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Gene: Siva1 MGI:1353606

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Gene Summary

Name:
SIVA1, apoptosis-inducing factor
Synonyms:
CD27bp

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
abnormal lens morphology Siva1tm1b(EUCOMM)Hmgu HOM   Early adult 1.66×10-06
increased fasting circulating glucose level Siva1tm1b(EUCOMM)Hmgu HOM Early adult 2.04×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

An assay measuring the expression of lacZ shows the tissue where the gene is expressed.

Anatomy Images Zygosity Mutant Expr
Brain  Wholemount images homozygote 100% (2 of 2)
Heart  Wholemount images homozygote 100% (2 of 2)
Kidney  Wholemount images homozygote 100% (2 of 2)
Ovary  Wholemount images homozygote Not available
Pituitary gland  Wholemount images homozygote 100% (2 of 2)
Spinal cord  Wholemount images homozygote 100% (2 of 2)
Stomach  Wholemount images homozygote 100% (2 of 2)
Submandibular gland  Wholemount images homozygote 50% (1 of 2)
Testis  Wholemount images homozygote 50% (1 of 2)
Thyroid gland  Wholemount images homozygote 100% (2 of 2)
Urinary bladder  Wholemount images homozygote 0.0% (0 of 2)
Uterus  Wholemount images homozygote Not available
Vas deferens  Wholemount images homozygote 0.0% (0 of 2)
Vesicular gland  Wholemount images homozygote Not available
White adipose tissue  Wholemount images homozygote 50% (1 of 2)
Adrenal gland N/A homozygote 0.0% (0 of 2)
Aorta N/A homozygote 0.0% (0 of 2)
Blood N/A homozygote 0.0% (0 of 2)
Bone marrow N/A homozygote 0.0% (0 of 2)
Bone N/A homozygote 0.0% (0 of 2)
Brainstem N/A homozygote 0.0% (0 of 2)
Brown adipose tissue N/A homozygote 0.0% (0 of 2)
Cartilage tissue N/A homozygote 0.0% (0 of 2)
Cecum N/A homozygote 0.0% (0 of 2)
Cerebellum N/A homozygote 0.0% (0 of 2)
Cerebral cortex N/A homozygote 0.0% (0 of 2)
Chest bone N/A homozygote 0.0% (0 of 2)
Colon N/A homozygote 0.0% (0 of 2)
Cranium N/A homozygote 0.0% (0 of 2)
Diaphragm N/A homozygote 0.0% (0 of 2)
Epididymis N/A homozygote Not available
Esophagus N/A homozygote 0.0% (0 of 2)
Eye N/A homozygote 0.0% (0 of 2)
Gall bladder N/A homozygote 0.0% (0 of 2)
Harderian gland N/A homozygote 0.0% (0 of 2)
Hindlimb N/A homozygote 0.0% (0 of 2)
Hippocampus N/A homozygote 0.0% (0 of 2)
Hypothalamus N/A homozygote 0.0% (0 of 2)
Large intestine N/A homozygote 0.0% (0 of 2)
Liver N/A homozygote 0.0% (0 of 2)
Lower urinary tract N/A homozygote 0.0% (0 of 2)
Lung N/A homozygote 0.0% (0 of 2)
Lymph node N/A homozygote 0.0% (0 of 2)
Main olfactory bulb N/A homozygote 0.0% (0 of 2)
Mammary gland N/A homozygote Not available
Mesenteric lymph node N/A homozygote 0.0% (0 of 2)
Olfactory lobe N/A homozygote 0.0% (0 of 2)
Oral epithelium N/A homozygote 0.0% (0 of 2)
Oviduct N/A homozygote Not available
Pancreas N/A homozygote 0.0% (0 of 2)
Parathyroid gland N/A homozygote 0.0% (0 of 2)
Parotid gland N/A homozygote 0.0% (0 of 2)
Penis N/A homozygote Not available
Peripheral nervous system N/A homozygote 0.0% (0 of 2)
Peyer's patch N/A homozygote 0.0% (0 of 2)
Prostate gland N/A homozygote Not available
Sciatic nerve N/A homozygote 0.0% (0 of 2)
Skeletal muscle N/A homozygote 0.0% (0 of 2)
Skin N/A homozygote 0.0% (0 of 2)
Small intestine N/A homozygote 0.0% (0 of 2)
Spleen N/A homozygote 0.0% (0 of 2)
Stomach pyloric region N/A homozygote 0.0% (0 of 2)
Striatum N/A homozygote 0.0% (0 of 2)
Sublingual gland N/A homozygote 0.0% (0 of 2)
Thymus N/A homozygote 0.0% (0 of 2)
Tongue N/A homozygote 0.0% (0 of 2)
Trachea N/A homozygote 0.0% (0 of 2)
Trigeminal V nerve N/A homozygote 0.0% (0 of 2)
Vagina N/A homozygote Not available
Vascular system N/A homozygote 0.0% (0 of 2)
No Embryo expression data was found for this gene.

Background staining occurs in wild type mice and embryos at an incidental rate.

Anatomy Background staining in controls (WT)
adrenal gland 0.0%
aorta 0.0%
blood
bone 0.0%
bone marrow
brain 0.0%
brainstem 0.0%
brown adipose tissue 0.0%
cartilage tissue 0.0%
cecum 0.0%
cerebellum 0.0%
cerebral cortex 0.0%
chest bone
colon
cranium
diaphragm 0.0%
epididymis Unavailable
esophagus 0.0%
eye 0.0%
gall bladder 0.0%
harderian gland
heart 0.0%
hindlimb 0.0%
hippocampus 0.0%
hypothalamus 0.0%
kidney 0.0%
large intestine 0.0%
liver 0.0%
lower urinary tract 0.0%
lung 0.0%
lymph node 0.0%
main olfactory bulb 0.0%
mammary gland 0.0%
mesenteric lymph node
olfactory lobe 0.0%
oral epithelium 0.0%
ovary 0.0%
oviduct 0.0%
pancreas 0.0%
parathyroid gland 0.0%
parotid gland 0.0%
penis 0.0%
peripheral nervous system 0.0%
peyers patch 0.0%
pituitary gland 0.0%
prostate gland 0.0%
sciatic nerve 0.0%
skeletal muscle 0.0%
skin 0.0%
small intestine 0.0%
spinal cord 0.0%
spleen 0.0%
stomach 0.0%
stomach pyloric region 0.0%
striatum 0.0%
sublingual gland 0.0%
submandibular gland 0.0%
testis 0.0%
thymus 0.0%
thyroid gland 0.0%
tongue 0.0%
trachea 0.0%
trigeminal v nerve 0.0%
urinary bladder
uterus 0.0%
vagina 0.0%
vas deferens Unavailable
vascular system 0.0%
vesicular gland Unavailable
white adipose tissue 0.0%
No Embryo expression data was found for this gene.

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Adult LacZ

LacZ Images Wholemount

19 Images

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X-ray

XRay Images Whole Body Lateral Orientation

4 Images

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Electrocardiogram (ECG)

Waveform Image

14 Images

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X-ray

XRay Images Whole Body Dorso Ventral

4 Images

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Human diseases caused by Siva1 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Siva1 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Ectopia Lentis 2, Isolated, Autosomal Recessive
Ectopia lentis OMIM:225100
Ectopia Lentis 1, Isolated, Autosomal Dominant
Ectopia lentis OMIM:129600
Cataract 29
Cataract OMIM:115800
Hereditary Hyperferritinemia-Cataract Syndrome
Cataract ORPHA:163
Cataract 36
Cataract OMIM:613887
Cataract 35
Cataract OMIM:609376
Cataract 45
Developmental cataract OMIM:616851
Cataract 4, Multiple Types
Developmental cataract OMIM:115700
Cataract 38
Developmental cataract OMIM:614691
Cataract 13 With Adult I Phenotype
Developmental cataract OMIM:116700
Cataract 37
Developmental cataract OMIM:614422
Cataract And Congenital Ichthyosis
Cataract OMIM:212400
Maturity-Onset Diabetes Of The Young, Type 3
Hyperglycemia, Type II diabetes mellitus, Maturity-onset diabetes of the young OMIM:600496
Corneal Dystrophy, Groenouw Type I
Punctate corneal dystrophy, Cataract, Nodular corneal dystrophy, Granular corneal dystrophy OMIM:121900
Cataract 47
Microcornea, Cataract, Glycosuria OMIM:612018
Maturity-Onset Diabetes Of The Young, Type 10
Diabetic ketoacidosis, Hyperglycemia, Diabetes mellitus, Maturity-onset diabetes of the young OMIM:613370
Cataract 12, Multiple Types
Progressive cataract, Developmental cataract OMIM:611597
Hyperproinsulinemia
Hyperglycemia, Hyperinsulinemia OMIM:616214
Cataract 42
Cataract, Developmental cataract OMIM:115900
Pupillary Membrane, Persistence Of
Developmental cataract, Megalocornea, Persistent pupillary membrane OMIM:178900
Trichomegaly
Cataract OMIM:190330
Glycogen Storage Disease 0, Liver
Postprandial hyperglycemia, Neonatal hypoglycemia, Fasting hypoglycemia OMIM:240600
Glaucoma 3, Primary Congenital, D
Corneal opacity, Primary congenital glaucoma, Ectopia lentis OMIM:613086
Cataract-Microcornea Syndrome
Cataract, Corneal opacity, Corneal dystrophy, Microcornea, Iris coloboma ORPHA:1377
Aniridia, Microcornea, And Spontaneously Reabsorbed Cataract
Microcornea, Cataract, Aniridia OMIM:106230
Microphthalmia, Isolated, With Coloboma 3
Cataract, Iris coloboma OMIM:610092
Exfoliation Syndrome
Cataract, Abnormal lens morphology, Anisocoria, Pseudoexfoliation, Pigment deposition in the trab... OMIM:177650
Cataract 10, Multiple Types
Nuclear cataract, Zonular cataract, Posterior Y-sutural cataract, Developmental cataract OMIM:600881
Anterior Segment Dysgenesis 8
Iridodonesis, Cataract, Ectopia lentis, Uveal ectropion, Hypoplasia of the iris, Iris transillumi... OMIM:617319
Megalocornea
Iridodonesis, Cataract, Mosaic corneal dystrophy, Deep anterior chamber, Iris transillumination d... OMIM:309300
Cataract 14, Multiple Types
Zonular cataract OMIM:601885
Diabetes Mellitus, Transient Neonatal, 1
Transient neonatal diabetes mellitus, Hyperglycemia OMIM:601410
Cataract 1, Multiple Types
Microcornea, Posterior subcapsular cataract, Nuclear cataract, Pulverulent cataract OMIM:116200
Hypogonadism, Male, With Mental Retardation And Skeletal Anomalies
Glucose intolerance, Hyperglycemia OMIM:307500
Cataract 3, Multiple Types
Nuclear pulverulent cataract, Sutural cataract, Cerulean cataract, Developmental cataract OMIM:601547
Aniridia-Intellectual Disability Syndrome
Aniridia, Cataract, Ectopia lentis ORPHA:1068
Aniridia 2
Aniridia, Iris coloboma, Cataract, Lens subluxation OMIM:617141
Proximal Myotonic Myopathy
Cataract ORPHA:606
Cataract 5, Multiple Types
Pulverulent cataract, Nuclear cataract, Lamellar cataract, Anterior polar cataract, Zonular cataract OMIM:116800
Cataract 20, Multiple Types
Lamellar cataract, Membranous cataract, Sutural cataract, Cortical cataract OMIM:116100
Ectopia Lentis Et Pupillae
Cataract, Ectopia lentis, Iris transillumination defect, Ectopia pupillae, Persistent pupillary m... OMIM:225200
Anterior Segment Dysgenesis 7
Cataract, Corneal opacity, Sclerocornea, Microcornea, Buphthalmos, Anterior synechiae of the ante... OMIM:269400
Diabetes Mellitus, Permanent Neonatal, 4
Type I diabetes mellitus, Diabetic ketoacidosis, Hyperglycemia OMIM:618858
Peters Anomaly
Central opacification of the cornea, Developmental glaucoma, Anterior synechiae of the anterior c... ORPHA:708
Essential Fructosuria
Hyperglycemia ORPHA:2056
Maturity-Onset Diabetes Of The Young, Type 13
Hyperglycemia, Diabetes mellitus, Maturity-onset diabetes of the young, Maternal diabetes OMIM:616329
Cataract 39, Multiple Types
Lamellar cataract, Anterior polar cataract, Developmental cataract OMIM:615188
Diabetes Mellitus, Transient Neonatal, 3
Transient neonatal diabetes mellitus, Hyperglycemia, Maternal diabetes OMIM:610582
Anterior Segment Dysgenesis 1
Microcornea, Opacification of the corneal stroma, Peters anomaly, Posterior polar cataract, Ocula... OMIM:107250
Cataract 30, Multiple Types
Posterior polar cataract, Diffuse nuclear cataract, Pulverulent cataract OMIM:116300
Diabetes Mellitus, Permanent Neonatal, 1
Type I diabetes mellitus, Hyperglycemia, Diabetes mellitus OMIM:606176
Cataract 41
Nuclear cataract OMIM:116400
Cataract 18
Nuclear cataract OMIM:610019
Cataract, Age-Related Nuclear
Nuclear cataract OMIM:601371
Anterior Segment Dysgenesis 2
Cataract, Corneal opacity, Sclerocornea, Microcornea, Posterior synechiae of the anterior chamber... OMIM:610256
Amoebic Keratitis
Iris atrophy, Cataract, Abnormal corneal epithelium morphology, Abnormal anterior chamber morphol... ORPHA:67043
Cataract 31, Multiple Types
Posterior subcapsular cataract, Anterior subcapsular cataract, Nuclear cataract OMIM:605387
Pineal Hyperplasia, Insulin-Resistant Diabetes Mellitus, And Somatic Abnormalities
Hypoglycemia, Insulin-resistant diabetes mellitus, Hyperinsulinemia, Diabetic ketoacidosis, Fasti... OMIM:262190
Maturity-Onset Diabetes Of The Young, Type 8, With Exocrine Dysfunction
Hyperglycemia, Maturity-onset diabetes of the young OMIM:609812
Kyrle Disease
Posterior subcapsular cataract OMIM:149500
Cataract 43
Posterior subcapsular cataract OMIM:616279
Cataract 33, Multiple Types
Lamellar cataract, Nuclear cataract, Cortical cataract OMIM:611391
Cataract 15, Multiple Types
Lamellar cataract, Nuclear cataract, Cortical cataract OMIM:615274
Type 1 Diabetes Mellitus
Hyperglycemia, Diabetes mellitus OMIM:222100
Diabetes Mellitus, Permanent Neonatal, 3
Type I diabetes mellitus, Hyperglycemia, Glycosuria OMIM:618857
Cataract 32, Multiple Types
Anterior polar cataract OMIM:115650
Mody
Transient neonatal diabetes mellitus, Insulin-resistant diabetes mellitus, Diabetic ketoacidosis,... ORPHA:552
Familial Renal Glucosuria
Hyperglycemia, Insulin resistance, Abnormal oral glucose tolerance, Glycosuria ORPHA:69076
Cataract 23, Multiple Types
Lamellar cataract OMIM:610425

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

There is no histopathology data for Siva1

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Siva1.

No publications found that use IMPC mice or data for Siva1.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Siva1tm1b(EUCOMM)Hmgu Reporter-tagged deletion allele (with selection cassette) Mice
Siva1tm1a(EUCOMM)Hmgu KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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