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Gene: Tnfsf14 MGI:1355317

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
tumor necrosis factor (ligand) superfamily, member 14
Synonyms:
LIGHT,  HVEM-L

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Tnfsf14 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Tnfsf14 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Monocyte Chemotactic Disorder
Cutaneous anergy OMIM:252250
Okt4 Epitope Deficiency
Abnormal T cell morphology OMIM:613949
Osteomesopyknosis
Increased bone mineral density, Sclerotic vertebral body, Kyphosis, Abnormal form of the vertebra... ORPHA:2777
Retinal Telangiectasia And Hypogammaglobulinemia
Reduced delayed hypersensitivity, Decreased circulating IgG level OMIM:267900
Pa Polymorphism Of Alpha-2-Globulin
Abnormal immunoglobulin level OMIM:260100
Immunodeficiency, X-Linked, With Deficiency Of 115,000 Dalton Surface Glycoprotein
Abnormality of T cell physiology OMIM:308220
Endosteal Hyperostosis, Worth Type
Craniofacial hyperostosis, Sclerotic vertebral body, Generalized osteosclerosis, Abnormal rib mor... ORPHA:2790
Immunodeficiency 24
Lymphopenia, Decreased CD4:CD8 ratio, Decreased circulating IgG2 level, Reduced proportion of muc... OMIM:615897
Ghosal Hematodiaphyseal Dysplasia
Craniofacial hyperostosis, Splenomegaly, Abnormal form of the vertebral bodies, Abnormal cortical... ORPHA:1802
Candidiasis, Familial, 1
Cutaneous anergy OMIM:114580
Melorheostosis With Osteopoikilosis
Osteopoikilosis, Abnormal cortical bone morphology ORPHA:1879
Immunodeficiency 18
Decreased proportion of CD3-positive T cells, Defective T cell proliferation, Lymphopenia OMIM:615615
Gnathodiaphyseal Dysplasia
Osteopenia, Thickened cortex of long bones, Scoliosis ORPHA:53697
Hyperostosis Corticalis Generalisata
Generalized osteosclerosis, Abnormal cortical bone morphology, Cranial hyperostosis ORPHA:3416
Metatropic Dysplasia
Abnormal intervertebral disk morphology, Abnormal enchondral ossification, Kyphosis, Abnormal rib... ORPHA:2635
Caffey Disease
Periosteal thickening of long tubular bones, Cortical thickening of long bone diaphyses, Scoliosi... ORPHA:1310
Hereditary Sensory And Autonomic Neuropathy Type 2
Hyperlordosis, Osteolysis, Foot acroosteolysis, Reduced bone mineral density, Abnormal cortical b... ORPHA:970
Immunodeficiency, Partial Combined, With Absence Of Hla Determinants And Beta-2-Microglobulin From Lymphocytes
T lymphocytopenia, Decreased circulating IgG level OMIM:242870
Osteochondrosis Of The Metatarsal Bone
Chondritis, Thickened cortex of bones, Sclerosis of foot bone ORPHA:564003
Immunodeficiency 11A
Decreased proportion of CD4+CD25+ regulatory T cells, Decreased circulating antibody level, Agamm... OMIM:615206
Sclerosteosis
Craniofacial hyperostosis, Increased bone mineral density, Abnormal cortical bone morphology ORPHA:3152
Pyle Disease
Platyspondyly, Scoliosis, Thin bony cortex, Reduced bone mineral density OMIM:265900
Splenomegaly Syndrome With Splenic Germinal Center Hypoplasia And Reduced Circulating T Helper Cells
Cutaneous anergy OMIM:183350
Reticular Dysgenesis
Impaired T cell function, Lack of T cell function OMIM:267500
Endosteal Hyperostosis, Autosomal Dominant
Sclerotic vertebral body, Hyperostosis, Metacarpal diaphyseal endosteal sclerosis, Clavicular scl... OMIM:144750
Ck Syndrome
Kyphosis, Abnormal cortical bone morphology, Scoliosis, Hyperlordosis OMIM:300831
Proteus Syndrome
Kyphoscoliosis, Splenomegaly, Mandibular hyperostosis, Spinal canal stenosis, Calvarial hyperosto... OMIM:176920
Combined Cellular And Humoral Immune Defects With Granulomas
T lymphocytopenia, Decreased circulating IgG level, B lymphocytopenia OMIM:233650
Dysplastic Cortical Hyperostosis, Kozlowski-Tsuruta Type
Splenomegaly, Increased bone mineral density, Abnormal cortical bone morphology ORPHA:2204
Immunodeficiency 73C With Defective Neutrophil Chemotaxis And Hypogammaglobulinemia
Decreased circulating total IgM, Decreased circulating IgG level, B lymphocytopenia, Abnormally l... OMIM:618987
Lethal Congenital Contracture Syndrome Type 1
Abnormal cortical bone morphology, Abnormal rib morphology, Abnormal form of the vertebral bodies... ORPHA:1486
Wiskott-Aldrich Syndrome 2
Defective T cell proliferation, Reduced natural killer cell activity OMIM:614493
Weismann-Netter Syndrome
Kyphosis, Abnormal form of the vertebral bodies, Scoliosis, Abnormal cortical bone morphology, An... ORPHA:3344
Immunodeficiency With Hyper-Igm, Type 3
Impaired Ig class switch recombination, Impaired memory B cell generation, Increased circulating ... OMIM:606843
Eiken Syndrome
Abnormal trabecular bone morphology, Absence of the sacrum, Delayed epiphyseal ossification, Abno... ORPHA:79106
Caspase 8 Deficiency
Complete or near-complete absence of specific antibody response to unconjugated pneumococcus vacc... OMIM:607271
Spondylometaphyseal Dysplasia, Pagnamenta Type
Platyspondyly, Thoracic kyphosis, Thin bony cortex OMIM:619638
Familial Expansile Osteolysis
Osteolysis, Thin bony cortex OMIM:174810
Immunodeficiency 105
Impaired lymphocyte transformation with phytohemagglutinin, Decreased circulating IgG level, Panc... OMIM:619924
Ollier Disease
Abnormal cartilage morphology, Osteolysis, Multiple enchondromatosis, Platyspondyly, Anemia ORPHA:296
Caffey Disease
Calvarial hyperostosis, Subperiosteal bone formation, Cortical irregularity, Periosteal thickenin... OMIM:114000
Osteogenesis Imperfecta, Type Xxii
Multiple small vertebral fractures, Thin bony cortex, Reduced bone mineral density OMIM:619795
Vitamin D-Dependent Rickets, Type 2B, With Normal Vitamin D Receptor
Delayed epiphyseal ossification, Rickets, Sparse bone trabeculae, Generalized bone demineralizati... OMIM:600785
Hemosiderosis, Pulmonary, With Deficiency Of Gamma-A Globulin
Decreased circulating IgA level OMIM:235500
Autosomal Recessive Primary Microcephaly
Abnormal cortical bone morphology ORPHA:2512
Van Buchem Disease
Increased bone mineral density, Cranial hyperostosis, Thickened cortex of long bones OMIM:239100
Grant Syndrome
Abnormal cortical bone morphology, Decreased skull ossification, Abnormal rib morphology ORPHA:2097
Angioosteohypotrophic Syndrome
Abnormal trabecular bone morphology, Thin bony cortex ORPHA:75508
Immunodeficiency 103, Susceptibility To Fungal Infections
Abnormal B cell count, Increased circulating IgE level, Hypereosinophilia, Abnormal proportion of... OMIM:212050
Immunodeficiency 99 With Hypogammaglobulinemia And Autoimmune Cytopenias
Absent specific antibody response, Decreased proportion of CD4+CD25+ regulatory T cells, Autoimmu... OMIM:619846
Immunodeficiency 66
Defective T cell proliferation OMIM:618847
Wormian Bone-Multiple Fractures-Dentinogenesis Imperfecta-Skeletal Dysplasia
Abnormal cortical bone morphology ORPHA:166277
Osteopetrosis, Autosomal Dominant 1
Generalized osteosclerosis, Abnormality of the vertebral column, Osteopetrosis, Calvarial osteosc... OMIM:607634
Immunodeficiency, X-Linked, With Magnesium Defect, Epstein-Barr Virus Infection, And Neoplasia
Decreased proportion of CD4-positive T cells, Autoimmune thrombocytopenia, Splenomegaly, Decrease... OMIM:300853
Osteogenesis Imperfecta, Type Xviii
Vertebral compression fracture, Thin ribs, Biconcave vertebral bodies, Generalized osteoporosis, ... OMIM:617952
Dentin Dysplasia With Sclerotic Bones
Cortical sclerosis OMIM:125440
Immunodeficiency 64 With Lymphoproliferation
Increased proportion autoreactive unresponsive CD21-/low B cells, Decreased proportion of CD4-pos... OMIM:618534
Immunodeficiency, Common Variable, 2
Impaired T cell function, Recurrent pneumonia, Bronchiectasis, Conjunctivitis, Recurrent sinusiti... OMIM:240500
Immunodeficiency, Common Variable, 1
Pneumonia, Impaired T cell function, Recurrent pneumonia, Bronchiectasis, Decreased circulating t... OMIM:607594
Griscelli Syndrome, Type 2
Reduced delayed hypersensitivity OMIM:607624
Florid Cemento-Osseous Dysplasia
Abnormal trabecular bone morphology, Multiple bony cystic lesions, Abnormal bone structure ORPHA:83451
Lung Disease, Immunodeficiency, And Chromosome Breakage Syndrome
Decreased proportion of CD8-positive T cells, Increased circulating IgE level, Increased circulat... OMIM:617241
Vitamin D Hydroxylation-Deficient Rickets, Type 1B
Enlargement of the costochondral junction, Delayed epiphyseal ossification, Rickets, Bulging of t... OMIM:600081
Gorham-Stout Disease
Osteopenia, Osteolysis involving bones of the upper limbs, Osteolysis, Osteolysis involving bones... ORPHA:73
Immunodeficiency 81
Decreased proportion of CD4-positive T cells, Recurrent cutaneous abscess formation, Autoimmune h... OMIM:619374
Gm1-Gangliosidosis, Type Ii
Splenomegaly, Hypoplastic vertebral bodies, Platyspondyly, Sea-blue histiocytosis, Scoliosis, Tho... OMIM:230600
Legg-Calvé-Perthes Disease
Cartilage destruction ORPHA:2380
Craniometadiaphyseal Dysplasia, Wormian Bone Type
Osteopenia, Increased bone mineral density, Wide anterior fontanel, Vertebral arch anomaly, Broad... ORPHA:85184
Cranio-Osteoarthropathy
Abnormal cortical bone morphology ORPHA:1525
Craniodiaphyseal Dysplasia, Autosomal Dominant
Craniofacial hyperostosis, Thickened ribs, Cortical sclerosis, Craniofacial osteosclerosis, Diaph... OMIM:122860
Autoimmune Lymphoproliferative Syndrome
Autoimmune hemolytic anemia, Eosinophilia, Autoimmune thrombocytopenia, Increased circulating IgA... OMIM:601859
Severe Combined Immunodeficiency Due To Complete Rag1/2 Deficiency
Decreased circulating IgG level, Abnormal B cell count, Abnormal T cell count, Autoimmune hemolyt... ORPHA:331206
Melnick-Needles Syndrome
Craniofacial hyperostosis, Abnormal rib morphology, Osteolytic defects of the phalanges of the ha... ORPHA:2484
Severe Combined Immunodeficiency Due To Adenosine Deaminase Deficiency
Increased circulating IgE level, Lack of T cell function, T lymphocytopenia, B lymphocytopenia, L... ORPHA:277
Short Stature, Brussels Type
Delayed epiphyseal ossification, Calcification of cartilage ORPHA:2867
Familial Hemophagocytic Lymphohistiocytosis
Increased circulating interleukin 6 concentration, Skin rash, Maculopapular exanthema, Reduced na... ORPHA:540
Hypophosphatemic Rickets With Hypercalciuria, Hereditary
Enlargement of the costochondral junction, Delayed epiphyseal ossification, Rickets, Bulging of t... OMIM:241530
Adult Acute Respiratory Distress Syndrome
Increased circulating interleukin 6 concentration, Pneumonia, Abnormal circulating interleukin co... ORPHA:70578
Spondyloepiphyseal Dysplasia Tarda
Back pain, Abnormally ossified vertebrae, Increased bone mineral density, Lumbar hyperlordosis, K... ORPHA:93284
Intermediate Osteopetrosis
Back pain, Sandwich appearance of vertebral bodies, Cortical sclerosis, Generalized osteosclerosi... ORPHA:210110
Metaphyseal Dysplasia, Braun-Tinschert Type
Osteopenia, Increased bone mineral density, Sclerosis of proximal finger phalanx, Scoliosis, Scle... ORPHA:85188
T-B+ Severe Combined Immunodeficiency Due To Il-7Ralpha Deficiency
Eosinophilia, Autoimmune thrombocytopenia, Increased circulating IgA level, Decreased proportion ... ORPHA:169154
Acute Lung Injury
Acute pancreatitis, Increased circulating interleukin 6 concentration, Pneumonia, Abnormality of ... ORPHA:178320
Osteogenesis Imperfecta, Type X
Osteopenia, Multiple rib fractures, Thoracic scoliosis, Thin ribs, Decreased calvarial ossificati... OMIM:613848
Immunodeficiency 73B With Defective Neutrophil Chemotaxis And Lymphopenia
Decreased circulating IgG level, Pancytopenia, Decreased lymphocyte proliferation in response to ... OMIM:618986
Aregenerative Anemia
Pancytopenia, Erythroid hypoplasia, Reticulocytopenia, Bone marrow hypocellularity, Neutropenia, ... ORPHA:101096
Vitamin D Hydroxylation-Deficient Rickets, Type 1A
Enlargement of the costochondral junction, Delayed epiphyseal ossification, Rickets, Bulging of t... OMIM:264700
Autosomal Recessive Hypophosphatemic Rickets
Abnormal trabecular bone morphology, Increased bone mineral density, Osteomalacia, Craniosynostos... ORPHA:289176
Familial Osteodysplasia, Anderson Type
Missing ribs, Kyphosis, Abnormal rib morphology, Abnormal form of the vertebral bodies, Scoliosis... ORPHA:2769
Hypophosphatemic Rickets, X-Linked Recessive
Osteomalacia, Delayed epiphyseal ossification, Rickets, Sparse bone trabeculae, Hypophosphatemic ... OMIM:300554
Pulmonary Fibrosis And/Or Bone Marrow Failure Syndrome, Telomere-Related, 6
Pancytopenia, Decreased circulating antibody level, Bone marrow hypocellularity, Abnormally low T... OMIM:619767
Severe Combined Immunodeficiency, Autosomal Recessive, T Cell-Negative, B Cell-Positive, Nk Cell-Negative
Impaired lymphocyte transformation with phytohemagglutinin, Absent natural killer cells, Decrease... OMIM:600802
Immunodeficiency 96
Increased proportion of gamma-delta T cells, Decreased circulating total IgM, Defective T cell pr... OMIM:619774
Vulvovaginal Gingival Syndrome
Abnormality of tumor necrosis factor secretion ORPHA:83453
Hypocalcemic Vitamin D-Dependent Rickets
Osteomalacia, Enlargement of the costochondral junction, Delayed epiphyseal ossification, Rickets... ORPHA:289157
Vitamin D-Dependent Rickets, Type 2A
Delayed epiphyseal ossification, Rickets, Bulging of the costochondral junction, Sparse bone trab... OMIM:277440
Macrophage Activation Syndrome
Increased inflammatory response, Increased circulating interleukin 6 concentration, Hepatitis, In... ORPHA:158061
Immunodeficiency With Hyper-Igm, Type 1
Decreased circulating IgG level, Dysgammaglobulinemia, Impaired Ig class switch recombination, In... OMIM:308230
Lethal Kniest-Like Dysplasia
Anterior rib cupping, Short neck, Wide anterior fontanel, Abnormal cartilage morphology, Abnormal... ORPHA:2347
Autoimmune Lymphoproliferative Syndrome, Type Iia
Autoimmune hemolytic anemia, Eosinophilia, Autoimmune thrombocytopenia, Increased circulating IgA... OMIM:603909
Fibrous Dysplasia Of Bone
Thin bony cortex, Cortical irregularity, Osteomalacia, Fibrous dysplasia of the bones, Rickets, O... ORPHA:249
T-B+ Severe Combined Immunodeficiency Due To Gamma Chain Deficiency
Decreased circulating IgG level, Lymphopenia, Decreased proportion of naive T cells, Abnormal imm... ORPHA:276
Pachydermoperiostosis
Splenomegaly, Osteoporosis, Osteolysis, Scoliosis, Abnormal cortical bone morphology, Anemia ORPHA:2796
Peroxisome Biogenesis Disorder 12A (Zellweger)
Wide anterior fontanel, Abnormal cortical bone morphology OMIM:614886
Dent Disease 1
Osteomalacia, Delayed epiphyseal ossification, Rickets, Sparse bone trabeculae, Thin bony cortex OMIM:300009
Sweet Syndrome
Predominantly dermal neutrophilic infiltrate, Myositis, Increased circulating interleukin 6 conce... ORPHA:3243
Osteopetrosis, Autosomal Recessive 7
Abnormal trabecular bone morphology, Multiple rib fractures, Splenomegaly, Osteopetrosis, Anemia OMIM:612301
Kniest Dysplasia
Short neck, Hypoplasia of the odontoid process, Delayed epiphyseal ossification, Vertebral wedgin... ORPHA:485
Multicentric Osteolysis, Nodulosis, And Arthropathy
Osteopenia, Kyphoscoliosis, Osteoporosis, Osteolysis involving tarsal bones, Metatarsal osteolysi... OMIM:259600
Immunodeficiency By Defective Expression Of Mhc Class Ii
Pancytopenia, Autoimmune hemolytic anemia, Autoimmune thrombocytopenia, Abnormal CD4:CD8 ratio, N... ORPHA:572
T-B+ Severe Combined Immunodeficiency Due To Jak3 Deficiency
Impaired lymphocyte transformation with phytohemagglutinin, Decreased circulating IgG level, Abse... ORPHA:35078
Weill-Marchesani Syndrome 1
Lumbar hyperlordosis, Spinal canal stenosis, Scoliosis, Broad ribs, Thin bony cortex OMIM:277600
Intellectual Developmental Disorder, X-Linked, Syndromic, Snyder-Robinson Type
Kyphoscoliosis, Short neck, Osteoporosis, Scoliosis, Vertebral compression fracture, Thin bony co... OMIM:309583
Bare Lymphocyte Syndrome, Type Ii
Viral hepatitis, Cholangitis, Chronic mucocutaneous candidiasis, Agammaglobulinemia, Panhypogamma... OMIM:209920
Psoriasis-Related Juvenile Idiopathic Arthritis
Anterior uveitis, Psoriasiform dermatitis, Skin rash, Iridocyclitis, Oligoarthritis, Uveitis, Ent... ORPHA:85436
Kniest Dysplasia
Short neck, Delayed epiphyseal ossification, Coronal cleft vertebrae, Platyspondyly, Lumbar kypho... OMIM:156550
Osteopetrosis, Autosomal Recessive 9
Anemia, Increased bone mineral density, Osteopetrosis, Cortical sclerosis OMIM:620366
T-Cell Immunodeficiency With Thymic Aplasia
Aplasia of the thymus, Hepatosplenomegaly, T lymphocytopenia, Abnormally low T cell receptor exci... OMIM:242700
Oculodentodigital Dysplasia
Hyperostosis, Abnormal cortical bone morphology, Cranial hyperostosis, Abnormal form of the verte... ORPHA:2710
Severe Combined Immunodeficiency With Sensitivity To Ionizing Radiation
Aplasia of the thymus, Eosinophilia, Splenomegaly, Increased circulating IgE level, B lymphocytop... OMIM:602450
Lenz-Majewski Hyperostotic Dwarfism
Increased bone mineral density, Kyphosis, Cranial hyperostosis, Osteopetrosis, Scoliosis, Facial ... ORPHA:2658
Immunodeficiency 58
Recurrent cutaneous abscess formation, Eczema, Allergic rhinitis, Seborrheic dermatitis, Recurren... OMIM:618131
Stüve-Wiedemann Syndrome
Osteopenia, Sacral dimple, Osteoporosis, Scoliosis, Abnormal cortical bone morphology, Thickened ... ORPHA:3206
Faciocardiomelic Syndrome
Osteopenia, Cuboid-shaped vertebral bodies, Thin bony cortex OMIM:612731
Frank-Ter Haar Syndrome
Osteopenia, Anterior concavity of thoracic vertebrae, Kyphoscoliosis, Wide anterior fontanel, Kyp... OMIM:249420
Lissencephaly Type 3-Metacarpal Bone Dysplasia Syndrome
Epiphyseal stippling, Abnormal cartilage matrix, Abnormal bone structure ORPHA:86822
Spondyloocular Syndrome
Osteopenia, Vertebral compression fracture, Platyspondyly, Thin bony cortex OMIM:605822
Dent Disease
Osteomalacia, Delayed epiphyseal ossification, Rickets, Sparse bone trabeculae, Thin bony cortex ORPHA:1652
Osteogenesis Imperfecta
Osteopenia, Multiple rib fractures, Cervical kyphosis, Kyphosis, Osteoporosis, Abnormal rib morph... ORPHA:666
Rothmund-Thomson Syndrome
Osteopenia, Abnormal trabecular bone morphology, Aplastic anemia, Reduced bone mineral density, N... ORPHA:2909
Craniotubular Dysplasia, Ikegawa Type
Increased intervertebral space, Sclerosis of skull base, Platyspondyly, Broad ribs, Thin bony cortex OMIM:619727
Immunodeficiency 73A With Defective Neutrophil Chemotaxis And Leukocytosis
Abnormally low T cell receptor excision circle level, Macrocytic anemia, Neutrophilia, Leukocytos... OMIM:608203
Aspartylglucosaminuria
Splenomegaly, Scoliosis, Anterior beaking of lumbar vertebrae, Beaking of vertebral bodies, Abnor... ORPHA:93
Weill-Marchesani Syndrome 2
Lumbar hyperlordosis, Spinal canal stenosis, Scoliosis, Broad ribs, Thin bony cortex OMIM:608328
Rothmund-Thomson Syndrome Type 1
Osteopenia, Abnormal trabecular bone morphology, Aplastic anemia, Neutropenia, Leukemia, Anemia ORPHA:221008
Mulibrey Nanism
Thickened cortex of long bones OMIM:253250
Rothmund-Thomson Syndrome Type 2
Osteopenia, Abnormal trabecular bone morphology, Aplastic anemia, Neutropenia, Leukemia, Anemia ORPHA:221016
Car T Cell Therapy-Associated Cytokine Release Syndrome
Increased circulating interleukin 6 concentration, Abnormality of interleukin secretion, Abnormal... ORPHA:542323
Wiskott-Aldrich Syndrome
Impaired lymphocyte transformation with phytohemagglutinin, Autoimmune hemolytic anemia, Absent m... OMIM:301000
Orotic Aciduria
Impaired T cell function OMIM:258900
Rajab Interstitial Lung Disease With Brain Calcifications 1
Osteopenia, Thin bony cortex, Pancytopenia, Rickets, Reduced bone mineral density, Scoliosis, Anemia OMIM:613658
Camptodactyly Syndrome, Guadalajara Type 3
Osteopenia, Short neck, Abnormal rib morphology, Spina bifida occulta, Thickened cortex of long b... ORPHA:488434
Hereditary Orotic Aciduria
Impaired T cell function ORPHA:30
Purine Nucleoside Phosphorylase Deficiency
Sinusitis, Pneumonia, Impaired T cell function, Decreased lymphocyte proliferation in response to... OMIM:613179
Obesity Due To Congenital Leptin Deficiency
Decreased T cell activation ORPHA:66628
Inflammatory Bowel Disease, Immunodeficiency, And Encephalopathy
Eosinophilic infiltration of the esophagus, Perianal abscess, Increased circulating IgE level, Pa... OMIM:618213
Congenital Disorder Of Glycosylation, Type Iil
Decreased specific anti-polysaccharide antibody level, Impaired T cell function OMIM:614576
T-Cell Immunodeficiency With Thymic Aplasia
Sinusitis, Pneumonia, Atypical or prolonged hepatitis, Thyroiditis, Decreased lymphocyte prolifer... ORPHA:83471
Alkaptonuria
Intervertebral disk calcification, Cartilage destruction, Calcification of cartilage, Reduced bon... ORPHA:56
Obesity Due To Leptin Receptor Gene Deficiency
Decreased T cell activation ORPHA:179494
Larsen-Like Syndrome, Lethal Type
Abnormal cartilage matrix OMIM:245650
Encephalocraniocutaneous Lipomatosis
Craniofacial hyperostosis, Abnormal cartilage morphology, Bone cyst, Osteolysis ORPHA:2396
Acrodermatitis Enteropathica, Zinc-Deficiency Type
Impaired T cell function OMIM:201100
Adult-Onset Still Disease
Cartilage destruction, Splenomegaly, Leukocytosis, Neutrophilia ORPHA:829
Stuve-Wiedemann Syndrome 1
Ovoid vertebral bodies, Short neck, Osteoporosis, Thin ribs, Scoliosis, Thickened cortex of long ... OMIM:601559
Schimke Immuno-Osseous Dysplasia
Bone marrow hypocellularity, Impaired T cell function, Abnormal lymphocyte physiology ORPHA:1830
Infection-Related Hemolytic Uremic Syndrome
Hemolytic anemia, Brain abscess, Increased circulating interleukin 6 concentration, Leukocytosis,... ORPHA:544482
Kenny-Caffey Syndrome, Type 2
Increased bone mineral density, Thickened cortex of long bones, Anemia OMIM:127000
Schinzel-Giedion Midface Retraction Syndrome
Sacrococcygeal teratoma, Increased density of long bones, Short neck, Splenopancreatic fusion, Hy... OMIM:269150
Multiple Osteochondromas
Neuropathic spinal arthropathy, Abnormal cartilage morphology, Rib exostoses, Abnormal bone struc... ORPHA:321
Sarcoidosis, Susceptibility To, 1
Abnormality of T cell physiology, Iridocyclitis, Bronchiectasis, Uveitis, Arthritis, Inflammation... OMIM:181000
Hypoparathyroidism-Sensorineural Deafness-Renal Disease Syndrome
Abnormality of T cell physiology ORPHA:2237
Velocardiofacial Syndrome
Impaired T cell function OMIM:192430
Progeroid Short Stature With Pigmented Nevi
Impaired T cell function OMIM:176690
17Q11 Microdeletion Syndrome
Osteopenia, Kyphosis, Osteoporosis, Osteolysis, Abnormality of the vertebral column, Beaking of v... ORPHA:97685
Moderate Hemophilia A
Cartilage destruction ORPHA:169805
22Q11.2 Deletion Syndrome
Impaired T cell function ORPHA:567
Reactive Arthritis
Cartilage destruction ORPHA:29207
Digeorge Syndrome
Impaired T cell function OMIM:188400

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Tnfsf14

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Tnfsf14.

No publications found that use IMPC mice or data for Tnfsf14.

Order Mouse and ES Cells

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MGI Allele Allele Type Produced
Tnfsf14tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Tnfsf14tm2e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Tnfsf14tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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