Gene: Fscn1 MGI:1352745
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The IMPC applies a panel of phenotyping screens to characterise single-gene knockout mice by comparison to wild types. Click on the different tabs to visualise significant phenotypes identified by the IMPC, as well as all data that was measured.
Phenotype | System | Allele | Zyg | Sex | Life Stage | P Value |
---|---|---|---|---|---|---|
abnormal behavior | Fscn1tm1.1(KOMP)Vlcg | HET | Early adult | 2.37×10-06 | ||
decreased thigmotaxis | Fscn1tm1.1(KOMP)Vlcg | HET | Early adult | 2.37×10-06 | ||
hyperactivity | Fscn1tm1.1(KOMP)Vlcg | HET | Early adult | 5.49×10-11 | ||
preweaning lethality, incomplete penetrance | Fscn1tm1.1(KOMP)Vlcg | HOM | Early adult | 0.00 |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Adrenal gland | Section images | heterozygote | 100% (3 of 3) |
Brain | Section images | heterozygote | 100% (3 of 3) |
Brown adipose tissue | Section images | heterozygote | 100% (1 of 1) |
Cerebellum | Section images | heterozygote | 33.33% (1 of 3) |
Colon | Section images | heterozygote | 100% (1 of 1) |
Diaphragm | Section images | heterozygote | 100% (1 of 1) |
Epididymis | Section images | heterozygote | 100% (1 of 1) |
Esophagus | Section images | heterozygote | 33.33% (1 of 3) |
Eye | Section images | heterozygote | 100% (3 of 3) |
Gonadal fat pad | Section images | heterozygote | 100% (1 of 1) |
Heart | Section images | heterozygote | 66.67% (2 of 3) |
Ileum | Section images | heterozygote | 100% (1 of 1) |
Kidney | Section images | heterozygote | 100% (3 of 3) |
Liver | Section images | heterozygote | 100% (3 of 3) |
Lung | Section images | heterozygote | 33.33% (1 of 3) |
Mesenteric adipose tissue | Section images | heterozygote | 100% (1 of 1) |
Midbrain | Section images | heterozygote | 100% (1 of 1) |
Olfactory lobe | Section images | heterozygote | 66.67% (2 of 3) |
Pancreas | Section images | heterozygote | 100% (3 of 3) |
Penis | Section images | heterozygote | 100% (1 of 1) |
Peyer's patch | Section images | heterozygote | 66.67% (2 of 3) |
Prostate gland | Section images | heterozygote | 66.67% (2 of 3) |
Quadriceps | Section images | heterozygote | 100% (1 of 1) |
Sciatic nerve | Section images | heterozygote | 100% (1 of 1) |
Skin | Section images | heterozygote | 33.33% (1 of 3) |
Spinal cord | Section images | heterozygote | 100% (3 of 3) |
Spleen | Section images | heterozygote | 100% (3 of 3) |
Testis | Section images | heterozygote | 33.33% (1 of 3) |
Thymus | Section images | heterozygote | 66.67% (2 of 3) |
Tongue | Section images | heterozygote | 100% (1 of 1) |
Trigeminal V nerve | Section images | heterozygote | 100% (1 of 1) |
White adipose tissue | Section images | heterozygote | 66.67% (2 of 3) |
Aorta | N/A | heterozygote | 0.0% (0 of 3) |
Blood | N/A | heterozygote | Not available |
Bone marrow | N/A | heterozygote | 0.0% (0 of 1) |
Bone | N/A | heterozygote | 100% (2 of 2) |
Brainstem | N/A | heterozygote | 0.0% (0 of 3) |
Cartilage tissue | N/A | heterozygote | 0.0% (0 of 3) |
Cecum | N/A | heterozygote | 66.67% (2 of 3) |
Cerebral cortex | N/A | heterozygote | 66.67% (2 of 3) |
Chest bone | N/A | heterozygote | Not available |
Duodenum | N/A | heterozygote | 0.0% (0 of 1) |
Gall bladder | N/A | heterozygote | Not available |
Harderian gland | N/A | heterozygote | 0.0% (0 of 1) |
Hindlimb | N/A | heterozygote | Not available |
Hippocampus | N/A | heterozygote | 0.0% (0 of 3) |
Hypothalamus | N/A | heterozygote | 0.0% (0 of 3) |
Jejunum | N/A | heterozygote | 0.0% (0 of 1) |
Large intestine | N/A | heterozygote | 33.33% (1 of 3) |
Lower urinary tract | N/A | heterozygote | 0.0% (0 of 3) |
Lymph node | N/A | heterozygote | 0.0% (0 of 3) |
Mammary gland | N/A | heterozygote | 0.0% (0 of 3) |
Mesenteric lymph node | N/A | heterozygote | 0.0% (0 of 1) |
Ovary | N/A | heterozygote | 0.0% (0 of 3) |
Oviduct | N/A | heterozygote | 0.0% (0 of 3) |
Parathyroid gland | N/A | heterozygote | 0.0% (0 of 1) |
Parotid gland | N/A | heterozygote | 0.0% (0 of 1) |
Peripheral nervous system | N/A | heterozygote | 66.67% (2 of 3) |
Pituitary gland | N/A | heterozygote | 0.0% (0 of 3) |
Skeletal muscle | N/A | heterozygote | 66.67% (2 of 3) |
Small intestine | N/A | heterozygote | 33.33% (1 of 3) |
Stomach pyloric region | N/A | heterozygote | Not available |
Stomach | N/A | heterozygote | 0.0% (0 of 3) |
Striatum | N/A | heterozygote | 0.0% (0 of 3) |
Sublingual gland | N/A | heterozygote | 0.0% (0 of 1) |
Submandibular gland | N/A | heterozygote | 0.0% (0 of 1) |
Thyroid gland | N/A | heterozygote | 66.67% (2 of 3) |
Trachea | N/A | heterozygote | 0.0% (0 of 3) |
Urinary bladder | N/A | heterozygote | 0.0% (0 of 1) |
Uterus | N/A | heterozygote | 0.0% (0 of 3) |
Vagina | N/A | heterozygote | Not available |
Vas deferens | N/A | heterozygote | 0.0% (0 of 1) |
Vascular system | N/A | heterozygote | 0.0% (0 of 3) |
Vesicular gland | N/A | heterozygote | 0.0% (0 of 1) |
An assay measuring the expression of lacZ shows the tissue where the gene is expressed.
Anatomy | Images | Zygosity | Mutant Expr |
---|---|---|---|
Axial skeleton | N/A | heterozygote | 100% (2 of 2) |
N/A | Ambiguous | ||
Brain | N/A | heterozygote | 40% (2 of 5) |
Brain | N/A | homozygote | Ambiguous |
Central nervous system ganglion | N/A | heterozygote | 100% (2 of 2) |
N/A | Ambiguous | ||
Ear | N/A | heterozygote | 40% (2 of 5) |
Ear | N/A | homozygote | Ambiguous |
Embryo | N/A | heterozygote | 40% (2 of 5) |
Embryo | N/A | homozygote | Ambiguous |
Eye | N/A | heterozygote | 40% (2 of 5) |
Eye | N/A | homozygote | Ambiguous |
Footplate | N/A | heterozygote | 40% (2 of 5) |
Footplate | N/A | homozygote | Ambiguous |
Forebrain | N/A | heterozygote | 40% (2 of 5) |
Forebrain | N/A | homozygote | Ambiguous |
Forelimb | N/A | heterozygote | 40% (2 of 5) |
Forelimb | N/A | homozygote | Ambiguous |
Gut | N/A | heterozygote | 100% (2 of 2) |
N/A | Ambiguous | ||
Handplate | N/A | heterozygote | 40% (2 of 5) |
Handplate | N/A | homozygote | Ambiguous |
Head | N/A | heterozygote | 40% (2 of 5) |
Head | N/A | homozygote | Ambiguous |
Heart | N/A | heterozygote | 40% (2 of 5) |
Heart | N/A | homozygote | Ambiguous |
Hindbrain | N/A | heterozygote | 40% (2 of 5) |
Hindbrain | N/A | homozygote | Ambiguous |
Hindlimb | N/A | heterozygote | 40% (2 of 5) |
Hindlimb | N/A | homozygote | Ambiguous |
Liver | N/A | heterozygote | 40% (2 of 5) |
Liver | N/A | homozygote | Ambiguous |
Lung | N/A | heterozygote | 40% (2 of 5) |
Lung | N/A | homozygote | Ambiguous |
Mandibular process | N/A | heterozygote | 40% (2 of 5) |
Mandibular process | N/A | homozygote | Ambiguous |
Maxillary process | N/A | heterozygote | 40% (2 of 5) |
Maxillary process | N/A | homozygote | Ambiguous |
Midbrain | N/A | heterozygote | 40% (2 of 5) |
Midbrain | N/A | homozygote | Ambiguous |
Nose | N/A | heterozygote | 100% (2 of 2) |
N/A | Ambiguous | ||
Oral cavity | N/A | heterozygote | 40% (2 of 5) |
Oral cavity | N/A | homozygote | Ambiguous |
Chorioallantoic placenta | N/A | heterozygote | 100% (5 of 5) |
Chorioallantoic placenta | N/A | homozygote | 100% (3 of 3) |
Skeleton | N/A | heterozygote | 100% (2 of 2) |
N/A | Ambiguous | ||
Skin | N/A | heterozygote | 40% (2 of 5) |
Skin | N/A | homozygote | Ambiguous |
Spinal cord | N/A | heterozygote | 100% (2 of 2) |
N/A | Ambiguous | ||
Tail somite | N/A | heterozygote | 40% (2 of 5) |
Tail somite | N/A | homozygote | Ambiguous |
Tail | N/A | heterozygote | 40% (2 of 5) |
Tail | N/A | homozygote | Ambiguous |
Trachea | N/A | heterozygote | 100% (2 of 2) |
N/A | Ambiguous | ||
Urinary system | N/A | heterozygote | 100% (2 of 2) |
N/A | Ambiguous |
Background staining occurs in wild type mice and embryos at an incidental rate.
Anatomy | Background staining in controls (WT) |
---|---|
adrenal gland | 0.67% (4 of 598) |
aorta | 0.17% (1 of 598) |
blood | 0.0% |
bone | 0.0% |
bone marrow | 0.0% |
brain | 0.84% (5 of 598) |
brainstem | 0.33% (2 of 598) |
brown adipose tissue | 0.0% |
cartilage tissue | 0.17% (1 of 598) |
cecum | 5.73% (22 of 384) |
cerebellum | 0.5% (3 of 598) |
cerebral cortex | 0.33% (2 of 598) |
chest bone | Unavailable |
colon | 15.71% (22 of 140) |
diaphragm | 0.0% |
duodenum | 3.57% (5 of 140) |
epididymis | 14.29% (21 of 147) |
esophagus | 1.66% (7 of 422) |
eye | 0.0% |
gall bladder | 0.0% |
gonadal fat pad | 0.0% |
harderian gland | 0.71% (1 of 140) |
heart | 0.33% (2 of 598) |
hindlimb | 0.0% |
hippocampus | 0.5% (3 of 598) |
hypothalamus | 0.33% (2 of 598) |
ileum | 14.29% (20 of 140) |
jejunum | 8.57% (12 of 140) |
kidney | 4.52% (27 of 598) |
large intestine | 5.35% (32 of 598) |
liver | 0.0% |
lower urinary tract | 0.17% (1 of 598) |
lung | 0.33% (2 of 598) |
lymph node | 0.17% (1 of 598) |
mammary gland | 0.0% |
mesenteric adipose tissue | 0.0% |
mesenteric lymph node | 0.31% (1 of 323) |
midbrain | 0.0% |
olfactory lobe | 0.33% (2 of 598) |
ovary | 0.17% (1 of 598) |
oviduct | 0.0% |
pancreas | 0.84% (5 of 598) |
parathyroid gland | 0.17% (1 of 576) |
parotid gland | 0.0% |
penis | 0.0% |
peripheral nervous system | 0.33% (2 of 598) |
peyers patch | 0.0% |
pituitary gland | 0.17% (1 of 598) |
prostate gland | 2.17% (13 of 598) |
quadriceps | 0.0% |
sciatic nerve | 0.0% |
skeletal muscle | 0.0% |
skin | 0.17% (1 of 598) |
small intestine | 5.35% (32 of 598) |
spinal cord | 0.5% (3 of 598) |
spleen | 0.5% (3 of 598) |
stomach | 3.68% (22 of 598) |
stomach pyloric region | 0.0% |
striatum | 0.5% (3 of 598) |
sublingual gland | 0.0% |
submandibular gland | 1.38% (2 of 145) |
testis | 1% (6 of 598) |
thymus | 0.17% (1 of 598) |
thyroid gland | 3.01% (18 of 598) |
tongue | 3.57% (5 of 140) |
trachea | 0.5% (3 of 598) |
trigeminal v nerve | 0.0% |
urinary bladder | 0.0% |
uterus | 0.33% (2 of 598) |
vagina | 0.0% |
vas deferens | 4.56% (18 of 395) |
vascular system | 0.0% |
vesicular gland | 0.0% |
white adipose tissue | 0.0% |
Background staining occurs in wild type mice and embryos at an incidental rate.
Background staining occurs in wild type embryos at a measurable rate.
Anatomy | Background staining in controls(WT) |
---|---|
axial skeleton | 1.56% (1 of 64) |
brain | 1.18% (6 of 510) |
central nervous system ganglion | 1.37% (1 of 73) |
ear | 0.2% (1 of 510) |
embryo | 0.39% (2 of 511) |
eye | 0.2% (1 of 510) |
footplate | 0.2% (1 of 510) |
forebrain | 0.2% (1 of 510) |
forelimb | 0.2% (1 of 510) |
gut | 1.69% (1 of 59) |
handplate | 0.2% (1 of 510) |
head | 0.98% (5 of 510) |
heart | 0.2% (1 of 510) |
hindbrain | 1.18% (6 of 510) |
hindlimb | 0.2% (1 of 510) |
liver | 0.2% (1 of 505) |
lung | 0.2% (1 of 505) |
mandibular process | 0.2% (1 of 510) |
maxillary process | 0.2% (1 of 510) |
midbrain | 0.2% (1 of 510) |
nose | 1.28% (1 of 78) |
oral cavity | 0.2% (1 of 505) |
placenta | 16.67% (7 of 42) |
skeleton | 1.28% (1 of 78) |
skin | 0.2% (1 of 510) |
spinal cord | 1.39% (1 of 72) |
tail | 0.2% (1 of 510) |
tail somite group | 0.2% (1 of 510) |
trachea | 1.69% (1 of 59) |
urinary system | 1.69% (1 of 59) |
Human diseases caused by Fscn1 mutations
The analysis uses data from IMPC, along with published data on other mouse mutants, in comparison to human disease reports in OMIM, Orphanet, and DECIPHER.
Phenotype comparisons summarize the similarity of mouse phenotypes with human disease phenotypes.
The table below shows human diseases predicted to be associated to Fscn1 by phenotypic similarity.
IMPC related publications
The table below lists publications which used either products generated by the IMPC or data produced by the phenotyping efforts of the IMPC. These publications have also been associated to Fscn1.
There are 1 publication which use IMPC produced mice or data.
Title | Journal | IMPC Allele | PubMed ID |
---|---|---|---|
Mouse T cell priming is enhanced by maturation-dependent stiffening of the dendritic cell cortex. | eLife (July 2020) | Fscn1tm1(KOMP)Vlcg | PMC7417170 |
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MGI Allele | Allele Type | Produced |
---|---|---|
Fscn1tm1(KOMP)Vlcg | Reporter-tagged deletion allele (with selection cassette) | Mice, ES Cells |
Fscn1tm1a(EUCOMM)Hmgu | KO first allele (reporter-tagged insertion with conditional potential) | Targeting vectors, ES Cells |
Fscn1tm1.1(KOMP)Vlcg | Reporter-tagged deletion allele (post Cre, with no selection cassette) | Mice, Tissue |
Fscn1tm1e(EUCOMM)Hmgu | Targeted, non-conditional allele | ES Cells |
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