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Gene: Hdgfl3 MGI:1352760

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Gene Summary

Name:
HDGF like 3
Synonyms:
Hdgfrp3,  HRP-3,  2700022B06Rik

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IMPC Data Collections

IMPC Phenotype Summary

Significant
Not Significant
Not tested

View all our phenotype data below

Phenotypes

The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.

Phenotype System Allele Zyg Sex Life Stage P Value
decreased lean body mass Hdgfl3em1(IMPC)Tcp HOM   Early adult 4.19×10-05
abnormal eye morphology Hdgfl3em1(IMPC)Tcp HOM Early adult 0.00
increased total body fat amount Hdgfl3em1(IMPC)Tcp HOM   Early adult 1.80×10-05
decreased bone mineral content Hdgfl3em1(IMPC)Tcp HOM Late adult 6.75×10-06
decreased lean body mass Hdgfl3em1(IMPC)Tcp HOM Late adult 1.01×10-05
enlarged urinary bladder Hdgfl3em1(IMPC)Tcp HOM Late adult 0.00
increased exploration in new environment Hdgfl3em1(IMPC)Tcp HOM Late adult 7.64×10-09
increased exploration in new environment Hdgfl3em1(IMPC)Tcp HOM Middle aged adult 9.32×10-05
decreased grip strength Hdgfl3em1(IMPC)Tcp HOM Middle aged adult 2.49×10-05
hyperactivity Hdgfl3em1(IMPC)Tcp HOM   Early adult 1.77×10-07
decreased grip strength Hdgfl3em1(IMPC)Tcp HOM Late adult 1.46×10-07
abnormal skin morphology Hdgfl3em1(IMPC)Tcp HOM Early adult 0.00
decreased body length Hdgfl3em1(IMPC)Tcp HOM Late adult 4.44×10-05
decreased grip strength Hdgfl3em1(IMPC)Tcp HOM   Early adult 3.81×10-05

Download data as:  TSV  XLS

Select physiological systems to view:
Viewing: all phenotypes
Select physiological systems to view:
Viewing: all phenotypes

lacZ Expression

Expression data not available

Associated Images

Images submitted by IMPC centres for a selection of procedures. Each set of images is available to view in our image comparator.

Gross Pathology and Tissue Collection

Images

8 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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Gross Pathology and Tissue Collection

Images

8 Images

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Eye Morphology

Images Ophthalmoscopy

132 Images

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Eye Morphology

Images Slit Lamp

81 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Eye Morphology

Images Ophthalmoscopy

59 Images

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X-ray

XRay Images Skull Lateral Orientation

10 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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Histopathology

Images

17 Images

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X-ray

XRay Images Skull Dorso Ventral Orientation

10 Images

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X-ray

XRay Images Whole Body Lateral Orientation

10 Images

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Histopathology

Images

2 Images

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X-ray

XRay Images Whole Body Dorso Ventral

10 Images

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Electrocardiogram (ECG)

Waveform Image

1 Images

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Human diseases caused by Hdgfl3 mutations

The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.

Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.

No human diseases associated to this gene by orthology or annotation.

The table below shows human diseases predicted to be associated to Hdgfl3 by phenotypic similarity.

Disease Similarity of
phenotypes		 Matching phenotypes Source
Attention Deficit-Hyperactivity Disorder
Hyperactivity, Attention deficit hyperactivity disorder OMIM:143465
Ank3-Related Intellectual Disability-Sleep Disturbance Syndrome
Hyperactivity, Bruxism, Aggressive behavior, Large for gestational age ORPHA:356996
Schizophrenia 15
Hyperactivity OMIM:613950
22q13 deletion syndrome (Phelan-Mcdermid syndrome)
Hyperactivity DECIPHER:20
Intellectual Developmental Disorder, Autosomal Recessive 37
Hyperactivity, Bruxism, Aggressive behavior OMIM:615493
Potocki-Lupski syndrome (17p11.2 duplication syndrome)
Hyperactivity DECIPHER:19
Smith-Magenis syndrome
Hyperactivity, Abnormal repetitive mannerisms, Self-mutilation DECIPHER:8
Intellectual Developmental Disorder, X-Linked 109
Hyperactivity, Impulsivity, Aggressive behavior, Stereotypical body rocking, Agitation, Compulsiv... OMIM:309548
Fraxe Intellectual Disability
Hyperactivity, Impulsivity, Aggressive behavior, Stereotypical body rocking, Agitation, Compulsiv... ORPHA:100973
Intellectual Developmental Disorder With Epilepsy, Behavioral Abnormalities, And Coarse Facies
Self-injurious behavior, Hyperactivity, Aggressive behavior OMIM:619031
Intellectual Developmental Disorder, X-Linked, Syndromic, Houge Type
Hyperactivity, Impulsivity, Attention deficit hyperactivity disorder OMIM:301008
Intellectual Developmental Disorder, Autosomal Dominant 67
Motor tics, Hyperactivity, Compulsive behaviors, Attention deficit hyperactivity disorder OMIM:619927
8p23.1 deletion syndrome
Hyperactivity, Congenital diaphragmatic hernia DECIPHER:39
Intellectual Developmental Disorder, X-Linked, Syndromic, Pilorge Type
Hyperactivity, Inflexible adherence to routines OMIM:301076
Intellectual Developmental Disorder, Autosomal Recessive 75, With Neuropsychiatric Features And Variant Lissencephaly
Nail-biting, Hyperactivity, Aggressive behavior, Self-biting, Self-injurious behavior, Inappropri... OMIM:619827
Developmental Delay, Language Impairment, And Ocular Abnormalities
Hyperactivity, Inguinal hernia, Impulsivity, Aggressive behavior, Frequent temper tantrums, Atten... OMIM:620141
Intellectual Developmental Disorder, X-Linked 77
Hyperactivity OMIM:300454
Histidinemia
Hyperactivity ORPHA:2157

Histopathology

Summary table of phenotypes displayed during the Histopathology procedure which are considered significant. Full histopathology data table, including submitted images, can be accessed by clicking any row in this table.

Phenotype Allele Zygosity Sex Life Stage
Eye - MPATH pathological process term atrophy Hdgfl3em1(IMPC)Tcp HOM Late adult
Eye - MPATH pathological entity term epithelial hyperplasia Hdgfl3em1(IMPC)Tcp HOM Late adult
Eye - MPATH pathological process term developmental dysplasia Hdgfl3em1(IMPC)Tcp HOM Late adult

IMPC related publications

The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Hdgfl3.

No publications found that use IMPC mice or data for Hdgfl3.

Order Mouse and ES Cells

All available products are supplied via our member's centres or partnerships. When ordering a product from the IMPC you will be redirected to one of their websites or prompted to start an email.

MGI Allele Allele Type Produced
Hdgfl3em1(IMPC)Tcp Exon Deletion Mice, Tissue
Hdgfl3tm114221(L1L2_Bact_P) KO first allele (reporter-tagged insertion with conditional potential) Targeting vectors

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