Gene: Arhgef1

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Name
Rho guanine nucleotide exchange factor (GEF) 1
MGI ID
MGI:1353510
Synonyms
Lsc Lbcl2
Viability
Embryo viewer
N/A
Other links
Expression & images (0) Disease models (0) Order (1)
Significant
Not Significant
Not tested
Phenotype System Allele Zyg Sex Life Stage P Value
increased gamma-delta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
increased CD4-positive, alpha beta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
decreased dendritic cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
decreased memory-marker CD4-positive NK T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
increased effector memory CD8-positive, alpha-beta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
decreased immature NK cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
increased Ly6C low monocyte number Arhgef1tm1a(EUCOMM)Wtsi HOM Early adult 0.00
decreased Ly6C-positive immature NK cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
decreased memory-marker gamma-delta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
increased mature NK cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
decreased CD8-positive, alpha-beta T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
increased hematocrit Arhgef1tm1a(EUCOMM)Wtsi HOM Early adult 1.68×10-07
increased monocyte cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
increased KLRG1-positive NK cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
increased hemoglobin content Arhgef1tm1a(EUCOMM)Wtsi HOM Early adult 2.54×10-06
increased CD8-positive, alpha-beta memory T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Early adult 0.00
increased plasmacytoid dendritic cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
increased CD4-positive, alpha-beta memory T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM Early adult 0.00
increased Ly6C-positive NK T cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
preweaning lethality, incomplete penetrance Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
increased erythrocyte cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 6.24×10-06
decreased marginal zone B cell number Arhgef1tm1a(EUCOMM)Wtsi HOM   Early adult 0.00
increased circulating alkaline phosphatase level Arhgef1tm1a(EUCOMM)Wtsi HOM Early adult 1.09×10-08

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 Expression

Expression data not available

 Associated Images

Eye Morphology: Images Slit Lamp
3 Images
Eye Morphology: Images Ophthalmoscopy
1 Images
Legacy Phenotype Associated Images

 Disease Models

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MGI Allele Allele Type Produced
Arhgef1tm1a(EUCOMM)Wtsi KO first allele (reporter-tagged insertion with conditional potential) Mice, Targeting vectors, ES Cells

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