Not currently registered for phenotyping at IMPC
Phenotyping is currently not planned for a knockout strain of this gene.
Gene Summary
IMPC Data Collections
- No Body Weight Data
- No Embryo Imaging Data
- No Viability Data
Phenotyping is currently not planned for a knockout strain of this gene.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Exosc10 by phenotypic similarity.
Disease | Similarity of phenotypes |
Matching phenotypes | Source |
---|---|---|---|
Spermatogenic Failure 12 | Azoospermia, Infertility, Abnormal male germ cell morphology | OMIM:615413 |
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Exosc10.
There are 2 publications which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
EXOSC10/Rrp6 is essential for the eight-cell embryo/morula transition. | Developmental biology (December 2021) | Exosc10tm1a(KOMP)Wtsi | 34965385 |
EXOSC10/Rrp6 is post-translationally regulated in male germ cells and controls the onset of spermatogenesis. | Scientific reports (November 2017) | Exosc10tm1c(KOMP)Wtsi Exosc10tm1a(KOMP)Wtsi | PMC5678167 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Exosc10tm1e(KOMP)Wtsi | Targeted, non-conditional allele | ES Cells |
Exosc10tm1a(KOMP)Wtsi | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
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