The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Fbxl12 by phenotypic similarity.
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fbxl12.
There are 1 publication which use IMPC produced mice or data.
|Title||Journal||IMPC Allele||PubMed ID|
|Notch and the pre-TCR coordinate thymocyte proliferation by induction of the SCF subunits Fbxl1 and Fbxl12.||Nature immunology (August 2019)||Fbxl12tm1a(KOMP)Wtsi||PMC6754294|
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|MGI Allele||Allele Type||Produced|
|Fbxl12tm1e(KOMP)Wtsi||Targeted, non-conditional allele||ES Cells|
|Fbxl12tm1a(KOMP)Wtsi||KO first allele (reporter-tagged insertion with conditional potential)||Targeting vectors, ES Cells|