Sirt6 | sirtuin 6

GeneMGI:1354161Synonyms: 2810449N18Rik

Physiological systems

19 / 24 physiological systems tested

2 Significantly impacted by the knock-out

 Homeostasis/metabolism Hematopoietic system

17 No significant impact

5 Not tested

Data collections

LacZ expression
Histopathology
Images
How IMPC generates data
Viability data
Body weight measurements
Embryo imaging data
Gene metrics:2Significant phenotypes
1Associated diseases
Expression examined in:0Adult tissues
0Embryo tissues

Phenotypes

increased mean corpuscular hemoglobin concentration1 supporting datasetSirt6tm1a(EUCOMM)WtsiheterozygoteEarly adult1.94x10-5 
increased circulating cholesterol level1 supporting datasetSirt6tm1a(EUCOMM)WtsiheterozygoteEarly adult9.4x10-7 
* Does not have a P-value assigned because it was manually marked as significant.
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* This parameter was manually assessed for significance.
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lacZ Expression

Associated images

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Histopathology

IMPC related publications

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Sirt6tm1(KOMP)VlcgReporter-tagged deletion allele (with selection cassette)ES Cell
Sirt6tm1a(EUCOMM)WtsiKO first allele (reporter-tagged insertion with conditional potential)targeting vector
ES Cell
mouse
Sirt6tm1c(EUCOMM)WtsiWild type floxed exon (post-Flp)mouse
Sirt6tm1e(EUCOMM)WtsiTargeted, non-conditional alleleES Cell

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