Gene: Arhgef1

Name
Rho guanine nucleotide exchange factor (GEF) 1
MGI ID
MGI:1353510
Synonyms
Lsc Lbcl2
View
N/A
Other links
Expression & images (0) Disease models (0) Order (1)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
decreased CD8-positive, alpha-beta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased monocyte cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased Ly6C-positive NK T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased immature NK cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased memory-marker gamma-delta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased Ly6C low monocyte number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased effector memory CD8-positive, alpha-beta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased mature NK cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased dendritic cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased gamma-delta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased memory-marker CD4-positive NK T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased Ly6C-positive immature NK cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased CD4-positive, alpha beta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased plasmacytoid dendritic cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
decreased marginal zone B cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
preweaning lethality, incomplete penetrance Arhgef1tm1a(EUCOMM)Wtsi HOM n/a 0.00
increased KLRG1-positive NK cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00
increased effector memory CD4-positive, alpha-beta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM postnatal 0.00

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 Expression

Expression data not available

 Associated Images

Mesenteric Lymph Node Immunophenotyping: Images associated with FACS analysis
36 Images
Spleen Immunophenotyping: Images associated with FACS analysis
64 Images
Anti-nuclear antibody assay
10 Images
DSS Histology
8 Images

 Disease Models

No associations by disease annotation and gene orthology found.
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 Order Mouse and ES Cells

MGI Allele Allele Type Availability
Arhgef1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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