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Gene: Lats2 MGI:1354386

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Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
large tumor suppressor 2
Synonyms:
N/A

Order Alleles

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Lats2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Lats2 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Intellectual Developmental Disorder, Autosomal Recessive 54
Exaggerated startle response OMIM:617028
Microcephaly, Growth Restriction, And Increased Sister Chromatid Exchange 2
Intrauterine growth retardation, Increased susceptibility to spontaneous sister chromatid exchang... OMIM:618097
Fanconi Anemia, Complementation Group O
Chromosome breakage, Short stature, Abnormal heart morphology, Small thenar eminence, Neonatal death OMIM:613390
Lambert Syndrome
Aplasia/Hypoplasia of the cerebellum, Intrauterine growth retardation, Branchial anomaly, Ventric... ORPHA:1296
Cardiomyopathy, Dilated, 1R
Increased left ventricular end-diastolic volume, Congestive heart failure, Myofiber disarray, Dil... OMIM:613424
Nijmegen Breakage Syndrome-Like Disorder
Growth delay, Chromosomal breakage induced by ionizing radiation, Short stature OMIM:613078
Fanconi Anemia, Complementation Group J
Postnatal growth retardation, Intrauterine growth retardation, Chromosomal breakage induced by cr... OMIM:609054
Scleroderma, Familial Progressive
Calcinosis, Chromosome breakage, Abnormality of chromosome stability, Telangiectasia OMIM:181750
Immunodeficiency 54
Postnatal growth retardation, Chromosome breakage, Short stature, Intrauterine growth retardation OMIM:609981
Fanconi Anemia, Complementation Group Q
Growth delay, Chromosome breakage, Short stature, Primum atrial septal defect OMIM:615272
Cardiomyopathy, Dilated, 1C, With Or Without Left Ventricular Noncompaction
Increased left ventricular end-diastolic volume, Sudden cardiac death, Congestive heart failure, ... OMIM:601493
Intrauterine Growth Retardation With Increased Mitomycin C Sensitivity
Postnatal growth retardation, Intrauterine growth retardation, Abnormality of chromosome stability OMIM:600546
Fraxf Syndrome
Folate-dependent fragile site at Xq28 ORPHA:100974
Cardiomyopathy, Dilated, 1Aa, With Or Without Left Ventricular Noncompaction
Atrial fibrillation, Cardiac arrest, Myofiber disarray, Dilated cardiomyopathy, Atrioventricular ... OMIM:612158
Fanconi Anemia, Complementation Group D1
Intrauterine growth retardation, Short stature, Chromosomal breakage induced by crosslinking agents OMIM:605724
Fragile X Syndrome
Folate-dependent fragile site at Xq28, Mitral valve prolapse OMIM:300624
Left Ventricular Noncompaction 10
Increased left ventricular end-diastolic volume, Congestive heart failure, Dilated cardiomyopathy... OMIM:615396
Left Ventricular Noncompaction 8
Left ventricular diastolic dysfunction, Congestive heart failure, Dilated cardiomyopathy, Mitral ... OMIM:615373
Fragile X Syndrome
Folate-dependent fragile site at Xq28, Mitral valve prolapse ORPHA:908
Congenital Heart Block
First degree atrioventricular block, Gallop rhythm, Pericardial effusion, Patent foramen ovale, C... ORPHA:60041
Fanconi Anemia, Complementation Group I
Ventricular septal defect, Short stature, Atrial septal defect, Intrauterine growth retardation, ... OMIM:609053
Fanconi Anemia, Complementation Group T
Short stature, Facial palsy, Chromosomal breakage induced by crosslinking agents OMIM:616435
Left Ventricular Noncompaction 1
Noncompaction cardiomyopathy, Atrial fibrillation, Ventricular septal defect, Left ventricular no... OMIM:604169
Mitochondrial Complex Iv Deficiency, Nuclear Type 16
Short stature, Chromosomal breakage induced by crosslinking agents OMIM:619060
Radial-Renal Syndrome
Chromosome breakage, Short stature OMIM:179280
Fanconi Anemia, Complementation Group N
Postnatal growth retardation, Ventricular septal defect, Chromosomal breakage induced by crosslin... OMIM:610832
Cardiomyopathy, Familial Hypertrophic, 4
First degree atrioventricular block, Cardiomegaly, Atrioventricular block, Left bundle branch blo... OMIM:115197
Dandy-Walker Syndrome
Dilated fourth ventricle, Hydrocephalus, Agenesis of cerebellar vermis, Partial absence of cerebe... OMIM:220200
X-Linked Mandibulofacial Dysostosis
Short stature, Cryptorchidism, Branchial anomaly, Pulmonic stenosis, Webbed neck, Abnormal mitral... ORPHA:1131
Mosaic Variegated Aneuploidy Syndrome 4
Abnormality of chromosome stability OMIM:620153
Fanconi Anemia, Complementation Group S
Chromosome breakage, Short stature OMIM:617883
Verheij Syndrome
Branchial cyst, Ventricular septal defect, Short stature, Short neck, Growth delay, Intrauterine ... OMIM:615583
Fanconi Anemia, Complementation Group G
Growth delay, Abnormality of chromosome stability OMIM:614082
Congenital Muscular Dystrophy With Cerebellar Involvement
Dilated fourth ventricle, Occipital encephalocele, Fusion of the cerebellar hemispheres, Calf mus... ORPHA:370959
Familial Dilated Cardiomyopathy With Conduction Defect Due To Lmna Mutation
Sinoatrial block, Atrial flutter, Atrial fibrillation, Sudden cardiac death, Cardiac conduction a... ORPHA:300751
Ataxia-Telangiectasia
Skeletal muscle atrophy, Abnormality of chromosome stability, Telangiectasia of the skin, Short s... ORPHA:100
X-Linked Microcephaly-Growth Retardation-Prognathism-Cryptorchidism Syndrome
Branchial cyst, Ankle flexion contracture, Cryptorchidism, Knee flexion contracture, Severe postn... ORPHA:435938
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome
Bicuspid aortic valve, Ventricular septal defect, Cryptorchidism, Increased nuchal translucency, ... ORPHA:453499
Intellectual Developmental Disorder, Autosomal Dominant 48
Cerebellar dysplasia, Dilated fourth ventricle, Cerebellar vermis hypoplasia, Ventricular septal ... OMIM:617751
Fanconi Anemia, Complementation Group V
Short stature, Chromosomal breakage induced by crosslinking agents OMIM:617243
Cardiomyopathy, Dilated, 1A
Atrial flutter, Atrial fibrillation, First degree atrioventricular block, Sudden cardiac death, P... OMIM:115200
Combined Oxidative Phosphorylation Deficiency 10
Cardiomegaly, Pericardial effusion, Pleural effusion, Bradycardia, Intrauterine growth retardatio... OMIM:614702
Fanconi Anemia, Complementation Group F
Short stature, Polyhydramnios, Atrial septal defect, Intrauterine growth retardation, Chromosomal... OMIM:603467
Fanconi Anemia, Complementation Group E
Short stature, Abnormal heart morphology, Deficient excision of UV-induced pyrimidine dimers in D... OMIM:600901
Fanconi Anemia, Complementation Group C
Ventricular septal defect, Short stature, Flexion contracture, Deficient excision of UV-induced p... OMIM:227645
Fanconi Anemia, Complementation Group R
Growth delay, Hydrocephalus, Chromosomal breakage induced by crosslinking agents OMIM:617244
Congenital Pulmonary Lymphangiectasia
Tricuspid regurgitation, Congestive heart failure, Hydrops fetalis, Chylopericardium, Growth dela... ORPHA:2414
Dyskeratosis Congenita, Autosomal Recessive 8
Chromosomal breakage induced by crosslinking agents, Petechiae, Intrauterine growth retardation OMIM:620133
Fanconi Anemia, Complementation Group A
Short stature, Abnormal heart morphology, Deficient excision of UV-induced pyrimidine dimers in D... OMIM:227650
Mitochondrial Complex Iv Deficiency, Nuclear Type 11
Dilated fourth ventricle, Torticollis, Foot dorsiflexor weakness, Cerebellar vermis atrophy OMIM:619054
Bloom Syndrome
Chromosome breakage, Abnormality of chromosome stability, Postnatal growth retardation, Growth de... OMIM:210900
N Syndrome
Abnormality of chromosome stability OMIM:310465
Fanconi Anemia, Complementation Group U
Growth delay, Chromosome breakage, Unilateral facial palsy OMIM:617247
Autosomal Dominant Charcot-Marie-Tooth Disease Type 2A2
Distal lower limb amyotrophy, Hand muscle weakness, Quadriceps muscle weakness, Abnormal spinal c... ORPHA:99947
Branchiogenic-Deafness Syndrome
Branchial cyst, Branchial fistula, Short stature OMIM:609166
Cardiomyopathy, Dilated, 1D
Prolonged QT interval, Increased left ventricular end-diastolic volume, Atrial fibrillation, Sudd... OMIM:601494
Dandy-Walker Malformation With Postaxial Polydactyly
Dilated fourth ventricle, Agenesis of cerebellar vermis, Patent ductus arteriosus, Hydrocephalus,... OMIM:220220
Hyperekplexia-Epilepsy Syndrome
Exaggerated startle response ORPHA:163985
Fanconi Anemia, Complementation Group L
Chromosome breakage, Hydrocephalus, Growth delay, Intrauterine growth retardation, Chromosomal br... OMIM:614083
Lymphatic Malformation 8
Nonimmune hydrops fetalis, Polyhydramnios, Pericardial effusion, Stillbirth, Pleural effusion, Ge... OMIM:618773
Sick Sinus Syndrome 2
Aortic regurgitation, Paroxysmal atrial fibrillation, Atrial fibrillation, Cardiac arrest, Sudden... OMIM:163800
Congenital Tricuspid Valve Dysplasia
Tricuspid regurgitation, Cardiomegaly, Pericardial effusion, Anomalous pulmonary venous return, A... ORPHA:555874
Hydrops Fetalis
Nonimmune hydrops fetalis, Polyhydramnios, Lymphedema, Pericardial effusion, Abnormal heart morph... ORPHA:1041
Bone Marrow Failure Syndrome 3
Chromosome breakage, Short stature, Intrauterine growth retardation OMIM:617052
Glycogen Storage Disease Of Heart, Lethal Congenital
Prolonged QRS complex, Cardiomegaly, Pericardial effusion, Shortened PR interval, Cardiomyopathy,... OMIM:261740
Spinocerebellar Ataxia, Autosomal Recessive 13
Cerebellar atrophy, Dilated fourth ventricle, Short stature, Retrocerebellar cyst, Inferior cereb... OMIM:614831
Fanconi Anemia, Complementation Group B
Abnormality of chromosome stability, Ventricular septal defect, Hydrocephalus, Growth delay, Intr... OMIM:300514
Holoprosencephaly
Encephalocele, Ventricular septal defect, Abnormal pulmonary valve morphology, Congenital diaphra... ORPHA:2162
Fanconi Anemia, Complementation Group D2
Short stature, Hydrocephalus, Abnormal heart morphology, Deficient excision of UV-induced pyrimid... OMIM:227646
Spinocerebellar Ataxia, Autosomal Recessive 2
Dilated fourth ventricle, Short stature, Cerebellar hypoplasia, Cerebellar vermis atrophy OMIM:213200
Transcobalamin Deficiency
Abnormality of chromosome stability ORPHA:859
Fanconi Anemia, Complementation Group P
Growth delay, Short stature, Chromosomal breakage induced by crosslinking agents OMIM:613951
Primary Effusion Lymphoma
Pericardial effusion, Pleural effusion ORPHA:48686
X-Linked Intellectual Disability-Acromegaly-Hyperactivity Syndrome
Folate-dependent fragile site at Xq28 ORPHA:85327
Choanal Atresia And Lymphedema
Pericardial effusion, Lymphedema OMIM:613611
Branchiogenic Deafness Syndrome
Branchial cyst, Branchial fistula, Short stature ORPHA:50815
Icf Syndrome
Communicating hydrocephalus, Abnormality of chromosome stability, Short stature, Macroglossia, Um... ORPHA:2268
Cortical Dysplasia, Complex, With Other Brain Malformations 6
Dilated fourth ventricle, Cerebellar vermis hypoplasia OMIM:615771
Branchiootic Syndrome 1
Branchial fistula OMIM:602588
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To A Point Mutation
Bicuspid aortic valve, Ventricular septal defect, Cryptorchidism, Increased nuchal translucency, ... ORPHA:453504
Neurodevelopmental Disorder-Craniofacial Dysmorphism-Cardiac Defect-Skeletal Anomalies Syndrome Due To 9Q21.3 Microdeletion
Bicuspid aortic valve, Ventricular septal defect, Cryptorchidism, Increased nuchal translucency, ... ORPHA:352665
Riddle Syndrome
Conjunctival telangiectasia, Short stature, Intraventricular hemorrhage, Telangiectasia, Chromoso... ORPHA:420741
Severe X-Linked Intellectual Disability, Gustavson Type
Dilated fourth ventricle, Ventricular septal defect, Contractures of the large joints, Lateral ve... ORPHA:3078
Branchiootic Syndrome 3
Branchial cyst OMIM:608389
Poretti-Boltshauser Syndrome
Dilated fourth ventricle, Cerebellar cyst, Cerebellar vermis hypoplasia, Cerebellar dysplasia OMIM:615960
Ataxia-Intellectual Disability-Oculomotor Apraxia-Cerebellar Cysts Syndrome
Dilated fourth ventricle, Cerebellar dysplasia, Elongated superior cerebellar peduncle, Inferior ... ORPHA:370022
Distal 22Q11.2 Microduplication Syndrome
Branchial fistula, Ventricular septal defect, Camptodactyly of finger, Cryptorchidism, Patent duc... ORPHA:261337
Hyperekplexia 2
Exaggerated startle response OMIM:614619
Developmental And Epileptic Encephalopathy 68
Exaggerated startle response OMIM:618201
Cardiomyopathy, Dilated, 1S
Tricuspid regurgitation, Bicuspid aortic valve, Sudden cardiac death, Congestive heart failure, D... OMIM:613426
Developmental And Epileptic Encephalopathy 8
Exaggerated startle response OMIM:300607
Lymphatic Malformation 7
Nonimmune hydrops fetalis, Edema, Lymphedema, Facial edema, Pericardial effusion, Increased nucha... OMIM:617300
Aromatic L-Amino Acid Decarboxylase Deficiency
Torticollis, Exaggerated startle response, Oculogyric crisis, Limb tremor, Choreoathetosis, Athet... OMIM:608643
Branchiootorenal Syndrome 1
Branchial cyst, Branchial fistula, Facial palsy OMIM:113650
Meckel Syndrome, Type 10
Dilated fourth ventricle, Occipital encephalocele, Anencephaly, Cerebellar hypoplasia, Camptodact... OMIM:614175
Neurodevelopmental Disorder With Hypotonia, Stereotypic Hand Movements, And Impaired Language
Dilated fourth ventricle, Lateral ventricle dilatation, Ventriculomegaly OMIM:613443
Distal 22Q11.2 Microdeletion Syndrome
Branchial fistula, Ventricular septal defect, Camptodactyly of finger, Short stature, Growth dela... ORPHA:261330
Autosomal Recessive Cerebelloparenchymal Disorder Type 3
Cerebellar atrophy, Short stature, Dilated fourth ventricle, Cerebellar vermis atrophy ORPHA:1170
Autosomal Recessive Cutis Laxa Type 2A
Dilated fourth ventricle, Cerebellar vermis hypoplasia, Postnatal growth retardation, Cerebellar ... ORPHA:357058
Meningioma
Facial palsy, Cerebral hemorrhage, Hydrocephalus, Upper limb muscle weakness, Syncope, Chromosoma... ORPHA:2495
Lig4 Syndrome
Growth delay, Abnormality of chromosome stability, Telangiectasia of the skin ORPHA:99812
Hyperekplexia 3
Exaggerated startle response OMIM:614618
Bor Syndrome
Branchial cyst, Facial palsy ORPHA:107
Stiff Person Spectrum Disorder
Exaggerated startle response ORPHA:3198
Branchiootic Syndrome
Branchial fistula, Facial palsy ORPHA:52429
Ataxia-Telangiectasia-Like Disorder
Cerebellar atrophy, Cerebellar vermis hypoplasia, Dilated fourth ventricle, Short stature ORPHA:251347
Spinocerebellar Ataxia 1
Dilated fourth ventricle, Skeletal muscle atrophy, Dorsal column degeneration, Spinocerebellar at... OMIM:164400
Machado-Joseph Disease Type 3
Abnormal lower motor neuron morphology, Dilated fourth ventricle, Cerebellar atrophy, Skeletal mu... ORPHA:276244
Mitochondrial Complex Iii Deficiency, Nuclear Type 10
Persistent fetal circulation, Ventricular septal defect, Pericardial effusion, Bradycardia, Intra... OMIM:618775
Cartilage-Hair Hypoplasia
Abnormality of chromosome stability, Rhizomelia, Heart block, Aplasia/Hypoplasia of the abdominal... ORPHA:175
Zaki Syndrome
Dilated fourth ventricle, Cerebellar vermis hypoplasia, Short stature, Congenital diaphragmatic h... OMIM:619648
Mutilating Hereditary Sensory Neuropathy With Spastic Paraplegia
Abnormal spinal cord morphology, Distal amyotrophy ORPHA:139578
Facial Dysmorphism-Developmental Delay-Behavioral Abnormalities Syndrome Due To Wac Point Mutation
Branchial anomaly, Ventriculomegaly ORPHA:466950
Wars2-Related Combined Oxidative Phosphorylation Defect
Cerebellar atrophy, Dilated fourth ventricle, Cerebellar vermis hypoplasia, Cardiomyopathy, Later... ORPHA:572798
Oligomeganephronia
Branchial cyst, Secundum atrial septal defect, Congenital diaphragmatic hernia ORPHA:2260
Gm2 Gangliosidosis, Ab Variant
Exaggerated startle response, Dystonia ORPHA:309246
Spinocerebellar Ataxia 2
Cerebellar atrophy, Dilated fourth ventricle, Distal amyotrophy, Spinocerebellar tract degenerati... OMIM:183090
Spinocerebellar Ataxia, Autosomal Recessive 33
Dilated fourth ventricle, Cerebellar hypoplasia OMIM:620208
Immunodeficiency 80 With Or Without Congenital Cardiomyopathy
Nonimmune hydrops fetalis, Pericardial effusion, Endocardial fibroelastosis, Restrictive cardiomy... OMIM:619313
Very Long Chain Acyl-Coa Dehydrogenase Deficiency
Prolonged QT interval, Exercise-induced rhabdomyolysis, Tachycardia, Ventricular septal defect, P... ORPHA:26793
Machado-Joseph Disease Type 1
Cerebellar atrophy, Skeletal muscle atrophy, Dilated fourth ventricle, Distal lower limb amyotrop... ORPHA:276238
Machado-Joseph Disease Type 2
Cerebellar atrophy, Skeletal muscle atrophy, Dilated fourth ventricle, Distal lower limb amyotrop... ORPHA:276241
Fanconi Anemia
Abnormality of chromosome stability, Short stature, Spina bifida, Hydrocephalus, Growth delay, In... ORPHA:84
Branchial Arch Abnormalities, Choanal Atresia, Athelia, Hearing Loss, And Hypothyroidism Syndrome
Branchial cyst, Natal tooth, Short stature, Facial palsy, Hydrocele testis, Atrial septal defect,... OMIM:620186
Machado-Joseph Disease
Cerebellar atrophy, Distal amyotrophy, Dilated fourth ventricle, Spinocerebellar tract degeneration OMIM:109150
Hyperekplexia 1
Exaggerated startle response OMIM:149400
Asparagine Synthetase Deficiency
Dilated fourth ventricle, Diaphragmatic eventration, Cerebellar vermis hypoplasia, Hypoplasia of ... OMIM:615574
Stiff-Person Syndrome
Exaggerated startle response, Opisthotonus OMIM:184850
8Q24.3 Microdeletion Syndrome
Branchial cyst, Infancy onset short-trunk short stature, Ventricular septal defect, Short stature... ORPHA:508488
Spastic Paraplegia, Optic Atrophy, And Neuropathy
Exaggerated startle response OMIM:609541
15Q11.2 Microdeletion Syndrome
Dilated fourth ventricle, Ventricular septal defect, Abnormal heart morphology, Total anomalous p... ORPHA:261183
Lissencephaly Due To Tuba1A Mutation
Dilated fourth ventricle, Cerebellar vermis hypoplasia, Ventriculomegaly ORPHA:171680
Tay-Sachs Disease
Exaggerated startle response OMIM:272800
Spastic Tetraplegia And Axial Hypotonia, Progressive
Exaggerated startle response OMIM:618598
Spastic Paraplegia-Optic Atrophy-Neuropathy Syndrome
Exaggerated startle response ORPHA:320406
Neurodevelopmental Disorder With Cerebellar Atrophy And With Or Without Seizures
Tremor, Exaggerated startle response, Truncal titubation OMIM:618056
Treacher-Collins Syndrome
Encephalocele, Branchial fistula, Patent ductus arteriosus, Cryptorchidism ORPHA:861
Neurodevelopmental Disorder With Speech Impairment And With Or Without Seizures
Exaggerated startle response OMIM:620114
Pulmonary Capillary Hemangiomatosis
Pulmonary edema, Diffuse alveolar hemorrhage, Pericardial effusion, Right ventricular failure, Pe... ORPHA:199241
Joubert Syndrome 6
Dilated fourth ventricle, Enlarged fossa interpeduncularis, Cerebellar vermis hypoplasia, Elongat... OMIM:610688
Keratoderma Hereditarium Mutilans
Abnormal spinal cord morphology ORPHA:494
Gm2-Gangliosidosis, Ab Variant
Exaggerated startle response, Dystonia OMIM:272750
Neurodegeneration With Developmental Delay, Early Respiratory Failure, Myoclonic Seizures, And Brain Abnormalities
Tremor, Exaggerated startle response OMIM:620327
Leukodystrophy, Hypomyelinating, 13
Exaggerated startle response OMIM:616881
Meckel Syndrome, Type 1
Dilated fourth ventricle, Occipital encephalocele, Natal tooth, Ventriculomegaly, Camptodactyly o... OMIM:249000
Sudden Infant Death With Dysgenesis Of The Testes Syndrome
Exaggerated startle response OMIM:608800
Sandhoff Disease, Infantile Form
Exaggerated startle response ORPHA:309155
Branchiooculofacial Syndrome
Agenesis of cerebellar vermis, Facial palsy, Short neck, Postnatal growth retardation, Cryptorchi... OMIM:113620
Solitary Bone Cyst
Abnormal spinal cord morphology, Muscular edema ORPHA:83468
Congenital Disorder Of Glycosylation, Type Ia
Cerebellar atrophy, Dilated fourth ventricle, Pericarditis, Cerebellar vermis hypoplasia, Olivopo... OMIM:212065
Cardiac-Urogenital Syndrome
Prolonged bleeding time, Tachycardia, Cor triatrium sinister, Ventricular septal defect, Dextroca... OMIM:618280
Mosaic Trisomy 20
Ventricular septal defect, Long neck, Abnormal spinal cord morphology, Cryptorchidism, Dysplastic... ORPHA:1724
Revesz Syndrome
Intrauterine growth retardation, Abnormality of chromosome stability OMIM:268130
Neurodevelopmental Disorder With Dysmorphic Facies And Cerebellar Hypoplasia
Dilated fourth ventricle, Cerebellar vermis hypoplasia, Ventricular septal defect, Flexion contra... OMIM:619306
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome Due To A Point Mutation
Exaggerated startle response, Dystonia ORPHA:438216
Limb Body Wall Complex
Encephalocele, Ventricular septal defect, Diastasis recti, Spina bifida, Congenital diaphragmatic... ORPHA:2369
Witteveen-Kolk Syndrome
Branchial fistula, Unilateral cryptorchidism, Short stature, Congenital diaphragmatic hernia, Con... OMIM:613406
Neurodevelopmental Disorder With Or Without Seizures And Gait Abnormalities
Exaggerated startle response OMIM:617864
Crimean-Congo Hemorrhagic Fever
Bundle branch block, Abnormal left ventricular function, Ecchymosis, Internal hemorrhage, Pericar... ORPHA:99827
Intellectual Developmental Disorder With Microcephaly And Pontine And Cerebellar Hypoplasia
Dilated fourth ventricle, Short stature, Hypoplasia of the pons, Postnatal growth retardation, Ce... OMIM:300749
Spinal Arteriovenous Metameric Syndrome
Abnormal spinal cord morphology, Spinal arteriovenous malformation ORPHA:53721
Tay-Sachs Disease
Tremor, Exaggerated startle response, Laryngeal dystonia, Dystonia ORPHA:845
Glycine Encephalopathy With Normal Serum Glycine
Exaggerated startle response OMIM:617301
Nijmegen Breakage Syndrome
Skeletal muscle atrophy, Abnormality of chromosome stability, Short stature, Rhabdomyosarcoma ORPHA:647
Sandhoff Disease
Exaggerated startle response OMIM:268800
Acute Disseminated Encephalomyelitis
Nuchal rigidity, Abnormal spinal cord morphology, Abnormal cerebellum morphology, Myelitis ORPHA:83597
Neurocardiofaciodigital Syndrome
Dilated fourth ventricle, Cerebellar vermis hypoplasia, Short stature, Patent ductus arteriosus, ... OMIM:619869
Developmental And Epileptic Encephalopathy 49
Exaggerated startle response OMIM:617281
Craniofacial Microsomia 1
Occipital encephalocele, Ventricular septal defect, Hypoplasia of facial musculature, Patent duct... OMIM:164210
X-Linked Cerebral Adrenoleukodystrophy
Myelopathy, Abnormal spinal cord morphology, Facial myokymia, Hamstring contractures ORPHA:139396
Plaa-Associated Neurodevelopmental Disorder
Exaggerated startle response, Dystonia ORPHA:521426
Gm1 Gangliosidosis Type 1
Exaggerated startle response, Dystonia ORPHA:79255
Amoebiasis Due To Free-Living Amoebae
Myocardial necrosis, Stiff neck, Abnormal medulla oblongata morphology, Facial palsy, Abnormal ce... ORPHA:68
Posterior Column Ataxia-Retinitis Pigmentosa Syndrome
Abnormal spinal cord morphology, Flexion contracture of finger, Camptodactyly ORPHA:88628
Tetrasomy 9P
Pericarditis, Myositis, Dextrocardia, Short neck, Cryptorchidism, Abnormal spinal cord morphology... ORPHA:3310
Superficial Siderosis
Cerebellar atrophy, Enlarged sylvian cistern, Atrophy of the spinal cord, Abnormal spinal cord mo... ORPHA:247245
Muscular Dystrophy-Dystroglycanopathy (Congenital With Brain And Eye Anomalies), Type A, 4
Exaggerated startle response OMIM:253800
Neurodevelopmental Disorder With Progressive Microcephaly, Spasticity, And Brain Anomalies
Exaggerated startle response OMIM:617527
Orofaciodigital Syndrome Type 14
Dilated fourth ventricle, Ventricular septal defect, Short neck, Bilateral cryptorchidism, Patent... ORPHA:434179
Adrenomyeloneuropathy
Atrophy of the spinal cord, Abnormal spinal cord morphology, Dorsal column degeneration, Leg musc... ORPHA:139399
Arima Syndrome
Dilated fourth ventricle, Agenesis of cerebellar vermis, Cerebellar vermis hypoplasia, Growth del... OMIM:243910
X-Linked Female Restricted Facial Dysmorphism-Short Stature-Choanal Atresia-Intellectual Disability
Dilated fourth ventricle, Ventriculomegaly, Cerebellar vermis hypoplasia, Short stature, Aplasia/... ORPHA:480880
Neurodevelopmental Disorder With Microcephaly, Epilepsy, And Hypomyelination
Exaggerated startle response OMIM:618367
Primary Sjögren Syndrome
Abnormal cerebellum morphology, Abnormal spinal cord morphology, Myositis ORPHA:289390
Pura-Related Severe Neonatal Hypotonia-Seizures-Encephalopathy Syndrome
Exaggerated startle response, Dystonia ORPHA:438213
Neurodevelopmental-Craniofacial Syndrome With Variable Renal And Cardiac Abnormalities
Exaggerated startle response OMIM:619522

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Lats2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Lats2.

No publications found that use IMPC mice or data for Lats2.

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MGI Allele Allele Type Produced
Lats2tm1e(KOMP)Wtsi Targeted, non-conditional allele ES Cells
Lats2tm1a(KOMP)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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