray matter heterotopia, Lissencephaly, Spasticity, Pachygyria...	OMIM:300067
Spinal Muscular Atrophy, Segmental	Abnormal anterior horn cell morphology	OMIM:183020
Charcot-Marie-Tooth syndrome type 1A (CMT1A)	Decreased motor nerve conduction velocity, Abnormal motor neuron morphology	DECIPHER:29
Periventricular Heterotopia With Microcephaly, Autosomal Recessive	Periventricular nodular heterotopia, Hypotonia, Generalized hypotonia, Periventricular heterotopia	OMIM:608097
Juvenile Primary Lateral Sclerosis	Spastic tetraparesis, Spastic dysarthria, Dysphagia, Abnormal upper motor neuron morphology, Spas...	ORPHA:247604
Lissencephaly 3	Agyria, Periventricular laminar heterotopia, Hypotonia, Spastic tetraplegia, Gray matter heteroto...	OMIM:611603
Microcephaly 2, Primary, Autosomal Recessive, With Or Without Cortical Malformations	Hyperactivity, Spastic tetraparesis, Aggressive behavior, Impulsivity, Polymicrogyria, Simplified...	OMIM:604317
Microlissencephaly	Subcortical heterotopia, Periventricular heterotopia, Simplified gyral pattern, Hypertonia, Lisse...	ORPHA:1083
Cortical Dysplasia, Complex, With Other Brain Malformations 10	Hypotonia, Spastic tetraplegia, Hypertonia, Lissencephaly, Periventricular ribbonlike heterotopia	OMIM:618677
Chiari Malformation Type Ii	Spina bifida, Myelomeningocele, Hydrocephalus, Hypotonia, Opisthotonus, Cervical myelopathy, Gray...	OMIM:207950
Primary Lateral Sclerosis, Juvenile	Appendicular spasticity, Spastic tetraparesis, Spastic dysarthria, Pseudobulbar paralysis, Spasti...	OMIM:606353
Dystonia 1, Torsion, Autosomal Dominant	Torticollis, Generalized dystonia, Writer's cramp, Tremor, Torsion dystonia, Hypotonia, Blepharos...	OMIM:128100
Sub-Cortical Nodular Heterotopia	Polymicrogyria, Spasticity, Subcortical heterotopia, Abnormality of neuronal migration	ORPHA:101029
Neuronopathy, Distal Hereditary Motor, Autosomal Dominant 14	Abnormal lower motor neuron morphology	OMIM:607641
Mohr-Tranebjaerg Syndrome	Dystonia, Tremor, Spasticity, Dysphagia, Abnormal posturing	OMIM:304700
Acalvaria	Hydrocephalus, Holoprosencephaly, Spina bifida, Abnormality of neuronal migration	ORPHA:945
Nodular Neuronal Heterotopia	Abnormality of neuronal migration	ORPHA:2149
Primary Lateral Sclerosis	Abnormal lower motor neuron morphology, Atrophy of the spinal cord, Progressive spastic parapares...	ORPHA:35689
Chudley-Mccullough Syndrome	Gray matter heterotopia, Hydrocephalus, Polymicrogyria	OMIM:604213
Spinocerebellar Ataxia Type 2	Kinetic tremor, Postural tremor, Abnormal cortical gyration, Spinal cord posterior columns myelin...	ORPHA:98756
Spastic Paralysis, Infantile-Onset Ascending	Abnormal lower motor neuron morphology, Spastic paraplegia, Spastic tetraplegia, Dysphagia	OMIM:607225
Lissencephaly 5	Occipital encephalocele, Hydrocephalus, Spastic paraplegia, Subcortical band heterotopia, Hypoton...	OMIM:615191
Amyotrophic Lateral Sclerosis 22 With Or Without Frontotemporal Dementia	Amyotrophic lateral sclerosis	OMIM:616208
Developmental Delay, Behavioral Abnormalities, And Neuropsychiatric Disorders	Periventricular nodular heterotopia, Abnormal repetitive mannerisms, Hypotonia, Attention deficit...	OMIM:620065
Amyotrophic Lateral Sclerosis 2, Juvenile	Abnormal lower motor neuron morphology, Lower limb spasticity, Amyotrophic lateral sclerosis, Gen...	OMIM:205100
Ossification Of The Posterior Longitudinal Ligament Of Spine	Spinal cord compression, Myelopathy	OMIM:602475
Congenital Arthrogryposis With Anterior Horn Cell Disease	Abnormal anterior horn cell morphology, Paucity of anterior horn motor neurons, Generalized hypot...	OMIM:611890
Maternal Hyperthermia-Induced Birth Defects	Hypertonia, Hypotonia, Abnormality of neuronal migration	ORPHA:2216
Amyotrophic Lateral Sclerosis 23	Degeneration of anterior horn cells, Amyotrophic lateral sclerosis	OMIM:617839
Cobblestone Lissencephaly Without Muscular Or Ocular Involvement	Occipital encephalocele, Hydrocephalus, Gray matter heterotopia, Dysgyria, Type II lissencephaly	ORPHA:352682
Amyotrophic Lateral Sclerosis-Parkinsonism/Dementia Complex 1	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis	OMIM:105500
Band Heterotopia	Hydrocephalus, Subcortical band heterotopia, Gray matter heterotopia, Spasticity, Polymicrogyria	OMIM:600348
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 4	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Disinhibition, Dysphagia	OMIM:616439
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 3	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Disinhibition, Dysphagia	OMIM:616437
Amyotrophic Lateral Sclerosis, Susceptibility To, 25	Amyotrophic lateral sclerosis	OMIM:617921
Symmetrical Thalamic Calcifications	Spasticity, Hypertonia, Abnormality of neuronal migration	ORPHA:1314
Polymicrogyria Due To Tubb2B Mutation	Perisylvian polymicrogyria, Gray matter heterotopia, Lissencephaly, Attention deficit hyperactivi...	ORPHA:300573
Amyotrophic Lateral Sclerosis 15 With Or Without Frontotemporal Dementia	Athetosis, Amyotrophic lateral sclerosis, Dysphagia, Dystonia	OMIM:300857
Amyotrophic Lateral Sclerosis 4, Juvenile	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Pallor of dorsal columns o...	OMIM:602433
Sporadic Infantile Bilateral Striatal Necrosis	Resting tremor, Infantile axial hypotonia, Dysphagia, Titubation, Dystonia, Progressive extrapyra...	ORPHA:225147
Classic Pantothenate Kinase-Associated Neurodegeneration	Generalized dystonia, Spasticity, Opisthotonus, Attention deficit hyperactivity disorder, Dysphag...	ORPHA:216866
Neuronopathy, Distal Hereditary Motor, Autosomal Recessive 4	Abnormal lower motor neuron morphology, Respiratory insufficiency due to muscle weakness	OMIM:611067
Autosomal Recessive Cerebellar Ataxia-Movement Disorder Syndrome	Abnormal lower motor neuron morphology	ORPHA:95434
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2A2	Restless legs, Postural tremor, Abnormal spinal cord morphology, Hydrocephalus, Hand tremor	ORPHA:99947
Polyglucosan Body Neuropathy, Adult Form	Abnormal upper motor neuron morphology, Orthostatic hypotension, Neurogenic bladder	OMIM:263570
Congenital Muscular Dystrophy Without Intellectual Disability	Neonatal hypotonia, Gray matter heterotopia, Pachygyria, Generalized hypotonia	ORPHA:370980
Cerebral Palsy, Spastic Quadriplegic, 3	Spastic tetraplegia, Spastic diplegia, Gray matter heterotopia, Dysphagia, Spasticity	OMIM:617008
Bilateral Striopallidodentate Calcinosis	Abnormality of neuronal migration	ORPHA:1980
Amyotrophic Lateral Sclerosis 5, Juvenile	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Respiratory insufficiency ...	OMIM:602099
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia	Abnormal spinal cord morphology, Spastic paraplegia, Spasticity, Progressive spastic paraplegia	ORPHA:139578
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 6	Abnormal lower motor neuron morphology, Lower limb spasticity, Amyotrophic lateral sclerosis, Dys...	OMIM:613954
Muscular Dystrophy-Dystroglycanopathy (Congenital With Impaired Intellectual Development), Type B, 6	Pachygyria, Hypotonia, Generalized hypotonia, Abnormality of neuronal migration	OMIM:608840
Mismatch Repair Cancer Syndrome 4	Gray matter heterotopia	OMIM:619101
Leber Congenital Amaurosis	Encephalocele, Hypotonia, Abnormality of neuronal migration	ORPHA:65
Huntington Disease-Like 1	Restlessness, Abnormal posturing, Generalized hypotonia	ORPHA:157941
Boucher-Neuhauser Syndrome	Abnormal upper motor neuron morphology, Spasticity, Intention tremor	OMIM:215470
Hemimegalencephaly	Gray matter heterotopia, Pachygyria, Polymicrogyria, Abnormal neuron morphology	ORPHA:99802
Lissencephaly 6 With Microcephaly	Periventricular heterotopia, Simplified gyral pattern, Microlissencephaly, Lissencephaly, Spastic...	OMIM:616212
Spinal Muscular Atrophy-Progressive Myoclonic Epilepsy Syndrome	Abnormal lower motor neuron morphology, Tremor, Dysphagia	ORPHA:2590
Subependymal Nodular Heterotopia	Occipital encephalocele, Myelomeningocele, Meningocele, Abnormality of neuronal migration, Gray m...	ORPHA:101030
Lissencephaly Syndrome, Norman-Roberts Type	4-layered lissencephaly, Abnormality of neuronal migration, Microlissencephaly, Abnormal muscle t...	ORPHA:89844
Polycystic Lipomembranous Osteodysplasia With Sclerosing Leukoencephalopathy 1	Aggressive behavior, Inappropriate behavior, Disinhibition, Abnormal upper motor neuron morpholog...	OMIM:221770
Neurocutaneous Melanocytosis	Death in infancy, Meningocele, Syringomyelia, Abnormality of neuronal migration	ORPHA:2481
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 7	Encephalocele, Death in infancy, Subcortical heterotopia, Agyria, Hydrocephalus, Hypotonia, Gray ...	OMIM:614643
Glutathionuria	Tremor, Gray matter heterotopia, Action tremor	OMIM:231950
Brain Small Vessel Disease 2	Polymicrogyria, Subcortical heterotopia, Spastic tetraplegia	OMIM:614483
Lethal Congenital Contracture Syndrome 1	Paucity of anterior horn motor neurons, Neonatal death	OMIM:253310
Frontotemporal Dementia With Motor Neuron Disease	Abnormal lower motor neuron morphology, Disinhibition, Dysphagia, Abnormal upper motor neuron mor...	ORPHA:275872
Keratoderma Hereditarium Mutilans	Self-injurious behavior, Abnormal spinal cord morphology	ORPHA:494
Cntnap2-Related Developmental And Epileptic Encephalopathy	Lower limb spasticity, Hyperactivity, Aggressive behavior, Abnormal neuron morphology, Hypotonia,...	ORPHA:163681
3-Hydroxyisobutyric Aciduria	Abnormality of neuronal migration	OMIM:236795
Frontotemporal Dementia And/Or Amyotrophic Lateral Sclerosis 1	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis	OMIM:105550
Thanatophoric Dysplasia Type 2	Encephalocele, Hydrocephalus, Hypotonia, Abnormality of neuronal migration, Holoprosencephaly	ORPHA:93274
Mega-Corpus-Callosum Syndrome With Cerebellar Hypoplasia And Cortical Malformations	Simplified gyral pattern, Generalized hypotonia, Periventricular heterotopia	OMIM:618273
Intellectual Developmental Disorder, X-Linked 12	Tremor, Spasticity, Hypotonia, Abnormality of neuronal migration	OMIM:300957
Amyotrophic Lateral Sclerosis 21	Abnormal lower motor neuron morphology, Amyotrophic lateral sclerosis, Decreased nerve conduction...	OMIM:606070
Methylmalonic Aciduria And Homocystinuria, Cblj Type	Abnormal posturing, Hypotonia	OMIM:614857
Inclusion Body Myopathy With Paget Disease Of Bone And Frontotemporal Dementia	Amyotrophic lateral sclerosis, Cranial nerve compression, Abnormal motor neuron morphology	ORPHA:52430
Poretti-Boltshauser Syndrome	Gray matter heterotopia, Hypotonia, Generalized hypotonia	OMIM:615960
Periventricular Nodular Heterotopia 7	Axial hypotonia, Hypotonia, Gray matter heterotopia, Periventricular nodular heterotopia, Polymic...	OMIM:617201
Edinburgh Malformation Syndrome	Hydrocephalus, Hypertonia, Abnormality of neuronal migration	ORPHA:1895
Microcephaly And Chorioretinopathy, Autosomal Recessive, 2	Simplified gyral pattern, Periventricular heterotopia	OMIM:616171
Peroxisome Biogenesis Disorder 13A (Zellweger)	Axial hypotonia, Hypotonia, Gray matter heterotopia, Generalized hypotonia, Neonatal death, Polym...	OMIM:614887
Walker-Warburg Syndrome	Abnormal cortical gyration, Hydrocephalus, Hypotonia, Abnormality of neuronal migration, Macrogyr...	ORPHA:899
Infantile-Onset X-Linked Spinal Muscular Atrophy	Degeneration of anterior horn cells, Abnormal anterior horn cell morphology, Generalized hypotoni...	ORPHA:1145
Joubert Syndrome	Encephalocele, Tremor, Hydrocephalus, Hypotonia, Abnormality of neuronal migration, Polymicrogyria	ORPHA:475
O'Sullivan-Mcleod Syndrome	Hyperintensity of MRI T2 signal of the spinal cord, Atrophy of the spinal cord, Tremor	ORPHA:99965
Dysplastic Cortical Hyperostosis, Kozlowski-Tsuruta Type	Abnormality of neuronal migration	ORPHA:2204
Posterior Column Ataxia-Retinitis Pigmentosa Syndrome	Truncal titubation, Abnormal spinal cord morphology, Generalized hypotonia	ORPHA:88628
Neonatal Adrenoleukodystrophy	Hypotonia, Abnormality of neuronal migration	ORPHA:44
Machado-Joseph Disease Type 3	Abnormal lower motor neuron morphology, Dysphagia, Degeneration of anterior horn cells, Spinocere...	ORPHA:276244
Unilateral Polymicrogyria	Axial hypotonia, Perisylvian polymicrogyria, Spastic tetraplegia, Appendicular hypotonia, Pseudob...	ORPHA:268943
Joubert Syndrome 30	Gray matter heterotopia, Hypotonia	OMIM:617622
Autosomal Recessive Primary Microcephaly	Gray matter heterotopia, Pachygyria	ORPHA:2512
Periventricular Nodular Heterotopia 1	Gray matter heterotopia, Abnormality of neuronal migration	OMIM:300049
Fragile X Syndrome	Hyperactivity, Recurrent hand flapping, Periventricular heterotopia, Self-biting	OMIM:300624
Desmosterolosis	Abnormal cortical gyration, Rigidity, Hydrocephalus, Abnormality of neuronal migration, Macrogyri...	ORPHA:35107
Spastic Paraplegia 9A, Autosomal Dominant	Resting tremor, Lower limb spasticity, Spastic paraplegia, Abnormal upper motor neuron morphology...	OMIM:601162
Sandifer Syndrome	Abnormal posturing, Torticollis	ORPHA:71272
Laryngotracheoesophageal Cleft Type 4	Abnormal lower motor neuron morphology, Respiratory insufficiency	ORPHA:93941
Thanatophoric Dysplasia	Gray matter heterotopia, Hydrocephalus, Hypotonia	ORPHA:2655
Galloway-Mowat Syndrome	Aqueductal stenosis, Hypotonia, Abnormality of neuronal migration, Hypertonia, Pachygyria	ORPHA:2065
Radio-Tartaglia Syndrome	Impulsivity, Aggressive behavior, Tremor, Hypotonia, Gray matter heterotopia, Attention deficit h...	OMIM:619312
Man1B1-Cdg	Resting tremor, Periventricular heterotopia, Polyphagia, Infantile muscular hypotonia	ORPHA:397941
Developmental Delay With Variable Neurologic And Brain Abnormalities	Gray matter heterotopia, Spasticity	OMIM:619694
Thanatophoric Dysplasia, Type I	Neonatal death, Gray matter heterotopia, Hydrocephalus, Hypotonia	OMIM:187600
Hydrocephalus, Congenital, 2, With Or Without Brain Or Eye Anomalies	Communicating hydrocephalus, Hydrocephalus, Simplified gyral pattern, Hypotonia, Gray matter hete...	OMIM:615219
9Q21.13 Microdeletion Syndrome	Gray matter heterotopia, Syringomyelia	ORPHA:531151
Neurodegeneration With Brain Iron Accumulation 4	Abnormal lower motor neuron morphology, Generalized dystonia, Impulsivity, Tremor, Dystonia, Orom...	OMIM:614298
Neu-Laxova Syndrome	Abnormal cortical gyration, Spina bifida, Abnormality of neuronal migration, Macrogyria, Opisthot...	ORPHA:2671
Alg11-Cdg	Axial hypotonia, Opisthotonus, Gray matter heterotopia, Hypertonia, Infantile muscular hypotonia,...	ORPHA:280071
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 13	Communicating hydrocephalus, Occipital encephalocele, Severe muscular hypotonia, Hydrocephalus, A...	OMIM:615287
Spinal Arteriovenous Metameric Syndrome	Abnormal spinal cord morphology, Spinal arteriovenous malformation	ORPHA:53721
Neurodevelopmental Disorder With Seizures, Microcephaly, And Brain Abnormalities	Frontal polymicrogyria, Hypotonia, Spastic tetraplegia, Gray matter heterotopia, Hypertonia, Dyst...	OMIM:620024
Oculocerebrocutaneous Syndrome	Gray matter heterotopia, Orbital encephalocele	OMIM:164180
Congenital Osteogenesis Imperfecta-Microcephaly-Cataracts Syndrome	Abnormality of neuronal migration	ORPHA:2772
Joubert Syndrome With Oculorenal Defect	Encephalocele, Hydrocephalus, Hypotonia, Abnormality of neuronal migration	ORPHA:2318
Li-Ghorbani-Weisz-Hubshman Syndrome	Attention deficit hyperactivity disorder, Periventricular heterotopia	OMIM:618974
Congenital Muscular Dystrophy With Cerebellar Involvement	Occipital encephalocele, Hydrocephalus, Gray matter heterotopia, Polymicrogyria, Type II lissence...	ORPHA:370959
Neurodevelopmental Disorder With Neuromuscular And Skeletal Abnormalities	Periventricular heterotopia, Aggressive behavior, Hydrocephalus, Hypotonia, Self-injurious behavior	OMIM:619833
Hypomelanosis Of Ito	Gray matter heterotopia	OMIM:300337
3C Syndrome	Death in infancy, Hydrocephalus, Hypotonia, Abnormality of neuronal migration	ORPHA:7
Vici Syndrome	Gray matter heterotopia, Abnormal posturing, Hypotonia, Dysphagia	OMIM:242840
Hypertelorism-Hypospadias-Polysyndactyly Syndrome	Encephalocele, Abnormal cortical gyration, Exencephaly, Abnormality of neuronal migration, Macrog...	ORPHA:2211
Solitary Bone Cyst	Abnormal spinal cord morphology	ORPHA:83468
16P13.11 Microdeletion Syndrome	Abnormality of neuronal migration, Self-injurious behavior, Hypertonia, Holoprosencephaly, Compul...	ORPHA:261236
Methylmalonate Semialdehyde Dehydrogenase Deficiency	Periventricular heterotopia, Hypotonia, Dystonia	OMIM:614105
X-Linked Cerebral Adrenoleukodystrophy	Lower limb spasticity, Hyperactivity, Spastic tetraparesis, Myelopathy, Abnormal spinal cord morp...	ORPHA:139396
Tetrasomy 18P	Abnormality of neuronal migration	ORPHA:3307
Congenital Disorder Of Deglycosylation 2	Gray matter heterotopia, Polymicrogyria, Hypotonia, Dysphagia	OMIM:619775
Coffin-Lowry Syndrome	Death in early adulthood, Hypotonia, Abnormality of neuronal migration, Self-injurious behavior, ...	ORPHA:192
Bilateral Perisylvian Polymicrogyria	Lower limb spasticity, Perisylvian predominant thick cortex pachygyria, Spastic tetraplegia, Dysp...	ORPHA:98889
Vici Syndrome	Gray matter heterotopia, Death in infancy, Hypotonia	ORPHA:1493
Pyruvate Dehydrogenase E1-Beta Deficiency	Pachygyria, Hypotonia, Periventricular heterotopia	ORPHA:255138
Japanese Encephalitis	Hyperintensity of MRI T2 signal of the spinal cord, Anorexia, Paucity of anterior horn motor neur...	ORPHA:79139
Joubert Syndrome With Hepatic Defect	Occipital encephalocele, Tremor, Hydrocephalus, Hypotonia, Abnormality of neuronal migration	ORPHA:1454
Alkuraya-Kucinskas Syndrome	Gray matter heterotopia, Hydrocephalus, Lissencephaly, Generalized hypotonia	OMIM:617822
Agenesis Of Corpus Callosum, Cardiac, Ocular, And Genital Syndrome	Axial hypotonia, Impulsivity, Periventricular heterotopia, Self-injurious behavior, Attention def...	OMIM:618929
Van Maldergem Syndrome 1	Subcortical band heterotopia, Simplified gyral pattern, Hypotonia, Gray matter heterotopia, Gener...	OMIM:601390
Thanatophoric Dysplasia Type 1	Gray matter heterotopia, Hydrocephalus, Hypotonia	ORPHA:1860
Carnitine Palmitoyltransferase Ii Deficiency, Lethal Neonatal	Death in infancy, Hypotonia, Abnormality of neuronal migration, Neonatal hypotonia, Polymicrogyria	OMIM:608836
Autosomal Recessive Chorioretinopathy-Microcephaly Syndrome	Hypertonia, Abnormality of neuronal migration	ORPHA:2518
Pseudo-Torch Syndrome 2	Gray matter heterotopia, Polymicrogyria, Generalized hypotonia	OMIM:617397
Holoprosencephaly	Encephalocele, Hydrocephalus, Spinal cord tumor, Hypotonia, Spinal dysraphism, Abnormality of neu...	ORPHA:2162
Holoprosencephaly 14	Alobar holoprosencephaly, Aqueductal stenosis, Periventricular heterotopia, Hydrocephalus, Gray m...	OMIM:619895
Brain Abnormalities, Neurodegeneration, And Dysosteosclerosis	Periventricular heterotopia, Rigidity, Hydrocephalus, Spastic tetraplegia, Inappropriate laughter...	OMIM:618476
Midface Hypoplasia, Obesity, Developmental Delay, And Neonatal Hypotonia	Neonatal hypotonia, Gray matter heterotopia, Generalized hypotonia	OMIM:608624
Carnitine Palmitoyl Transferase Ii Deficiency, Neonatal Form	Pachygyria, Hydrocephalus, Abnormality of neuronal migration, Generalized hypotonia, Polymicrogyria	ORPHA:228308
Neurodevelopmental Disorder With Hypotonia, Neonatal Respiratory Insufficiency, And Thermodysregulation	Gray matter heterotopia, Spasticity, Hypotonia	OMIM:618797
Skeletal Dysplasia, Mild, With Joint Laxity And Advanced Bone Age	Hypotonia, Attention deficit hyperactivity disorder, Periventricular heterotopia	OMIM:618870
Carnitine Palmitoyltransferase Ii Deficiency	Polymicrogyria, Hydrocephalus, Pachygyria, Abnormality of neuronal migration	ORPHA:157
Orofaciodigital Syndrome Xvi	Gray matter heterotopia, Hypotonia	OMIM:617563
Peroxisome Biogenesis Disorder 1A (Zellweger)	Hypotonia, Dysphagia, Gray matter heterotopia, Generalized hypotonia, Death in childhood, Polymic...	OMIM:214100
Microcephalic Cortical Malformations-Short Stature Due To Rttn Deficiency	Periventricular heterotopia, Simplified gyral pattern, Lobar holoprosencephaly, Self-injurious be...	ORPHA:468631
Pagod Syndrome	Encephalocele, Death in infancy, Spina bifida, Meningocele, Abnormality of neuronal migration	ORPHA:991
Multiple Acyl-Coa Dehydrogenase Deficiency	Gray matter heterotopia, Hypotonia, Dysphagia	ORPHA:26791
Orofaciodigital Syndrome Type 6	Tremor, Hypotonia, Generalized hypotonia, Abnormality of neuronal migration	ORPHA:2754
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome	Gray matter heterotopia, Syringomyelia, Hypotonia, Bruxism	ORPHA:453499
Adrenomyeloneuropathy	Atrophy of the spinal cord, Abnormal spinal cord morphology, Progressive spastic paraparesis, Dor...	ORPHA:139399
Progressive Non-Fluent Aphasia	Abnormal lower motor neuron morphology, Restlessness	ORPHA:100070
Aicardi Syndrome	Spina bifida, Hypotonia, Gray matter heterotopia, Generalized hypotonia, Pachygyria, Polymicrogyria	OMIM:304050
Miller-Dieker Lissencephaly Syndrome	Gray matter heterotopia, Lissencephaly, Infantile muscular hypotonia, Pachygyria, Agyria, Progres...	OMIM:247200
Acute Disseminated Encephalomyelitis	Abnormal spinal cord morphology, Myelitis, Aggressive behavior	ORPHA:83597
Opitz-Kaveggia Syndrome	Hydrocephalus, Hypotonia, Gray matter heterotopia, Attention deficit hyperactivity disorder, Neon...	OMIM:305450
Periventricular Nodular Heterotopia	Periventricular heterotopia	ORPHA:98892
Ventriculomegaly With Cystic Kidney Disease	Gray matter heterotopia, Hydrocephalus	OMIM:219730
Splenogonadal Fusion-Limb Defects-Micrognathia Syndrome	Abnormality of neuronal migration	ORPHA:2063
Cerebrofacioarticular Syndrome	Gray matter heterotopia, Self-injurious behavior, Infantile muscular hypotonia	ORPHA:314679
Van Maldergem Syndrome 2	Gray matter heterotopia, Periventricular nodular heterotopia, Subcortical band heterotopia, Hypot...	OMIM:615546
Koolen-De Vries Syndrome	Gray matter heterotopia, Hyperactivity, Impulsivity, Generalized hypotonia	OMIM:610443
Bohring-Opitz Syndrome	Gray matter heterotopia, Hypotonia	OMIM:605039
6Q Terminal Deletion Syndrome	Periventricular heterotopia, Abnormality of neuronal migration, Gray matter heterotopia, Infantil...	ORPHA:75857
Arima Syndrome	Hypotonia, Gray matter heterotopia, Generalized hypotonia, Occipital meningocele, Polydipsia	OMIM:243910
Superficial Siderosis	Atrophy of the spinal cord, Abnormal spinal cord morphology, Dysgyria	ORPHA:247245
Periventricular Nodular Heterotopia 9	Gray matter heterotopia, Attention deficit hyperactivity disorder, Compulsive behaviors, Perivent...	OMIM:618918
Mosaic Trisomy 20	Abnormal spinal cord morphology, Hypotonia, Infantile muscular hypotonia	ORPHA:1724
Tetrasomy 9P	Hyperactivity, Abnormal spinal cord morphology, Hydrocephalus, Inappropriate behavior, Lissenceph...	ORPHA:3310
16Q24.3 Microdeletion Syndrome	Periventricular heterotopia, Dysphagia	ORPHA:261250
Neuromuscular Oculoauditory Syndrome	Generalized hypotonia, Periventricular heterotopia	OMIM:618733
Intellectual Disability Syndrome Due To A Dyrk1A Point Mutation	Abnormal repetitive mannerisms, Abnormality of neuronal migration, Attention deficit hyperactivit...	ORPHA:464311
Limb Body Wall Complex	Encephalocele, Spina bifida, Abnormal spinal cord morphology, Myelomeningocele, Hydrocephalus, An...	ORPHA:2369
Acromelic Frontonasal Dysostosis	Encephalocele, Gray matter heterotopia, Periventricular nodular heterotopia	OMIM:603671
Microcephalic Osteodysplastic Primordial Dwarfism, Type I	Death in infancy, Abnormal cortical gyration, Hydrocephalus, Microlissencephaly, Gray matter hete...	OMIM:210710
Genitourinary And/Or Brain Malformation Syndrome	Gray matter heterotopia, Polymicrogyria, Holoprosencephaly, Attention deficit hyperactivity disorder	OMIM:618820
Smith-Lemli-Opitz Syndrome	Death in infancy, Hyperactivity, Aggressive behavior, Periventricular heterotopia, Hydrocephalus,...	OMIM:270400
Orofaciodigital Syndrome I	Gray matter heterotopia, Myelomeningocele, Abnormal cortical gyration, Hydrocephalus	OMIM:311200
Fontaine Progeroid Syndrome	Death in infancy, Periventricular heterotopia, Hydrocephalus, Gray matter heterotopia, Generalize...	OMIM:612289
Holoprosencephaly-Radial Heart Renal Anomalies Syndrome	Holoprosencephaly, Abnormality of neuronal migration	ORPHA:3186
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation	Gray matter heterotopia, Hypotonia, Bruxism	ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion	Gray matter heterotopia, Hypotonia, Bruxism	ORPHA:352665
Amoebiasis Due To Free-Living Amoebae	Restlessness, Abnormal spinal cord morphology	ORPHA:68
Nijmegen Breakage Syndrome	Abnormality of neuronal migration, Attention deficit hyperactivity disorder	ORPHA:647
Hydrolethalus Syndrome 1	Abnormal cortical gyration, Anencephaly, Gray matter heterotopia, Stillbirth, Severe hydrocephalus	OMIM:236680
Orofaciodigital Syndrome Xiv	Occipital encephalocele, Periventricular heterotopia, Simplified gyral pattern, Holoprosencephaly...	OMIM:615948
Mismatch Repair Cancer Syndrome 1	Gray matter heterotopia	OMIM:276300
Genitopatellar Syndrome	Periventricular heterotopia, Hypotonia, Generalized hypotonia, Dysphagia, Pachygyria	OMIM:606170
Primary Sjögren Syndrome	Abnormal spinal cord morphology	ORPHA:289390
Orofaciodigital Syndrome Type 14	Hypotonia, Periventricular heterotopia	ORPHA:434179
Proteus Syndrome	Gray matter heterotopia	ORPHA:744
Mowat-Wilson Syndrome Due To Monosomy 2Q22	Periventricular heterotopia, Dysphagia, Bruxism, Spasticity, Polymicrogyria, Abnormal repetitive ...	ORPHA:261537
Mowat-Wilson Syndrome	Periventricular heterotopia, Hypotonia, Bruxism, Dysphagia, Spasticity, Polymicrogyria, Abnormal ...	ORPHA:2152
Mowat-Wilson Syndrome Due To A Zeb2 Point Mutation	Periventricular heterotopia, Dysphagia, Bruxism, Spasticity, Polymicrogyria, Abnormal repetitive ...	ORPHA:261552

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Olig2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Olig2.

No publications found that use IMPC mice or data for Olig2.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele	Allele Type	Produced
Olig2^em1(IMPC)Ics	Deletion	Mice
Olig2^{tm270519(L1L2_Bact_P)}	KO first allele (reporter-tagged insertion with conditional potential)	Targeting vectors
Olig2^{tm1e(EUCOMM)Hmgu}	Targeted, non-conditional allele	ES Cells

Sequence

Guides

Sequence	Guide sequence	pam	chr	start	stop	strand	Genome build	gRNA Concentration	Truncated Guide	Reversed	Sanger service	Guide format	Guide source

Nucleases

Nuclease type	Nuclease class

Genotype primers

Sequence	Name

The IMPC Newsletter

Get highlights of the most important data releases, news and events, delivered straight to your email inbox

Subscribe to newsletter

My Genes

About the IMPC

Data

Human Diseases

Publications

News

Blog

Help

IMPC Cloud

Contact us