Not currently registered for phenotyping at IMPC

Phenotyping is currently not planned for a knockout strain of this gene.

Gene Summary

Name:
spalt like transcription factor 2
Synonyms:
Msal-2

IMPC Data Collections

  • No Body Weight Data
  • No Embryo Imaging Data
  • No Viability Data

IMPC Phenotype Summary

Significant
Not Significant
Not tested

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Phenotype associated images not available

Human diseases caused by Sall2 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

The table below shows human diseases associated to Sall2 by orthology or direct annotation.

Disease Similarity of
phenotypes
Matching phenotypes Source
Coloboma, Ocular, Autosomal Recessive
OMIM:216820

The table below shows human diseases predicted to be associated to Sall2 by phenotypic similarity.

Disease Similarity of
phenotypes
Matching phenotypes Source
Neural Tube Defects, Folate-Sensitive
Spinal dysraphism OMIM:601634
Granulomas, Congenital Cerebral
Neonatal death OMIM:306300
Genitourinary Tract Anomalies
Neonatal death OMIM:305690
Spina Bifida-Hypospadias Syndrome
Spinal dysraphism, Spina bifida ORPHA:3176
Neural Tube Defects, X-Linked
Spina bifida, Anencephaly OMIM:301410
Anencephaly 1
Anencephaly, Spina bifida OMIM:206500
Myelopathy, Htlv-1-Associated
Myelopathy OMIM:159580
Pyknoachondrogenesis
Stillbirth OMIM:265880
Isolated Anencephaly/Exencephaly
Anencephaly ORPHA:1048
Frontal Encephalocele
Spina bifida, Encephalocele, Hydrocephalus ORPHA:1931
Ophthalmoplegia, External, And Myopia
Spina bifida OMIM:311000
Acalvaria
Holoprosencephaly, Spina bifida, Hydrocephalus ORPHA:945
Dysraphism-Cleft Lip/Palate-Limb Reduction Defects Syndrome
Anencephaly, Spina bifida ORPHA:2476
Neural Tube Defects, Susceptibility To
Spina bifida occulta, Anencephaly, Myelomeningocele, Hydrocephalus OMIM:182940
Craniorachischisis
Myelomeningocele, Cervical spina bifida, Anencephaly, Sirenomelia, Spinal dysraphism ORPHA:63260
Schisis Association
Anencephaly, Spina bifida, Encephalocele ORPHA:63862
Camptodactyly With Muscular Hypoplasia, Skeletal Dysplasia, And Abnormal Palmar Creases
Spina bifida OMIM:211960
Fryns Microphthalmia Syndrome
Neural tube defect OMIM:600776
Nevus Comedonicus Syndrome
Spina bifida occulta, Spina bifida ORPHA:64754
Chiari Malformation Type Ii
Myelomeningocele, Spina bifida, Cervical myelopathy, Hydrocephalus OMIM:207950
Caudal Duplication
Spina bifida, Myelomeningocele ORPHA:1756
Acropectorovertebral Dysplasia
Spina bifida ORPHA:957
Aprosencephaly Syndrome
Aprosencephaly, Anencephaly OMIM:207770
Amish Lethal Microcephaly
Death in infancy, Spina bifida ORPHA:99742
Sirenomelia
Spina bifida, Sirenomelia ORPHA:3169
Isolated Klippel-Feil Syndrome
Spina bifida ORPHA:2345
Hypertelorism-Hypospadias-Polysyndactyly Syndrome
Exencephaly, Encephalocele ORPHA:2211
Blepharocheilodontic Syndrome 1
Neural tube defect OMIM:119580
Anophthalmia Plus Syndrome
Spina bifida ORPHA:1104
Cerebrocostomandibular Syndrome
Myelomeningocele, Hydranencephaly, Spina bifida, Death in infancy, Meningocele ORPHA:1393
Male Pseudohermaphroditism/Mental Retardation Syndrome, Verloes Type
Cervical spina bifida OMIM:600122
Camptodactyly Syndrome, Guadalajara Type 1
Spina bifida ORPHA:1327
Lung Agenesis-Heart Defect-Thumb Anomalies Syndrome
Death in infancy, Spina bifida ORPHA:1120
Czeizel-Losonci Syndrome
Spina bifida occulta, Spina bifida, Myelomeningocele, Hydrocephalus ORPHA:2437
Iniencephaly
Myelomeningocele, Anencephaly, Spinal dysraphism, Spina bifida, Hydrocephalus, Holoprosencephaly,... ORPHA:63259
Waardenburg Syndrome Type 1
Spina bifida, Meningocele ORPHA:894
Fountain Syndrome
Spina bifida occulta, Spina bifida ORPHA:3219
Posterior Meningocele
Occipital meningocele, Lipomyelomeningocele, Neural tube defect, Hydrocephalus, Meningocele ORPHA:268810
Pelvis-Shoulder Dysplasia
Spina bifida, Hydranencephaly, Hydrocephalus ORPHA:2839
Lumbar Syndrome
Spina bifida, Myelomeningocele ORPHA:83628
Pagod Syndrome
Death in infancy, Spina bifida, Meningocele, Encephalocele ORPHA:991
Vacterl With Hydrocephalus
Hydrocephalus, Spina bifida, Aqueductal stenosis, Arrhinencephaly ORPHA:3412
Trisomy 20P
Umbilical hernia, Spina bifida ORPHA:261318
Waardenburg Syndrome, Type 1
Spina bifida, Myelomeningocele OMIM:193500
Trisomy 18
Holoprosencephaly, Spina bifida, Anencephaly ORPHA:3380
Limb Body Wall Complex
Short umbilical cord, Myelomeningocele, Anencephaly, Spina bifida, Hydrocephalus, Spina bifida oc... ORPHA:2369
Mosaic Trisomy 9
Spina bifida ORPHA:99776
Cloacal Exstrophy
Spina bifida, Myelomeningocele ORPHA:93929
Nail-Patella Syndrome
Spina bifida OMIM:161200
Neu-Laxova Syndrome
Spina bifida ORPHA:2671
Fibular Hemimelia
Spina bifida ORPHA:93323
Focal Dermal Hypoplasia
Umbilical hernia, Spina bifida ORPHA:2092
Thrombocytopenia-Absent Radius Syndrome
Death in infancy, Spina bifida OMIM:274000
Basal Cell Nevus Syndrome
Spina bifida, Hydrocephalus OMIM:109400
Neu-Laxova Syndrome 1
Short umbilical cord, Hydranencephaly, Spina bifida, Small placenta, Stillbirth OMIM:256520
Hallermann-Streiff Syndrome
Spina bifida OMIM:234100
Neurofibromatosis, Type I
Spina bifida, Aqueductal stenosis, Hydrocephalus OMIM:162200
Jacobsen Syndrome
Death in infancy, Spina bifida ORPHA:2308
22Q11.2 Deletion Syndrome
Occipital myelomeningocele, Spina bifida, Hydrocephalus, Umbilical hernia, Meningocele, Arrhinenc... ORPHA:567
Intellectual Disability-Cardiac Anomalies-Short Stature-Joint Laxity Syndrome
Spina bifida ORPHA:508498
Campomelic Dysplasia
Spinal dysraphism, Spina bifida, Hydrocephalus OMIM:114290
Aicardi Syndrome
Spina bifida OMIM:304050
Fanconi Anemia
Umbilical hernia, Spina bifida, Hydrocephalus ORPHA:84
Koolen-De Vries Syndrome Due To A Point Mutation
Spina bifida, Hydrocephalus ORPHA:363965
17Q21.31 Microdeletion Syndrome
Spina bifida, Hydrocephalus ORPHA:363958
Neurodevelopmental Disorder With Dysmorphic Facies And Thin Corpus Callosum
Spina bifida OMIM:619480
Vater/Vacterl Association
Occipital encephalocele, Spina bifida, Patent urachus OMIM:192350
Split Cord Malformation
Myelomeningocele, Cervical spina bifida, Lipomyelomeningocele, Hydrocephalus, Meningocele ORPHA:573278
Exstrophy-Epispadias Complex
Spina bifida, Hydrocephalus ORPHA:322
Coloboma, Ocular, Autosomal Recessive
OMIM:216820

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Sall2

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Sall2.

No publications found that use IMPC mice or data for Sall2.

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MGI Allele Allele Type Produced
Sall2tm1(KOMP)Wtsi Reporter-tagged deletion allele (with selection cassette) Targeting vectors, ES Cells
Sall2tm1e(EUCOMM)Hmgu Targeted, non-conditional allele ES Cells
Sall2tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors, ES Cells

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