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Gene: Exosc10 MGI:1355322

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
exosome component 10
Synonyms:
Pmscl2,  p4,  PM-Scl,  p3,  PM/Scl-100,  RRP6,  p2

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IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Exosc10 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Exosc10 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Spermatogenic Failure 12
Azoospermia, Infertility, Abnormal male germ cell morphology OMIM:615413

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Exosc10

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Exosc10.

There are 2 publications which use IMPC produced mice or data.

Title Journal IMPC Allele PubMed ID
EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition. Developmental biology (December 2021) Exosc10tm1a(KOMP)Wtsi 34965385
EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis. Scientific reports (November 2017) Exosc10tm1c(KOMP)Wtsi Exosc10tm1a(KOMP)Wtsi PMC5678167

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Exosc10tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Exosc10tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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