Acsl4 | acyl-CoA synthetase long-chain family member 4

GeneMGI:1354713Synonyms: Facl4, 9430020A05Rik, +2 more

Physiological systems

20 / 24 physiological systems tested

7 Significantly impacted by the knock-out

 Homeostasis/metabolism Adipose tissue Growth/size/body region Limbs/digits/tail Hematopoietic system Skeleton Mortality/aging

13 No significant impact

4 Not tested

Gene metrics:8Significant phenotypes
3Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

abnormal tibia morphology1 supporting datasetAcsl4tm1a(EUCOMM)WtsihemizygoteEarly adult8.36x10-5 
decreased circulating chloride level1 supporting datasetAcsl4tm1a(EUCOMM)WtsiheterozygoteEarly adult7.07x10-5 
increased total body fat amount1 supporting datasetAcsl4tm1a(EUCOMM)WtsiheterozygoteEarly adult2.29x10-5 
decreased body weight3 supporting datasetsAcsl4tm1a(EUCOMM)WtsihemizygoteEarly adult7.44x10-6 
thrombocytopenia1 supporting datasetAcsl4tm1a(EUCOMM)WtsiheterozygoteEarly adult9.29x10-5 
decreased body length1 supporting datasetAcsl4tm1a(EUCOMM)WtsihomozygoteEarly adult3.1x10-11 
preweaning lethality, incomplete penetrance1 supporting datasetAcsl4tm1a(EUCOMM)WtsihomozygoteEarly adultN/A * 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Acsl4tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse

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